Increased Circulating Matrix Metalloproteinase-2 in Patients with Hypertrophic Cardiomyopathy with Systolic Dysfunction

フォーマット:

論文

責任表示:

Noji, Yoshihiro ; Shimizu, Masami ; Ino, Hidekazu ; Higashikata, Toshinori ; Yamaguchi, Masato ; Nohara, Atsushi ; Horita, Takahiro ; Shimizu, Kuniyoshi ; Ito, Yuji ; Matsuda, Takeshi ; Namura, Masanobu ; Mabuchi, Hiroshi

言語:

英語

出版情報:

日本循環器学会, 2004-04-01

著者名:

Noji, Yoshihiro

Shimizu, Masami

Ino, Hidekazu

Higashikata, Toshinori

Yamaguchi, Masato

Nohara, Atsushi

Horita, Takahiro

Shimizu, Kuniyoshi

Ito, Yuji

Matsuda, Takeshi

Namura, Masanobu

Mabuchi, Hiroshi

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掲載情報:

Circulation Journal

ISSN:

1346-9843      

巻:

68

通号:

4

開始ページ:

355

終了ページ:

360

バージョン:

publisher

概要:

金沢大学大学院医学系研究科　<br />Background: Some patients with hypertrophic cardiomyopathy (HCM) develop left ventricular (LV) wall thinning associated with LV dilatation and systolic dysfunction. Recently, matrix metalloproteinases (MMPs) and ti … ssue inhibitors of MMPs (TIMPS) were reported to be involved in ventricular remodeling, however, little is known about MMPs and TIMPs in patients with HCM. Methods and Results: Enzyme-linked immunoassays were used to measure the plasma concentrations of MMP-2, MMP-3, MMP-9, TIMP-1, and TIMP-2 in 11 patients with HCM accompanied by systolic dysfunction (fractional shortening (FS) <25%, group A), 17 patients with HCM who had preserved systolic function (FS ≥25%, group B), and 50 age-matched clinically healthy control subjects (mean age: 57 years). The concentration of MMP-2 in group A was significantly higher than in group B and the control subjects (1,124±84, 792±49, 809+26 ng/ml, respectively), whereas there was no significant difference between group B and the control subjects. MMP-2 concentrations significantly increased as the New York Heart Association functional class increased in patients with HCM. TIMP-2 was also significantly higher in group A patients than in group B and the control subjects (45.3±4.7, 34.6±2.2, 33.7±1.8 ng/ml, respectively), but there was no difference between group B and control subjects. TIMP-1 was significantly higher in HCM patients than in control subjects. MMP-3 and MMP-9 concentrations did not differ among the 3 groups. Both MMP-2 and TIMP-2 correlated significantly with FS and LV dimension, negatively and positively, respectively. Conclusions: These results suggest that changes in the release and activity of MMP-2 and TIMP-2 may be associated with the mechanisms responsible for cardiac remodeling in patients with HCM. 続きを見る

URL:

http://hdl.handle.net/2297/7196