Cholesterol-years score is associated with development of senile degenerative aortic stenosis in heterozygous familial hypercholesterolemia.

フォーマット:

論文

責任表示:

Nozue, Tsuyoshi ; Kawashiri, Masa-aki ; Higashikata, Toshinori ; Nohara, Atsushi ; Inazu, Akihiro ; Kobayashi, Junji ; Koizumi, Junji ; Yamagishi, Masakazu ; Mabuchi, Hiroshi ; 川尻, 剛照 ; 野原, 淳 ; 稲津, 明広 ; 小林, 淳二 ; 小泉, 順二 ; 山岸, 正和 ; 馬渕, 宏

言語:

英語

出版情報:

Japan Atherosclerosis Society = 日本動脈硬化学会, 2006-12-28

著者名:

Nozue, Tsuyoshi

Kawashiri, Masa-aki

Higashikata, Toshinori

Nohara, Atsushi

Inazu, Akihiro

Kobayashi, Junji

Koizumi, Junji

Yamagishi, Masakazu

Mabuchi, Hiroshi

川尻, 剛照

野原, 淳

稲津, 明広

小林, 淳二

小泉, 順二

山岸, 正和

馬渕, 宏

続きを見る

掲載情報:

Journal of Atherosclerosis and Thrombosis

ISSN:

1340-3478      

巻:

13

通号:

6

開始ページ:

323

終了ページ:

328

バージョン:

publisher

概要:

We retrospectively evaluated the frequency and identified the factors associated with the development of aortic stenosis (AS) in 96 patients with heterozygous familial hypercholesterolemia (FH). The frequency of AS was 31% (4/13) and that o … f critical stenosis was 15% (2/13) in older patients over the age of 70 years. All 4 patients with AS were female aged more than 70 years who were diagnosed with FH when aged more than 60 years. There were no significant differences in conventional coronary risk factors; however, the age at cardiac catheterization, age at diagnosis of FH and the cholesterol-years score (CYS) with AS were significantly higher than those without AS (p=0.006, p=0.017, p=0.021, respectively). In multiple regression analysis, CYS was a significant independent predictor for the development of AS (p=0.037) in 13 older patients over the age of 70 years. These results suggest that physicians should be aware that AS needs attention in older patients with heterozygous FH, especially women who have been diagnosed late in life and those who have been inadequately treated.<br />出版者照会後に全文公開 続きを見る

URL:

http://hdl.handle.net/2297/48551