Neurotransmitter release: vacuolar ATPase V0 sector c-subunits in possible gene or cell therapies for Parkinson’s, Alzheimer’s, and psychiatric diseases

フォーマット:

論文

責任表示:

Higashida, Haruhiro ; Yokoyama, Shigeru ; Tsuji, Chiharu ; Muramatsu, Shin-ichi

言語:

英語

出版情報:

日本生理学会 = Physiological Sciences of Japan / Springer Tokyo, 2017-01-01

著者名:

• Higashida, Haruhiro
• Yokoyama, Shigeru
• Tsuji, Chiharu
• Muramatsu, Shin-ichi

掲載情報:

Journal of Physiological Sciences

ISSN:

1880-6546      

巻:

67

通号:

1

開始ページ:

11

終了ページ:

17

バージョン:

author

概要:

We overview the 16-kDa proteolipid mediatophore, the transmembrane c-subunit of the V0 sector of the vacuolar proton ATPase (ATP6V0C) that was shown to mediate the secretion of acetylcholine. Acetylcholine, serotonin, and dopamine (DA) are released from cell soma and/or dendrites if ATP6V0C is expressed in cultured cells. Adeno-associated viral vector-mediated gene transfer of ATP6V0C into the caudate putamen enhanced the depolarization-induced overflow of endogenous DA in … Parkinson-model mice. Motor impairment was ameliorated in hemiparkinsonian model mice when ATP6V0C was expressed with DA-synthesizing enzymes. The review discusses application in the future as a potential tool for gene therapy, cell transplantation therapy, and inducible pluripotent stem cell therapy in neurological diseases, from the view point of recent findings regarding vacuolar ATPase. © 2016, The Physiological Society of Japan and Springer Japan. 続きを見る

URL:

http://hdl.handle.net/2297/46720