Exhaled nitric oxide levels in patients with atopic cough and cough variant asthma

フォーマット:

論文

責任表示:

Fujimura, Masaki ; Ohkura, Noriyuki ; Abo, Miki ; Furusho, Shiho ; Waseda, Yuko ; Ichikawa, Yukari ; Hara, Johsuke

言語:

英語

出版情報:

Blackwell Publishing, 2008-03-01

著者名:

Fujimura, Masaki

Ohkura, Noriyuki

Abo, Miki

Furusho, Shiho

Waseda, Yuko

Ichikawa, Yukari

Hara, Johsuke

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掲載情報:

Respirology

ISSN:

1323-7799      

巻:

13

通号:

3

開始ページ:

359

終了ページ:

364

バージョン:

author

概要:

金沢大学大学院医薬保健研究域医学系<br />Background and objective: Atopic cough (AC) is an established clinical entity in Japan, in which patients present with a chronic persistent non-productive cough. Exhaled nitric oxide (NO) is a biomarker of eosin … ophilic airway inflammation. The present study examined whether exhaled NO levels were increased in AC in comparison with cough variant asthma (CVA) and bronchial asthma (BA). Methods: Consecutive patients presenting with an isolated cough lasting at least 8 weeks were enrolled in the study. The aetiology of the chronic cough was determined according to the Japanese Respiratory Society guidelines for management of cough. Exhaled NO, capsaicin cough sensitivity (capsaicin concentration eliciting five or more coughs (C5)) and bronchial reversibility were measured at the patients' first visit. Bronchial responsiveness (PC20 to methacholine) was measured at their second visit following a 6-day course of bronchodilator therapy. Results: There were 58 patients recruited and fully investigated; of these 9 and 11 patients were diagnosed with AC and CVA, respectively, as single causes of chronic cough. Ten patients with BA who had not received corticosteroid therapy in the previous 4 weeks and who attended the same clinic in the same time period acted as controls. Exhaled NO levels in patients with AC were significantly lower than those in patients with CVA and BA. There was no significant difference in the exhaled NO levels between patients with CVA and BA. Conclusions: Exhaled NO may reflect eosinophilic inflammation of peripheral airways and its measurement may be useful in differentiating CVA from AC and other causes of chronic non-productive cough. © 2008 The Authors. 続きを見る

URL:

http://hdl.handle.net/2297/9771