絶食時のラットを用いたビペリデンの体内動態変動要因の解析

フォーマット:

論文

責任表示:

石崎, 純子 ; 横川, 弘一 ; 中島, 恵美 ; 永野, 耐造 ; 前田, 均 ; 市村, 藤雄

言語:

日本語

出版情報:

日本医療薬学会, 1991-10-01

著者名:

石崎, 純子

横川, 弘一

中島, 恵美

永野, 耐造

前田, 均

市村, 藤雄

続きを見る

掲載情報:

病院薬学

ISSN:

0389-9098      

巻:

17

通号:

5

開始ページ:

322

終了ページ:

329

バージョン:

publisher

概要:

大学院自然科学研究科分子作用学<br />金沢大学医学部付属病院薬剤部<br />金沢大学大学院医学系研究科<br />Analysis of fasting effect on biperiden distribution in rats was examined. The plasma concentration at 24hr after i. v. injection of 3.2 mg/kg varied between 0.4 … ng/ml (10-week-old fasted rats) and 1.4 ng/ml (10-week-old normal rats). The steady state distribution volume of biperiden in the fasted rats was smaller by 2/3 than that in the normal rats. The determined percentage of fat tissue per body weight reduced from 7.6 to 2.35 was caused by fasting. There was a good cerrelation between the steady state distribution volume of biperiden per lean mass body weight and the fat volume per lean mass body weight (r=0.989) in four different groups (10-week-old fasted 4-, 10-, and 50-week-old normal rats). The fat/plasma concentration ratios at 8hr after the i. v. injection varied between 380 (10-week-old normal rats) and 550 (10-week-old fasted rats), whereas the brain/plasma concentration ratios were identical to those at steady state among the two groups. The time courses of biperiden concentration in plasma, brain, and fat were simulated using a physiological pharmacokinetic model. There was reasonable agreement between the model predictions and the observed data, suggesting that the change in the fat volume is a dominant determinant of the distribution volume of biperiden in rats. Changes in fasted tissue and plasma concentrations are discussed in relation to the clinical usefulness of the blood level monitoring. 続きを見る

URL:

http://hdl.handle.net/2297/6255