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Relationship between advanced glycation end products and plaque progression in patients with acute coronary syndrome: the JAPAN-ACS Sub-study.

フォーマット:
論文
責任表示:
Fukushima, Yoshifumi ; Daida, Hiroyuki ; Morimoto, Takeshi ; Kasai, Takatoshi ; Miyauchi, Katsumi ; Yamagishi, Sho-ichi ; Takeuchi, Masayoshi ; Hiro, Takafumi ; Kimura, Takeshi ; Nakagawa, Yoshihisa ; Yamagishi, Masakazu ; Ozaki, Yukio ; Matsuzaki, Masunori
言語:
英語
出版情報:
BioMed Central, 2013-07-01
著者名:
Fukushima, Yoshifumi
Daida, Hiroyuki
Morimoto, Takeshi
Kasai, Takatoshi
Miyauchi, Katsumi
Yamagishi, Sho-ichi
Takeuchi, Masayoshi
Hiro, Takafumi
Kimura, Takeshi
Nakagawa, Yoshihisa
Yamagishi, Masakazu
Ozaki, Yukio
Matsuzaki, Masunori
続きを見る
掲載情報:
Cardiovascular Diabetology
ISSN:
1475-2840  CiNii Research  Webcat Plus  JAIRO
巻:
12
通号:
1
開始ページ:
5
バージョン:
publisher
概要:
Background: The Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome (JAPAN-ACS) trial demonstrated that early aggressive statin therapy in patients with ACS significantly reduces plaque volume (PV). Advanced glycation end products (AGEs) and the receptors of AGEs (RAGE) may lead to angiopathy in diabetes mellitus (DM) and may affect on the development of coronary PV. The present sub-study of JAPAN-ACS investigates the association between AGEs and RAGE, and PV.Methods: Intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) was undertaken, followed by the initiation of statin treatment (either 4 mg/day of pitavastatin or 20 mg/day of atorvastatin), in patients with ACS. In the 208 JAPAN-ACS subjects, PV using IVUS in non-culprit segment > 5 mm proximal or distal to the culprit lesion and, serum levels of AGEs and soluble RAGE (sRAGE) were measured at baseline and 8-12 months after PCI.Results: At baseline, no differences in the levels of either AGEs or sRAGE were found between patients with DM and those without DM. The levels of AGEs decreased significantly with statin therapy from 8.6 ± 2.2 to 8.0 ± 2.1 U/ml (p < 0.001), whereas the levels of sRAGE did not change. There were no significant correlations between changes in PV and the changes in levels of AGEs as well as sRAGE. However, high baseline AGEs levels were significantly associated with plaque progression (odds ratio, 1.21; 95% confidence interval, 1.01 - 1.48; p = 0.044) even after adjusting for DM in multivariate logistic regression models.Conclusions: High baseline AGEs levels were associated with plaque progression in the JAPAN-ACS trial. This relationship was independent of DM. These findings suggest AGEs may be related to long-term glucose control and other oxidative stresses in ACS.Trial registration: NCT00242944. © 2013 Fukushima et al.; licensee BioMed Central Ltd. 続きを見る
URL:
http://hdl.handle.net/2297/48242
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Fukushima, Yoshifumi, Daida, Hiroyuki, Morimoto, Takeshi, Kasai, Takatoshi, Miyauchi, Katsumi, Yamagishi, Sho-ichi, &hellip;

BioMed Central Ltd.

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