Metabolic imaging using SPECT

フォーマット:

論文

責任表示:

Taki, Junichi ; Matsunari, Ichiro

言語:

英語

出版情報:

Springer Verlag, 2007-06-01

著者名:

• Taki, Junichi
• Matsunari, Ichiro

掲載情報:

European Journal of Nuclear Medicine and Molecular Imaging

ISSN:

1619-7070      

巻:

34

通号:

1

開始ページ:

S34

終了ページ:

S48

バージョン:

author

概要:

金沢大学医学部附属病院核医学診療科<br />Introduction: In normal condition, the heart obtains more than two-thirds of its energy from the oxidative metabolism of long chain fatty acids, although a wide variety of substrates such as glucose, lactate, ke … tone bodies and amino acids are also utilised. In ischaemic myocardium, on the other hand, oxidative metabolism of free fatty acid is suppressed and anaerobic glucose metabolism plays a major role in residual oxidative metabolism. Therefore, metabolic imaging can be an important technique for the assessment of various cardiac diseases and conditions. Materials and methods: In SPECT, several iodinated fatty acid traces have been introduced and studied. Of these, 123I-labelled 15-(p-iodophenyl)3-R, S-methylpentadecanoic acid (BMIPP) has been the most commonly used tracer in clinical studies, especially in some of the European countries and Japan. Results and discussion: In this review article, several fatty acid tracers for SPECT are characterised, and the mechanism of uptake and clinical utility of BMIPP are discussed in detail. © 2007 Springer-Verlag. 続きを見る

URL:

http://hdl.handle.net/2297/6864