Quinolizidines. XXVII. Racemic and chiral syntheses of the Neisosperma and Ochrosia alkaloid ochropposinine

Quinolizidines. XXVII. Racemic and chiral syntheses of the Neisosperma and Ochrosia alkaloid ochropposinine

フォーマット:

論文

責任表示:

Fujii, Tozo ; Ohba, Masashi ; Tachinami, Tsuyoshi ; Miyajima, Hisae

言語:

英語

出版情報:

日本薬学会, 1990-05-25

著者名:

掲載情報:

Chemical & pharmaceutical bulletin

ISSN:

0009-2363

巻:

38

通号:

5

開始ページ:

1200

終了ページ:

1204

バージョン:

publisher

概要:

The first total synthesis of ochropposinine (1), a Neisosperma and Ochrosia alkaloid, has been accomplished in the form of a racemic modification by means of an initial coupling of the lactim ether (±)-3 with 5 and succeeding steps proceeding through the intermediates (±)-7,(±)-8,(±)-9,(±)-10,and (±)-11. A parallel synthetic route starting with (+)-3 produced the chiral target molecule … (-)-1 via the intermediates (+)-7,(+)-8,(+)-9,10,and (-)-11. As a result, the absolute configuration of ochropposinine has been unequivocally established to be that represented by formula (-)-1. 続きを見る

URL:

http://hdl.handle.net/2297/7593

タイトル・著者・出版者が同じ資料

詳細

主題:	Bischler-Napieralski cyclization; Neisosperma alkaloid; Ochrosia alkaloid; chiral synthesis; hydride reduction; indoloquinolizidine alkaloid synthesis; keto amide cyclization; lactim ether alkylation; ochropposinine; oxazolium salt reduction
受理日:	1990-05-25

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