Liver steatosis is associated with insulin resistance in skeletal muscle rather than in the liver in Japanese patients with non-alcoholic fatty liver disease

フォーマット:

論文

責任表示:

Kato, Ken-ichiro ; Takeshita, Yumie ; Misu, Hirofumi ; Zen, Yoh ; Kaneko, Shuichi ; Takamura, Toshinari

言語:

英語

出版情報:

Blackwell Publishing, 2015-03-01

著者名:

Kato, Ken-ichiro

Takeshita, Yumie

Misu, Hirofumi

Zen, Yoh

Kaneko, Shuichi

Takamura, Toshinari

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掲載情報:

Journal of Diabetes Investigation

ISSN:

2040-1116      

巻:

6

通号:

2

開始ページ:

158

終了ページ:

163

バージョン:

publisher

概要:

Aims/Introduction: To examine the association between liver histological features and organ-specific insulin resistance indices calculated from 75-g oral glucose tolerance test data in patients with non-alcoholic fatty liver disease. Materials and Methods: Liver biopsy specimens were obtained from 72 patients with non-alcoholic fatty liver disease, and were scored for steatosis, grade and stage. Hepatic and skeletal muscle insulin resistance indices (hepatic insulin … resistance index and Matsuda index, respectively) were calculated from 75-g oral glucose tolerance test data, and metabolic clearance rate was measured using the euglycemic hyperinsulinemic clamp method. Results: The degree of hepatic steatosis, and grade and stage of non-alcoholic steatohepatitis were significantly correlated with Matsuda index (steatosis r = -0.45, P < 0.001; grade r = -0.54, P < 0.001; stage r = -0.37, P < 0.01), but not with hepatic insulin resistance index. Multiple regression analyses adjusted for age, sex, body mass index and each histological score showed that the degree of hepatic steatosis (coefficient = -0.22, P < 0.05) and grade (coefficient = -0.40, P < 0.01) were associated with Matsuda index, whereas the association between stage and Matsuda index (coefficient = -0.07, P = 0.593) was no longer significant. A similar trend was observed for the association between steatosis and metabolic clearance rate (coefficient = -0.62, P = 0.059). Conclusions: Liver steatosis is associated with insulin resistance in skeletal muscle rather than in the liver in patients with non-alcoholic fatty liver disease, suggesting a central role of fatty liver in the development of peripheral insulin resistance and the existence of a network between the liver and skeletal muscle. 続きを見る

URL:

http://hdl.handle.net/2297/41400