Diabetes mellitus is a major negative determinant of coronary plaque regression during statin therapy in patients with acute coronary syndrome: serial intravascular ultrasound observations from the Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome Trial (the JAPAN-ACS Trial).

フォーマット:

論文

責任表示:

Hiro, Takafumi ; Kimura, Takeshi ; Morimoto, Takeshi ; Miyauchi, Katsumi ; Nakagawa, Yoshihisa ; Yamagishi, Masakazu ; Ozaki, Yukio ; Kimura, Kazuo ; Saito, Satoshi ; Yamaguchi, Tetsu ; Daida, Hiroyuki ; Matsuzaki, Masunori ; The JAPAN-ACS Investigators ; 山岸, 正和

言語:

英語

出版情報:

Japanese Circulation Society = 日本循環器学会, 2010-05-12

著者名:

Hiro, Takafumi

Kimura, Takeshi

Morimoto, Takeshi

Miyauchi, Katsumi

Nakagawa, Yoshihisa

Yamagishi, Masakazu

Ozaki, Yukio

Kimura, Kazuo

Saito, Satoshi

Yamaguchi, Tetsu

Daida, Hiroyuki

Matsuzaki, Masunori

The JAPAN-ACS Investigators

山岸, 正和

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掲載情報:

Circulation journal

ISSN:

1346-9843      

巻:

74

通号:

6

開始ページ:

1165

終了ページ:

1174

バージョン:

publisher

概要:

Background: The Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome (JAPAN-ACS) trial has found that early aggressive statin therapy in patients with acute coronary syndrome (ACS) significantly reduces the plaq … ue volume (PV) of non-culprit coronary lesions. The purpose of the present study was to evaluate clinical factors that have an impact on plaque regression using statin therapy. Methods and Results: Serial intravascular ultrasound observations over 8-12 months were performed in 252 ACS patients receiving pitavastatin or atorvastatin. Linear regression analysis identified the presence of diabetes mellitus (DM) and PV at baseline as inhibiting factors, and serum remnant-like particle-cholesterol level at baseline as a significant factor significantly affecting the degree of plaque regression. Significant correlation between % change of PV and low-density lipoprotein cholesterol (LDL-C) level was found in patients with DM (n=73, P<0.05, r=0.4), whereas there was no significant correlation between the 2 parameters in patients without DM (n=178). Conclusions: The regression of coronary plaque induced by statin therapy after ACS was weaker in diabetic patients than their counterparts. Moreover, vigorous reduction of the LDL-C levels might induce a greater degree of plaque regression in ACS patients with DM.  (Circ J 2010; 74: 1165 - 1174)<br />出版者照会後に全文公開 続きを見る

URL:

http://hdl.handle.net/2297/48520