1.

論文
論文
1. Preparation of 1-hydroxyindole derivatives and a new route to 2-substituted indoles
Kawasaki, Toshiya ; Kodama, Atsushi ; Nishida, Tokiko ; Shimizu, Kazuhisa ; Somei, Masanori
出版情報: Heterocycles.  32  pp.221-227,  1991-01-01.  日本複素環化学研究所
URL: http://hdl.handle.net/2297/4320
概要: 金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部
2.

論文
論文
2. A simple synthesis of 7-substituted 1-acetyl-2,3-dihydroindoles
Somei, Masanori ; Kawasaki, Toshiya ; Ohta, Toshiharu
出版情報: Heterocycles.  27  pp.2363-2365,  1988-01-01.  日本複素環化学研究所
URL: http://hdl.handle.net/2297/4312
概要: 金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部
3.

論文
論文
3. A simple synthesis of the indole alkaloid bipolaramide and its derivatives
Somei, Masanori ; Kawasaki, Toshiya
出版情報: Chemical and Pharmaceutical Bulletin.  37  pp.3426-3428,  1989-01-01.  Pharmaceutical Society of Japan = 日本薬学会
URL: http://hdl.handle.net/2297/43984
概要: The first total synthesis of bipolaramide was achieved in 47% overall yield from (2S__-)-2, 3-dihydroindole-2-carboxylic acid in three steps, utilizing thallium chemistry. Some derivatives, with dihalogeno or dialkenyl substituents at the 4 … and 11 positions of (6aS__--cis)-6a, 7, 13a, 14-tetrahydropyrazino[1, 2-a : 4, 5-a']diindole-6, 13-dione have also prepared 続きを見る
4.

論文
論文
4. The first and simple synthesis of indole alkaloid, bipolaramide
Somei, Masanori ; Kawasaki, Toshiya
出版情報: Heterocycles.  42  pp.281-287,  1996-01-01.  日本複素環化学研究所
URL: http://hdl.handle.net/2297/4339
概要: 金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />The first and simple total synthesis of bipolaramide was achieved in 31 % overa … ll yield from (2S)-2,3-dihydroindole-2-carboxylic acid in three (or two) steps. Derivatives of bipolaramide having halogen, alkenyl, nitro, or azido substitueras were also prepared. 続きを見る
5.

論文
論文
5. The chemistry of 1-hydroxyindoles : syntheses of methyl 1-hydroxyindole-3-acetate, N__-b-acetyl-1- hydroxy-tryptamine, (±)- and (S__-)-1- hydroxytryptophan derivatives
Somei, Masanori ; Kawasaki, Toshiya ; Shimizu, Kazuhisa ; Fukui, Yoshikazu ; Ohta, Toshiharu
出版情報: Chemical and Pharmaceutical Bulletin.  39  pp.1905-1907,  1991-01-01.  Pharmaceutical Society of Japan = 日本薬学会
URL: http://hdl.handle.net/2297/44235
概要: Methyl 1-hydroxyindole-3-acetate, (±)-2-acetoamino-3-(10hydroxyindol-3-yl)propanol, N__-b-acetyl-1-hydroxytryptamine, (± … )- and (S__-)-(+)-N__-b-acetyl-1-hydroxytryptophan methyl ester, which are needed for inspecting our hypothesis regarding the metabolism of tryptophan, were prepared for the first time. The structural proof of (±)-N__-b-acetyl-1-hydroxytryptophan methyl ester by X-ray crysatllographic analysis is also reported. 続きを見る
6.

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論文
6. Nucleophilic substitution reaction of 1-methoxy-6-nitro-indole
Yamada, Koji ; Kawasaki, Toshiya ; Fujita, Tomomi ; Somei, Masanori
出版情報: Heterocycles.  55  pp.1151-1159,  2001-06-01.  日本複素環化学研究所
URL: http://hdl.handle.net/2297/4367
概要: 金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />Nucleophilic substitution reaction of 1-methoxy-6-nitroindole (1) was examined. … In the reaction with sodium methoxide or sodium cyanide as a nucleophile, 2- and 3-methoxy-6-nitroindoles, and 7-cyano-6-nitroindole were obtained, respectively. A novel methylene homologation at the 3-position was found in the reaction of 1 with sodium methyl sulfide or potassium salt of diethyl malonate to give 3-methylthiomethytyl-6-nitroindole and its 2-methylthio derivative, and diethyl 2-(6-nitroindol-3-yl)methylmalonate, respectively. Possible reaction mechanism is discussed. 続きを見る