Preparations of melatonin and 1-hydroxymelatonin, and its novel nucleophilic dimerization to (±)-3a,3a'-bispyrrolo[2,3-b]indoles

Preparations of melatonin and 1-hydroxymelatonin, and its novel nucleophilic dimerization to (±)-3a,3a'-bispyrrolo[2,3-b]indoles

フォーマット:

論文

責任表示:

Somei, Masanori ; Oshikiri, Naoki ; Hasegawa, Masakazu ; Yamada, Fumio

言語:

英語

出版情報:

日本複素環化学研究所, 1999-06-01

著者名:

掲載情報:

Heterocycles

巻:

51

通号:

6

開始ページ:

1237

終了ページ:

1242

バージョン:

publisher

概要:

金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />A unique synthetic method for melatonin was established through biologically promising synthetic intermediates. 1-Hydroxymelatonin was prepared as crystals for the first time. It reacted with 85% formic acid to give (±)-3a,3a'-bispyrrolo[2,3-b]indole compound, whose structure was unequivocally determined by X-Ray crystallographic analysis

URL:

http://hdl.handle.net/2297/4353

タイトル・著者・出版者が同じ資料

詳細

主題:	dimerization; melatonin; melatonin derivative
受理日:	1999-06-01

類似資料:

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1 論文 Syntheses of melatonin and its derivatives Somei, Masanori, Fukui, Yoshikazu, Hasegawa, Masakazu, Oshikiri, Naoki, Hayashi, Toshikatsu 日本複素環化学研究所	7 論文 A novel synthetic method of pyrrolo[2,3-b]indoles and its application to the synthesis of (±)-debromoflustramine B1 Somei, Masanori, Yamada, Fumio, Izumi, Tomoyuki, Nakajou, Masahiro 日本複素環化学研究所
2 論文 A novel dimerization of 1-hydroxyindoles Hasegawa, Masakazu, Tabata, Matsuko, Satoh, Keiichi, Yamada, Fumio, Somei, Masanori 日本複素環化学研究所	8 論文 The first preparation of the unstable 1-hydroxy-2,3-dimethylindole, andstructural determination of its air-oxidized product,3-hydroxy-2,3-dimethyl-3H-indole … Yamada, Fumio, Kawanishi, Atsuko, Tomita, Akiko, Somei, Masanori Arkat USA
3 論文 Water-soluble melatonins: Syntheses of melatonins carrying a glycosyl group at the 1-position Iwaki, Takako, Fujita, Yasuaki, Yamada, Fumio, Somei, Masanori 日本複素環化学研究所	9 論文 Synthesis of 3a-(indol-3-yl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole core of leptosins D-F based on nucleophilic substitution reaction on indole nucleus Yamada, Fumio, Goto, Aya, Somei, Masanori 日本複素環化学研究所
4 論文 Nucleophilic substitution reaction of 3-acetyl-1-methoxyindole and its application for the synthesis of novel 2-substituted methyl 2,3-dihydro-1- … Somei, Masanori, Nakajou, Masahiro, Teramoto, Tsuyoshi, Tanimoto, Asuka, Yamada, Fumio 日本複素環化学研究所	10 論文 Nucleophilic substitution reaction in indole chemistry: A synthesis of novel 7β-substituted yohimbine and 4aα-substituted 1,2,3,4-tetrahydro-β-carboline … Yoshino, Katsumasa, Yamada, Fumio, Somei, Masanori Japan Institute of Heterocyclic Chemistry = 日本複素環化学研究所
5 論文 Nucleophilic substitution reactions on indole nucleus: Formation of (3a,8a-cis)-1,2,3,3a,8,8a-hexahydropyrrolo-[2,3-b]indoles having a substituent at the … Yamada, Fumio, Goto, Aya, Hasegawa, Masakazu, Kobayashi, Kensuke, Somei, Masanori, 山田, 文夫, 染井, 正徳 Japan Institute of Heterocyclic Chemistry	11 論文 A novel preparation of 3-hydroxy-3H-indole-3-ethanamines and -3H-indole-3-acetamides having either a 4-morpholinyl or 1-pyrrolidinyl group at the 2-position Hayashi, Toshikatsu, Nakai, Yu-ya, Yamada, Fumio, Somei, Masanori 日本複素環化学研究所
6 論文 Reactions of 1-methoxy-3-(2-nitrovinyl)indole with nucleophiles: An interesting solvent effect and a novel preparation of 3-substituted 1-methoxyindoles Yamada, Koji, Yamada, Fumio, Somei, Masanori 日本複素環化学研究所	12 論文 Nucleophilic substitution reaction in indole chemistry: 1-methoxy-6-nitroindole-3-carbaldehyde as a versatile building block for 2,3,6-trisubstituted indoles Yamada, Koji, Yamada, Fumio, Shiraishi, Takei, Tomioka, Saori, Somei, Masanori The Japan Institute of Heterocyclic Chemistry / Elsevier