Clinicopathological significance of antinuclear antibodies in non-alcoholic steatohepatitis

Clinicopathological significance of antinuclear antibodies in non-alcoholic steatohepatitis

フォーマット:

論文

責任表示:

Niwa, Hideki ; Sasaki, Motoko ; Haratake, Joji ; Kasai, Takahiko ; Katayanagi, Kazuyoshi ; Kurumaya, Hiroshi ; Matsuda, Shinji ; Minato, Hiroshi ; Zen, Yoh ; Uchiyama, Akio ; Miwa, Atsuo ; Saito, Katsuhiko ; Sudo, Yoshiko ; Nakanuma, Yasuni

言語:

英語

出版情報:

Elsevier, 2007-11-01

著者名:

Katayanagi, Kazuyoshi

掲載情報:

Hepatology Research

ISSN:

1386-6346

巻:

37

通号:

11

開始ページ:

923

終了ページ:

931

バージョン:

author

概要:

金沢大学大学院医学系研究科がん細胞学<br />Aim: Serum antinuclear antibodies (ANA) are occasionally noted in patients with non-alcoholic steatohepatitis (NASH). We examined the significance of ANA in NASH. Methods: We compared clinicopathological featur … es in patients with ANA-positive NASH (n = 35) and ANA-negative NASH (n = 36). Inflammatory cell profiles and the distribution of oxidative stress markers were also examined immunohistochemically. Results: ANA-positive NASH was significantly associated with female gender (P = 0.005), high degree of portal inflammation (P = 0.039), interface activity (P = 0.036) and hepatocellular ballooning (P = 0.0008). In addition, ANA of high titer (320-fold or more) was significantly associated with the histological grade and stage of NASH (P = 0.02). The degree of steatosis wais rather mild in the high-titer ANA group(P = 0.01). The analysis of inflammatory cell profiles revealed that CD3-positive T cells were predominant and plasma cells were rather few in the portal area and hepatic lobules in both ANA-positive and ANA-negative groups. There was no difference in the distribution of oxidative stress markers between ANA-positive and ANA-negative groups. Conclusion: These findings suggest that the presence of ANA may be related to the progression of NASH and that a different type of autoimmune mechanism may be involved in the pathogenesis of NASH with ANA, compared to the pathogenesis of autoimmune hepatitis. © 2007 The Japan Society of Hepatology. 続きを見る

URL:

http://hdl.handle.net/2297/7120

タイトル・著者・出版者が同じ資料

詳細

主題:	Antinuclear antibody; Autoimmunity; Non-alcoholic steatohepatitis; Portal inflammation
受理日:	2007-11-01

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