Impact of Total Risk Management on Coronary Plaque Regression in Diabetic Patients with Acute Coronary Syndrome.

フォーマット:

論文

責任表示:

Naito, Ryo ; Miyauchi, Katsumi ; Daida, Hiroyuki ; Morimoto, Takeshi ; Hiro, Takafumi ; Kimura, Takeshi ; Nakagawa, Yoshihisa ; Yamagishi, Masakazu ; Ozaki, Yukio ; Matsuzaki, Masunori ; for the aJAPAN-ACS Investigators ; 山岸, 正和

言語:

英語

出版情報:

Japan Atherosclerosis Society = 日本動脈硬化学会, 2016-08-01

著者名:

Naito, Ryo

Miyauchi, Katsumi

Daida, Hiroyuki

Morimoto, Takeshi

Hiro, Takafumi

Kimura, Takeshi

Nakagawa, Yoshihisa

Yamagishi, Masakazu

Ozaki, Yukio

Matsuzaki, Masunori

for the aJAPAN-ACS Investigators

山岸, 正和

続きを見る

掲載情報:

Journal of Atherosclerosis and Thrombosis

ISSN:

1340-3478      

巻:

23

通号:

8

開始ページ:

922

終了ページ:

931

バージョン:

publisher

概要:

Aim: Diabetic patients with coronary artery disease have a high incidence of cardiovascular events, which was associated with increased coronary plaque volume. Low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) play pivotal … roles in the progression of coronary plaque. Several trials have shown that intervention for a single risk factor reduced the development of coronary plaque progression. However, it remained uncertain whether total risk management for LDL-C, BP, and glycosylated Hb (HbA1c) has a beneficial effect on coronary plaque volume in diabetic patients. Methods: This study was a sub-study of the JAPAN-ACS that was a prospective, randomized, open-label trial that evaluated the impact of intensive lipid-lowering therapy on coronary plaque volume in patients with acute coronary syndrome (ACS). Among a total of 252 patients, 73 diabetic patients were analyzed. We examined the impact of total risk management (LDL-C ＜80 mg/dL, systolic BP ＜130 mmHg, and HbA1c ＜6.5%) on changes in coronary plaque volume. The patients were divided into four groups according to the number of risk factors that achieved the target value. Results: Baseline characteristics were similar among the groups. The degree of coronary plaque regression was greater in patients who achieved total risk management. The number of risk factors that achieved the target level was associated with the extent of the coronary plaque volume reduction in a dose-dependent manner. Conclusion: Total risk management that focused on LDL-C, BP, and HbA1c had a beneficial impact on the coronary plaque regression in diabetic patients with ACS.<br />出版者照会後に全文公開 続きを見る

URL:

http://hdl.handle.net/2297/48529