Lispro is superior to regular insulin in transient intensive insulin therapy in type 2 diabetes

フォーマット:

論文

責任表示:

Murase, Yuko ; Yagi, Kunimasa ; Sugihara, Masako ; Chujo, Daisuke ; Otsuji, Michiko ; Muramoto, Hiroaki ; Mabuchi, Hiroshi

言語:

英語

出版情報:

日本内科学会, 2004-09-01

著者名:

Murase, Yuko

Yagi, Kunimasa

Sugihara, Masako

Chujo, Daisuke

Otsuji, Michiko

Muramoto, Hiroaki

Mabuchi, Hiroshi

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掲載情報:

Internal Medicine

ISSN:

0918-2918      

巻:

43

通号:

9

開始ページ:

779

終了ページ:

786

バージョン:

publisher

概要:

金沢大学大学院医学系研究科　<br />Objective. The optimal approach to relatively recent onset type 2 diabetes patients is still unknown. We speculated that the use of short-acting insulin analogs might be of particular benefit in this context. Patie … nts and Methods. To explore this possibility, we compared the effect on β- and α-cell function of transient intensive insulin therapy using lispro versus human regular insulin in a total of 21 type 2 diabetic patients who were randomly assigned to 14-days intensive insulin therapy consisting of bedtime NPH insulin plus three injections of mealtime lispro (n=11) or regular insulin (n=10). The dosages of both types of insulin were adjusted to attain preprandial glucose levels of <6.1 mmol/l within 1 week with similar rates of glucose decline. An oral glucose tolerance test (OGTT) was performed at day 0 (baseline), 7, and 14; plasma glucose, serum insulin, and plasma glucagon responses over 0-120 minutes were measured, and calculated as the area under the curve (AUC). Results. Lispro led to a significant reduction in glucose-AUC and also an increase in insulin-AUC versus regular insulin on day 7. Glucagon secretion following OGTT was well suppressed with lispro on day 14 compared to regular insulin. Conclusion. Two-week intensive insulin therapy with lispro appeared to be more effective than that with regular insulin in type 2 diabetes in attaining both more rapid β-cell rest and greater suppression of glucagon. These changes may provide significant long-term benefits. 続きを見る

URL:

http://hdl.handle.net/2297/7194