Chemokines

フォーマット:

論文

責任表示:

Mukaida, Naofumi

言語:

英語

出版情報:

Elsevier, 2014-12-15

著者名:

Mukaida, Naofumi  

掲載情報:

Reference Module in Biomedical Research

巻:

2014

開始ページ:

1056

バージョン:

author

概要:

Chemokines are a family of structurally related cytokines with four cysteines at their well-conserved positions. Most chemokines are secreted proteins with a molecular weight about 10. kDa and their α helix structure at carboxyl-terminal portion is responsible for preferential binding to proteoglycans on the vascular endothelial cells and to extracellular matrix proteins. Chemokine receptors comprise a large branch of the rhodopsin family of … cell-surface G-protein-coupled receptors with seven-transmembrane domains. Chemokines bind their corresponding receptors, thereby modulating the movement and functions of their target cells, particularly leukocyte trafficking, under physiological and pathological conditions. © 2014 Elsevier Inc. All rights reserved.<br />[Book Chapter] 続きを見る

URL:

http://hdl.handle.net/2297/43880