The acyclic retinoid peretinoin inhibits hepatitis C virus replication and infectious virus release in vitro

フォーマット:

論文

責任表示:

Shimakami, Tetsuro ; Honda, Masao ; Shirasaki, Takayoshi ; Takabatake, Riuta ; Liu, Fanwei ; Murai, Kazuhisa ; Shiomoto, Takayuki ; Funaki, Masaya ; Yamane, Daisuke ; Murakami, Seishi ; Lemon, Stanley M. ; Kaneko, Shuichi

言語:

英語

出版情報:

Nature Publishing Group, 2014-04-15

著者名:

Shimakami, Tetsuro

Honda, Masao

Shirasaki, Takayoshi

Takabatake, Riuta

Liu, Fanwei

Murai, Kazuhisa

Shiomoto, Takayuki

Funaki, Masaya

Yamane, Daisuke

Murakami, Seishi

Lemon, Stanley M.

Kaneko, Shuichi

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掲載情報:

Scientific Reports

ISSN:

2045-2322      

巻:

4

開始ページ:

4688

バージョン:

publisher

概要:

Clinical studies suggest that the oral acyclic retinoid Peretinoin may reduce the recurrence of hepatocellular carcinoma (HCC) following surgical ablation of primary tumours. Since hepatitis C virus (HCV) infection is a major cause of HCC, we assessed whether Peretinoin and other retinoids have any effect on HCV infection. For this purpose, we measured the effects of several retinoids on the replication of genotype 1a, 1b, and 2a HCV in vitro. Peretinoin inhibited RNA … replication for all genotypes and showed the strongest antiviral effect among the retinoids tested. Furthermore, it reduced infectious virus release by 80-90% without affecting virus assembly. These effects could be due to reduced signalling from lipid droplets, triglyceride abundance, and the expression of mature sterol regulatory element-binding protein 1c and fatty acid synthase. These negative effects of Peretinoin on HCV infection may be beneficial in addition to its potential for HCC chemoprevention in HCV-infected patients. 続きを見る

URL:

http://hdl.handle.net/2297/45592