1.

図書

図書
出版情報: Paris : A. Colin
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2.

論文

論文
Hoshikawa, Takaya ; Tanji, Kei ; Matsuo, Jun-ichi ; Ishibashi, Hiroyuki
出版情報: Chemical and Pharmaceutical Bulletin.  60  pp.548-553,  2012-04-01.  Pharmaceutical Society of Japan = 日本薬学会
URL: http://hdl.handle.net/2297/31381
概要: Intramolecular [2+2] cycloaddition of γ,δ-unsaturated ketenes derived from hex-5-enoyl chloride derivatives gave bicyclo[2.1.1]hexan-5-ones with complete regioselectivity. © 2012 The Pharmaceutical Society of Japan.
3.

図書

図書
World Congress of Gastroenterology
出版情報: Basel ; New York : S. Karger
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4.

電子ブック

EB
出版情報: 中山書店, 2002.3
オンライン: https://elib.maruzen.co.jp/elib/html/BookDetail/Id/3000001081
5.

論文

論文
土成, 昭弘 ; 保木井, 利之 ; 下林, 修 ; 金岡, 千嘉男
出版情報: Journal of the Ceramic Society of Japan.  100  pp.918-923,  1992-07-01.  The Ceramic Society of Japan
URL: http://hdl.handle.net/2297/24631
概要: In a permeable MgO ceramic containing TiO_2 and Al_2O_3 as matrix MgO ・ Al_2O_3-2MgO・TiO_2 solid solutions were detected and no Al_2O_3・TiO_2 was observed. Therefore, the solid state reaction among MgO, TiO_2 and Al_2O_3 with excess MgO was studied at various firing temperatures. The formation mechanism of MgO・Al_2O_3-2MgO・TiO_2 solid solutions was studied from the results of interface reactions between MgO-TiO_2 and MgO-Al_2O_3. MgO・Al_2O_3-2MgO・TiO_2 solid solutions were detected at 1573-1673 K and increased with the firing temperature. 2MgO・TiO_2 was formed in the system MgO-TiO_2, but was not produced in the system MgO-TiO_2-Al_2O_3, because the amount of Mg diffusion at the interface of aggregate and matrix additives was not enough due to the large aggregate size of MgO. MgO・Al_2O_3 and 2MgO・TiO_2 formed at the interface between MgO-TiO_2 and MgO-Al_2O_3 decreased with the firing time at 1873 K. On the other hand, MgO・Al_2O_3-2MgO・TiO_2 solid solutions increased. Mg was recognized in the matrix without addition of MgO as a matrix. Al diffused in the layer of MgO-TiO_2, in opposition Ti diffused in the layer of MgO-Al_2O_3 by EPMA analysis. From the above results, the formation mechanism of a MgO・Al_2O_3-2MgO・TiO_2 solid solution was proposed; (1) Mg diffusion at the interface of MgO aggregate and matrix additives, (2) formation of MgO・TiO_2 and MgO・Al_2O_3, (3) formation of 2MgO・TiO_2 due to the reaction with MgO・TiO_2 and MgO, (4) reaction of the solid solution with MgO・Al_2O_3 and 2MgO・TiO_2. In the reactions between MgO・TiO2 and MgO-Al_2O_3 the product layer of MgO・Al_2O_3-2MgO・TiO_2 solid solution increased as the firing time increased. The diffusion coefficient of Mg was about 4.8×10^<-7>(cm^2/s), in a good agreement with that of Mg which was reported. 続きを見る
6.

論文

論文
Nishida, Yuki ; Miyamori, Hisashi ; Thompson, Erik W. ; Takino, Takahisa ; Endo, Yoshio ; Sato, Hiroshi
出版情報: Cancer Research.  68  pp.9096-9104,  2008-11-01.  American Association for Cancer Research
URL: http://hdl.handle.net/2297/12472
概要: 金沢大学がん研究所がん病態制御<br />The suggested model for pro-matrix metalloproteinase-2 (proMMP-2) activation by membrane type 1 MMP (MT1-MMP) implicates the complex between MT1-MMP and tissue inhibitor of MMP-2 (TIMP-2) as a receptor for proMMP-2. To dissect this model and assess the pathologic significance of MMP-2 activation, an artificial receptor for proMMP-2 was created by replacing the signal sequence of TIMP-2 with cytoplasmic/transmembrane domain of type II transmembrane mosaic serine protease (MSP-T2). Unlike TIMP-2, MSP-T2 served as a receptor for proMMP-2 without inhibiting MT1-MMP, and generated TIMP-2-free active MMP-2 even at a low level of MT1-MMP. Thus, MSP-T2 did not affect direct cleavage of the substrate testican-1 by MT1-MMP, whereas TIMP-2 inhibited it even at the level that stimulates proMMP-2 processing. Expression of MSP-T2 in HT1080 cells enhanced MMP-2 activation by endogenous MT1-MMP and caused intensive hydrolysis of collagen gel. Expression of MSP-T2 in U87 glioma cells, which express a trace level of endogenous MT1-MMP, induced MMP-2 activation and enhanced cell-associated protease activity, activation of extracellular signal-regulated kinase, and metastatic ability into chick embryonic liver and lung. MT1-MMP can exert both maximum MMP-2 activation and direct cleavage of substrates with MSP-T2, which cannot be achieved with TIMP-2. These results suggest that MMP-2 activation by MT1-MMP potentially amplifies protease activity, and combination with direct cleavage of substrate causes effective tissue degradation and enhances tumor invasion and metastasis, which highlights the complex role of TIMP-2. MSP-T2 is a unique tool to analyze physiologic and pathologic roles of MMP-2 and MT1-MMP in comparison with TIMP-2. ©2008 American Association for Cancer Research.全文公開200911 続きを見る
7.

論文

論文
Somei, Masanori ; Yamada, Fumio ; Yamazaki, Yoshihisa ; Shinkura, Akiko
出版情報: Chemical and Pharmaceutical Bulletin.  44  pp.21-28,  1996-01-01.  Pharmaceutical Society of Japan = 日本薬学会
URL: http://hdl.handle.net/2297/43982
概要: We developed a novel synthesis of 2-aminoindan derivatives, having a 2-methyl-1-propenyl group at the 1-position and oxygen functional groups in the benzene ring, in 8 or 9 steps from vanillin.
8.

論文

論文
Nakamura, Akiko ; Nakajima, Miki ; Higashi, Eriko ; Yamanaka, Hiroyuki ; Yokoi, Tsuyoshi
出版情報: Pharmacogenetics and genomics.  18  pp.709-720,  2008-08-01.  Lippincott, Williams & Wilkins
URL: http://hdl.handle.net/2297/12396
概要: 医薬保健研究域薬学系<br />OBJECTIVES: Human uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7) plays important roles in the metabolism of some clinical drugs, carcinogens, and steroid hormones. The molecular mechanisms of the inducible expression of UGT2B7 in response to xenobiotics have not been fully clarified. We sought to investigate whether the UGT2B7 is under the control of NF-E2 p45-related factor 2 (Nrf2), a key transcriptional factor regulating the expression of cytoprotective enzymes. METHODS: HepG2, HuH7, HLE, and Caco-2 cells were treated with sulforaphane (SFN), and the UGT2B7 mRNA levels were determined by real-time reverse transcriptase PCR. These cells were genotyped for the UGT2B7*2 (H268Y) allele using the PCR-restriction fragment length polymorphism method. Luciferase analyses and gel shift analyses were performed to identify the responsive regions for Nrf2 signaling. RESULTS: The UGT2B7 mRNA was induced by SFN in HepG2 and HuH7 genotyped as UGT2B7*1/*1, but not in HLE and Caco-2 cells genotyped as UGT2B7*2/*2. In HepG2 cells, the UGT2B7 protein level and morphine glucuronosyltransferase activity were also significantly induced by SFN. The induction was prominently decreased with small interfering RNA for Nrf2. In the 5'-flanking region (-2.5 kb) of the UGT2B7*2 allele, a 324-base pair insertion at -2067 and 12 single nucleotide polymorphisms simultaneously existed. Luciferase analyses and gel shift analyses revealed that an antioxidant responsive element at -1170 was responsible for the transactivation by Nrf2. In addition, a region from -990 to -858 on the UGT2B7*1 allele was also responsible for the transactivation by Nrf2. Abrogation of the Nrf2-dependent transactivation of the UGT2B7*2 allele was owing to the single nucleotide polymorphism -900A>G. CONCLUSION: UGT2B7 is transcriptionally regulated by Nrf2, but the mechanism is hindered by polymorphisms in the promoter region of UGT2B7*2. The allele-specific mechanism may cause variability of the glucuronidation in response to oxidative stress.全文公開200908 続きを見る
9.

図書

図書
出版情報: Durham, N.C. : Duke University Press
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10.

電子ブック

EB
出版情報: メディカ出版
オンライン: https://elib.maruzen.co.jp/elib/html/BookDetail/Id/3000072329
11.

電子ブック

EB
出版情報: メディカ出版
オンライン: https://elib.maruzen.co.jp/elib/html/BookDetail/Id/3000011933
12.

図書

図書
edited with translation and explanatory notes by S.D. Joshi and J.A.F. Roodbergen
出版情報: Poona : University of Poona, 1973
シリーズ名: Publications of the Centre of Advanced Study in Sanskrit ; class C ; no. 7
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13.

論文

論文
Yamada, Fumio ; Kawanishi, Atsuko ; Tomita, Akiko ; Somei, Masanori
出版情報: Arkivoc.  2003  pp.102-111,  2003-01-01.  Arkat USA
URL: http://hdl.handle.net/2297/19723
概要: 1-Hydroxy-2,3-dimethylindole (1) has been prepared for the first time. Under atmospheric oxygen, 1 was converted rapidly into 3-hydroxy-2,3-dimethyl- 3H-indole N-oxide (2). The structure was deduced, based on its products obtained by the reaction with Ac2O in pyridine and confirmed by X-ray single crystallographic analysis. 続きを見る
14.

論文

論文
Nakano, Takeo ; Soeta, Takahiro ; Endo, Kohei ; Inomata, Katsuhiko ; Ukaji, Yutaka
出版情報: Journal of Organic Chemistry.  78  pp.12654-12661,  2013-12-20.  American Chemical Society
URL: http://hdl.handle.net/2297/36468
概要: The sequential 1,4-elimination reaction of (E)-4-alkoxy-2-butenyl benzoates and [1,2]-Wittig rearrangement gave (2Z,4E)- 2,4-pentadien-1-ols stereoselectively. Z-Selective formation of intermediary vinyl ethers, whose stereochemistry was well elucidated by the "syn-effect", was achieved by treatment of the 2-butenyl benzoates with KOH in the presence of Pd catalyst. The subsequent [1,2]-Wittg rearrangement by use of n-BuLi proceeded with retention of the stereochemistry of the intermediary vinyl ethers. © 2013 American Chemical Society. 続きを見る
15.

図書

図書
出版情報: 東京 : オーム社
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16.

視聴覚資料

AV
出版情報: [New York] : RCA , Tokyo : BMG Victor [distributor]
所蔵情報: loading…
17.

図書

図書
出版情報: [東京] : 翔泳社
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18.

論文

論文
Murata, Yasue ; Kinoshita, Hideki ; Inomata, Katsuhiko
出版情報: Bulletin of the Chemical Society of Japan.  69  pp.3339-3344,  1996-01-01.  The Chemical Society of Japan = 日本化学会
URL: http://hdl.handle.net/2297/38263
概要: The syntheses of 3,4-disubstituted 2-tosylpyrroles and 5-tosyl-1,5-dihydro-2H-pyrrol-2-ones were accomplished via 3,4-disubstituted 2-iodo-5-tosylpyrroles starting from ethyl 3,4-disubstituted 2-pyrrolecarboxylates.
19.

電子ブック

EB
Dickens, Brian.
出版情報: Gaithersburg, MD
オンライン: ジャーナル/ブックへリンク
20.

論文

論文
Higuchi, Akihiro ; Erina Oonishi ; Kawakita, Tetsuya ; Tsubota, Kazuo ; 樋口, 明弘
出版情報: Molecular Vision.  22  pp.446-453,  2016-04-30.  Molecular Vision
URL: http://hdl.handle.net/2297/00062813
概要: 金沢大学先端科学・社会共創推進機構<br />Purpose: 2-hydroxy estradiol (2-OHE2) is a catechol derivative of 17β -Estradiol (E2) and it is s ynthesized from E2 catalyzed by cytochrome P4501A1. Previous studies reported that 2-OHE2 is a physiologic antioxidant in lipoproteins, liver microsomes, and the brain. Catechol derivatives show an anti-inflammatory effect through the inhibition of prostaglandin endoperoxide synthase (PGS) activity. Corneal erosion caused by dry eye is related to an increase in oxidative stress and inflammation in ocular surface cells. We investigated the therapeutic effects of 2-OHE2 on corneal damage caused by dry eye. Methods: Steroidal radical scavenging activity was confirmed through the electron spin resonance (ESR) method. PGS activity was measured using the COX Fluorescent Activity Assay Kit. To evaluate the effect of 2-OHE2 on the treatment for dry eye, 2-OHE2 was applied as an eye drop experiment using dry eye model rats. Results: 2-OHE2 scavenged tyrosyl radical and possibly suppressed oxidative stress in corneal epithelial cells. In addition, 2-OHE2 inhibited PGS activity, and 2-OHE2 is probably a competitive inhibitor of PGS. Corneal PGS activity was upregulated in the dry eye group. Therefore, 2-OHE2 eye drops improved corneal erosion in dry eye model rats. Conclusions: 2-OHE2 is a candidate for the treatment of dry eye through the suppression of inflammation and oxidative stress in the cornea. © 2016 Molecular Vision. 続きを見る
21.

論文

論文
Somei, Masanori ; Hayashi, Hiroyuki ; Ohmoto, Shinobu
出版情報: Heterocycles.  44  pp.169-176,  1997-01-01.  日本複素環化学研究所
URL: http://hdl.handle.net/2297/4341
概要: 金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部<br />Indigo was converted to 2,2′-bisindole by the direct reduction with zinc in ace tic acid and acetic anhydride under argon or hydrogen atmosphere. Reduction with tin and iron afforded 3-acetoxy-2,2′-bisindole predominantly. Useful building blocks such as 1-acetyl-2,3-dihydro-, 3-acetoxy-3′-acetyl-, and 3-acetoxy-1,3′-diacetyl-2,2′-bisindoles were also produced depending on metal and reaction conditions. 続きを見る
22.

図書

図書
Dubuisson, Bernard
出版情報: Paris : Hermes Science
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23.

図書

図書
出版情報: 東京 : 講談社
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24.

図書

図書
出版情報: London : W. Collins
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25.

図書

図書
von Gerhard Timpe
出版情報: Berlin : Duncker & Humblot, c1983
シリーズ名: Strafrechtliche Abhandlungen ; n.F., Bd. 50
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26.

図書

図書
hrsg. von Karl-Heinz Fingerhut, Eduard Haueis und Otfried Hoppe
出版情報: Stuttgart : Metzler
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27.

図書

図書
Federation of European Biochemical Societies
出版情報: Oxford ; New York : Pergamon Press
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28.

論文

論文
Nakata, Shunji ; Kato, Takashi ; Ozaki, Shinya ; Kawae, Takeshi ; Morimoto, Akiharu
出版情報: Thin Solid Films.  542  pp.242-245,  2013-09-02.  Elsevier B.V.
URL: http://hdl.handle.net/2297/35657
概要: Thin film Al2O3/Al-rich Al2O 3/SiO2 structures were fabricated on p-Si substrates. Radio-frequency magnetron co-sputteri ng was used to form Al-rich Al 2O3 thin film as the charge-trapping layer of nonvolatile Al2O3 memory. Capacitance-voltage measurements showed a large hysteresis due to charge trapping in the Al-rich Al2O 3 layer. The charge trap density was estimated to be 42.7 × 1018 cm- 3, which is the largest value ever reported for an Al-rich Al2O3 layer; it is six times larger than that of a conventional metal-nitride-oxide-silicon memory. Thermal annealing was found to reduce the leakage current of the Al2O3 blocking layer, thereby providing this structure with better data retention at room temperature than an as-deposited one. In addition, the annealed structure was found to exhibit good data retention even at 100 C. © 2013 Elsevier B.V. All rights reserved. 続きを見る
29.

図書

図書
Deutsche Chemische Gesellschaft ; Beilstein, Friedrich Konrad, 1838-1906 ; Richter, Friedrich, 1896-1961
出版情報: Berlin : Springer, 1941-1957
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30.

論文

論文
Suzuki, Masatatsu ; Sugisawa, Toshiharu ; Uehara, Akira
出版情報: Bulletin of the Chemical Society of Japan.  63  pp.1115-1120,  1990-01-01.  The Chemical Society of Japan = 日本化学会
URL: http://hdl.handle.net/2297/38282
概要: Two dinuclear cobalt(II,II) complexes, [Co2(tpdp)(CH3COO)](ClO4)2·0.5H2O (1) and [Co2(tmdp)(CH3COO)](ClO4)2·H2O (2), wer e prepared, where Htpdp and Htmdp are 1,3-bis[bis(2-pyridylmethyl)amino]-2-propanol and 1,5-bis[bis(2-pyridylmethyl)amino]-3-pentanol respectively. Their electronic spectral and magnetic data revealed that 1 and 2 are five-coordinate in the high-spin state, in the same manner as [Co2(bpmp)(CH3COO)]2+ (3) (Hbpmp=2,6-bis[bis(2-pyridylmethyl)aminomethyl]-4-methylphenol). The complexes reacted with molecular oxygen to form μ-peroxo complexes in dichloromethane and acetonitrile. The oxygen affinity of the complexes decreased in the order of 3>2>1. The relationships between the oxygen affinities and (1) the donor abilities of dinucleating ligands, (2) the energies of the charge-transfer bands (O22− to Co3+) of the μ-peroxo complexes, and (3) the redox potentials of the Co3+–O2−–Co3+/Co3+–O22−–Co3+ couple indicated that a steric effect arising from the dinucleating ligands contributes significantly to the oxygen affinities of the complexes. 続きを見る
31.

論文

論文
Inami, Shinnosuke ; Nishio, Masaki ; Hayashi, Yoshihito ; Isobe, Kiyoshi ; Kameda, Hiroyuki ; Shimoda, Tatsuya
出版情報: European Journal of Inorganic Chemistry.  pp.5253-5258,  2009-11-26.  Wiley-Blackwell
URL: http://hdl.handle.net/2297/20361
概要: 金沢大学理工研究域物質化学系<br />An all-inorganic complex, [Mn2{(CVO3) 5}2]6- (1), was synthesized, and the structure determination r eveals a dinuclear manganese complex coordinated by two cyclic pentavanadate ligands. The cyclic pentavanadate units sandwich the edge-sharing octahedral dimanganese core through, coordination of the oxido group of the pentavanadate. A. dinuclear cobalt complex with, a cyclic decavanadate, [Co 2(OH2)2(VO3)10]6- (2), was also synthesized. The structure analysis reveals a dinuclear cobalt complex with a macrocyclic decavanadate, which is composed of 10 VO4 units joined by the vertex. Sharings. The CoO6 octahedrons are edge-shared, with each cobalt octahedron coordinated to five oxido groups from the decavanadate. The remaining site is occupied by - water. The coordinated water molecules are supported with hydrogen bonds in two directions. Complex 2 in acetonitrile shows no reactivity with dioxygen even at low temperature, and the cyclic voltammogram of 2 shows no redox chemistry in acetonitrile. Complex 2 exhibits chromism by water exposure both, in the solid state and. in acetonitrile. Complex 2 is green-yellow in color, and. the addition of water causes the complex to turn brown. After heating the sample, it returns to its original color in a reversible manner. The EXAFS data in acetonitrile is also reported, and is consistent with the solid-state structure. © Wiley-VCH Verlag GmbH & Co. KGaA. 続きを見る
32.

図書

図書
United States. Congress. Senate. Select Committee on Small Business. Subcommittee on Monopoly
出版情報: Washington : U.S. Govt. Print. Off., 1972-1973
シリーズ名: Role of giant corporations ; . Hearings before the Subcommittee on Monopoly of the Select Committee on Small Business, United States Senate, Ninety-second Congress, first session, on the role of giant corporations in the American and world economies ; pt. 2-2B . Corporate secrecy
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33.

論文

論文
Sawanomukai, Takashi ; Iwatsubo, Yoshikane ; Naruhashi, Naohiro
出版情報: 植物地理・分類研究 = The journal of phytogeography and toxonomy.  51  pp.131-136,  2003-12-25.  植物地理・分類学会 = The Society for the Study of Phytogeography and Taxonomy
URL: http://hdl.handle.net/2297/48612
概要: Chromosome counts of 16 species and two varieties of Scutellaria(Lamiaceae)collected from 45 localities in Ja-pan were r eported. First counts were the following 11 taxa : S . amabilis(2n=26), S . brachyspica(2n=26), S . in-dica var. parvifolia(2n=26), S . iyoensis(2n=26), S . kiusiana(2n=26), S . laeteviolacea var. laeteviolacea(2n =26), S . laeteviolacea var. maekawae(2n=26), S . muramatsui(2n=26), S . pekinensis var. transitra(2n=28), S . shikokiana(2n=28)and S . tsusimensis(2n=26). New counts were reported in S . dependens(2n=28), S . strigil-losa(2n=30)and S . yezoensis(2n=30). Chromosome counts for S . barbata(2n=26), S . guilielmii(2n=28), S . indica var. indica(2n=26)and S . rubropunctata var. rubropunctata(2n=26)were confirmed. 続きを見る
34.

論文

論文
Ikeda, Masazumi ; Ohtani, Shinji ; Okada, Michiyo ; Minakuchi, Emi ; Sato, Tatsunori ; Ishibashi, Hiroyuki
出版情報: Heterocycles.  47  pp.181-186,  1998-01-01.  (株)日本複素環化学研究所
URL: http://hdl.handle.net/2297/3280
35.

論文

論文
Somei, Masanori ; Kodama, Atsushi
出版情報: Heterocycles.  34  pp.1285-1288,  1992-01-01.  日本複素環化学研究所
URL: http://hdl.handle.net/2297/4326
概要: 金沢大学大学院自然科学研究科生理活性物質科学<br />金沢大学薬学部
36.

論文

論文
Matsuo, Jun-ichi ; Okuno, Ryosuke ; Takeuchi, Kosuke ; Kawano, Mizuki ; Ishibashi, Hiroyuki
出版情報: Tetrahedron Letters.  51  pp.3736-3737,  2010-07-21.  Elsevier
URL: http://hdl.handle.net/2297/24795
概要: 金沢大学医薬保健研究域薬学系<br />Optimized reaction conditions for the preparation of various 2-monosubstituted 3-ethoxycyclobutanone s are described. 2-Monoalkyl 3-ethoxycyclobutanones were efficiently prepared by the reaction of the corresponding carboxylic acid chlorides and an excess amount of ethyl vinyl ether in the presence of diisopropylethylamine at 90 °C in a sealed tube. 2-Monoaryl 3-ethoxycyclobutanones were prepared by using 2,6-lutidine as a base in the above-mentioned procedure. © 2010 Published by Elsevier Ltd. All rights reserved. 続きを見る
37.

論文

論文
Matsuo, Junichi ; Okuno, Ryosuke ; Takeuchi, Kosuke ; Kawano, Mizuki ; Ishibashi, Hiroyuki
出版情報: Tetrahedron Letters.  51  pp.3736-3737,  2010-07-21.  Elsevier
URL: http://hdl.handle.net/2297/24569
概要: 金沢大学医薬保健研究域薬学系<br />Optimized reaction conditions for the preparation of various 2-monosubstituted 3-ethoxycyclobutanone s are described. 2-Monoalkyl 3-ethoxycyclobutanones were efficiently prepared by the reaction of the corresponding carboxylic acid chlorides and an excess amount of ethyl vinyl ether in the presence of diisopropylethylamine at 90 °C in a sealed tube. 2-Monoaryl 3-ethoxycyclobutanones were prepared by using 2,6-lutidine as a base in the above-mentioned procedure. © 2010 Elsevier Ltd. All rights reserved. 続きを見る
38.

論文

論文
Nishida, Y. ; Miyamori, H. ; Thompson, E.W. ; Takino, Takahisa ; Sato, H.
出版情報: Cancer Research Institution Report = がん研究所年報.  2006-2008  pp.27-,  2009-03-01.  金沢大学がん研究所 = Kanazawa University Cancer Research Institute
URL: http://hdl.handle.net/2297/18011
概要: Division of Molecular Viology and Oncology
39.

図書

図書
Алексей Каплер
出版情報: Москва : Искусство, 1984
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40.

図書

図書
Gustav Ehrismann
出版情報: München : C. H. Beck, 1918-
シリーズ名: Handbuch des deutschen Unterrichts an höheren Schulen ; Bd. 6, Tl. 1-2
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41.

論文

論文
Tsutiya, Ryokichi
出版情報: The science reports of the Kanazawa University=金沢大学理科報告.  2  pp.35-41,  1953-03-01.  the Faculty of Science Kanazawa University
URL: http://hdl.handle.net/2297/33713
42.

論文

論文
Tsutiya, Ryokichi
出版情報: The science reports of the Kanazawa University=金沢大学理科報告.  2  pp.43-48,  1953-03-01.  the Faculty of Science Kanazawa University
URL: http://hdl.handle.net/2297/33714
43.

論文

論文
Sumiyoshi, T. ; Kido, H. ; Sakamoto, H. ; Urasaki, K. ; Suzuki, K. ; Yamaguchi, N. ; Mori, Hirofumi ; Shiba, Kazuhiro ; Yokogawa, K. ; 柴, 和弘
出版情報: Pharmacology, Biochemistry and Behavior.  47  pp.553-557,  1994.  日本アイソトープ協会 Japan Radioisotope Association
URL: http://hdl.handle.net/2297/00065223
概要: 金沢大学疾患モデル総合研究センター<br />An in vivo receptor binding technique was applied to evaluate the affinities of risperidone and h aloperidol for dopamine-D2 receptors (D2) and serotonin-5-HT2 receptors (5-HT2) in rat brain with [3H]YM-09151-2 and [3H]ketanserin as selective ligands. Radioactivities were obtained in the striatum, frontal cortex, and cerebellum of the rats treated with the ligands. Time course study of receptor occupancy at 25 to 250 min after single doses of the drugs (1 mg/kg, IP) showed higher 5-HT2 occupancy in the frontal cortex and lower D2 occupancy in the striatum by risperidone than by haloperidol. Dose-response analysis of receptor occupancy revealed risperidone demonstrated higher binding affinity for 5-HT2 than for D2, while the reverse was observed with haloperidol. It appeared that risperidone (1 mg/kg, IP), but not haloperidol (1 mg/kg, IP), demonstrated regional selectivity in D2 occupancy favouring frontal cortex more than the striatum. That risperidone displayed a higher ratio of 5-HT2 to D2 in occupancy than haloperidol is in agreement with the previous findings obtained in vitro. © 1994. 続きを見る
44.

論文

論文
Sugimoto, Hideki ; Nagayama, Toshihiko ; Maruyama, Sachihito ; Fujinami, Shuhei ; Yasuda, Yuichi ; Suzuki, Masatatsu ; Uehara, Akira
出版情報: Bulletin of the Chemical Society of Japan.  71  pp.2267-2279,  1998-01-01.  The Chemical Society of Japan = 日本化学会
URL: http://hdl.handle.net/2297/38280
概要: A new dinucleating ligand containing a sterically bulky imidazolyl group, Ph-Htidp (N,N,N′,N′-tetrakis[(1-methyl-4,5-dip henyl-2-imidazolyl)methyl]-1,3-diamino-2-propanol), and its μ-alkoxo-diiron(II) complexes [Fe2(Ph-tidp)(RCO2)](ClO4)2, (RCO2 = C6H5CO2 (1), C6F5CO2 (2), CF3CO2 (3), and C2H5CO2 (4)), were synthesized. The structure of complex 1 was determined by X-ray crystallography. Complex 1 crystallizes in the monoclinic space group P21/c with a = 13.464(2), b = 19.223(4), c = 31.358(4) Å, β = 92.84(2)°, and Z = 4. The complex has a doubly-bridged structure with μ-alkoxo of Ph-tidp and μ-benzoate; the two iron centers have a distorted five-coordinate structure with N3O2 donor set. All the complexes showed fairly good reversible oxygenation below −30 °C in CH2Cl2, which was monitored by UV-vis and NMR spectroscopies, and dioxygen up-take measurements. Introduction of 4,5-diphenyl substituents into 2-imidazolyl group stabilized the μ-peroxo diiron species against irreversible oxidation, just as introduction of 6-methyl substituent into 2-pyridyl group did. Phenyl substituents appear to weaken the electron donor ability of a dinucleating ligand to stabilize divalent oxidation state of iron and to form a hydrophobic cavity for a O2 binding site, which would suppress the irreversible oxidation and facilitate the reversible oxygenation. Dioxygen affinities of the Ph-tidp and Me4-tpdp diiron(II), and the tpdp and bpmp dicobalt(II) complexes were measured, [Fe2(Me4-tpdp)(RCO2)]2+ (RCO2 = C6H5CO2 and RCO2 = CF3CO2) and [Co2(L)(RCO2)]2+ (L = tpdp, RCO2 = CH3CO2, and L = bpmp, RCO2 = C6F5CO2, and CF3CO2), where Me4-tpdp, tpdp, and bpmp are N,N,N′,N′-tetrakis[(6-methyl-2-pyridyl)methyl]-1,3-diamino-2-propanolate, N,N,N′,N′-tetrakis(2-pyridylmethyl)-1,3-diamino-2-propanolate, and 2,6-bis[bis(2-pyridylmethyl)aminomethyl]-4-methylphenolate, respectively. Within a series of the Ph-tidp diiron(II) complexes, dioxygen affinity is well correlated with electron donor ability of bridging carboxylates (1 (C6H5CO2) > 2 (C6F5CO2) > 3 (CF3CO2)). In contrast to the above trend, dioxygen affinities of the Ph-tidp complexes are lower than those of the Me4-tpdp complexes, although electron donor abilities of the Me4-tpdp complexes are weaker than those of the Ph-tidp complexes. Significant enhancement of dioxygen affinity was observed for both iron and cobalt complexes with 2,6-bis(aminomethyl)phenolate bridging skeleton compared to the complexes with a 1,3-diamino-2-propanolate bridging one. Thermodynamic study suggested that the observed enhancement is mainly attributable to a favorable entropy effect along with a steric effect. 続きを見る
45.

図書

図書
出版情報: 大阪 : パレード , 東京 : まぐまぐ
所蔵情報: loading…
46.

図書

図書
出版情報: London : Europa Pub., 1927-
所蔵情報: loading…
47.

論文

論文
Ihara, Yoshinori ; Satake, Yasuhiro ; Fujimoto, Yumi ; Senda, Hitoshi ; Suzuki, Masatatsu ; Uehara, Akira
出版情報: Bulletin of the Chemical Society of Japan.  64  pp.2349-2352,  1991-01-01.  日本化学会=The Chemical Society of Japan
URL: http://hdl.handle.net/2297/37512
概要: The structures of two diaquabis(N,N-dialkylethylenediamine)nickel(II) chlorides ([Ni(H2O)2(diamine)2]Cl2·nH2O) were dete rmined by X-ray crystallographic studies, where diamine is N,N-dimethylethylenediamine(NN-dmen) or N,N-diethylethylenediamine (NN-deen). Both complexes are trans and crystallize in the monoclinic space group P21⁄n. The unit cell parameters of the NN-dmen complex, NiCl2C8N4O2H32, are a=7.531(1), b=13.092(1), c=9.591 Å, β=107.76(1)°, and Z=2, and those of the NN-deen complex, NiCl2C12N4O2H36, are a=9.154(1), b=8.692(1), c=12.395(2) Å, β=104.46(1)°, and Z=2. In trans-[Ni(H2O)2(NN-dmen)2]Cl2·2H2O and trans-[Ni(H2O)2(NN-deen)2]Cl2, the Ni–NMe2 and Ni–NEt2 bond distances (2.183 and 2.271 Å) are much longer than the Ni–NH2 distances (2.078 and 2.064 Å), forming tetragonally distorted octahedrons with four close in-plane neighbors(N2O2) and two remote axial ones(N2). It is apparent that this distortion originates from the steric requirement of N-substituted groups. Such a distortion significantly affects the electronic spectra of these complexes. 続きを見る
48.

論文

論文
Yokota, Shinichi ; Higashi, Eriko ; Fukami, Tatsuki ; Yokoi, Tsuyoshi ; Nakajima, Miki
出版情報: Biochemical Pharmacology.  81  pp.289-294,  2011-01-15.  Elsevier
URL: http://hdl.handle.net/2297/25430
概要: 金沢大学医薬保健研究域薬学系<br />Human CYP2A6 is responsible for the metabolism of nicotine and coumarin as well as the metabolic act ivation of tobacco-related nitrosamines. Earlier studies revealed that CYP2A6 activity was increased by dietary cadmium or cruciferous vegetables, but the underlying mechanisms remain to be clarified. In the present study, we investigated the possibility that Nrf2 might be involved in the regulation of CYP2A6. Real-time RT-PCR analysis revealed that the CYP2A6 mRNA level in human hepatocytes was significantly (P < 0.01, 1.4-fold) induced by 10 μM sulforaphane (SFN), a typical activator of Nrf2. A computer-based search identified three putative antioxidant response elements (AREs) in the 5′-flanking region of the CYP2A6 gene at positions -1212, -2444, and -3441, termed ARE1, ARE2, and ARE3, respectively. Electrophoretic mobility shift assays demonstrated that Nrf2 bound only to ARE1. Luciferase assays using HepG2 cells revealed that the overexpression of Nrf2 significantly increased the reporter activities of the constructs containing a 30-bp fragment that included ARE1. However, the activity of the construct containing the intact 5′-flanking region (-1 to -1395) including ARE1 was not increased by the overexpression of Nrf2. In contrast, when the reporter construct was injected into mice via the tail vein, the reporter activity in the liver was significantly (P < 0.05, 1.9-fold) increased by SFN (1 mg/head) administration. In conclusion, we found that human CYP2A6 is regulated via Nrf2, suggesting that CYP2A6 is induced under oxidative stress. © 2010 Elsevier Inc. All rights reserved. 続きを見る
49.

論文

論文
Iwasa, Junko ; Miyoshi, Ken-ichi
出版情報: The science reports of the Kanazawa University=金沢大学理科報告.  24  pp.1-8,  1979-06-01.  the Faculty of Science Kanazawa University
URL: http://hdl.handle.net/2297/34036
50.

論文

論文
Watanabe, Hiroyuki ; Okada, G. ; Ohtsubo, K. ; Yao, F. ; Jiang, P.H. ; Sawabu, Norio
出版情報: Cancer Research Institute report.  2003-2005  pp.77-,  2006-03-01.  金沢大学がん研究所
URL: http://hdl.handle.net/2297/2625