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Effect of rosuvastatin on coronary atheroma in stable coronary artery disease: multicenter coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese subjects (COSMOS).
- フォーマット:
- 論文
- 責任表示:
- Takayama, Tadateru ; Hiro, Takafumi ; Yamagishi, Masakazu ; Daida, Hiroyuki ; Hirayama, Atsushi ; Saito, Satoshi ; Yamaguchi, Tetsu ; Matsuzaki, Masunori ; The COSMOS Investigators ; 山岸, 正和
- 言語:
- 英語
- 出版情報:
- Japanese Circulation Society = 日本循環器学会, 2009-10-23
- 著者名:
Takayama, Tadateru Hiro, Takafumi Yamagishi, Masakazu Daida, Hiroyuki Hirayama, Atsushi Saito, Satoshi Yamaguchi, Tetsu Matsuzaki, Masunori The COSMOS Investigators 山岸, 正和 - 掲載情報:
- Circulation journal
- ISSN:
- 1346-9843
- 巻:
- 73
- 通号:
- 11
- 開始ページ:
- 2110
- 終了ページ:
- 2117
- バージョン:
- publisher
- 概要:
- Background: It has been suggested that intensive lipid-lowering therapy using statins significantly decreases atheromatous plaque volume. The effect of rosuvastatin on plaque volume in patients with stable coronary artery disease (CAD), inc … luding those receiving prior lipid-lowering therapy, was examined in the present study. Methods and Results: A 76-week open-label trial was performed at 37 centers in Japan. Eligible patients began treatment with rosuvastatin 2.5 mg/day, which could be increased at 4-week intervals to ≤20 mg/day. A total of 214 patients underwent intravascular ultrasound (IVUS) at baseline; 126 patients had analyzable IVUS images at the end of the study. The change in the serum low-density lipoprotein-cholesterol level from baseline to end of follow-up was -38.6 ±16.9%, whereas that of high-density lipoprotein-cholesterol was +19.8 ±22.9% (both P<0.0001). Percent change of plaque volume, the primary endpoint, was -5.1 ±14.1% (P<0.0001). Conclusions: Rosuvastatin exerted significant regression of coronary plaque volume in Japanese patients with stable CAD, including those who had previously used other lipid-lowering drugs. Rosuvastatin might be useful in the setting of secondary prevention in patients with stable CAD. (Circ J 2009; 73: 2110-2117)<br />出版者照会後に全文公開 続きを見る
- URL:
- http://hdl.handle.net/2297/48506
類似資料:
Japanese Circulation Society = 日本循環器学会 |
Japan Atherosclerosis Society = 日本動脈硬化学会 |
Japanese Circulation Society = 日本循環器学会 |
Japanese Circulation Society = 日本循環器学会 |
Japanese Circulation Society = 日本循環器学会 | |
Japanese Circulation Society = 日本循環器学会 |
Japanese Circulation Society = 日本循環器学会 |
Japan Atherosclerosis Society = 日本動脈硬化学会 |