Prevention of hepatocellular carcinoma development associated with chronic hepatitis by anti-Fas ligand antibody therapy

フォーマット:

論文

責任表示:

Nakamoto, Yasunari ; Kaneko, Shuichi ; Fan, Hong ; Momoi, Takashi ; Tsutsui, Hiroko ; Nakanishi, Kenji ; Kobayashi, Kenichi ; Suda, Takashi

言語:

英語

出版情報:

Rockefeller University Press, 2002-10-21

著者名:

Nakamoto, Yasunari

Kaneko, Shuichi

Fan, Hong

Momoi, Takashi

Tsutsui, Hiroko

Nakanishi, Kenji

Kobayashi, Kenichi

Suda, Takashi

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掲載情報:

Journal of Experimental Medicine

ISSN:

0022-1007      

巻:

96

通号:

8

開始ページ:

1105

終了ページ:

1111

バージョン:

publisher

概要:

金沢大学がん研究所がん病態制御<br />A persistent immune response to hepatitis viruses is a well-recognized risk factor for hepatocellular carcinoma. However, the molecular and cellular basis for the procarcinogenic potential of the immune response i … s not well defined. Here, using a unique animal model of chronic hepatitis that induces hepatocellular carcinogenesis, we demonstrate that neutralization of the activity of Fas ligand prevented hepatocyte apoptosis, proliferation, liver inflammation, and the eventual development of hepatocellular carcinoma. The results indicate that Fas ligand is involved not only in direct hepatocyte killing but also in the process of inflammation and hepatocellular carcinogenesis in chronic hepatitis. This is the first demonstration that amelioration of chronic inflammation by some treatment actually caused reduction of cancer development. 続きを見る

URL:

http://hdl.handle.net/2297/7453