Efficacy of colestimide coadministered with atorvastatin in Japanese patients with heterozygous familial hypercholesterolemia (FH)

Efficacy of colestimide coadministered with atorvastatin in Japanese patients with heterozygous familial hypercholesterolemia (FH)

フォーマット:

論文

責任表示:

Kawashiri, Masaaki ; Higashikata, Toshinori ; Nohara, Atsushi ; Kobayashi, Junji ; Inazu, Akihiro ; Koizumi, Junji ; Mabuchi, Hiroshi

言語:

英語

出版情報:

日本循環器学会, 2005-05-01

著者名:

Kawashiri, Masaaki

Higashikata, Toshinori

掲載情報:

Circulation Journal

ISSN:

1346-9843

巻:

69

通号:

5

開始ページ:

515

終了ページ:

520

バージョン:

publisher

概要:

金沢大学大学院医学系研究科　<br />Background: Colestimide, a 2-methylimidazole-epichlorohydrin polymer, is a new bile-acid-sequestering resin, that is 4-fold as powerful at lowering low-density lipoprotein cholesterol (LDL-C) as the conventional re … sin (cholestyramine). Moreover, colestimide has excellent patient compliance because it is available in tablet form. Methods and Results: The clinical efficacy of colestimide coadministered with atorvastatin on lipid and apolipoprotein concentrations was examined in 15 patients (M/F = 10/5, mean±SE age=54±9 years) with heterozygous familial hypercholesterolemia (FH). After a period of wash-out of any lipid-lowering drugs, atorvastatin (20-40mg) was administered to patients for at least 8 weeks, and then 3 g of colestimide was administered for a further 8 weeks. Total and LDL-C significantly (<0.0001) decreased by 35% from 361 to 233mg/dl and 41% from 274 to 161 mg/dl, respectively. Addition of colestimide caused a further significant 12% and 20% reduction, respectively, from the initial values to 205 and 129 mg/dl, respectively. Colestimide was also effective in reducing serum LDL-C concentrations in heterozygous FH patients with hypertriglyceridemia (triglycerides ≥150mg/dl). Conclusions: When monotherapy with atorvastatin is insufficient to treat severely hypercholesterolemic patients, such as those with heterozygous FH, colestimide acts to reinforce the action of statins. 続きを見る

URL:

http://hdl.handle.net/2297/7212

タイトル・著者・出版者が同じ資料

詳細

主題:	Atorvastatin; Colestimide; Familial hypercholesterolemia
受理日:	2005-05-01

類似資料:

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2 論文 Difference in the risk factors for coronary, renal and other peripheral arteriosclerosis in heterozygous familial hypercholesterolemia Yagi, Kunimasa, Hifumi, Senshu, Nohara, Atsushi, Higashikata, Toshinori, Inazu, Akihiro, Mizuno, Kiyoo, Namura, … 日本循環器学会	8 論文 Marked aortic valve stenosis progression after receiving long-term aggressive cholesterol-lowering therapy using low-density lipoprotein apheresis in a patient … Tsuchida, Masayuki, Kawashiri, Masa-aki, Tada, Hayato, Takata, Mutsuko, Nohara, Atsushi, Ino, Hidekazu, Inazu, Akihiro, … Japanese Circulation Society = 日本循環器学会
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