Lactams. XI. Construction of Lactam Carbonyl Function in 1,3-Disubstituted Piperidines by Mercuric Acetate-EDTA Oxidation : Effects of Carbonyl and Related Groups at the 3-Position

フォーマット:

論文

責任表示:

Fujii, Tozo ; Ohba, Masashi ; Yoshifuji, Shigeyuki

言語:

英語

出版情報:

日本薬学会, 1977-11-25

著者名:

• Fujii, Tozo
• Ohba, Masashi
• Yoshifuji, Shigeyuki

掲載情報:

Chemical & pharmaceutical bulletin

ISSN:

0009-2363      

巻:

25

通号:

11

開始ページ:

3042

終了ページ:

3048

バージョン:

publisher

概要:

1-(3,4-Dimethyoxyphenyl)-2-(3-substituted piperidino) ethanols (3a-d), which carry the carbamoyl, methoxycarbonyl, acetyl, and 1,1-ethylenedioxyethyl group as the 3-substituent in the piperidine ring, have been prepared from 3-substituted pyridines (type 1) through 1-(3,4-dimethoxyphenacyl) pyridinium bromides (type 2). In the mercuric acetate-EDTA oxidation of 3a-d, these 3-substituents have been found to orient the lactam carbonyl formation to the … 6-position almost exclusively. It is suggested that the 3-substituents exert both steric and electronic effects. 続きを見る

URL:

http://hdl.handle.net/2297/7599