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Clinical efficacy and cytokine network-modulating effects of tacrolimus in myasthenia gravis

フォーマット:
論文
責任表示:
Furukawa, Yutaka ; Yoshikawa, Hiroaki ; Iwasa, Kazuo ; Yamada, Masahito
言語:
英語
出版情報:
Elsevier, 2008-03-01
著者名:
掲載情報:
Journal of Neuroimmunology
ISSN:
0165-5728  CiNii Research  Webcat Plus  JAIRO
巻:
195
通号:
1-2
開始ページ:
108
終了ページ:
115
バージョン:
author
概要:
金沢大学保健管理センター<br />115<br />To clarify the long-term efficacy, safety and the cytokine network-modulating effects of tacrolimus in myasthenia gravis, medical records of 86 newly diagnosed consecutive patients and nine steroid-dep … endent patients were retrospectively reviewed, and peripheral blood mononuclear cells (PBMC) were cultured for the cytokine profile. Steroid reduction effects were observed by using tacrolimus, and no serious adverse effects were observed. The culture study showed reduced IL-12, IL-17, IFN-γ, GM-CSF, TNF-α and MIP-1β, and elevated IL-10 in the PBMC from patients who received tacrolimus, which suggests inhibition of T cells and macrophages, and enhancement of type 1 regulatory T cells. © 2008 Elsevier B.V. All rights reserved. 続きを見る
URL:
http://hdl.handle.net/2297/9510
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