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| 1.
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Somei, Masanori ; Yamada, Fumio ; Yamazaki, Yoshihisa ; Shinkura, Akiko
概要:
We developed a novel synthesis of 2-aminoindan derivatives, having a 2-methyl-1-propenyl group at the 1-position and oxygen functional groups in the benzene ring, in 8 or 9 steps from vanillin.
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| 2.
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Yamada, Fumio ; Kawanishi, Atsuko ; Tomita, Akiko ; Somei, Masanori
概要:
1-Hydroxy-2,3-dimethylindole (1) has been prepared for the first time. Under atmospheric oxygen, 1 was converted rapidly into 3-hydroxy-2,3-dimethyl- 3H-indole N-oxide (2). The structure was deduced, based on its products obtained
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by the reaction with Ac2O in pyridine and confirmed by X-ray single crystallographic analysis.
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| 3.
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Somei, Masanori ; Hayashi, Hiroyuki ; Ohmoto, Shinobu
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />Indigo was converted to 2,2′-bisindole by the direct reduction with zinc in ace
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tic acid and acetic anhydride under argon or hydrogen atmosphere. Reduction with tin and iron afforded 3-acetoxy-2,2′-bisindole predominantly. Useful building blocks such as 1-acetyl-2,3-dihydro-, 3-acetoxy-3′-acetyl-, and 3-acetoxy-1,3′-diacetyl-2,2′-bisindoles were also produced depending on metal and reaction conditions.
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| 4.
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Somei, Masanori ; Kodama, Atsushi
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部
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| 5.
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Yamada, Koji ; Somei, Masanori
概要:
Photoirradiation of 1-ethoxy-2-phenylindole in methanol and the reaction of 1-hydroxy-2-phenylindole with tosyl chloride
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produced 6-ethoxy- and 6-tosyloxy-2-phenylindoles, respectively, as minor products. The latter was derived to 6-ethoxy-2-phenylindole. The structure is determined by direct comparison of the spectral data with those of the authentic 4-, 5-, 6-, and 7-ethoxy-2-phenylindoles whose syntheses are reported in detail. © 2012 The Japan Institute of Heterocyclic Chemistry.
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| 6.
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Yamada, Fumio ; Fukui, Yoshikazu ; Iwaki, Takako ; Ogasawara, Sachiko ; Okigawa, Masaki ; Tanaka, Satomi ; Somei, Masanori
概要:
A simple and new method for the preparation of optically active methyl 3a-chloro-, 3a-bromo-, 3a-hydroxy-, and 3a-alkoxy
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-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylates has been developed. © 2006 The Japan Institute of Heterocyclic Chemistry All rights reserved.
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| 7.
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Fukui, Yoshikazu ; Somei, Masanori
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />3-Substituted (3S,6S)-6-(1-hydroxyindol-3-ylmethyl)-2,5-piperazinediones are pr
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epared for the first time. They are shown to be suitable intermediates for the synthesis of 3,10b-disubstituted (3S,5aR,10bS,11as)-1,3,4,5a,6,10b,11, 11a-octahydro-2H-pyrazino[1',2': 1,5]pyrrolo[2,3-b]indole-1,4-dione derivatives.
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| 8.
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Somei, Masanori ; Kobayashi, Tetsuya
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部
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| 9.
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Yamada, Fumio ; Goto, Aya ; Hasegawa, Masakazu ; Kobayashi, Kensuke ; Somei, Masanori ; 山田, 文夫 ; 染井, 正徳
概要:
金沢大学医薬保健研究域薬学系<br />Various nucleophiles, such as indole, 1,2,3-trimethoxybenzene, anisole, phenol, and pyrrole, reacted
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with 1-hydroxy-Nb-trifluoroacetyltryptamine under the presence of mesyl chloride to give novel series of (3a,8acis)- 1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indoles having a substituent at the 3aposition. Their structures and by-products were strictly determined. © 2017 The Japan Institute of Heterocyclic Chemistry.<br />Embargo Period 12 months
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| 10.
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Somei, Masanori ; Hayashi, Hiroyuki ; Izumi, Tohru ; Ohmoto, Shinobu
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部
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| 11.
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Yamada, Koji ; Yamada, Fumio ; Shiraishi, Takei ; Tomioka, Saori ; Somei, Masanori
概要:
1-Methoxy-6-nitroindole-3-carbaldehyde is proved to be a versatile electrophile and reacts regioselectively at the 2-pos
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ition with various types of nucleophiles providing 2,3,6-trisubstituted indole derivatives. The reaction is applicable for the preparation of a novel pyrimido[1,2-a]indole derivative. © 2009 The Japan Institute of Heterocyclic Chemistry All rights reserved.
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| 12.
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Yamada, Fumio ; Fukui, Yoshikazu ; Iwaki, Takako ; Ogasawara, Sachiko ; Okigawa, Masaki ; Tanaka, Satomi ; Somei, Masanori
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />A simple and new method for the preparation of optically active methyl 3a-chlor
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o-, 3a-bromo-, 3a-hydroxy-, and 3a-alkoxy-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylates has been developed. © 2006 The Japan Institute of Heterocyclic Chemistry All rights reserved.
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| 13.
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Hayashi, Hiroyuki ; Ohmoto, Shinobu ; Somei, Masanori
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />The first simple total syntheses of 6-cyano-5-methoxy- (1a) and -12-methylindolo[2,3-a]carba
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zolc (1b) are attained from indigo (2) in only five and six steps, respectively. Preparations of 5-hydroxy- (13), 5-bromoindolo[2,3-a]carbazole (14), and a novel spiro compound (7) are also included.
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| 14.
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Kaneko, Chikara ; Fujii, Harue ; Kawai, Shinji ; Hashiba, Kazuhiko ; Karasawa, Yoshio ; Wakai, Masue ; Hayashi, Reiko ; Somei, Masanori
概要:
Irradiation (≥300 nm) of methyl 2-phenyl-3, 1-benzoxazepine-5-carboxylate in an alcohol afforded the Z-isomer of methyl
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3-alkoxy-2-(2-benzamidophenyl)-acrylate as the major addition product. In contrast, thermal reaction of the oxazepine with a primary alcohol in the presence of triethylamine led to the exclusive formation of the corresponding E-isomer. The same kinds of Michael addition products were also obtained stereoselectively from 3, 1-benzoxazepines having an acetyl group at the 5-position under these conditions. The interrelation between the stereoisomers obtained from the oxazepine and an alcohol under these two conditions was established by photochemical equilibration, and the stereochemistry of the two isomers was determined by proton magnetic resonance spectroscopy. An explanation is proposed for the observed stereoselectivities in the two kinds (photochemical and thermal) of reactions.
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| 15.
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Kaneko, Chikara ; Naito, Toshihiko ; Hashiba, Marimi ; Fujii, Harue ; Somei, Masanori
概要:
Two alkaloids, 1-methyl-4-(3-methylbut-2-enyloxy)-2-quinolone (revenine : IIc) and 4-methoxy-1-methyl-2-quinolone (IIa), were synthesized by means of a photochemical rearrangement reaction of the corresponding
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4-alkoxy-2-methylquinoline 1-oxide (Ic and Ia), which were conveniently prepared from 4-chloro-2-methylquinoline 1-oxide (XVII), which in turn is readily obtainable from 2-methylquinoline 1-oxide via the 4-nitrated compound (XVIII). The mechanism of the photo-rearrangement reaction of 4-alkoxy-2-methylquinoline 1-oxides (Ia-d) in methanol is discussed.
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| 16.
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Yamada, Koji ; Tanaka, Yoshio ; Somei, Masanori
概要:
Nb-Acyl- and Nb-acyl-1-hydroxytryptamines are found to be novel and structurally simple (α2-blocker for the treatment of erectile dysfunction. © 2009 The Japan Institute of Heterocyclic Chemistry All rights reserved.
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| 17.
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Hayashi, Hiroyuki ; Suzuki, Yoshiaki ; Somei, Masanori
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />Starting from indigo, simple synthetic methods for 6-cyano-5-methoxy- 12-methyl
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indolo[2,3-a]carbazole and novel 6-aminoindolo[2,3-a]thiazolo-[5,4- c]carbazoles are achieved using only conventional reagents.
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| 18.
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Sato, Masako ; Suzuki, Yoshiaki ; Yamada, Fumio ; Somei, Masanori
概要:
Various derivatives of (6R (*),6aR (*))-6-chloro-6a-hydroxy-5, 6,6a,12-tetrahydroindolo[2,3-a]carbazole-5-one (8) and 6-
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cyano-5- hydroxyindolo[2,3-a]-carbazole (9) are prepared. Preparations of (6R (*),6aR (*),11aR (*))-6-chloro-11a-cyano-6a-hydroxy- (11) and 12-substituted 6-(Z)-aminomethylidene-5,6,6a, 11,11a,12-hexahydroindolo[2,3-a] carbazole-5-ones (15) are also reported. © 2010 The Japan Institute of Heterocyclic Chemistry Received.
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| 19.
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Somei, Masanori ; Yamada, Fumio ; Kato, Jun ; Suzuki, Yoshiaki ; Ueda, Yoshinori
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />Their Diels-Alder reaction produced 11-alkyl-, 11-allyl-, and 11-β-glycosylindo
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lo[2,3-a]carbazoles. Formation of a novel 6,7-dihydro-13H-cyclopentano[mn]indolo[3,2-c]acridine derivative is also reported.
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| 20.
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Iwaki, Takako ; Yamada, Fumio ; Funaki, Shiho ; Somei, Masanori
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />Three methods have been newly developed for the synthesis of 1,2,3,3a,8,8a-hexa
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hydropyrrolo[2,3-b]indoles. Employing them, 3a-chloro-, 3a-bromo-, 3a-hydroxy-, and various 3a-alkoxy-1,2,3,3a,8,8a-hexahydropyrrolo[2, 3-b]indoles are now readily available.
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| 21.
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Somei, Masanori ; Ohnishi, Hiroyuki
概要:
The first synthesis of (±)-paniculidine B is achieved from 2-nitrotoluene in seven steps with an overall yield of 16%.
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| 22.
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Somei, Masanori ; Nakajou, Masahiro ; Teramoto, Tsuyoshi ; Tanimoto, Asuka ; Yamada, Fumio
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />A simple synthetic route was established for 3-acetyl-1-methoxyindole, which wa
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s found to undergo nucleophilic substitution reactions selectively at the 2-position. Applying the reaction, novel 2-substituted methyl 2,3- dihydro-1-methyl-3-oxo-5H-pyrido[4,3-b]indole-4-carboxylates were prepared.
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| 23.
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Chikara, Kaneko ; Momose, Yu ; Maeda, Tsuyoshi ; Naito, Toshihiko ; Somei, Masanori
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部
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| 24.
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Yamada, Koji ; Yamada, Fumio ; Somei, Masanori
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />Nucleophiles react with 1-methoxy-3-(2-nitrovinyl)indole (3) at the 2-position regioselectiv
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ely in a dipolar aprotic solvent (DMF or HMPA), while in THF they undergo Michael addition to the β-carbon of nitrovinyl side chain. Depending on bases employed, the resultant Michael addition products (6d, 10, and 11) are found to undergo interesting cyclizations to give novel 3-substituted 1-methoxyindoles (7, 9, and 12).
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| 25.
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Somei, Masanori ; Noguchi, Koichi ; Yamada, Fumio
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />1-Hydroxyyohimbine was prepared for the first time. Its skeletal rearrangement
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reaction either directly into 2-oxindole or into 3-oxindole derivatives by a series of reaction is reported. 1-Hydroxyyohimbine and some of its derivatives showed potent α2 blocking activity.
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| 26.
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Kawasaki, Toshiya ; Kodama, Atsushi ; Nishida, Tokiko ; Shimizu, Kazuhisa ; Somei, Masanori
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部
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| 27.
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Somei, Masanori ; Matsubara, Mari ; Natsume, Mitsutaka
概要:
Pyridazino[2, 3-a]indole derivatives, such as (3a-c), (5a), (6a), (10), (12a-b), (13), (14), (19), (20), and (21) were prepared from 1-aminoindoles. as-Triazino[1, 6-a]indole derivatives, such as (17) and (18) were also prepared.
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| 28.
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Nakai, Yu-ya ; Goto, Aya ; Yamada, Fumio ; Somei, Masanori
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />Syntheses of N-2-(1-hydroxyindol-3-yl)ethyl-1-hydroxyindole-3-acetamide (3a) an
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d -indole-3-acetamide (4a) are reported. They undergo nucleophilic substitution reaction at the 1-position upon reaction with indole in 85% formic acid to give new type compounds, N-2-[1-(indol-3-yl)indol-3-yl]ethylindole-3-acetamide (13), N-2-(indol-3-yl)ethyl-(14), and N-2-[1-(indol-3-yl)indol-3-yl]ethyl-1-(indol-3-yl)indole-3-acetamide (15).
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| 29.
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Hasegawa, Masakazu ; Nagahama, Yoshiyuki ; Kobayashi, Kensuke ; Hayashi, Masumi ; Somei, Masanori
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />Formations of 6-mesyloxytryptamines and 1-substituted 3a-(4- chlorobutoxy)-1,2,
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3,3a,8,8a-hexahydropyrrolo[2,3-b]indoles were newly found in the reactions of Nb-substituted 1-hydroxytryptamines with mesyl chloride in THF. The latter compounds suggest that the intermediate indol-3-yl cations can trap THF and cleave the ether bond..
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| 30.
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Yamada, Fumio ; Goto, Aya ; Somei, Masanori
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />A simple and convenient synthetic methodology for 3a-(indol-3-yl)- 1,2,3,3a,8,8
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a-hexahydropyrrolo[2,3-b]indole, the core structure of leptosins D-F is developed by applying nucleophilic substitution reaction of 1- hydroxytryptamines.
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| 31.
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Somei, Masanori ; Yamada, Fumio ; Izumi, Tomoyuki ; Nakajou, Masahiro
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />1-Methoxy-3-(2-nitrovinyl)indole (4) functions as an electrophile and reacted w
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ith various nucleophiles regioselectively at the 2-position. Employing allyl alkoxides as nucleophiles, a novel synthetic method of pyrrolo[2,3-b]indoles has been elaborated. Utilizing the method, the synthesis of (±)-debromofIustramine B (10b) was achieved.
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| 32.
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Yamada, Koji ; Izumi, Tomoyuki ; Yamada, Fumio ; Somei, Masanori
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />1-Methoxy-3-(2-nitrovinyl)indole (1a) functions as an electrophile and reacts w
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ith various nucleophiles. In THF, nucleophiles undergo conjugate addition to the β-carbon of the nitroviyyl side chain of 1a, regioselectively. The resultant Michael addition products (4d and 8) cyclize to novel 3-substituted 1-methoxyindoles (5 and 7) depending on reaction conditions and a plausible mechanism is discussed. In dipolar aprotic solvent (DMF), nucleophiles react with 1a at the 2-position predominantly with concomitant liberation of the 1-methoxy group giving 2-substituted indoles. © 2005 The Japan Institute of Heterocyclic Chemistry.
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| 33.
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Yamada, Koji ; Tanaka, Yoshio ; Somei, Masanori
概要:
金沢大学医薬保健研究域薬学系<br />金沢大学名誉教授<br />Nb-Acyl- and Nb-acyl-1-hydroxytryptamines are found to be novel and structurally simpl
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e (α2-blocker for the treatment of erectile dysfunction. © 2009 The Japan Institute of Heterocyclic Chemistry All rights reserved.
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| 34.
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Somei, Masanori ; Yamada, Fumio ; Yamamura, Gaku
概要:
A simple synthetic method for 5H-pyrido[4, 3-b]indole (γ-carboline) derivatives having a methoxycarbonyl group at the 4-
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position was developed based on 1-hydroxyindole chemistry. By applying the method, various 3-substituted metyl 5H-pyrido[4, 3-b]indole-4-carboxylates and 2-substituted methyl 2, 3-dihydro-3-oxo-5H-pyrido[4, 3-b]indole-4-carboxylates were prepared.
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| 35.
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Somei, Masanori ; Kawasaki, Toshiya ; Ohta, Toshiharu
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部
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| 36.
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Somei, Masanori ; Sayama, Shinsuke ; Naka, Katsumi ; Yamada, Fumio
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部
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| 37.
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Somei, Masanori ; Sato, Haruhiko ; Komura, Naoko ; Kaneko, Chikara
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部
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| 38.
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Somei, Masanori ; Funamoto, Tetsuo ; Ohta, Toshiharu
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部
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| 39.
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Somei, Masanori ; Noguchi, Koichi ; Yoshino, Katsumasa ; Mori, Koichiro ; Asada, Mamiko ; Yamada, Fumio ; Tanaka, Yoshio ; Shigenobu, Koki ; Koike, Katsuo
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部
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| 40.
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Somei, Masanori ; Kawasaki, Toshiya
概要:
The first total synthesis of bipolaramide was achieved in 47% overall yield from (2S__-)-2, 3-dihydroindole-2-carboxylic acid in three steps, utilizing thallium chemistry. Some derivatives, with dihalogeno or dialkenyl substituents at the 4
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and 11 positions of (6aS__--cis)-6a, 7, 13a, 14-tetrahydropyrazino[1, 2-a : 4, 5-a']diindole-6, 13-dione have also prepared
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| 41.
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Somei, Masanori ; Iwaki, Takako ; Yamada, Fumio ; Tanaka, Yoshio ; Shigenobu, Koki ; Koike, Katsuo ; Suzuki, Nobuo ; Hattori, Atsuhiko
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />According to the definition of the ideal synthetic method, an example aimed at
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the leads for an α2 blocker, an inhibitor of platelet aggregation, and an anti-osteoporosis agent is established starting from tryptamine. The originality rate, the intellectual property, and the application potential factors of the method are 71, 54, and 100, respectively. The method employs only conventional reagents and reaction conditions without using any protecting groups.{A figure is presented}. © 2006 The Japan Institute of Heterocyclic Chemistry
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| 42.
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Somei, Masanori ; Noguchi, Koichi ; Yamagami, Ryutaro ; Kawada, Yumiko ; Yamada, Koji ; Yamada, Fumio
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />Novel 9-hydroxy-β-carboline derivatives were produced for the first time. A nov
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el rearrangement reaction of 1, 2, 3, 4-tetrahydro-9-hydroxy-β-carbolines was discovered to give 3, 3-disubstituted oxindoles, which was successfully applied to the total synthesis of (±)-coerulescine.
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| 43.
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Somei, Masanori ; Yamada, Fumio ; Suzuki, Yoshiaki ; Ohmoto, Shinobu ; Hayashi, Hiroyuki
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />For evaluating the effectiveness of organic synthesis, both intellectual property factor (IP
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F) and application potential factor (APF) are proposed. As a representative example, a highly effective synthetic method with IPF value of 53.8 and APF value of 100 has been established starting from indigo directing toward an antibiotic, 6-cyano-5-methoxy-12-methylindolo[2,3-a]carbazole, using only conventional reagents without using any protecting groups. © 2004 The Japan Institute of Heterocyclic Chemistry All rights reserved.
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| 44.
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Somei, Masanori ; Oshikiri, Naoki ; Hasegawa, Masakazu ; Yamada, Fumio
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />A unique synthetic method for melatonin was established through biologically pr
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omising synthetic intermediates. 1-Hydroxymelatonin was prepared as crystals for the first time. It reacted with 85% formic acid to give (±)-3a,3a'-bispyrrolo[2,3-b]indole compound, whose structure was unequivocally determined by X-Ray crystallographic analysis
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| 45.
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Somei, Masanori ; Saida, Yoshihiro ; Funamoto, Tetsuo ; Ohta, Toshiharu
概要:
A simple four-step synthetic method for 7-iodo-, 7-bromo-and 7-chloroindole was established with high overall yield starting from 2, 3-dihydroindole. Several 7-substituted indoles carrying a carbon side chain and 7-methoxyindole were also
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synthesized.
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| 46.
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論文
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Somei, Masanori ; Kawasaki, Toshiya
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />The first and simple total synthesis of bipolaramide was achieved in 31 % overa
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ll yield from (2S)-2,3-dihydroindole-2-carboxylic acid in three (or two) steps. Derivatives of bipolaramide having halogen, alkenyl, nitro, or azido substitueras were also prepared.
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| 47.
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論文
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Kaneko, Chikara ; Naito, Toshihiko ; Momose, Yu ; Shimomura, Naoyuki ; Ohashi, Tetsuo ; Somei, Masanori
概要:
Cyclopentane ring annelation methods for 2-pyridone derivatives are provided by cyclobutane ring expansion of 1, 2-dihydrocyclobuta [c] pyridin-3 (4H)-ones having an appropriate function at the l-position. Since the latter compounds are
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readily accessible from 4-alkoxy-2-pyridones via our two-step procedure (Kaneko-Naito method), the methods seem to have wide applicability for the synthesis of cyclopenta [c] pyridines.
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| 48.
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Somei, Masanori ; Karasawa, Yoshio ; Shoda, Toshiya ; Kaneko, Chikara
概要:
A convenient synthesis of 5-substituted isocoumarin derivatives, such as 5-nitroisocoumarin (2), 5-aminoisocoumarin (8), 3, 4-dihydro-3-methoxy-5-nitroisocoumarin (3), and 5-amino-3,
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4-dihydro-3-methoxyisocoumarin (10), from 2-methyl-3-nitrobenzoic acid (1) is reported. Several synthetic routes to methyl indole-4-carboxylate (9) from methyl 2-methyl-3-nitrobenzoate (4) directly or via these isocoumarins (8 and 10) are also presented.
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| 49.
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Yoshino, Katsumasa ; Yamada, Fumio ; Somei, Masanori
概要:
金沢大学医薬保健研究域薬学系<br />金沢大学名誉教授<br />X-Ray analyses of 1-hydroxyyohimbine derivatives clearly show the deviation of the N(1
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)-O bond from the indole molecular plane. This phenomenon supports our working hypothesis "bishomoallylic conjugation". The deviation is responsible for the unprecedented nucleophilic substitution reaction in 1-hydroxyindole chemistry and effected the synthesis of novel 7β-heteroarylyohimbine and 4aα-heteroaryl-1,2,3,4-tetrahydro-β-carboline derivatives from the corresponding 1-hydroxyindole derivatives. © 2008 The Japan Institute of Heterocyclic Chemistry All rights reserved.
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| 50.
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論文
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Yamada, Fumio ; Shinmyo, Daisuke ; Nakajou, Masahiro ; Somei, Masanori
概要:
1-Methoxyindole-3-carbaldehyde is proved to be a versatile electrophile and reacts regioselectively at the 2-position wi
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th various types of nucleophiles providing 2-substituted indole-3-carbaldehydes. © 2012 The Japan Institute of Heterocyclic Chemistry.
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