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Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma
- フォーマット:
- 論文
- 責任表示:
- Adachi, Eri ; Sakai, Katsuya ; Nishiuchi, Takumi ; Imamura, Ryu ; Sato, Hiroki ; Matsumoto, Kunio
- 言語:
- 英語
- 出版情報:
- Impact Journals LLC, 2016-01-01
- 著者名:
Adachi, Eri Sakai, Katsuya Nishiuchi, Takumi Imamura, Ryu Sato, Hiroki Matsumoto, Kunio - 掲載情報:
- Oncotarget
- ISSN:
- 1949-2553
- 巻:
- 7
- 通号:
- 43
- 開始ページ:
- 70779
- 終了ページ:
- 70793
- バージョン:
- publisher
- 概要:
- A dynamic phenotypic change contributes to the metastatic progression and drug resistance in malignant melanoma. Nevertheless, mechanisms for a phenotypic change have remained to be addressed. Here, we show that Met receptor expression changes in a cell-autonomous manner and can distinguish phenotypical differences in growth, as well as in metastatic and drug-resistant characteristics. In metastatic melanoma, the cells are composed of Met-low and Met-high populations. … Met-low populations have stem-like gene expression profiles, are resistant to chemotherapeutic agents, and have shown abundant angiogenesis and rapid tumor growth in subcutaneous inoculation. Met-high populations have a differentiated phenotype, are relatively resistant to B-RAF inhibitor, and are highly metastatic to the lungs. Met plays a definitive role in lung metastasis because the lung metastasis of Met-high cells requires Met, and treatment of mice with the Met-containing exosomes from Methigh cells facilitates lung metastasis by Met-low cells. Clonal cell fate analysis showed the hierarchical phenotypical changes from Met-low to Met-high populations. Met-low cells either showed self-renewal or changed into Met-high cells, whereas Met-high cells remained Met-high. Clonal transition from Met-low to Met-high cells accompanied changes in the gene expression profile, in tumor growth, and in metastasis that were similar to those in Met-high cells. These findings indicate that malignant melanoma has the ability to undergo phenotypic change by a cell-intrinsic/autonomous mechanism that can be characterized by Met expression. 続きを見る
- URL:
- http://hdl.handle.net/2297/46523
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