1.

図書

図書
出版情報: Paris : A. Colin
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2.

論文

論文
Hoshikawa, Takaya ; Tanji, Kei ; Matsuo, Jun-ichi ; Ishibashi, Hiroyuki
出版情報: Chemical and Pharmaceutical Bulletin.  60  pp.548-553,  2012-04-01.  Pharmaceutical Society of Japan = 日本薬学会
URL: http://hdl.handle.net/2297/31381
概要: Intramolecular [2+2] cycloaddition of γ,δ-unsaturated ketenes derived from hex-5-enoyl chloride derivatives gave bicyclo[2.1.1]hexan-5-ones with complete regioselectivity. © 2012 The Pharmaceutical Society of Japan.
3.

図書

図書
World Congress of Gastroenterology
出版情報: Basel ; New York : S. Karger
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4.

電子ブック

EB
出版情報: 中山書店, 2002.3
オンライン: https://elib.maruzen.co.jp/elib/html/BookDetail/Id/3000001081
5.

論文

論文
土成, 昭弘 ; 保木井, 利之 ; 下林, 修 ; 金岡, 千嘉男
出版情報: Journal of the Ceramic Society of Japan.  100  pp.918-923,  1992-07-01.  The Ceramic Society of Japan
URL: http://hdl.handle.net/2297/24631
概要: In a permeable MgO ceramic containing TiO_2 and Al_2O_3 as matrix MgO ・ Al_2O_3-2MgO・TiO_2 solid solutions were detected and no Al_2O_3・TiO_2 was observed. Therefore, the solid state reaction among MgO, TiO_2 and Al_2O_3 with excess MgO was studied at various firing temperatures. The formation mechanism of MgO・Al_2O_3-2MgO・TiO_2 solid solutions was studied from the results of interface reactions between MgO-TiO_2 and MgO-Al_2O_3. MgO・Al_2O_3-2MgO・TiO_2 solid solutions were detected at 1573-1673 K and increased with the firing temperature. 2MgO・TiO_2 was formed in the system MgO-TiO_2, but was not produced in the system MgO-TiO_2-Al_2O_3, because the amount of Mg diffusion at the interface of aggregate and matrix additives was not enough due to the large aggregate size of MgO. MgO・Al_2O_3 and 2MgO・TiO_2 formed at the interface between MgO-TiO_2 and MgO-Al_2O_3 decreased with the firing time at 1873 K. On the other hand, MgO・Al_2O_3-2MgO・TiO_2 solid solutions increased. Mg was recognized in the matrix without addition of MgO as a matrix. Al diffused in the layer of MgO-TiO_2, in opposition Ti diffused in the layer of MgO-Al_2O_3 by EPMA analysis. From the above results, the formation mechanism of a MgO・Al_2O_3-2MgO・TiO_2 solid solution was proposed; (1) Mg diffusion at the interface of MgO aggregate and matrix additives, (2) formation of MgO・TiO_2 and MgO・Al_2O_3, (3) formation of 2MgO・TiO_2 due to the reaction with MgO・TiO_2 and MgO, (4) reaction of the solid solution with MgO・Al_2O_3 and 2MgO・TiO_2. In the reactions between MgO・TiO2 and MgO-Al_2O_3 the product layer of MgO・Al_2O_3-2MgO・TiO_2 solid solution increased as the firing time increased. The diffusion coefficient of Mg was about 4.8×10^<-7>(cm^2/s), in a good agreement with that of Mg which was reported. 続きを見る
6.

論文

論文
Nishida, Yuki ; Miyamori, Hisashi ; Thompson, Erik W. ; Takino, Takahisa ; Endo, Yoshio ; Sato, Hiroshi
出版情報: Cancer Research.  68  pp.9096-9104,  2008-11-01.  American Association for Cancer Research
URL: http://hdl.handle.net/2297/12472
概要: 金沢大学がん研究所がん病態制御<br />The suggested model for pro-matrix metalloproteinase-2 (proMMP-2) activation by membrane type 1 MMP (MT1-MMP) implicates the complex between MT1-MMP and tissue inhibitor of MMP-2 (TIMP-2) as a receptor for proMMP-2. To dissect this model and assess the pathologic significance of MMP-2 activation, an artificial receptor for proMMP-2 was created by replacing the signal sequence of TIMP-2 with cytoplasmic/transmembrane domain of type II transmembrane mosaic serine protease (MSP-T2). Unlike TIMP-2, MSP-T2 served as a receptor for proMMP-2 without inhibiting MT1-MMP, and generated TIMP-2-free active MMP-2 even at a low level of MT1-MMP. Thus, MSP-T2 did not affect direct cleavage of the substrate testican-1 by MT1-MMP, whereas TIMP-2 inhibited it even at the level that stimulates proMMP-2 processing. Expression of MSP-T2 in HT1080 cells enhanced MMP-2 activation by endogenous MT1-MMP and caused intensive hydrolysis of collagen gel. Expression of MSP-T2 in U87 glioma cells, which express a trace level of endogenous MT1-MMP, induced MMP-2 activation and enhanced cell-associated protease activity, activation of extracellular signal-regulated kinase, and metastatic ability into chick embryonic liver and lung. MT1-MMP can exert both maximum MMP-2 activation and direct cleavage of substrates with MSP-T2, which cannot be achieved with TIMP-2. These results suggest that MMP-2 activation by MT1-MMP potentially amplifies protease activity, and combination with direct cleavage of substrate causes effective tissue degradation and enhances tumor invasion and metastasis, which highlights the complex role of TIMP-2. MSP-T2 is a unique tool to analyze physiologic and pathologic roles of MMP-2 and MT1-MMP in comparison with TIMP-2. ©2008 American Association for Cancer Research.全文公開200911 続きを見る
7.

論文

論文
Somei, Masanori ; Yamada, Fumio ; Yamazaki, Yoshihisa ; Shinkura, Akiko
出版情報: Chemical and Pharmaceutical Bulletin.  44  pp.21-28,  1996-01-01.  Pharmaceutical Society of Japan = 日本薬学会
URL: http://hdl.handle.net/2297/43982
概要: We developed a novel synthesis of 2-aminoindan derivatives, having a 2-methyl-1-propenyl group at the 1-position and oxygen functional groups in the benzene ring, in 8 or 9 steps from vanillin.
8.

論文

論文
Nakamura, Akiko ; Nakajima, Miki ; Higashi, Eriko ; Yamanaka, Hiroyuki ; Yokoi, Tsuyoshi
出版情報: Pharmacogenetics and genomics.  18  pp.709-720,  2008-08-01.  Lippincott, Williams & Wilkins
URL: http://hdl.handle.net/2297/12396
概要: 医薬保健研究域薬学系<br />OBJECTIVES: Human uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7) plays important roles in the metabolism of some clinical drugs, carcinogens, and steroid hormones. The molecular mechanisms of the inducible expression of UGT2B7 in response to xenobiotics have not been fully clarified. We sought to investigate whether the UGT2B7 is under the control of NF-E2 p45-related factor 2 (Nrf2), a key transcriptional factor regulating the expression of cytoprotective enzymes. METHODS: HepG2, HuH7, HLE, and Caco-2 cells were treated with sulforaphane (SFN), and the UGT2B7 mRNA levels were determined by real-time reverse transcriptase PCR. These cells were genotyped for the UGT2B7*2 (H268Y) allele using the PCR-restriction fragment length polymorphism method. Luciferase analyses and gel shift analyses were performed to identify the responsive regions for Nrf2 signaling. RESULTS: The UGT2B7 mRNA was induced by SFN in HepG2 and HuH7 genotyped as UGT2B7*1/*1, but not in HLE and Caco-2 cells genotyped as UGT2B7*2/*2. In HepG2 cells, the UGT2B7 protein level and morphine glucuronosyltransferase activity were also significantly induced by SFN. The induction was prominently decreased with small interfering RNA for Nrf2. In the 5'-flanking region (-2.5 kb) of the UGT2B7*2 allele, a 324-base pair insertion at -2067 and 12 single nucleotide polymorphisms simultaneously existed. Luciferase analyses and gel shift analyses revealed that an antioxidant responsive element at -1170 was responsible for the transactivation by Nrf2. In addition, a region from -990 to -858 on the UGT2B7*1 allele was also responsible for the transactivation by Nrf2. Abrogation of the Nrf2-dependent transactivation of the UGT2B7*2 allele was owing to the single nucleotide polymorphism -900A>G. CONCLUSION: UGT2B7 is transcriptionally regulated by Nrf2, but the mechanism is hindered by polymorphisms in the promoter region of UGT2B7*2. The allele-specific mechanism may cause variability of the glucuronidation in response to oxidative stress.全文公開200908 続きを見る
9.

図書

図書
出版情報: Durham, N.C. : Duke University Press
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10.

電子ブック

EB
出版情報: メディカ出版
オンライン: https://elib.maruzen.co.jp/elib/html/BookDetail/Id/3000072329
11.

電子ブック

EB
出版情報: メディカ出版
オンライン: https://elib.maruzen.co.jp/elib/html/BookDetail/Id/3000011933
12.

図書

図書
edited with translation and explanatory notes by S.D. Joshi and J.A.F. Roodbergen
出版情報: Poona : University of Poona, 1973
シリーズ名: Publications of the Centre of Advanced Study in Sanskrit ; class C ; no. 7
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13.

論文

論文
Yamada, Fumio ; Kawanishi, Atsuko ; Tomita, Akiko ; Somei, Masanori
出版情報: Arkivoc.  2003  pp.102-111,  2003-01-01.  Arkat USA
URL: http://hdl.handle.net/2297/19723
概要: 1-Hydroxy-2,3-dimethylindole (1) has been prepared for the first time. Under atmospheric oxygen, 1 was converted rapidly into 3-hydroxy-2,3-dimethyl- 3H-indole N-oxide (2). The structure was deduced, based on its products obtained by the reaction with Ac2O in pyridine and confirmed by X-ray single crystallographic analysis. 続きを見る
14.

論文

論文
Nakano, Takeo ; Soeta, Takahiro ; Endo, Kohei ; Inomata, Katsuhiko ; Ukaji, Yutaka
出版情報: Journal of Organic Chemistry.  78  pp.12654-12661,  2013-12-20.  American Chemical Society
URL: http://hdl.handle.net/2297/36468
概要: The sequential 1,4-elimination reaction of (E)-4-alkoxy-2-butenyl benzoates and [1,2]-Wittig rearrangement gave (2Z,4E)- 2,4-pentadien-1-ols stereoselectively. Z-Selective formation of intermediary vinyl ethers, whose stereochemistry was well elucidated by the "syn-effect", was achieved by treatment of the 2-butenyl benzoates with KOH in the presence of Pd catalyst. The subsequent [1,2]-Wittg rearrangement by use of n-BuLi proceeded with retention of the stereochemistry of the intermediary vinyl ethers. © 2013 American Chemical Society. 続きを見る
15.

図書

図書
出版情報: 東京 : オーム社
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16.

視聴覚資料

AV
出版情報: [New York] : RCA , Tokyo : BMG Victor [distributor]
所蔵情報: loading…
17.

図書

図書
出版情報: [東京] : 翔泳社
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18.

論文

論文
Murata, Yasue ; Kinoshita, Hideki ; Inomata, Katsuhiko
出版情報: Bulletin of the Chemical Society of Japan.  69  pp.3339-3344,  1996-01-01.  The Chemical Society of Japan = 日本化学会
URL: http://hdl.handle.net/2297/38263
概要: The syntheses of 3,4-disubstituted 2-tosylpyrroles and 5-tosyl-1,5-dihydro-2H-pyrrol-2-ones were accomplished via 3,4-disubstituted 2-iodo-5-tosylpyrroles starting from ethyl 3,4-disubstituted 2-pyrrolecarboxylates.
19.

電子ブック

EB
Dickens, Brian.
出版情報: Gaithersburg, MD
オンライン: ジャーナル/ブックへリンク
20.

論文

論文
Higuchi, Akihiro ; Erina Oonishi ; Kawakita, Tetsuya ; Tsubota, Kazuo ; 樋口, 明弘
出版情報: Molecular Vision.  22  pp.446-453,  2016-04-30.  Molecular Vision
URL: http://hdl.handle.net/2297/00062813
概要: 金沢大学先端科学・社会共創推進機構<br />Purpose: 2-hydroxy estradiol (2-OHE2) is a catechol derivative of 17β -Estradiol (E2) and it is s ynthesized from E2 catalyzed by cytochrome P4501A1. Previous studies reported that 2-OHE2 is a physiologic antioxidant in lipoproteins, liver microsomes, and the brain. Catechol derivatives show an anti-inflammatory effect through the inhibition of prostaglandin endoperoxide synthase (PGS) activity. Corneal erosion caused by dry eye is related to an increase in oxidative stress and inflammation in ocular surface cells. We investigated the therapeutic effects of 2-OHE2 on corneal damage caused by dry eye. Methods: Steroidal radical scavenging activity was confirmed through the electron spin resonance (ESR) method. PGS activity was measured using the COX Fluorescent Activity Assay Kit. To evaluate the effect of 2-OHE2 on the treatment for dry eye, 2-OHE2 was applied as an eye drop experiment using dry eye model rats. Results: 2-OHE2 scavenged tyrosyl radical and possibly suppressed oxidative stress in corneal epithelial cells. In addition, 2-OHE2 inhibited PGS activity, and 2-OHE2 is probably a competitive inhibitor of PGS. Corneal PGS activity was upregulated in the dry eye group. Therefore, 2-OHE2 eye drops improved corneal erosion in dry eye model rats. Conclusions: 2-OHE2 is a candidate for the treatment of dry eye through the suppression of inflammation and oxidative stress in the cornea. © 2016 Molecular Vision. 続きを見る
21.

論文

論文
Somei, Masanori ; Hayashi, Hiroyuki ; Ohmoto, Shinobu
出版情報: Heterocycles.  44  pp.169-176,  1997-01-01.  日本複素環化学研究所
URL: http://hdl.handle.net/2297/4341
概要: 金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />Indigo was converted to 2,2′-bisindole by the direct reduction with zinc in ace tic acid and acetic anhydride under argon or hydrogen atmosphere. Reduction with tin and iron afforded 3-acetoxy-2,2′-bisindole predominantly. Useful building blocks such as 1-acetyl-2,3-dihydro-, 3-acetoxy-3′-acetyl-, and 3-acetoxy-1,3′-diacetyl-2,2′-bisindoles were also produced depending on metal and reaction conditions. 続きを見る
22.

図書

図書
Dubuisson, Bernard
出版情報: Paris : Hermes Science
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23.

図書

図書
出版情報: 東京 : 講談社
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24.

図書

図書
出版情報: London : W. Collins
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25.

図書

図書
von Gerhard Timpe
出版情報: Berlin : Duncker & Humblot, c1983
シリーズ名: Strafrechtliche Abhandlungen ; n.F., Bd. 50
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26.

図書

図書
hrsg. von Karl-Heinz Fingerhut, Eduard Haueis und Otfried Hoppe
出版情報: Stuttgart : Metzler
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27.

図書

図書
Federation of European Biochemical Societies
出版情報: Oxford ; New York : Pergamon Press
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28.

論文

論文
Nakata, Shunji ; Kato, Takashi ; Ozaki, Shinya ; Kawae, Takeshi ; Morimoto, Akiharu
出版情報: Thin Solid Films.  542  pp.242-245,  2013-09-02.  Elsevier B.V.
URL: http://hdl.handle.net/2297/35657
概要: Thin film Al2O3/Al-rich Al2O 3/SiO2 structures were fabricated on p-Si substrates. Radio-frequency magnetron co-sputteri ng was used to form Al-rich Al 2O3 thin film as the charge-trapping layer of nonvolatile Al2O3 memory. Capacitance-voltage measurements showed a large hysteresis due to charge trapping in the Al-rich Al2O 3 layer. The charge trap density was estimated to be 42.7 × 1018 cm- 3, which is the largest value ever reported for an Al-rich Al2O3 layer; it is six times larger than that of a conventional metal-nitride-oxide-silicon memory. Thermal annealing was found to reduce the leakage current of the Al2O3 blocking layer, thereby providing this structure with better data retention at room temperature than an as-deposited one. In addition, the annealed structure was found to exhibit good data retention even at 100 C. © 2013 Elsevier B.V. All rights reserved. 続きを見る
29.

図書

図書
Deutsche Chemische Gesellschaft ; Beilstein, Friedrich Konrad, 1838-1906 ; Richter, Friedrich, 1896-1961
出版情報: Berlin : Springer, 1941-1957
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30.

論文

論文
Suzuki, Masatatsu ; Sugisawa, Toshiharu ; Uehara, Akira
出版情報: Bulletin of the Chemical Society of Japan.  63  pp.1115-1120,  1990-01-01.  The Chemical Society of Japan = 日本化学会
URL: http://hdl.handle.net/2297/38282
概要: Two dinuclear cobalt(II,II) complexes, [Co2(tpdp)(CH3COO)](ClO4)2·0.5H2O (1) and [Co2(tmdp)(CH3COO)](ClO4)2·H2O (2), wer e prepared, where Htpdp and Htmdp are 1,3-bis[bis(2-pyridylmethyl)amino]-2-propanol and 1,5-bis[bis(2-pyridylmethyl)amino]-3-pentanol respectively. Their electronic spectral and magnetic data revealed that 1 and 2 are five-coordinate in the high-spin state, in the same manner as [Co2(bpmp)(CH3COO)]2+ (3) (Hbpmp=2,6-bis[bis(2-pyridylmethyl)aminomethyl]-4-methylphenol). The complexes reacted with molecular oxygen to form μ-peroxo complexes in dichloromethane and acetonitrile. The oxygen affinity of the complexes decreased in the order of 3>2>1. The relationships between the oxygen affinities and (1) the donor abilities of dinucleating ligands, (2) the energies of the charge-transfer bands (O22− to Co3+) of the μ-peroxo complexes, and (3) the redox potentials of the Co3+–O2−–Co3+/Co3+–O22−–Co3+ couple indicated that a steric effect arising from the dinucleating ligands contributes significantly to the oxygen affinities of the complexes. 続きを見る
31.

論文

論文
Inami, Shinnosuke ; Nishio, Masaki ; Hayashi, Yoshihito ; Isobe, Kiyoshi ; Kameda, Hiroyuki ; Shimoda, Tatsuya
出版情報: European Journal of Inorganic Chemistry.  pp.5253-5258,  2009-11-26.  Wiley-Blackwell
URL: http://hdl.handle.net/2297/20361
概要: 金沢大学理工研究域物質化学系<br />An all-inorganic complex, [Mn2{(CVO3) 5}2]6- (1), was synthesized, and the structure determination r eveals a dinuclear manganese complex coordinated by two cyclic pentavanadate ligands. The cyclic pentavanadate units sandwich the edge-sharing octahedral dimanganese core through, coordination of the oxido group of the pentavanadate. A. dinuclear cobalt complex with, a cyclic decavanadate, [Co 2(OH2)2(VO3)10]6- (2), was also synthesized. The structure analysis reveals a dinuclear cobalt complex with a macrocyclic decavanadate, which is composed of 10 VO4 units joined by the vertex. Sharings. The CoO6 octahedrons are edge-shared, with each cobalt octahedron coordinated to five oxido groups from the decavanadate. The remaining site is occupied by - water. The coordinated water molecules are supported with hydrogen bonds in two directions. Complex 2 in acetonitrile shows no reactivity with dioxygen even at low temperature, and the cyclic voltammogram of 2 shows no redox chemistry in acetonitrile. Complex 2 exhibits chromism by water exposure both, in the solid state and. in acetonitrile. Complex 2 is green-yellow in color, and. the addition of water causes the complex to turn brown. After heating the sample, it returns to its original color in a reversible manner. The EXAFS data in acetonitrile is also reported, and is consistent with the solid-state structure. © Wiley-VCH Verlag GmbH & Co. KGaA. 続きを見る
32.

図書

図書
United States. Congress. Senate. Select Committee on Small Business. Subcommittee on Monopoly
出版情報: Washington : U.S. Govt. Print. Off., 1972-1973
シリーズ名: Role of giant corporations ; . Hearings before the Subcommittee on Monopoly of the Select Committee on Small Business, United States Senate, Ninety-second Congress, first session, on the role of giant corporations in the American and world economies ; pt. 2-2B . Corporate secrecy
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33.

論文

論文
Sawanomukai, Takashi ; Iwatsubo, Yoshikane ; Naruhashi, Naohiro
出版情報: 植物地理・分類研究 = The journal of phytogeography and toxonomy.  51  pp.131-136,  2003-12-25.  植物地理・分類学会 = The Society for the Study of Phytogeography and Taxonomy
URL: http://hdl.handle.net/2297/48612
概要: Chromosome counts of 16 species and two varieties of Scutellaria(Lamiaceae)collected from 45 localities in Ja-pan were r eported. First counts were the following 11 taxa : S . amabilis(2n=26), S . brachyspica(2n=26), S . in-dica var. parvifolia(2n=26), S . iyoensis(2n=26), S . kiusiana(2n=26), S . laeteviolacea var. laeteviolacea(2n =26), S . laeteviolacea var. maekawae(2n=26), S . muramatsui(2n=26), S . pekinensis var. transitra(2n=28), S . shikokiana(2n=28)and S . tsusimensis(2n=26). New counts were reported in S . dependens(2n=28), S . strigil-losa(2n=30)and S . yezoensis(2n=30). Chromosome counts for S . barbata(2n=26), S . guilielmii(2n=28), S . indica var. indica(2n=26)and S . rubropunctata var. rubropunctata(2n=26)were confirmed. 続きを見る
34.

論文

論文
Ikeda, Masazumi ; Ohtani, Shinji ; Okada, Michiyo ; Minakuchi, Emi ; Sato, Tatsunori ; Ishibashi, Hiroyuki
出版情報: Heterocycles.  47  pp.181-186,  1998-01-01.  (株)日本複素環化学研究所
URL: http://hdl.handle.net/2297/3280
35.

論文

論文
Somei, Masanori ; Kodama, Atsushi
出版情報: Heterocycles.  34  pp.1285-1288,  1992-01-01.  日本複素環化学研究所
URL: http://hdl.handle.net/2297/4326
概要: 金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部
36.

論文

論文
Matsuo, Jun-ichi ; Okuno, Ryosuke ; Takeuchi, Kosuke ; Kawano, Mizuki ; Ishibashi, Hiroyuki
出版情報: Tetrahedron Letters.  51  pp.3736-3737,  2010-07-21.  Elsevier
URL: http://hdl.handle.net/2297/24795
概要: 金沢大学医薬保健研究域薬学系<br />Optimized reaction conditions for the preparation of various 2-monosubstituted 3-ethoxycyclobutanone s are described. 2-Monoalkyl 3-ethoxycyclobutanones were efficiently prepared by the reaction of the corresponding carboxylic acid chlorides and an excess amount of ethyl vinyl ether in the presence of diisopropylethylamine at 90 °C in a sealed tube. 2-Monoaryl 3-ethoxycyclobutanones were prepared by using 2,6-lutidine as a base in the above-mentioned procedure. © 2010 Published by Elsevier Ltd. All rights reserved. 続きを見る
37.

論文

論文
Matsuo, Junichi ; Okuno, Ryosuke ; Takeuchi, Kosuke ; Kawano, Mizuki ; Ishibashi, Hiroyuki
出版情報: Tetrahedron Letters.  51  pp.3736-3737,  2010-07-21.  Elsevier
URL: http://hdl.handle.net/2297/24569
概要: 金沢大学医薬保健研究域薬学系<br />Optimized reaction conditions for the preparation of various 2-monosubstituted 3-ethoxycyclobutanone s are described. 2-Monoalkyl 3-ethoxycyclobutanones were efficiently prepared by the reaction of the corresponding carboxylic acid chlorides and an excess amount of ethyl vinyl ether in the presence of diisopropylethylamine at 90 °C in a sealed tube. 2-Monoaryl 3-ethoxycyclobutanones were prepared by using 2,6-lutidine as a base in the above-mentioned procedure. © 2010 Elsevier Ltd. All rights reserved. 続きを見る
38.

論文

論文
Nishida, Y. ; Miyamori, H. ; Thompson, E.W. ; Takino, Takahisa ; Sato, H.
出版情報: Cancer Research Institution Report = がん研究所年報.  2006-2008  pp.27-,  2009-03-01.  金沢大学がん研究所 = Kanazawa University Cancer Research Institute
URL: http://hdl.handle.net/2297/18011
概要: Division of Molecular Viology and Oncology
39.

図書

図書
Алексей Каплер
出版情報: Москва : Искусство, 1984
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40.

図書

図書
Gustav Ehrismann
出版情報: München : C. H. Beck, 1918-
シリーズ名: Handbuch des deutschen Unterrichts an höheren Schulen ; Bd. 6, Tl. 1-2
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41.

論文

論文
Tsutiya, Ryokichi
出版情報: The science reports of the Kanazawa University=金沢大学理科報告.  2  pp.35-41,  1953-03-01.  the Faculty of Science Kanazawa University
URL: http://hdl.handle.net/2297/33713
42.

論文

論文
Tsutiya, Ryokichi
出版情報: The science reports of the Kanazawa University=金沢大学理科報告.  2  pp.43-48,  1953-03-01.  the Faculty of Science Kanazawa University
URL: http://hdl.handle.net/2297/33714
43.

論文

論文
Sumiyoshi, T. ; Kido, H. ; Sakamoto, H. ; Urasaki, K. ; Suzuki, K. ; Yamaguchi, N. ; Mori, Hirofumi ; Shiba, Kazuhiro ; Yokogawa, K. ; 柴, 和弘
出版情報: Pharmacology, Biochemistry and Behavior.  47  pp.553-557,  1994.  日本アイソトープ協会 Japan Radioisotope Association
URL: http://hdl.handle.net/2297/00065223
概要: 金沢大学疾患モデル総合研究センター<br />An in vivo receptor binding technique was applied to evaluate the affinities of risperidone and h aloperidol for dopamine-D2 receptors (D2) and serotonin-5-HT2 receptors (5-HT2) in rat brain with [3H]YM-09151-2 and [3H]ketanserin as selective ligands. Radioactivities were obtained in the striatum, frontal cortex, and cerebellum of the rats treated with the ligands. Time course study of receptor occupancy at 25 to 250 min after single doses of the drugs (1 mg/kg, IP) showed higher 5-HT2 occupancy in the frontal cortex and lower D2 occupancy in the striatum by risperidone than by haloperidol. Dose-response analysis of receptor occupancy revealed risperidone demonstrated higher binding affinity for 5-HT2 than for D2, while the reverse was observed with haloperidol. It appeared that risperidone (1 mg/kg, IP), but not haloperidol (1 mg/kg, IP), demonstrated regional selectivity in D2 occupancy favouring frontal cortex more than the striatum. That risperidone displayed a higher ratio of 5-HT2 to D2 in occupancy than haloperidol is in agreement with the previous findings obtained in vitro. © 1994. 続きを見る
44.

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論文
Sugimoto, Hideki ; Nagayama, Toshihiko ; Maruyama, Sachihito ; Fujinami, Shuhei ; Yasuda, Yuichi ; Suzuki, Masatatsu ; Uehara, Akira
出版情報: Bulletin of the Chemical Society of Japan.  71  pp.2267-2279,  1998-01-01.  The Chemical Society of Japan = 日本化学会
URL: http://hdl.handle.net/2297/38280
概要: A new dinucleating ligand containing a sterically bulky imidazolyl group, Ph-Htidp (N,N,N′,N′-tetrakis[(1-methyl-4,5-dip henyl-2-imidazolyl)methyl]-1,3-diamino-2-propanol), and its μ-alkoxo-diiron(II) complexes [Fe2(Ph-tidp)(RCO2)](ClO4)2, (RCO2 = C6H5CO2 (1), C6F5CO2 (2), CF3CO2 (3), and C2H5CO2 (4)), were synthesized. The structure of complex 1 was determined by X-ray crystallography. Complex 1 crystallizes in the monoclinic space group P21/c with a = 13.464(2), b = 19.223(4), c = 31.358(4) Å, β = 92.84(2)°, and Z = 4. The complex has a doubly-bridged structure with μ-alkoxo of Ph-tidp and μ-benzoate; the two iron centers have a distorted five-coordinate structure with N3O2 donor set. All the complexes showed fairly good reversible oxygenation below −30 °C in CH2Cl2, which was monitored by UV-vis and NMR spectroscopies, and dioxygen up-take measurements. Introduction of 4,5-diphenyl substituents into 2-imidazolyl group stabilized the μ-peroxo diiron species against irreversible oxidation, just as introduction of 6-methyl substituent into 2-pyridyl group did. Phenyl substituents appear to weaken the electron donor ability of a dinucleating ligand to stabilize divalent oxidation state of iron and to form a hydrophobic cavity for a O2 binding site, which would suppress the irreversible oxidation and facilitate the reversible oxygenation. Dioxygen affinities of the Ph-tidp and Me4-tpdp diiron(II), and the tpdp and bpmp dicobalt(II) complexes were measured, [Fe2(Me4-tpdp)(RCO2)]2+ (RCO2 = C6H5CO2 and RCO2 = CF3CO2) and [Co2(L)(RCO2)]2+ (L = tpdp, RCO2 = CH3CO2, and L = bpmp, RCO2 = C6F5CO2, and CF3CO2), where Me4-tpdp, tpdp, and bpmp are N,N,N′,N′-tetrakis[(6-methyl-2-pyridyl)methyl]-1,3-diamino-2-propanolate, N,N,N′,N′-tetrakis(2-pyridylmethyl)-1,3-diamino-2-propanolate, and 2,6-bis[bis(2-pyridylmethyl)aminomethyl]-4-methylphenolate, respectively. Within a series of the Ph-tidp diiron(II) complexes, dioxygen affinity is well correlated with electron donor ability of bridging carboxylates (1 (C6H5CO2) > 2 (C6F5CO2) > 3 (CF3CO2)). In contrast to the above trend, dioxygen affinities of the Ph-tidp complexes are lower than those of the Me4-tpdp complexes, although electron donor abilities of the Me4-tpdp complexes are weaker than those of the Ph-tidp complexes. Significant enhancement of dioxygen affinity was observed for both iron and cobalt complexes with 2,6-bis(aminomethyl)phenolate bridging skeleton compared to the complexes with a 1,3-diamino-2-propanolate bridging one. Thermodynamic study suggested that the observed enhancement is mainly attributable to a favorable entropy effect along with a steric effect. 続きを見る
45.

図書

図書
出版情報: 大阪 : パレード , 東京 : まぐまぐ
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46.

図書

図書
出版情報: London : Europa Pub., 1927-
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47.

論文

論文
Ihara, Yoshinori ; Satake, Yasuhiro ; Fujimoto, Yumi ; Senda, Hitoshi ; Suzuki, Masatatsu ; Uehara, Akira
出版情報: Bulletin of the Chemical Society of Japan.  64  pp.2349-2352,  1991-01-01.  日本化学会=The Chemical Society of Japan
URL: http://hdl.handle.net/2297/37512
概要: The structures of two diaquabis(N,N-dialkylethylenediamine)nickel(II) chlorides ([Ni(H2O)2(diamine)2]Cl2·nH2O) were dete rmined by X-ray crystallographic studies, where diamine is N,N-dimethylethylenediamine(NN-dmen) or N,N-diethylethylenediamine (NN-deen). Both complexes are trans and crystallize in the monoclinic space group P21⁄n. The unit cell parameters of the NN-dmen complex, NiCl2C8N4O2H32, are a=7.531(1), b=13.092(1), c=9.591 Å, β=107.76(1)°, and Z=2, and those of the NN-deen complex, NiCl2C12N4O2H36, are a=9.154(1), b=8.692(1), c=12.395(2) Å, β=104.46(1)°, and Z=2. In trans-[Ni(H2O)2(NN-dmen)2]Cl2·2H2O and trans-[Ni(H2O)2(NN-deen)2]Cl2, the Ni–NMe2 and Ni–NEt2 bond distances (2.183 and 2.271 Å) are much longer than the Ni–NH2 distances (2.078 and 2.064 Å), forming tetragonally distorted octahedrons with four close in-plane neighbors(N2O2) and two remote axial ones(N2). It is apparent that this distortion originates from the steric requirement of N-substituted groups. Such a distortion significantly affects the electronic spectra of these complexes. 続きを見る
48.

論文

論文
Yokota, Shinichi ; Higashi, Eriko ; Fukami, Tatsuki ; Yokoi, Tsuyoshi ; Nakajima, Miki
出版情報: Biochemical Pharmacology.  81  pp.289-294,  2011-01-15.  Elsevier
URL: http://hdl.handle.net/2297/25430
概要: 金沢大学医薬保健研究域薬学系<br />Human CYP2A6 is responsible for the metabolism of nicotine and coumarin as well as the metabolic act ivation of tobacco-related nitrosamines. Earlier studies revealed that CYP2A6 activity was increased by dietary cadmium or cruciferous vegetables, but the underlying mechanisms remain to be clarified. In the present study, we investigated the possibility that Nrf2 might be involved in the regulation of CYP2A6. Real-time RT-PCR analysis revealed that the CYP2A6 mRNA level in human hepatocytes was significantly (P < 0.01, 1.4-fold) induced by 10 μM sulforaphane (SFN), a typical activator of Nrf2. A computer-based search identified three putative antioxidant response elements (AREs) in the 5′-flanking region of the CYP2A6 gene at positions -1212, -2444, and -3441, termed ARE1, ARE2, and ARE3, respectively. Electrophoretic mobility shift assays demonstrated that Nrf2 bound only to ARE1. Luciferase assays using HepG2 cells revealed that the overexpression of Nrf2 significantly increased the reporter activities of the constructs containing a 30-bp fragment that included ARE1. However, the activity of the construct containing the intact 5′-flanking region (-1 to -1395) including ARE1 was not increased by the overexpression of Nrf2. In contrast, when the reporter construct was injected into mice via the tail vein, the reporter activity in the liver was significantly (P < 0.05, 1.9-fold) increased by SFN (1 mg/head) administration. In conclusion, we found that human CYP2A6 is regulated via Nrf2, suggesting that CYP2A6 is induced under oxidative stress. © 2010 Elsevier Inc. All rights reserved. 続きを見る
49.

論文

論文
Iwasa, Junko ; Miyoshi, Ken-ichi
出版情報: The science reports of the Kanazawa University=金沢大学理科報告.  24  pp.1-8,  1979-06-01.  the Faculty of Science Kanazawa University
URL: http://hdl.handle.net/2297/34036
50.

論文

論文
Watanabe, Hiroyuki ; Okada, G. ; Ohtsubo, K. ; Yao, F. ; Jiang, P.H. ; Sawabu, Norio
出版情報: Cancer Research Institute report.  2003-2005  pp.77-,  2006-03-01.  金沢大学がん研究所
URL: http://hdl.handle.net/2297/2625
51.

図書

図書
herausgegeben von Wolf-Hartmut Friedrich und Walther Killy
出版情報: Frankfurt am Main : Fischer Bücherei, 1964-1965
シリーズ名: Das Fischer Lexikon ; 34, 35/1, 35/2
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52.

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図書
text, translation and notes by J.A.F. Roodbergen ; edited by S.D. Joshi
出版情報: Poona : University of Poona, 1974
シリーズ名: Publications of the Centre of Advanced Study in Sanskrit ; class C ; no. 9
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53.

論文

論文
Ihara, Yoshinori ; Tsuchiya, Ryokichi
出版情報: Bulletin of the Chemical Society of Japan.  57  pp.2829-2831,  1984-01-01.  日本化学会=The Chemicai Society of Japan
URL: http://hdl.handle.net/2297/37508
概要: The following ten nickel(II) complexes with meso- or dl-1,2-diphenyl-1,2-ethanediamine (abbreviated as meso-stien and dl-stien, respectively) were prepared, and their thermal behavior was investigated in the solid phase: [Ni(meso-stien)2]X2 (X=Cl, Br, I, NO3, or ClO4), [Ni(dl-stien)2]X2 (X=I or ClO4), and [Ni(H2O)2(dl-stien)2]X2 (X=Cl, Br, or NO3). The square planar bis(dl-stien) complex chloride, bromide, and nitrate obtained by thermal dehydration of their respective octahedral diaqua complexes were found by various techniques to be transformed, upon further heating, to the octahedral diacido bis(dl-stien) complexes. The complexes containing dl-stien have a stronger tendency to show such structural transformations than those containing meso-stien. The reason for this difference is discussed. 続きを見る
54.

論文

論文
Okado, Ryohei ; Nowaki, Aya ; Matsuo, Jun-ichi ; Ishibashi, Hiroyuki
出版情報: Chemical and Pharmaceutical Bulletin.  60  pp.21-22,  2012-01-01.  The Pharmaceutical Society of Japan = 日本薬学会
URL: http://hdl.handle.net/2297/30314
概要: A catalytic amount of tin(IV) chloride catalyzed formal [4+2] cycloaddition reaction of di-tert-butyl 2-ethoxycyclobutane-1,1-carboxylate with ketones or aldehydes to give diethyl 6-ethoxydihydro-2H-pyran-3,3(4H)-dicarboxylates, whereas two equivalents of trimethylsilyl triflate promoted tandem [4+2] cycloaddition and lactonization to afford 3-oxo-2,6-dioxabicyclo[2.2.2]octane-4-carboxylate esters. 続きを見る
55.

図書

図書
translated from the original Sanskrit with introduction and notes by Kamaleswar Bhattacharya ; text critically edited by E.H. Johnston and Arnold Kunst
出版情報: Delhi : Motilal Banarsidass, 1986
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56.

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図書
par le Maître indien Candrakīrti ; [traduit par] Cristina Anna Scherrer-Schaub
出版情報: Bruxelles : Institut belge des hautes études chinoises, 1991
シリーズ名: Mélanges chinois et bouddhiques ; v. 25
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57.

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図書
von F. Endemann
出版情報: Berlin : C. Heymann, [1900?]
シリーズ名: Lehrbuch des bürgerlichen Rechts : Einführung in das Studium des Bürgerlichen Gesetzbuchs / von F. Endemann ; Bd. 2
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目次情報:
Bd. 2, [1]. Sachenrecht
Bd. 2, [2]. Familienrecht
Bd. 2, [1]. Sachenrecht
Bd. 2, [2]. Familienrecht
58.

電子ブック

EB
出版情報: 中山書店, 2001.2
オンライン: https://elib.maruzen.co.jp/elib/html/BookDetail/Id/3000001743
59.

電子ブック

EB
出版情報: メヂカルフレンド社, 2018.2
オンライン: https://elib.maruzen.co.jp/elib/html/BookDetail/Id/3000074460
60.

図書

図書
im Auftrag des Organisationskomitees herausgegeben von Ernst Meissner
出版情報: Zürich ; Leipzig : Füssli, 1927
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61.

図書

図書
出版情報: ディスク1枚+パンフ2枚 
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62.

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図書
herausgegeben von Georg Jäger, Alberto Martino, Friedrich Sengle
出版情報: Tübingen : Max Niemeyer, 1976-
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63.

論文

論文
Miyamoto, Yoshiaki ; Wada, Norihiro ; Soeta, Takahiro ; Fujinami, Shuhei ; Inomata, Katsuhiko ; Ukaji, Yutaka
出版情報: Chemistry - An Asian Journal.  8  pp.824-831,  2013-04-01.  Wiley-VCH Verlag Berlin
URL: http://hdl.handle.net/2297/34680
概要: The stereoselective direct transformation of N-(propargylic)hydroxylamines into cis-2-acylaziridines was achieved by the combined use of AgBF4 and CuCl. Copper salts were found to promote the transformation of the intermediary 4-isoxazolines into 2-acylaziridines and both 3-aryl- and 3-alkyl-substituted 2-acylaziridines could be prepared by using this method. Furthermore, subsequent 1,3-dipolar cycloaddition of azomethine ylides that were generated in situ from the intermediary 2-acylaziridines with maleimides was achieved in a stereoselective one-pot procedure to afford the corresponding 2-acylpyrrolidines, which consisted of an octahydropyrrolo[3,4-c]pyrrole skeleton. Love the way ylide: The transformation of N-(propargylic) hydroxylamines into cis-2-acylaziridines and subsequent 1,3-dipolar cycloaddition of the in situ generated azomethine ylides with maleimides stereoselectively afforded 2-acylpyrrolidines. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 続きを見る
64.

論文

論文
Popivanova, Boryana K. ; Kostadinova, Feodora I. ; Mukaida, Naofumi
出版情報: Inflammation Research.  58  pp.S229-S233,  2014-01-01.  Birkhauser Verlag AG / Springer Verlag
URL: http://hdl.handle.net/2297/40608
概要: Azoxymethane (AOM) administration followed by repetitive dextran sulfate sodium (DSS) ingestion causes chronic colonic inflammation with macrophage infiltration and enhanced expression of a macrophage-tropic chemokine, CCL2, in wild-type (WT) mice. These mice eventually develop multiple colon tumors. In contrast, mice deficient in CCR2, a specific receptor for CCL2, exhibited less macrophage infiltration and attenuated tumor formation. WT mice transplanted with CCR2-deficient bone marrow developed fewer tumors after AOM and DSS treatment than either WT or CCR2-deficient mice transplanted with WT bone marrow. Furthermore, when injected to WT mice with multiple colon tumors, a CCL2 antagonist expression vector attenuated macrophage and granulocyte infiltration, and eventually reduced the numbers and sizes of tumors. These results implied the crucial involvement of the CCL2-CCR2 interactions in the development and progression of colon carcinoma associated with chronic inflammation. 続きを見る
65.

論文

論文
Begum, Zinnat A. ; Rahman, Ismail M. M. ; Tate, Yousuke ; Egawa, Yuji ; Maki, Teruya ; Hasegawa, Hiroshi
出版情報: Journal of Solution Chemistry.  41  pp.1713-1728,  2012-11-01.  Springer Science+Business Media
URL: http://hdl.handle.net/2297/32845
概要: The protonation and complex formation equilibria of two biodegradable aminopolycarboxylate chelants {dl-2-(2-carboxymeth yl)nitrilotriacetic acid (GLDA) and 3-hydroxy-2,2′-iminodisuccinic acid (HIDS)} with Ni 2+, Cu 2+, Zn 2+, Cd 2+ and Pb 2+ ions were investigated using the potentiometric method at a constant ionic strength of I = 0.10 mol·dm -3 (KCl) in aqueous solutions at 25 ± 0.1 °C. The stability constants of the proton-chelant and metal-chelant species for each metal ion were determined, and the concentration distributions of various complex species in solution were evaluated for each ion. The stability constants (log 10K ML) of the complexes containing Ni 2+, Cu 2+, Zn 2+, Cd 2+ and Pb 2+ ions followed the identical order of log 10K CuL > log 10K NiL > log 10K PbL > log 10K ZnL > log 10K CdL for either GLDA (13.03 > 12.74 > 11.60 > 11.52 > 10.31) or HIDS (12.63 > 11.30 > 10.21 > 9.76 > 7.58). In each case, the constants obtained for metal-GLDA complexes were larger than the corresponding constants for metal-HIDS complexes. The conditional stability constants (log 10 {Mathematical expression}) of the metal-chelant complexes containing GLDA and HIDS were calculated in terms of pH, and compared with the stability constants for EDTA and other biodegradable chelants. © 2012 Springer Science+Business Media New York. 続きを見る
66.

論文

論文
Begum, Zinnat A. ; Rahman, Ismail M. M. ; Tate, Yousuke ; Egawa, Yuji ; Maki, Teruya ; Hasegawa, Hiroshi
出版情報: Journal of Solution Chemistry.  41  pp.1713-1728,  2012-11-01.  Springer Science+Business Media
URL: http://hdl.handle.net/2297/34166
概要: The protonation and complex formation equilibria of two biodegradable aminopolycarboxylate chelants {dl-2-(2-carboxymeth yl)nitrilotriacetic acid (GLDA) and 3-hydroxy-2,2′-iminodisuccinic acid (HIDS)} with Ni 2+, Cu2+, Zn2+, Cd2+ and Pb 2+ ions were investigated using the potentiometric method at a constant ionic strength of I = 0.10 mol·dm-3 (KCl) in aqueous solutions at 25 ± 0.1 C. The stability constants of the proton-chelant and metal-chelant species for each metal ion were determined, and the concentration distributions of various complex species in solution were evaluated for each ion. The stability constants (log10 K ML) of the complexes containing Ni2+, Cu2+, Zn2+, Cd2+ and Pb2+ ions followed the identical order of log10 K CuL > log10 K NiL > log10 K PbL > log10 K ZnL > log10 K CdL for either GLDA (13.03 > 12.74 > 11.60 > 11.52 > 10.31) or HIDS (12.63 > 11.30 > 10.21 > 9.76 > 7.58). In each case, the constants obtained for metal-GLDA complexes were larger than the corresponding constants for metal-HIDS complexes. The conditional stability constants (log10 $$ K-{\text{ML}}^{'} $$) of the metal-chelant complexes containing GLDA and HIDS were calculated in terms of pH, and compared with the stability constants for EDTA and other biodegradable chelants. © 2012 Springer Science+Business Media New York. 続きを見る
67.

図書

図書
Nagarjuna ; aus dem chinesischen Text des Kumarajiva übersetzt und mit einem Kommentar herausgegeben von Lutz Geldsetzer
出版情報: Hamburg : Meiner, c2010
シリーズ名: Philosophische Bibliothek ; 610
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68.

図書

図書
Tadeusz Skorupski
出版情報: Tring : Institute of Buddhist Studies, 2002
シリーズ名: Buddhica Britannica ; . Series continua ; 9
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69.

図書

図書
Āryānāgārjunapādaiḥ Rajñe Sātavāhanāya likhitaḥ ; pratisaṃskartā Hindīrūpāntarakāraḥ, sampādakaśca Svāmī Dvārikādāsaśāstrī
出版情報: Vārāṇasī : Bauddhabhāratī, 1995
シリーズ名: बौद्धभारतीग्रन्थमाला ; 33
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70.

図書

図書
tasyāḥ Āṅglabhāṣāyā'nuvādakaḥ Sātakarimukharjī ; Hindībhāṣāyā'nuvādakaśca Svāmī Dvārikādāsaśāstrī
出版情報: Vārāṇasī : Bauddhabhāratī, 1994
シリーズ名: बौद्धभारतीग्रन्थमाला ; 30
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71.

図書

図書
translations and studies by Chr. Lindtner
出版情報: [Berkeley, Calif.] : Dharma Pub., c1986
シリーズ名: Tibetan translation series
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72.

図書

図書
edited by Heramba Chatterjee Sastri
出版情報: Calcutta : Saraswat Library, [1977]-
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73.

図書

図書
by Kenneth K. Inada
出版情報: Tokyo : Hokuseido Press, 1970
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74.

論文

論文
Kato, Takehiro ; Kotaka, Hiroki ; Ishii, Fumiyuki
出版情報: Molecular Simulation.  41  pp.892-895,  2014-10-09.  Taylor and Francis
URL: http://hdl.handle.net/2297/40164
概要: Using first-principles method, we investigated the electronic states of Bi2Te3 and Bi2Se3. We showed that both Bi2Te3 an d Bi2Se3 are insulators with a bulk band gap. In contrast, the surface states of Bi2Te3 and Bi2Se3 films have a metallic band connecting the conduction and valence bands. The films have an energy gap at the (Formula presented.) point when the film thickness is less than four quintuple layers (QLs), or about 30 Å. The energy gaps are closed at six QLs and four QLs for Bi2Te3 and Bi2Se3, respectively. We confirmed the metallicity up to nine QLs. Furthermore, we investigated the spin structures of nine-QL films at the Fermi energy in momentum space. We found that both the Bi2Te3 and Bi2Se3 films have Rashba-type spin textures; i.e. the surface states have spin–polarisation. To investigate the spatial distribution of the spin, we decomposed the expected values of the spin for each atom. The expected values of the spin are localised within the third QL from the surface. Our results of nine-QL films clearly show the boundary between the bulk and surface regions. 続きを見る
75.

図書

図書
出版情報: Providence, R.I. : American Mathematical Society, 1955-
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76.

論文

論文
Echizen, Kanae ; Hirose, Osamu ; Maeda, Yusuke ; Oshima, Masanobu
出版情報: Cancer Science.  107  pp.391-397,  2016-04-01.  Japanese Cancer Association / Blackwell Publishing Ltd
URL: http://hdl.handle.net/2297/45801
概要: Cyclooxygenase-2 (COX-2) and its downstream product prostaglandin E2 (PGE2) play a key role in generation of the inflamm atory microenvironment in tumor tissues. Gastric cancer is closely associated with Helicobacter pylori infection, which stimulates innate immune responses through Toll-like receptors (TLRs), inducing COX-2/PGE2 pathway through nuclear factor-κB activation. A pathway analysis of human gastric cancer shows that both the COX-2 pathway and Wnt/β-catenin signaling are significantly activated in tubular-type gastric cancer, and basal levels of these pathways are also increased in other types of gastric cancer. Expression of interleukin-11, chemokine (C-X-C motif) ligand 1 (CXCL1), CXCL2, and CXCL5, which play tumor-promoting roles through a variety of mechanisms, is induced in a COX-2/PGE2 pathway-dependent manner in both human and mouse gastric tumors. Moreover, the COX-2/PGE2 pathway plays an important role in the maintenance of stemness with expression of stem cell markers, including CD44, Prom1, and Sox9, which are induced in both gastritis and gastric tumors through a COX-2/PGE2-dependent mechanism. In contrast, disruption of Myd88 results in suppression of the inflammatory microenvironment in gastric tumors even when the COX-2/PGE2 pathway is activated, indicating that the interplay of the COX-2/PGE2 and TLR/MyD88 pathways is needed for inflammatory response in tumor tissues. Furthermore, TLR2/MyD88 signaling plays a role in maintenance of stemness in normal stem cells as well as gastric tumor cells. Accordingly, these results suggest that targeting the COX-2/PGE2 pathway together with TLR/MyD88 signaling, which would suppress the inflammatory microenvironment and maintenance of stemness, could be an effective preventive or therapeutic strategy for gastric cancer. © 2016 Japanese Cancer Association. 続きを見る
77.

図書

図書
谷口健英
出版情報: [Kanazawa] : 谷口健英, 1994
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78.

図書

図書
Nāgārjuna ; introduction, Sanskrit text, English translation, and annotation, David J. Kalupahana
出版情報: Albany, N.Y. : State University of New York Press, c1986
シリーズ名: SUNY series in Buddhist studies
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79.

論文

論文
Yamakawa, Daishi ; Kidoya, Hiroyasu ; Sakimoto, Susumu ; Jia, Weizhen ; Naito, Hisamichi ; Takakura, Nobuyuki ; 内藤, 尚道 ; 高倉, 伸幸
出版情報: Journal of Biological Chemistry.  288  pp.12469-12477,  2013-05-03.  American Society for Biochemistry and Molecular Biology / Elsevier
URL: http://hdl.handle.net/2297/00062983
概要: 金沢大学医薬保健研究域医学系<br />Tie2 is a receptor tyrosine kinase expressed on vascular endothelial cells (ECs). It has dual roles in promoting angiogenesis and stabilizing blood vessels, and it has been suggested that Tie2 forms dimers and/or oligomers in the absence of angiopoietin-1 (Ang1); however, the mechanism of ligand-independent dimerization of Tie2 and its biological significance have not been clarified. Using a bimolecular fluorescence complementation assay and a kinase-inactive Tie2 mutant, we show here that ligand-independent Tie2 dimerization is induced without Tie2 phosphorylation. Moreover, based on the fact that Tie1 never forms heterodimers with Tie2 in the absence of Ang1 despite having high amino acid sequence homology with Tie2, we searched for ligand-independent dimerization domains of Tie2 by reference to the difference with Tie1. We found that the YIA sequence of the intracellular domain of Tie2 corresponding to the LAS sequence in Tie1 is essential for this dimerization. When the YIA sequence was replaced by LAS in Tie2 (Tie2YIA/LAS), ligand-independent dimer was not formed in the absence of Ang1. When activation of Tie2YIA/LAS was induced by a high dose of Ang1, phosphorylation of Tie2 was limited compared with wild-type Tie2, resulting in retardation of activation of Erk downstream of Tie2. Therefore, these data suggest that ligand-independent dimerization of Tie2 is essential for a strong response upon stimulation with high dose Ang1. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. 続きを見る
80.

論文

論文
Aini, Nurul ; Shen, Zhenjiang
出版情報: International Review for Spatial Planning and Sustainable Development = IRSPSD International.  7  pp.97-112,  2019-10-15.  International Community of Spatial Planning and Sustainable Development / SPSD Press
URL: http://hdl.handle.net/2297/00057219
概要: Transportation has become one of the most significant contributors to CO2 in the world because of its fuel usage. Trees are planted on the roadside to reduce levels of CO2 in the air because trees have the ability to absorb CO2 to be used in the photosynthesis process. This ability will be maximized if the dispersion of CO2 is concentrated around the tree. However, there are some differing results from previous studies regarding this. Some research results have found trees can increase CO2 concentration and vice versa. Accordingly, this study aims to evaluate the effect of tree planting on the roadside in dispersing CO2 using a real 3D environment. The methods used in this research are CO2 emission analysis to obtain the amount of CO2. Then, Computational Fluid Dynamics (CFD) analysis is used to simulate the dispersion of CO2 in the study area both without trees and with trees. However, due to the mixing of air and CO2, this simulation uses a scalar mixing analysis. Some conditions are considered, such as the characteristics of buildings, the characteristics of trees, and environmental conditions. The result indicates that trees can decrease the velocity and increase the concentration of CO2 on the roadside but decrease CO2 concentration on the road. Tree planting can decrease the velocity by 4.3% in the value range 0.9-1 m/s. This condition increases CO2 concentration on the roadside. Trees can increase CO2 by 25% on the right of a roadside and increase CO2 concentration by 10% on the left side. 続きを見る
81.

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論文
Iwasaki, Yusaku ; Nakabayashi, Hajime ; Kakei, Masafumi ; Shimizu, Hiroyuki ; Mori, Masatomo ; Yada, Toshihiko
出版情報: Biochemical and Biophysical Research Communications.  390  pp.958-962,  2009-12-18.  Elsevier
URL: http://hdl.handle.net/2297/20509
概要: 金沢大学医薬保健研究域医学系<br />Nesfatin-1, processed from nucleobindin 2, is an anorexigenic peptide expressed in the brain and sev eral peripheral tissues including the stomach and pancreas. Peripheral, as well as intracerebroventricular, administration of nesfatin-1 suppresses feeding behavior, though underlying mechanisms are unknown. In this study, we examined effects of nesfatin-1 on cytosolic Ca2+ concentration ([Ca2+]i) in the neurons isolated from the vagal afferent nodose ganglion of mice. Nesfatin-1 at 10-10-10-8 M increased [Ca2+]i in the isolated neurons in a concentration-dependent manner, and at 10-8 M it increased [Ca2+]i in 33 out of 263 (12.5%) neurons. These responses were inhibited under Ca2+-free conditions and by N-type Ca2+ channel blocker, ω-conotoxin GVIA. All the nesfatin-1-responsive neurons also exhibited [Ca2+]i responses to capsaicin and cholecystokinin-8. These results provide direct evidence that nesfatin-1 activates vagal afferent neurons by stimulating Ca2+ influx through N-type channels, demonstrating the machinery through which peripheral nesfatin-1 can convey signals to the brain. © 2009 Elsevier Inc. All rights reserved. 続きを見る
82.

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論文
Murahashi, Tsuyoshi ; Kizu, Ryoichi ; Kakimoto, Hitoshi ; Toriba, Akira ; Hayakawa, Kazuichi
出版情報: Journal of Health Science.  45  pp.244-250,  1999-01-01.  日本薬学会 = The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/44960
概要: Diesel-engine exhaust and airborne particulates were collected in downtown and suburban areas and five mutagenic nitroarenes (2-nitrofluoranthene (NF), 1-, 2- and 4-nitropyrenes (NPs) and 6-nitrochrysene (NC) in benzene-ethanol extracts were determined by high-performance liquid chromatography with chemiluminescence detection. 1- and 4-NPs and 6-NC were found in diesel-engine exhaust particulates, however, 2-NF and 2-NP were not detected. On the other hand, all five nitroarenes were found in airborne particulates. Diurnal concentration patterns of 4-NP and 6-NC in the downtown area were similar to the pattern of 1-NP, but the patterns of 2-NF and 2-NP were different from the pattern of 1-NP. These results strongly suggested that 2-NF and 2-NP are formed in the atmosphere. Of the five nitroarenes, 2-NF had the largest suburban / downtown concentration ratio. 2- and 4-NPs and 6-NC all showed larger ratios than did 1-NP. These results showed that 2-NF and 2-NP were formed in the atmosphere, but that the secondary formation of 4-NP and 6-NC were not known. Taking mutagenic activity and the atmospheric concentration into consideration, the mutagenic contribution of 2-NF was estimated to be comparable with that of 1-NP in the downtown area, and more than that of 1-NP in the suburban area. This result suggested that the mutagenic contribution of the minor nitroarenes formed in urban air might not be negligible. 続きを見る
83.

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論文
Hinoi, Eiichi ; Wang, Liyang ; Fujimori, Sayumi ; Yoneda, Yukio
出版情報: Hard Tissue Biology.  14  pp.280-281,  2005-01-01.  日本硬組織研究技術学会 = The Hard Tissue Biology Network Association(JHTBNet)
URL: http://hdl.handle.net/2297/28376
概要: 金沢大学医薬保健研究域薬学系<br />Nuclear factor E2-related factor 2 (nrf2) is accepted as an important transcription factor in the re gulation of many phase II detoxifying enzymes and oxidative-stress-inducible genes in many tissues including bone and cartilage. However, little attention has been paid to precise role of nrf2 on osteoblasts and chondrocytes. In the present study, we therefore investigated the role of nrf2 in the regulation of cell proliferation, differentiation and maturation using both MC3T3-E1 and ATDC5 cells. In MC3T3-E1 cells stably transfected with nrf2 (MC3T3-E1-nrf2 clone), the differentiation-dependent induction of alkaline phosphatase activity was significantly inhibited in addition to decrease of the mineralized matrix formation. Moreover, expression of mRNAs for osteocalcin and type I collagen was also markedly attenuated in MC3T3E1-nrf2 clone but not in MC3T3E1-empty vector clone. These inhibitory effect on cell differentiation was also observed in ATDC5 cells stably transfected with nrf2. Moreover, nrf2 significantly impaired the runx2-dependent enhancement of osteocalcin promoter activity. These data suggest that nrf2 may negatively regulate the differentiation of both osteoblasts and chondrocytes through inhibition of the runx2 dependent transcriptional activity. 続きを見る
84.

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論文
Aoki, Katsuyuki ; Koseki, Jun-ichi ; Takeda, Shuichi ; Aburada, Masaki ; Miyamoto, Kenichi
出版情報: Chemical and Pharmaceutical Bulletin.  55  pp.922-925,  2007-06-01.  日本薬学会
URL: http://hdl.handle.net/2297/6594
概要: 金沢大学医学部附属病院薬剤部<br />It has already been reported that 3-(indol-2-yl)quinoxalin-2-ones 1)? have a potent inhibitory effec t on the growth of tumor cells based on anti-angiogenesis activity. We have also carried out a structure-activity relationship (SAR) study of 3-(indol-2-yl)quinoxalin-2-ones, which showed a potent inhibitory activity toward the vascular endothelial growth factor (VEGF)-induced proliferation of human mesangial cells and the VEGF-induced auto-phosphorylation of human umbilical vein endothelial cells.2) Moreover, one of these compounds has a potent medicinal effect based on anti-angiogenic action, by oral administration2) (Chart 1, 9). However, since the existing synthetic methods1) for the preparation of 3-(indol-2-yl)quinoxalin-2-ones consist of multiple steps some of which require strict anhydrous conditions, a convenient and simple synthetic method in place of the existing method is desirable. As a result of the investigations into the synthetic procedures, 3-(3-substituted indol-2-yl)quinoxalin-2-ones can be easily prepared by the condensation of 3-substituted indoles with quinoxalin-2-ones in the presence of trifluoroacetic acid (TFA). Herein, we report the examination of these reaction conditions and the application of this new synthetic method to the synthesis of the derivatives as VEGF inhibitors. © 2007 Pharmaceutical Society of Japan. 続きを見る
85.

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出版情報: Frankfurt a.M ; Bern ; Las Vegas : Peter Lang
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86.

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図書
Friedrich Rive
出版情報: Aalen : Scientia
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87.

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図書
edited by C. Robert Helms and Bruce E. Deal
出版情報: New York : Plenum Press, c1988
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88.

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図書
出版情報: Paris : Beauchesne
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89.

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Yoshimura, Osamu ; Ueda, Kazumasa ; Yamamoto, Yoshikazu
出版情報: Analytical Sciences.  4  pp.623-627,  1988-01-01.  Japan Society for Analytical Chemistry = 日本分析化学会
URL: http://hdl.handle.net/2297/48688
概要: 2-(2-Thiazolylazo)-4-methoxyphenol (TAMP) forms a brownish 2:1 complex with iron(ll) in the presence of ascorbic acid; t he complex has a characteristic absorption at 784 nm in chloroform. By utilizing this peculiar absorption, selective spectrophotometry determination of iron has been developed. The optimum pH for iron extraction lies between 5.0-9.3 and Beer's law holds up to 5.0 ng/ml of iron. Many type of ions are tolerable. The method was successfully applied to the determination of iron in river waters. The extraction constant of iron(ll) complex was log Kex=-2.50±0.12 and the extraction mechanism was kinetically investigated. The complexation rate was first-order with respect to iron(ll) and TAMP concentrations and independent of ascorbic acid concentration. From these results, the major extraction rate-determining step was concluded to be a 1:1 complexation reaction between iron(ll) and dissociated TAMP. Kinetic data and activation parameters for the first-order reaction were determined and discussed. © 1988, The Japan Society for Analytical Chemistry. All rights reserved. 続きを見る
90.

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Kawashima, Hiroshi
出版情報: Kanazawa English Studies.  13  pp.133-143,  1971-10-10.  金沢大学英文学会 = The Society of English Literature, Kanazawa University
URL: http://hdl.handle.net/2297/37428
91.

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Maeda, Hajime ; Matsuda, Shoji ; Mizuno, Kazuhiko
出版情報: Journal of Photochemistry and Photobiology A: Chemistry.  206  pp.129-133,  2009-08-15.  Elsevier BV
URL: http://hdl.handle.net/2297/18991
概要: 金沢大学理工研究域物質化学系<br />Photoreactions of 2-cyano-6-methoxynaphthalene with methoxy-substituted 1,2-diarylcyclopropanes in b enzene give 2-cyano-1-(1,3-diarylpropyl)-6-methoxynaphthalenes. The excellent regioselectivity seen in these processes can be explained by initial formation of singlet exciplexes, in which the dipoles of each component are oriented in opposite directions. © 2009 Elsevier B.V. All rights reserved. 続きを見る
92.

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Hori, Osamu
出版情報: data.  2015-04-24. 
URL: http://hdl.handle.net/2297/41494
93.

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その他
Hori, Osamu
出版情報: data.  2015-04-24. 
URL: http://hdl.handle.net/2297/41493
94.

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その他
Hori, Osamu
出版情報: data.  2015-04-24. 
URL: http://hdl.handle.net/2297/41490
95.

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その他
Hori, Osamu
出版情報: data.  2015-04-24. 
URL: http://hdl.handle.net/2297/41489
96.

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その他
Hori, Osamu
出版情報: data.  2015-04-24. 
URL: http://hdl.handle.net/2297/41487
97.

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その他
Hori, Osamu
出版情報: data.  2015-04-24. 
URL: http://hdl.handle.net/2297/41486
98.

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editus iussu et auctoritate consilii ab academiis societatibusque diversarum nationum electi
出版情報: Leipzig : B.G. Teubner, 1971-
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99.

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Matsuo, Jun-ichi ; Okuno, Ryosuke ; Ishibashi, Hiroyuki
出版情報: Tetrahedron Letters.  53  pp.2257-2259,  2012-04-25.  Elsevier
URL: http://hdl.handle.net/2297/31380
概要: 2-Carbomethoxycyclobutanone reacted with N-phenyl-C-arylnitrones to afford methyl 5-oxo-2-[aryl(phenylamino)methyl]tetra hydrofuran-2-carboxylates by the catalysis of indium(III) triflate in the presence of magnesium sulfate. © 2012 Elsevier Ltd. All rights reserved. 続きを見る
100.

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論文
Matsuo, Jun-ichi ; Okuno, Ryosuke ; Ishibashi, Hiroyuki
出版情報: Tetrahedron Letters.  53  pp.2257-2259,  2012-04-25.  Elsevier
URL: http://hdl.handle.net/2297/30315
概要: 2-Carbomethoxycyclobutanone reacted with N-phenyl-C-arylnitrones to afford methyl 5-oxo-2-[aryl(phenylamino)methyl]tetra hydrofuran-2-carboxylates by the catalysis of indium(III) triflate in the presence of magnesium sulfate. © 2012 Elsevier Ltd. All rights reserved. 続きを見る