金沢大学附属図書館 OPAC plus

概要: Transportation has become one of the most significant contributors to CO2 in the world because of its fuel usage. Trees are planted on the roadside to reduce levels of CO2 in the air because trees have the ability to absorb CO2 to be used … in the photosynthesis process. This ability will be maximized if the dispersion of CO2 is concentrated around the tree. However, there are some differing results from previous studies regarding this. Some research results have found trees can increase CO2 concentration and vice versa. Accordingly, this study aims to evaluate the effect of tree planting on the roadside in dispersing CO2 using a real 3D environment. The methods used in this research are CO2 emission analysis to obtain the amount of CO2. Then, Computational Fluid Dynamics (CFD) analysis is used to simulate the dispersion of CO2 in the study area both without trees and with trees. However, due to the mixing of air and CO2, this simulation uses a scalar mixing analysis. Some conditions are considered, such as the characteristics of buildings, the characteristics of trees, and environmental conditions. The result indicates that trees can decrease the velocity and increase the concentration of CO2 on the roadside but decrease CO2 concentration on the road. Tree planting can decrease the velocity by 4.3% in the value range 0.9-1 m/s. This condition increases CO2 concentration on the roadside. Trees can increase CO2 by 25% on the right of a roadside and increase CO2 concentration by 10% on the left side. 続きを見る

概要: 金沢大学ナノ生命科学研究所<br />Agitoxin-2 (AgTx2) from scorpion venom is a potent blocker of K+ channels. The docking model has been … elucidated, but it remains unclear whether binding dynamics are described by a two-state model (AgTx2-bound and AgTx2-unbound) or a more complicated mechanism, such as induced fit or conformational selection. Here, we observed the binding dynamics of AgTx2 to the KcsA channel using high-speed atomic force microscopy. From images of repeated binding and dissociation of AgTx2 to the channel, single-molecule kinetic analyses revealed that the affinity of the channel for AgTx2 increased during persistent binding and decreased during persistent dissociation. We propose a four-state model, including high- and low-affinity states of the channel, with relevant rate constants. An induced-fit pathway was dominant and accelerated binding by 400 times. This is the first analytical imaging of scorpion toxin binding in real time, which is applicable to various biological dynamics including channel ligands, DNA-modifier proteins, and antigen-antibody complexes. 続きを見る

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