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| 1.
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論文
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土成, 昭弘 ; 保木井, 利之 ; 下林, 修 ; 金岡, 千嘉男
概要:
In a permeable MgO ceramic containing TiO_2 and Al_2O_3 as matrix MgO ・ Al_2O_3-2MgO・TiO_2 solid solutions were detected
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and no Al_2O_3・TiO_2 was observed. Therefore, the solid state reaction among MgO, TiO_2 and Al_2O_3 with excess MgO was studied at various firing temperatures. The formation mechanism of MgO・Al_2O_3-2MgO・TiO_2 solid solutions was studied from the results of interface reactions between MgO-TiO_2 and MgO-Al_2O_3. MgO・Al_2O_3-2MgO・TiO_2 solid solutions were detected at 1573-1673 K and increased with the firing temperature. 2MgO・TiO_2 was formed in the system MgO-TiO_2, but was not produced in the system MgO-TiO_2-Al_2O_3, because the amount of Mg diffusion at the interface of aggregate and matrix additives was not enough due to the large aggregate size of MgO. MgO・Al_2O_3 and 2MgO・TiO_2 formed at the interface between MgO-TiO_2 and MgO-Al_2O_3 decreased with the firing time at 1873 K. On the other hand, MgO・Al_2O_3-2MgO・TiO_2 solid solutions increased. Mg was recognized in the matrix without addition of MgO as a matrix. Al diffused in the layer of MgO-TiO_2, in opposition Ti diffused in the layer of MgO-Al_2O_3 by EPMA analysis. From the above results, the formation mechanism of a MgO・Al_2O_3-2MgO・TiO_2 solid solution was proposed; (1) Mg diffusion at the interface of MgO aggregate and matrix additives, (2) formation of MgO・TiO_2 and MgO・Al_2O_3, (3) formation of 2MgO・TiO_2 due to the reaction with MgO・TiO_2 and MgO, (4) reaction of the solid solution with MgO・Al_2O_3 and 2MgO・TiO_2. In the reactions between MgO・TiO2 and MgO-Al_2O_3 the product layer of MgO・Al_2O_3-2MgO・TiO_2 solid solution increased as the firing time increased. The diffusion coefficient of Mg was about 4.8×10^<-7>(cm^2/s), in a good agreement with that of Mg which was reported.
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| 2.
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論文
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Somei, Masanori ; Yamada, Fumio ; Yamazaki, Yoshihisa ; Shinkura, Akiko
概要:
We developed a novel synthesis of 2-aminoindan derivatives, having a 2-methyl-1-propenyl group at the 1-position and oxygen functional groups in the benzene ring, in 8 or 9 steps from vanillin.
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| 3.
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Murata, Yasue ; Kinoshita, Hideki ; Inomata, Katsuhiko
概要:
The syntheses of 3,4-disubstituted 2-tosylpyrroles and 5-tosyl-1,5-dihydro-2H-pyrrol-2-ones were accomplished via 3,4-disubstituted 2-iodo-5-tosylpyrroles starting from ethyl 3,4-disubstituted 2-pyrrolecarboxylates.
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| 4.
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Somei, Masanori ; Hayashi, Hiroyuki ; Ohmoto, Shinobu
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />Indigo was converted to 2,2′-bisindole by the direct reduction with zinc in ace
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tic acid and acetic anhydride under argon or hydrogen atmosphere. Reduction with tin and iron afforded 3-acetoxy-2,2′-bisindole predominantly. Useful building blocks such as 1-acetyl-2,3-dihydro-, 3-acetoxy-3′-acetyl-, and 3-acetoxy-1,3′-diacetyl-2,2′-bisindoles were also produced depending on metal and reaction conditions.
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| 5.
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論文
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Suzuki, Masatatsu ; Sugisawa, Toshiharu ; Uehara, Akira
概要:
Two dinuclear cobalt(II,II) complexes, [Co2(tpdp)(CH3COO)](ClO4)2·0.5H2O (1) and [Co2(tmdp)(CH3COO)](ClO4)2·H2O (2), wer
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e prepared, where Htpdp and Htmdp are 1,3-bis[bis(2-pyridylmethyl)amino]-2-propanol and 1,5-bis[bis(2-pyridylmethyl)amino]-3-pentanol respectively. Their electronic spectral and magnetic data revealed that 1 and 2 are five-coordinate in the high-spin state, in the same manner as [Co2(bpmp)(CH3COO)]2+ (3) (Hbpmp=2,6-bis[bis(2-pyridylmethyl)aminomethyl]-4-methylphenol). The complexes reacted with molecular oxygen to form μ-peroxo complexes in dichloromethane and acetonitrile. The oxygen affinity of the complexes decreased in the order of 3>2>1. The relationships between the oxygen affinities and (1) the donor abilities of dinucleating ligands, (2) the energies of the charge-transfer bands (O22− to Co3+) of the μ-peroxo complexes, and (3) the redox potentials of the Co3+–O2−–Co3+/Co3+–O22−–Co3+ couple indicated that a steric effect arising from the dinucleating ligands contributes significantly to the oxygen affinities of the complexes.
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| 6.
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Ikeda, Masazumi ; Ohtani, Shinji ; Okada, Michiyo ; Minakuchi, Emi ; Sato, Tatsunori ; Ishibashi, Hiroyuki
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| 7.
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論文
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Somei, Masanori ; Kodama, Atsushi
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部
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| 8.
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Sumiyoshi, T. ; Kido, H. ; Sakamoto, H. ; Urasaki, K. ; Suzuki, K. ; Yamaguchi, N. ; Mori, Hirofumi ; Shiba, Kazuhiro ; Yokogawa, K. ; 柴, 和弘
概要:
金沢大学疾患モデル総合研究センター<br />An in vivo receptor binding technique was applied to evaluate the affinities of risperidone and h
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aloperidol for dopamine-D2 receptors (D2) and serotonin-5-HT2 receptors (5-HT2) in rat brain with [3H]YM-09151-2 and [3H]ketanserin as selective ligands. Radioactivities were obtained in the striatum, frontal cortex, and cerebellum of the rats treated with the ligands. Time course study of receptor occupancy at 25 to 250 min after single doses of the drugs (1 mg/kg, IP) showed higher 5-HT2 occupancy in the frontal cortex and lower D2 occupancy in the striatum by risperidone than by haloperidol. Dose-response analysis of receptor occupancy revealed risperidone demonstrated higher binding affinity for 5-HT2 than for D2, while the reverse was observed with haloperidol. It appeared that risperidone (1 mg/kg, IP), but not haloperidol (1 mg/kg, IP), demonstrated regional selectivity in D2 occupancy favouring frontal cortex more than the striatum. That risperidone displayed a higher ratio of 5-HT2 to D2 in occupancy than haloperidol is in agreement with the previous findings obtained in vitro. © 1994.
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| 9.
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論文
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Sugimoto, Hideki ; Nagayama, Toshihiko ; Maruyama, Sachihito ; Fujinami, Shuhei ; Yasuda, Yuichi ; Suzuki, Masatatsu ; Uehara, Akira
概要:
A new dinucleating ligand containing a sterically bulky imidazolyl group, Ph-Htidp (N,N,N′,N′-tetrakis[(1-methyl-4,5-dip
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henyl-2-imidazolyl)methyl]-1,3-diamino-2-propanol), and its μ-alkoxo-diiron(II) complexes [Fe2(Ph-tidp)(RCO2)](ClO4)2, (RCO2 = C6H5CO2 (1), C6F5CO2 (2), CF3CO2 (3), and C2H5CO2 (4)), were synthesized. The structure of complex 1 was determined by X-ray crystallography. Complex 1 crystallizes in the monoclinic space group P21/c with a = 13.464(2), b = 19.223(4), c = 31.358(4) Å, β = 92.84(2)°, and Z = 4. The complex has a doubly-bridged structure with μ-alkoxo of Ph-tidp and μ-benzoate; the two iron centers have a distorted five-coordinate structure with N3O2 donor set. All the complexes showed fairly good reversible oxygenation below −30 °C in CH2Cl2, which was monitored by UV-vis and NMR spectroscopies, and dioxygen up-take measurements. Introduction of 4,5-diphenyl substituents into 2-imidazolyl group stabilized the μ-peroxo diiron species against irreversible oxidation, just as introduction of 6-methyl substituent into 2-pyridyl group did. Phenyl substituents appear to weaken the electron donor ability of a dinucleating ligand to stabilize divalent oxidation state of iron and to form a hydrophobic cavity for a O2 binding site, which would suppress the irreversible oxidation and facilitate the reversible oxygenation. Dioxygen affinities of the Ph-tidp and Me4-tpdp diiron(II), and the tpdp and bpmp dicobalt(II) complexes were measured, [Fe2(Me4-tpdp)(RCO2)]2+ (RCO2 = C6H5CO2 and RCO2 = CF3CO2) and [Co2(L)(RCO2)]2+ (L = tpdp, RCO2 = CH3CO2, and L = bpmp, RCO2 = C6F5CO2, and CF3CO2), where Me4-tpdp, tpdp, and bpmp are N,N,N′,N′-tetrakis[(6-methyl-2-pyridyl)methyl]-1,3-diamino-2-propanolate, N,N,N′,N′-tetrakis(2-pyridylmethyl)-1,3-diamino-2-propanolate, and 2,6-bis[bis(2-pyridylmethyl)aminomethyl]-4-methylphenolate, respectively. Within a series of the Ph-tidp diiron(II) complexes, dioxygen affinity is well correlated with electron donor ability of bridging carboxylates (1 (C6H5CO2) > 2 (C6F5CO2) > 3 (CF3CO2)). In contrast to the above trend, dioxygen affinities of the Ph-tidp complexes are lower than those of the Me4-tpdp complexes, although electron donor abilities of the Me4-tpdp complexes are weaker than those of the Ph-tidp complexes. Significant enhancement of dioxygen affinity was observed for both iron and cobalt complexes with 2,6-bis(aminomethyl)phenolate bridging skeleton compared to the complexes with a 1,3-diamino-2-propanolate bridging one. Thermodynamic study suggested that the observed enhancement is mainly attributable to a favorable entropy effect along with a steric effect.
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| 10.
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論文
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Ihara, Yoshinori ; Satake, Yasuhiro ; Fujimoto, Yumi ; Senda, Hitoshi ; Suzuki, Masatatsu ; Uehara, Akira
概要:
The structures of two diaquabis(N,N-dialkylethylenediamine)nickel(II) chlorides ([Ni(H2O)2(diamine)2]Cl2·nH2O) were dete
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rmined by X-ray crystallographic studies, where diamine is N,N-dimethylethylenediamine(NN-dmen) or N,N-diethylethylenediamine (NN-deen). Both complexes are trans and crystallize in the monoclinic space group P21⁄n. The unit cell parameters of the NN-dmen complex, NiCl2C8N4O2H32, are a=7.531(1), b=13.092(1), c=9.591 Å, β=107.76(1)°, and Z=2, and those of the NN-deen complex, NiCl2C12N4O2H36, are a=9.154(1), b=8.692(1), c=12.395(2) Å, β=104.46(1)°, and Z=2. In trans-[Ni(H2O)2(NN-dmen)2]Cl2·2H2O and trans-[Ni(H2O)2(NN-deen)2]Cl2, the Ni–NMe2 and Ni–NEt2 bond distances (2.183 and 2.271 Å) are much longer than the Ni–NH2 distances (2.078 and 2.064 Å), forming tetragonally distorted octahedrons with four close in-plane neighbors(N2O2) and two remote axial ones(N2). It is apparent that this distortion originates from the steric requirement of N-substituted groups. Such a distortion significantly affects the electronic spectra of these complexes.
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| 11.
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図書
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par le Maître indien Candrakīrti ; [traduit par] Cristina Anna Scherrer-Schaub
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| 12.
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図書
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Āryānāgārjunapādaiḥ Rajñe Sātavāhanāya likhitaḥ ; pratisaṃskartā Hindīrūpāntarakāraḥ, sampādakaśca Svāmī Dvārikādāsaśāstrī
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| 13.
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図書
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tasyāḥ Āṅglabhāṣāyā'nuvādakaḥ Sātakarimukharjī ; Hindībhāṣāyā'nuvādakaśca Svāmī Dvārikādāsaśāstrī
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| 14.
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図書
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谷口健英
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| 15.
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論文
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Murahashi, Tsuyoshi ; Kizu, Ryoichi ; Kakimoto, Hitoshi ; Toriba, Akira ; Hayakawa, Kazuichi
概要:
Diesel-engine exhaust and airborne particulates were collected in downtown and suburban areas and five mutagenic nitroarenes (2-nitrofluoranthene (NF), 1-, 2- and 4-nitropyrenes (NPs) and 6-nitrochrysene (NC) in benzene-ethanol extracts
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were determined by high-performance liquid chromatography with chemiluminescence detection. 1- and 4-NPs and 6-NC were found in diesel-engine exhaust particulates, however, 2-NF and 2-NP were not detected. On the other hand, all five nitroarenes were found in airborne particulates. Diurnal concentration patterns of 4-NP and 6-NC in the downtown area were similar to the pattern of 1-NP, but the patterns of 2-NF and 2-NP were different from the pattern of 1-NP. These results strongly suggested that 2-NF and 2-NP are formed in the atmosphere. Of the five nitroarenes, 2-NF had the largest suburban / downtown concentration ratio. 2- and 4-NPs and 6-NC all showed larger ratios than did 1-NP. These results showed that 2-NF and 2-NP were formed in the atmosphere, but that the secondary formation of 4-NP and 6-NC were not known. Taking mutagenic activity and the atmospheric concentration into consideration, the mutagenic contribution of 2-NF was estimated to be comparable with that of 1-NP in the downtown area, and more than that of 1-NP in the suburban area. This result suggested that the mutagenic contribution of the minor nitroarenes formed in urban air might not be negligible.
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| 16.
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図書
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Trautl Brandstaller (Hg.)
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| 17.
その他 |
その他
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金沢大学資料館
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| 18.
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論文
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Ngwe, Hla ; Kinoshita, Hideki ; Inomata, Katsuhiko
概要:
Diethyl 3,4-disubstituted 1,5-dihydro-5-oxo-2H-pyrrol-2-ylphosphonates were regioselectively prepared by acidic hydrolysis of diethyl 3,4-disubstituted 5-bromo-2-pyrrolylphosphonates. The resulting 1,5-dihydro-2H-pyrrol-2-ones
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readily underwent the coupling reaction with various aldehydes to afford the corresponding 1,5-dihydro-5-methylene-2H-pyrrol-2-ones including pyrromethenone derivatives in good yields. A series of these reactions was successfully applied to the synthesis of C/D-rings component of phycocyanobilin.
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| 19.
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論文
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Ihara, Yoshinori ; Sakino, Tomomi ; Ishikawa, Mieko ; Koyata, Takanori
概要:
The solid-phase thermal reactions of trans-diaquabis(diamine)nickel(II) complexes (trans-[Ni(diamine)2(H2O)2]X2) were in
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vestigated by means of TG/DTA and DSC, and high-temperature electronic spectrometry, where the diamine is an optically active diamine such as (1S,2S)-1,2-diphenyl-1,2-ethanediamine or (S)-4-methyl-1,2-pentanediamine, and X is Cl−, Br−, or NO3−. Several complexes were peculiarly transformed into cis-[NiX2(diamine)2] upon thermal deaquation-anation, and then isomerized to trans-[NiX2(diamine)2] upon further heating. The results were in contrast to the reactions of the complexes with the corresponding racemic diamines which underwent a simple deaquation-anation, retaining an original trans configuration. The differences must come from a slight difference in the conformation of diamine ligands between trans-[Ni(R-diamine)(S-diamine)(H2O)2]X2 which is obtained for the rac-diamines and trans-[Ni(R- or S-diamine)2(H2O)2]X2 which is obtained for the optically active diamines.
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| 20.
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論文
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Sumiyoshi, T. ; Kido, H. ; Sakamoto, H. ; Urasaki, K. ; Suzuki, K. ; Yamaguchi, N. ; Mori, Hirofumi ; Shiba, Kazuhiro ; 森, 厚文 ; 柴, 和弘
概要:
金沢大学疾患モデル総合研究センター<br />An in vivo receptor binding technique was applied to evaluate the affinities of clozapine (20 mg/
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kg), RMI-81582 (20 mg/kg), and haloperidol (1 mg/kg) for dopamine D1, D2 and serotonin 5-HT2 receptors in rat brain with [3H]-SCH23390, [3H]-YM-09151-2, and [3H]-ketanserin as selective ligands. The time course study of receptor occupancy at 25 to 250 min after intraperitoneal administration of the drugs showed higher 5-HT2 and lower D2 receptor occupancies of clozapine and RMI-81582 than those of haloperidol both in the striatum and frontal cortex. The 5-HT2/D2 ratios of receptor occupancy for clozapine and RMI-81582 were about 6 to 8 times higher than that for haloperidol. Stable occupancies of D1 receptors were observed only with RMI-81582 and clozapine, the former demonstrating the higher occupancy. These findings are in agreement with the previous findings obtained under in vitro conditions and may account for some part of the properties of atypical antipsychotic drugs. © 1994.
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| 21.
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論文
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Watanabe, Chikara
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| 22.
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図書
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野上彌生子著
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| 23.
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論文
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Kayatani, Takayuki ; Hayashi, Yoshihito ; Suzuki, Masatatsu ; Inomata, Katsuhiko ; Uehara, Akira
概要:
A dicopper(II) complex with a novel unsymmetric dinucleating ligand, H2L-1, which can provide donor atom, coordination n
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umber, and geometric asymmetries at metal centers, [Cu2(L-1)(CH3COO)]ClO4·H2O·0.5NaClO4 (1), was synthesized, where H2L-1 is a racemic 1-bis(2-pyridylmethyl)amino-3-salicylideneaminopropan-2-ol. The ligand is a hybrid one of 1,3-bis[bis(2-pyridylmethyl)amino]propan-2-ol (Htpdp) and 1,3-bis(salicylideneamino)propan-2-ol (H3L-2). Crystal structure of 1 was determined by X-ray crystallography. Complex 1 crystallizes in monoclinic space group C2/c with a = 42.704(8), b = 12.689(6), c = 29.008(9) Å, β = 128.28(1)°, and Z = 16. The crystal structure showed that two stereoisomers (1a and 1b) are present in solid state. This is attributable to the presence of an enantiomeric pair of L-1. Dinuclear cations consist of one square-planar site with a NO3 donor set and one five-coordinate site with a N3O2 donor set, which are linked by an endogenous alkoxide bridge of L-1 and an exogenous acetate bridge. A powdered sample of 1 shows weak antiferromagnetic interaction (2.60 B.M./Cu2 at 300 and 1.81 B.M./Cu2 at 5 K). Cryomagnetic data is analyzed using two exchange coupling constants, J1 = −0.18 cm−1 and J2 = −9.05 cm−1. EHMO calculations revealed that the observed weak antiferromagnetic interaction(s) compared with that found for [Cu2(L-2)(CH3COO)] (3) (J = −85 cm−1) is reasonably interpreted in terms of the energy gap and the nature of HOMO and LUMO. Some other physicochemical properties of the complex are discussed in comparison with those of the parent complexes, [Cu2(tpdp)(CH3COO)]2+ (2) and [Cu2(L-2)(CH3COO)] (3).
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| 24.
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日本銀行審査部編著
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| 25.
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図書
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edited by Előd Knuth, Lutz M. Wegner
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| 26.
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論文
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Ishibashi, Hiroyuki ; Higuchi, Masahiro ; Masuko, Hiromi ; Kodama, Kazuya ; Ikeda, Masazumi
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| 27.
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論文
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Somei, Masanori ; Kobayashi, Tetsuya
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部
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| 28.
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図書
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shu dga pa Ācārya-ṅag-dbaṅ-bsam-gtan ; [Jñānagarbha, lo tsā ba]
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| 29.
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Saaler, Sven
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| 30.
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図書
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edited by Zvi Rappoport and Yitzhak Apeloig
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| 31.
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図書
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by Frank Pierrepont Graves
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| 32.
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論文
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Somei, Masanori ; Hayashi, Hiroyuki ; Izumi, Tohru ; Ohmoto, Shinobu
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部
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| 33.
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論文
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| 34.
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図書
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34. Biochemistry, molecular biology, and physiology of phospholipase A[2] and its regulatory factors
edited by Anil B. Mukherjee
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| 35.
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図書
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edited by Patrick Y.-K. Wong and Edward A. Dennis
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| 36.
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図書
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begründet von Bernhard Wieczorek ; herausgegeben von Rolf A. Schütze
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| 37.
その他 |
その他
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| 38.
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Ialnazov, Dimiter
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| 39.
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図書
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by J. Mansfeld and D.T. Runia
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| 40.
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論文
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Hayashi, Hiroyuki ; Ohmoto, Shinobu ; Somei, Masanori
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />The first simple total syntheses of 6-cyano-5-methoxy- (1a) and -12-methylindolo[2,3-a]carba
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zolc (1b) are attained from indigo (2) in only five and six steps, respectively. Preparations of 5-hydroxy- (13), 5-bromoindolo[2,3-a]carbazole (14), and a novel spiro compound (7) are also included.
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| 41.
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図書
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edited by Saul Patai
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| 42.
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図書
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ouvrage dirigé par Jean Canavaggio, assisté de Bernard Darbord ... [et al.]
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| 43.
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論文
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Kinoshita, Hideki ; Tanaka, Shingo ; Nishimori, Natsu ; Dejima, Hiroshi ; Inomata, Katsuhiko
概要:
2-Hydroxymethyl-1-methylsulfonyl-3,4-disubstituted pyrroles and 2-hydroxymethyl-3,4-disubstituted pyrroles were effectively converted into the corresponding 2-(substituted methyl)pyrrole derivatives by the reaction with
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various nucleophiles in the presence of base. These products were further transformed to the corresponding porphyrins regioselectively under almost neutral or basic conditions.
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| 44.
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図書
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Yuanfang Liu
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| 45.
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図書
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edited by Peter Hamilton
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| 46.
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図書
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von Hartmut Aufderstraße ... [et al.]
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| 47.
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図書
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Wolfgang J. Koschnick
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| 48.
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論文
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Hayashi, Hiroyuki ; Suzuki, Yoshiaki ; Somei, Masanori
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />Starting from indigo, simple synthetic methods for 6-cyano-5-methoxy- 12-methyl
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indolo[2,3-a]carbazole and novel 6-aminoindolo[2,3-a]thiazolo-[5,4- c]carbazoles are achieved using only conventional reagents.
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| 49.
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von Hartmut Aufderstraße ... [et al.]
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| 50.
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von Fritz Peter Knapp
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| 51.
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edited by John Ravenhill
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| 52.
論文 |
論文
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Ihara, Yoshinori ; Satake, Yasuhiro ; Suzuki, Masatatsu ; Uehara, Akira
概要:
The thermochemical changes in coordination structure of diaquabis(N,N- or N,N′,-dialkylethylenediamine)nickel(II) comple
…
xes ([Ni(H2O)2(diamine)2]X2·nH2O) were reinvestigated by means of TG-DTA and electronic spectroscopy at room and elevated temperatures, where diamine is N,N (or N,N′-dimethylethylenediamine (NN- or NN′-dmen) or N,N-(or N,N′)-diethylethylenediamine (NN- or NN′-deen); X is Cl−, Br−, I−, or NO3−; n is 0, 1, 2, or 3. The diaqua complexes prepared were all trans except for cis-[Ni(H2O)2(NN-dmen)2]I2. The trans complexes with the symmetric (N,N′-dialkylsubstituted) diamines brought about a deaquation-anation upon heating, retaining the original trans configuration, while those with the asymmetric (N,N-dialkylsubstituted) diamines transformed into the cis complexes. In the case of the NN-dmen complexes, cis-halogenoaqua species were isolated as a stable intermediate during the thermal reactions. The complex nitrates changed to trans-dinitrato or cis-mononitrato species depending upon the diamines. The effects of the N-substituents in the diamines and of the anions on the patterns of thermal reactions were also discussed.
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| 53.
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post F. Boll et Æ. Boer secundis curis edidit Wolfgang Hübner
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| 54.
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Richard B. Fair, Bohumil Lojek chairs/editors
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| 55.
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山名一郎著
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| 56.
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Aristote, texte établi et traduit par Jean Aubonnet
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| 57.
視聴覚資料 |
ＡＶ
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Haydn
目次情報:
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| 58.
雑誌 |
雑誌
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| 59.
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総務庁統計局編
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| 60.
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総務庁統計局編
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| 61.
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Elaine Kirn, Pamela Hartmann
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| 62.
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editors, Ronald G. Crystal ... [et al.]
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| 63.
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John W. Morgan, Tomasz Mrowka, Daniel Ruberman
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| 64.
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Simmons, Richard VanNess
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| 65.
雑誌 |
雑誌
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| 66.
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論文
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上野, 英雄
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| 67.
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論文
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Hirata, Megumu
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| 68.
論文 |
論文
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Sarre, Friedrich
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| 69.
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Anders Nilsson
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| 70.
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Fredrick de Maré
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| 71.
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総務庁統計局編
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| 72.
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von Hartmut Aufderstraße ... [et al.]
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| 73.
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図書
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Andreas Disse
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| 74.
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edited by Daniel Garber, Michael Ayers, with the assistance of Roger Ariew and Alan Gabbey
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| 75.
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図書
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James Grant
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| 76.
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Thomas Hobbes ; edited by Noel Malcolm
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| 77.
論文 |
論文
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Kasahara, Yoshihito ; Miyawaki, Toshio ; Kato, Kimitaka ; Kanegane, Hirokazu ; Yachie, Akihiro ; Yokoi, Toru ; Taniguchi, Noboru
概要:
金沢大学大学院医学系研究科血管病態制御学<br />The present study was undertaken to elucidate different requirements for CD2-mediated activati
…
on of naive (CD45RO-) and memory (CD45RO+) CD4+ T cells. A mitogenic combination of anti-CD2 (anti-T112 and anti-T113) mAbs could effectively induce the proliferation of memory CD4+ T cells even in the absence of monocytes. In marked contrast, naive CD4+ T cells did not disclose any proliferative responses to antiCD2 mAbs, when monocytes were absent in culture. This differential responsiveness of naive and memory CD4+ T cells appeared to be related largely to a difference in IL-6 - producing ability between both populations. IL-6 among monocyte-derived cytokines could correct unresponsiveness of naive CD4+ T cells to anti-CD2 stimulation. Unlike naive CD4+ T cells, memory CD4+ T cells produced IL-6 by themselves, with its mRNA being expressed on anti-CD2 stimulation. Anti-IL-6R mAb significantly inhibited proliferation of memory CD4+ T cells seen in the anti-CD2-stimulated cultures without monocytes, indicating the involvement of their own production of IL-6 in CD2-mediated activation. The results suggest an essential role of IL-6 for triggering of CD4+ T cells via the CD2 molecule.
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| 78.
論文 |
論文
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Kasahara, Yoshihito ; Miyawaki, Toshio ; Kato, Kimitaka ; Kanegane, Hirokazu ; Yachie, Akihiro ; Yokoi, Tohru ; Taniguchi, Noboru
概要:
The present study was undertaken to elucidate different requirements for CD2-mediated activation of naive (CD45RO-) and memory (CD45RO+) CD4+ T cells. A mitogenic combination of anti-CD2 (anti-T112 and anti-T113) mAbs could
…
effectively induce the proliferation of memory CD4+ T cells even in the absence of monocytes. In marked contrast, naive CD4+ T cells did not disclose any proliferative responses to antiCD2 mAbs, when monocytes were absent in culture. This differential responsiveness of naive and memory CD4+ T cells appeared to be related largely to a difference in IL-6 - producing ability between both populations. IL-6 among monocyte-derived cytokines could correct unresponsiveness of naive CD4+ T cells to anti-CD2 stimulation. Unlike naive CD4+ T cells, memory CD4+ T cells produced IL-6 by themselves, with its mRNA being expressed on anti-CD2 stimulation. Anti-IL-6R mAb significantly inhibited proliferation of memory CD4+ T cells seen in the anti-CD2-stimulated cultures without monocytes, indicating the involvement of their own production of IL-6 in CD2-mediated activation. The results suggest an essential role of IL-6 for triggering of CD4+ T cells via the CD2 molecule.
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| 79.
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総務庁統計局編
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| 80.
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[составитель, автор вводной статьи А.Л. Литвин]
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| 81.
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edited by Carl Dawson and John Pfordresher
目次情報:
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| 82.
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International Commission on Radiological Protection. Committee 2
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| 83.
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edited by Steven L. McKnight, Keith R. Yamamoto
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| 84.
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International Commission on Radiological Protection. Committee 2
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| 85.
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United States. Congress. Senate. Committee on Banking and Currency
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| 86.
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図書
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edited by Georges J.D. Moyal
目次情報:
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| 87.
雑誌 |
雑誌
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| 88.
論文 |
論文
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上田, 正行
概要:
本学文学部・教授
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| 89.
論文 |
論文
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Ito, K. R. ; Tamura, Hiroshi
概要:
We investigate critical temperature of the classical O(N) spin model in two dimensions. We show that if N is large and there is a phase transition in the system, the critical inverse temperature gc obeys the bound gc(N)> const. N log N.
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| 90.
論文 |
論文
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Fujii, Tozo ; Ohba, Masashi
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| 91.
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図書
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Sponsored and co-sponsored by EIC ... [et al.]
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| 92.
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[publié par la Fondation pour le Lexicon Iconographicum Mythologiae Classicae ; rédaction, Hans Christoph Ackermann, Jean-Robert Gisler]
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| 93.
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Massia Kaneman-Pougatch ... [et al.]
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| 94.
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図書
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David L. Spector, Robert D. Goldman, Leslie A. Leinwand
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| 95.
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United States. Supreme Court ; Lawyers' Co-operative Publishing Company
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| 96.
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Society of Powder Technology, Japan
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| 97.
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American Law Institute ; Casner, A. James (Andrew James), 1907-
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| 98.
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図書
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Euler ; translated by John D. Blanton
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| 99.
論文 |
論文
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Somei, Masanori ; Nakajou, Masahiro ; Teramoto, Tsuyoshi ; Tanimoto, Asuka ; Yamada, Fumio
概要:
金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />A simple synthetic route was established for 3-acetyl-1-methoxyindole, which wa
…
s found to undergo nucleophilic substitution reactions selectively at the 2-position. Applying the reaction, novel 2-substituted methyl 2,3- dihydro-1-methyl-3-oxo-5H-pyrido[4,3-b]indole-4-carboxylates were prepared.
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| 100.
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図書
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Helmut Krasser
|
