Fibrocytes: A new insight into kidney fibrosis

フォーマット:

論文

責任表示:

Wada, Takashi ; Sakai, Norihiko ; Matsushima, Kouji ; Kaneko, Shuichi

言語:

英語

出版情報:

Nature Publishing Group, 2007-08-01

著者名:

• Wada, Takashi
• Sakai, Norihiko
• Matsushima, Kouji
• Kaneko, Shuichi

掲載情報:

Kidney International

ISSN:

0085-2538      

巻:

72

通号:

3

開始ページ:

269

終了ページ:

273

バージョン:

author

概要:

金沢大学医学部附属病院血液浄化療法部<br />Fibrocytes are supposed to be a circulating connective tissue cell progenitor, which consists of a novel population of peripheral blood cells. This distinct population of blood-borne cells shares markers of leu … kocytes as well as mesenchymal cells. Accumulating evidence indicates that fibrosis is characteristic of progressive chronic kidney diseases of any etiologies, resulting in kidney failure. We have uncovered that CCR7-positive fibrocytes migrate into the kidney in response to secondary lymphoid tissue chemokine (SLC/CCL21) and contribute to kidney fibrosis induced by unilateral ureteral obstruction in mice. In addition, the blockade of CCL21/CCR7 signaling by anti-CCL21 antibodies reduced kidney fibrosis, which was confirmed by a decrease in fibrosis in CCR7-null mice with concomitant reduction in macrophage recruitment along with reduced renal transcripts of monocyte chemoattractant protein-1 (MCP-1/CCL2). These findings suggest that fibrocytes dependent on CCL21/CCR7 signaling pathways contribute to the pathogenesis of kidney fibrosis, thereby providing that regulating fibrocytes may provide a novel therapeutic benefit for kidney fibrosis. © 2007 International Society of Nephrology. 続きを見る

URL:

http://hdl.handle.net/2297/6933