Preparation of 7-substituted 4,5-dihydro-7H-pyrano[3,4-c]-isoxazole derivatives

フォーマット:

論文

責任表示:

Yamada, Koji ; Yamada, Fumio ; Somei, Masanori

言語:

英語

出版情報:

日本複素環化学研究所, 2002-03-01

著者名:

• Yamada, Koji
• Yamada, Fumio
• Somei, Masanori

掲載情報:

Heterocycles

巻:

59

通号:

2

開始ページ:

685

終了ページ:

690

バージョン:

publisher

概要:

金沢大学大学院自然科学研究科生理活性物質科学<br />1-Hydroxytryptamine derivatives undergo nucleophilic substitution reaction on the indole nitrogen (Na) as a general reaction by the treatment with acid, providing a novel synthetic method for 1-aryltryptami … nes. Depending on the structures of nucleophiles, 5- and 7-substituted tryptamines can also be produced in addition to the 1-aryltryptamines.<br />An easy approach to 7-substituted 4,5-dihydro-7H-pyrano[3,4-c]-isoxazole derivatives (3a-b and 6a-d) is described by the reaction of 2-aryl substituted 1-nitro-3-oxa-6-heptynes (2, 5a and 5b) with n-BuLi, followed by treatment with acetic anhydride. 続きを見る

URL:

http://hdl.handle.net/2297/4374