Assessment of Coronary atherosclerosis in patients with familial hypercholesterolemia by coronary computed tomography angiography

Assessment of Coronary atherosclerosis in patients with familial hypercholesterolemia by coronary computed tomography angiography

フォーマット:

論文

責任表示:

Tada, Hayato ; Kawashiri, Masa-aki ; Okada, Hirofumi ; Teramoto, Ryota ; Konno, Tetsuo ; Yoshimuta, Tsuyoshi ; Sakata, Kenji ; Nohara, Atsushi ; Inazu, Akihiro ; Kobayashi, Junji ; Mabuchi, Hiroshi ; Yamagishi, Masakazu ; Hayashi, Kenshi

言語:

英語

出版情報:

Elsevier, 2015-03-15

著者名:

掲載情報:

American Journal of Cardiology

ISSN:

0002-9149

巻:

115

通号:

6

開始ページ:

724

終了ページ:

729

バージョン:

author

概要:

The aims of this study were (1) to determine whether the accumulation of coronary plaque burden assessed with coronary computed tomography angiography (CCTA) can predict future events and (2) to estimate the onset and progression of coronary atherosclerosis in patients with familial hypercholesterolemia (FH). Consecutive 101 Japanese patients with heterozygous FH (men= 52, mean age 56 ± 16years, mean low-density lipoprotein cholesterol 264 ± 58mg/dl) … who underwent 64-detector row CCTA without known coronary artery disease were retrospectively evaluated by assigning a score (0 to 5) to each of 17 coronary artery segments according to the Society of Cardiovascular Computed Tomography guidelines. Those scores were summed and subsequently natural log transformed. The periods to major adverse cardiac events (MACE) were estimated using multivariable Cox proportional hazards models. During the follow-up period (median 941days), 21 MACE had occurred. Receiver operating characteristic curve analyses identified a plaque burden score of 3.35 (raw score 28.5) as the optimal cutoff for predicting a worse prognosis. Multivariate Coxregression analysis identified the presence of a plaque score ≥3.35 as a significant independent predictor of MACE (hazard ratio= 3.65; 95% confidence interval 1.32 to 25.84, p<0.05). The regression equations were Y= 0.68. X- 15.6 (r= 0.54, p <0.05) in male and Y= 0.74. X- 24.8 (r= 0.69, p <0.05) in female patients with heterozygous FH. In conclusion, coronary plaque burden identified in a noninvasive, quantitative manner was significantly associated with future coronary events in Japanese patients with heterozygous FH and that coronary atherosclerosis may start to develop, on average, at age 23 and 34years in male and female patients with heterozygous FH, respectively. 続きを見る

URL:

http://hdl.handle.net/2297/41369

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詳細

受理日:	2015-03-15

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1 論文 A novel type of familial hypercholesterolemia: Double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene Tada, Hayato, Kawashiri, Masa-aki, Ohtani, Rumiko, Noguchi, Tohru, Nakanishi, Chiaki, Konno, Tetsuo, Hayashia, Kenshi, … Elsevier Science Ireland	7 論文 Molecular genetic epidemiology of homozygous familial hypercholesterolemia in the Hokuriku district of Japan Mabuchi, Hiroshi, Nohara, Atsushi, Noguchi, Tohru, Kobayashi, Junji, Kawashiri, Masa-aki, Tada, Hayato, Nakanishi, … Elsevier
2 論文 A novel type of familial hypercholesterolemia: Double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene Tada, Hayato, Kawashiri, Masa-aki, Ohtani, Rumiko, Noguchi, Tohru, Nakanishi, Chiaki, Konno, Tetsuo, Hayashi, Kenshi, … Elsevier	8 論文 Molecular genetic epidemiology of homozygous familial hypercholesterolemia in the Hokuriku district of Japan Mabuchi, Hiroshi, Nohara, Atsushi, Noguchi, Tohru, Kobayashi, Junji, Kawashiri, Masaaki, Tada, Hayato, Nakanishi, … Elsevier
3 論文 A novel type of familial hypercholesterolemia: Double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene Tada, Hayato, Kawashiri, Masa-aki, Ohtani, Rumiko, Noguchi, Tohru, Nakanishi, Chiaki, Konno, Tetsuo, Hayashi, Kenshi, … Elsevier	9 論文 Autosomal Recessive Hypercholesterolemia: A Mild Phenotype of Familial Hypercholesterolemia: Insight from the Kinetic Study using Stable Isotope and Animal … Tada, Hayato, Kawashiri, Masa-aki, Nohara, Atsushi, Inazu, Akihiro, Kobayashi, Junji, Mabuchi, Hiroshi, Yamagishi, … Japan Atherosclerosis Society = 日本動脈硬化学会
4 論文 Changes in lipoprotein lipase and endothelial lipase mass in familial hypercholesterolemia during three-drug lipid-lowering combination therapy. Tada, Hayato, Kobayashi, Junji, Kawashiri, Masa-aki, Miyashita, Kazuya, Nohara, Atsushi, Inazu, Akihiro, Nakajima, … BioMed Central	10 論文 A novel method for determining functional LDL receptor activity in familial hypercholesterolemia: Application of the CD3/CD28 assay in lymphocytes Tada, Hayato, Kawashiri, Masaaki, Noguchi, Tohru, Mori, Mika, Tsuchida, Masayuki, Takata, Mutsuko, Nohara, Atsushi, … Elsevier
5 論文 Lipoprotein(a) in Familial Hypercholesterolemia With Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Gain-of-Function Mutations. Tada, Hayato, Kawashiri, Masa-aki, Yoshida, Taiji, Teramoto, Ryota, Nohara, Atsushi, Konno, Tetsuo, Inazu, Akihiro, … Japanese Circulation Society = 日本循環器学会	11 論文 Novel mutations of cholesteryl ester transfer protein (CETP) gene in Japanese hyperalphalipoproteinemic subjects Ohtani, Rumiko, Inazu, Akihiro, Noji, Yoshihiro, Wakasugi, Takanobu, Miwa, Kenji, Tada, Hayato, Kawashiri, Masa-aki, … Elsevier BV
6 論文 A Rare Coincidence of Sitosterolemia and Familial Mediterranean Fever Identified by Whole Exome Sequencing. Tada, Hayato, Kawashiri, Masa-aki, Okada, Hirofumi, Endo, Saori, Toyoshima, Yuka, Konno, Tetsuo, Nohara, Atsushi, Inazu, … Japan Atherosclerosis Society = 日本動脈硬化学会	12 論文 Identification of a novel missense mutation in the sterol 27-hydroxylase gene in two Japanese patients with cerebrotendinous xanthomatosis. Nozue, Tsuyoshi, Higashikata, Toshinori, Inazu, Akihiro, Kawashiri, Masa-aki, Nohara, Atsushi, Kobayashi, Junji, … Japanese Society of Internal Medicine = 日本内科学会