Inclusion body myositis with granuloma formation in muscle tissue

Inclusion body myositis with granuloma formation in muscle tissue

フォーマット:

論文

責任表示:

Sakai, Kenji ; Ikeda, Yoshihisa ; Ishida, Chiho ; Matsumoto, Yasuko ; Ono, Kenjiro ; Iwasa, Kazuo ; Yamada, Masahito

言語:

英語

出版情報:

Elsevier, 2015-09-01

著者名:

掲載情報:

Neuromuscular Disorders

ISSN:

0960-8966

巻:

25

通号:

9

開始ページ:

706

終了ページ:

712

バージョン:

author

概要:

Inclusion body myositis is a form of inflammatory myopathy. We identified 4 cases of inclusion body myositis showing granuloma formation in muscle tissue and aimed to assess the features of this atypical form of inclusion body myositis. We retrospectively reviewed consecutive patients who satisfied European Neuromuscular Centre IBM Research Diagnostic Criteria 2011. Then, we assessed clinical profiles and pathological findings in patients with inclusion … body myositis with granuloma and compared these findings with those of typical inclusion body myositis without granuloma. We identified 15 patients with inclusion body myositis. Four patients showed granuloma formation in muscle tissue in addition to typical pathological features of inclusion body myositis. Granulomas comprised a mixture of inflammatory cells, such as macrophages, epithelioid histiocytic cells, and lymphocytes. One patient was found to have mediastinal granulomatous lymphadenopathy; however, the evidence in other patients was insufficient for a diagnosis of systemic sarcoidosis. There were no significant differences between groups with and without granuloma regarding clinical manifestations, laboratory findings, response to immunomodulating therapies, or myopathological profiles. We established a new form of inclusion body myositis showing granuloma formation in muscle tissue. Inclusion body myositis and granuloma formation could have identical pathomechanisms concerning dysregulation of autophagy. © 2015 Elsevier B.V.<br />in Press / Embargo Period 12 months 続きを見る

URL:

http://hdl.handle.net/2297/43019

タイトル・著者・出版者が同じ資料

詳細

主題:	Autophagy; Granuloma; Inclusion body myositis; Rimmed vacuole
受理日:	2015-09-01

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