Gender difference in coronary events in relation to risk factors in Japanese hypercholesterolemic patients treated with low-dose simvastatin

フォーマット:

論文

責任表示:

Sasaki, Jun ; Kita, Toru ; Mabuchi, Hiroshi ; Matsuzaki, Masunori ; Matsuzawa, Yuji ; Nakaya, Noriaki ; Oikawa, Shinichi ; Saito, Yasushi ; Shimamoto, Kazuaki ; Kono, Suminori ; Itakura, Hiroshige

言語:

英語

出版情報:

日本循環器学会, 2006-01-01

著者名:

Sasaki, Jun

Kita, Toru

Mabuchi, Hiroshi

Matsuzaki, Masunori

Matsuzawa, Yuji

Nakaya, Noriaki

Oikawa, Shinichi

Saito, Yasushi

Shimamoto, Kazuaki

Kono, Suminori

Itakura, Hiroshige

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掲載情報:

Circulation Journal

ISSN:

1346-9843      

巻:

70

通号:

7

開始ページ:

810

終了ページ:

814

バージョン:

publisher

概要:

金沢大学大学院医学系研究科　<br />Background: Gender differences between the risk factors for coronary heart disease and coronary events were examined in the Japan Lipid Intervention Trial, a 6-year observational study. Methods and Results Men (12, … 575) and women (27,013) were analyzed for risk of coronary events (acute myocardial infarction and sudden cardiac death). Simvastatin reduced serum low-density lipoprotein cholesterol (LDL-C) by 27% in both genders, and increased serum high-density lipoprotein cholesterol (HDL-C) in men (5%) and women (4%). The incidence of coronary events was lower in women (0.64/1,000 patient-years) than in men (1.57/1,000 patient-years). The risk of coronary events increased by 18% in men and 21% in women with each 10 mg/dl elevation of LDL-C, and decreased by 39% in men and 33% in women with each 10 mg/dl elevation of HDL-C. The risk increased proportionally with aging in women, but not in men. Diabetes mellitus (DM) was more strongly related to the risk of coronary events for women (relative risk 3.07) than for men (relative risk 1.58). Conclusions: The incidence of coronary events is lower in women. Serum LDL-C is related to an increased risk of coronary events to the same extent in both genders. DM seems to be a more important risk factor in women, trading off the lower risk of coronary events among them. 続きを見る

URL:

http://hdl.handle.net/2297/7199