1.

図書

図書
出版情報: Paris : A. Colin
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2.

論文

論文
Hoshikawa, Takaya ; Tanji, Kei ; Matsuo, Jun-ichi ; Ishibashi, Hiroyuki
出版情報: Chemical and Pharmaceutical Bulletin.  60  pp.548-553,  2012-04-01.  Pharmaceutical Society of Japan = 日本薬学会
URL: http://hdl.handle.net/2297/31381
概要: Intramolecular [2+2] cycloaddition of γ,δ-unsaturated ketenes derived from hex-5-enoyl chloride derivatives gave bicyclo[2.1.1]hexan-5-ones with complete regioselectivity. © 2012 The Pharmaceutical Society of Japan.
3.

図書

図書
World Congress of Gastroenterology
出版情報: Basel ; New York : S. Karger
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4.

電子ブック

EB
出版情報: 中山書店, 2002.3
オンライン: https://elib.maruzen.co.jp/elib/html/BookDetail/Id/3000001081
5.

論文

論文
土成, 昭弘 ; 保木井, 利之 ; 下林, 修 ; 金岡, 千嘉男
出版情報: Journal of the Ceramic Society of Japan.  100  pp.918-923,  1992-07-01.  The Ceramic Society of Japan
URL: http://hdl.handle.net/2297/24631
概要: In a permeable MgO ceramic containing TiO_2 and Al_2O_3 as matrix MgO ・ Al_2O_3-2MgO・TiO_2 solid solutions were detected and no Al_2O_3・TiO_2 was observed. Therefore, the solid state reaction among MgO, TiO_2 and Al_2O_3 with excess MgO was studied at various firing temperatures. The formation mechanism of MgO・Al_2O_3-2MgO・TiO_2 solid solutions was studied from the results of interface reactions between MgO-TiO_2 and MgO-Al_2O_3. MgO・Al_2O_3-2MgO・TiO_2 solid solutions were detected at 1573-1673 K and increased with the firing temperature. 2MgO・TiO_2 was formed in the system MgO-TiO_2, but was not produced in the system MgO-TiO_2-Al_2O_3, because the amount of Mg diffusion at the interface of aggregate and matrix additives was not enough due to the large aggregate size of MgO. MgO・Al_2O_3 and 2MgO・TiO_2 formed at the interface between MgO-TiO_2 and MgO-Al_2O_3 decreased with the firing time at 1873 K. On the other hand, MgO・Al_2O_3-2MgO・TiO_2 solid solutions increased. Mg was recognized in the matrix without addition of MgO as a matrix. Al diffused in the layer of MgO-TiO_2, in opposition Ti diffused in the layer of MgO-Al_2O_3 by EPMA analysis. From the above results, the formation mechanism of a MgO・Al_2O_3-2MgO・TiO_2 solid solution was proposed; (1) Mg diffusion at the interface of MgO aggregate and matrix additives, (2) formation of MgO・TiO_2 and MgO・Al_2O_3, (3) formation of 2MgO・TiO_2 due to the reaction with MgO・TiO_2 and MgO, (4) reaction of the solid solution with MgO・Al_2O_3 and 2MgO・TiO_2. In the reactions between MgO・TiO2 and MgO-Al_2O_3 the product layer of MgO・Al_2O_3-2MgO・TiO_2 solid solution increased as the firing time increased. The diffusion coefficient of Mg was about 4.8×10^<-7>(cm^2/s), in a good agreement with that of Mg which was reported. 続きを見る
6.

論文

論文
Nishida, Yuki ; Miyamori, Hisashi ; Thompson, Erik W. ; Takino, Takahisa ; Endo, Yoshio ; Sato, Hiroshi
出版情報: Cancer Research.  68  pp.9096-9104,  2008-11-01.  American Association for Cancer Research
URL: http://hdl.handle.net/2297/12472
概要: 金沢大学がん研究所がん病態制御<br />The suggested model for pro-matrix metalloproteinase-2 (proMMP-2) activation by membrane type 1 MMP (MT1-MMP) implicates the complex between MT1-MMP and tissue inhibitor of MMP-2 (TIMP-2) as a receptor for proMMP-2. To dissect this model and assess the pathologic significance of MMP-2 activation, an artificial receptor for proMMP-2 was created by replacing the signal sequence of TIMP-2 with cytoplasmic/transmembrane domain of type II transmembrane mosaic serine protease (MSP-T2). Unlike TIMP-2, MSP-T2 served as a receptor for proMMP-2 without inhibiting MT1-MMP, and generated TIMP-2-free active MMP-2 even at a low level of MT1-MMP. Thus, MSP-T2 did not affect direct cleavage of the substrate testican-1 by MT1-MMP, whereas TIMP-2 inhibited it even at the level that stimulates proMMP-2 processing. Expression of MSP-T2 in HT1080 cells enhanced MMP-2 activation by endogenous MT1-MMP and caused intensive hydrolysis of collagen gel. Expression of MSP-T2 in U87 glioma cells, which express a trace level of endogenous MT1-MMP, induced MMP-2 activation and enhanced cell-associated protease activity, activation of extracellular signal-regulated kinase, and metastatic ability into chick embryonic liver and lung. MT1-MMP can exert both maximum MMP-2 activation and direct cleavage of substrates with MSP-T2, which cannot be achieved with TIMP-2. These results suggest that MMP-2 activation by MT1-MMP potentially amplifies protease activity, and combination with direct cleavage of substrate causes effective tissue degradation and enhances tumor invasion and metastasis, which highlights the complex role of TIMP-2. MSP-T2 is a unique tool to analyze physiologic and pathologic roles of MMP-2 and MT1-MMP in comparison with TIMP-2. ©2008 American Association for Cancer Research.全文公開200911 続きを見る
7.

論文

論文
Somei, Masanori ; Yamada, Fumio ; Yamazaki, Yoshihisa ; Shinkura, Akiko
出版情報: Chemical and Pharmaceutical Bulletin.  44  pp.21-28,  1996-01-01.  Pharmaceutical Society of Japan = 日本薬学会
URL: http://hdl.handle.net/2297/43982
概要: We developed a novel synthesis of 2-aminoindan derivatives, having a 2-methyl-1-propenyl group at the 1-position and oxygen functional groups in the benzene ring, in 8 or 9 steps from vanillin.
8.

論文

論文
Nakamura, Akiko ; Nakajima, Miki ; Higashi, Eriko ; Yamanaka, Hiroyuki ; Yokoi, Tsuyoshi
出版情報: Pharmacogenetics and genomics.  18  pp.709-720,  2008-08-01.  Lippincott, Williams & Wilkins
URL: http://hdl.handle.net/2297/12396
概要: 医薬保健研究域薬学系<br />OBJECTIVES: Human uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7) plays important roles in the metabolism of some clinical drugs, carcinogens, and steroid hormones. The molecular mechanisms of the inducible expression of UGT2B7 in response to xenobiotics have not been fully clarified. We sought to investigate whether the UGT2B7 is under the control of NF-E2 p45-related factor 2 (Nrf2), a key transcriptional factor regulating the expression of cytoprotective enzymes. METHODS: HepG2, HuH7, HLE, and Caco-2 cells were treated with sulforaphane (SFN), and the UGT2B7 mRNA levels were determined by real-time reverse transcriptase PCR. These cells were genotyped for the UGT2B7*2 (H268Y) allele using the PCR-restriction fragment length polymorphism method. Luciferase analyses and gel shift analyses were performed to identify the responsive regions for Nrf2 signaling. RESULTS: The UGT2B7 mRNA was induced by SFN in HepG2 and HuH7 genotyped as UGT2B7*1/*1, but not in HLE and Caco-2 cells genotyped as UGT2B7*2/*2. In HepG2 cells, the UGT2B7 protein level and morphine glucuronosyltransferase activity were also significantly induced by SFN. The induction was prominently decreased with small interfering RNA for Nrf2. In the 5'-flanking region (-2.5 kb) of the UGT2B7*2 allele, a 324-base pair insertion at -2067 and 12 single nucleotide polymorphisms simultaneously existed. Luciferase analyses and gel shift analyses revealed that an antioxidant responsive element at -1170 was responsible for the transactivation by Nrf2. In addition, a region from -990 to -858 on the UGT2B7*1 allele was also responsible for the transactivation by Nrf2. Abrogation of the Nrf2-dependent transactivation of the UGT2B7*2 allele was owing to the single nucleotide polymorphism -900A>G. CONCLUSION: UGT2B7 is transcriptionally regulated by Nrf2, but the mechanism is hindered by polymorphisms in the promoter region of UGT2B7*2. The allele-specific mechanism may cause variability of the glucuronidation in response to oxidative stress.全文公開200908 続きを見る
9.

図書

図書
出版情報: Durham, N.C. : Duke University Press
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10.

電子ブック

EB
出版情報: メディカ出版
オンライン: https://elib.maruzen.co.jp/elib/html/BookDetail/Id/3000072329