1.

論文
論文
1. Intramolecular [2+2] cycloaddition of homoallylketenes to bicyclo[2.1.1]hexan-5-ones
Hoshikawa, Takaya ; Tanji, Kei ; Matsuo, Jun-ichi ; Ishibashi, Hiroyuki
出版情報: Chemical and Pharmaceutical Bulletin.  60  pp.548-553,  2012-04-01.  Pharmaceutical Society of Japan = 日本薬学会
URL: http://hdl.handle.net/2297/31381
概要: Intramolecular [2+2] cycloaddition of γ,δ-unsaturated ketenes derived from hex-5-enoyl chloride derivatives gave bicyclo[2.1.1]hexan-5-ones with complete regioselectivity. © 2012 The Pharmaceutical Society of Japan.
2.

図書
図書
2. 2. Weltkongress für Gastroenterologie = 2nd World Congress of Gastroenterology = 2e Congres Mondial de Gastroentérologie = 2. Congreso Mundial de Gastroenterologia
World Congress of Gastroenterology
出版情報: Basel ; New York : S. Karger
3.

論文
論文
3. Activation of matrix metalloproteinase-2 (MMP-2) by membrane type 1 matrix metalloproteinase through an artificial receptor for ProMMP-2 generates active MMP-2
Nishida, Yuki ; Miyamori, Hisashi ; Thompson, Erik W. ; Takino, Takahisa ; Endo, Yoshio ; Sato, Hiroshi
出版情報: Cancer Research.  68  pp.9096-9104,  2008-11-01.  American Association for Cancer Research
URL: http://hdl.handle.net/2297/12472
概要: 金沢大学がん研究所がん病態制御<br />The suggested model for pro-matrix metalloproteinase-2 (proMMP-2) activation by membrane type 1 MMP … (MT1-MMP) implicates the complex between MT1-MMP and tissue inhibitor of MMP-2 (TIMP-2) as a receptor for proMMP-2. To dissect this model and assess the pathologic significance of MMP-2 activation, an artificial receptor for proMMP-2 was created by replacing the signal sequence of TIMP-2 with cytoplasmic/transmembrane domain of type II transmembrane mosaic serine protease (MSP-T2). Unlike TIMP-2, MSP-T2 served as a receptor for proMMP-2 without inhibiting MT1-MMP, and generated TIMP-2-free active MMP-2 even at a low level of MT1-MMP. Thus, MSP-T2 did not affect direct cleavage of the substrate testican-1 by MT1-MMP, whereas TIMP-2 inhibited it even at the level that stimulates proMMP-2 processing. Expression of MSP-T2 in HT1080 cells enhanced MMP-2 activation by endogenous MT1-MMP and caused intensive hydrolysis of collagen gel. Expression of MSP-T2 in U87 glioma cells, which express a trace level of endogenous MT1-MMP, induced MMP-2 activation and enhanced cell-associated protease activity, activation of extracellular signal-regulated kinase, and metastatic ability into chick embryonic liver and lung. MT1-MMP can exert both maximum MMP-2 activation and direct cleavage of substrates with MSP-T2, which cannot be achieved with TIMP-2. These results suggest that MMP-2 activation by MT1-MMP potentially amplifies protease activity, and combination with direct cleavage of substrate causes effective tissue degradation and enhances tumor invasion and metastasis, which highlights the complex role of TIMP-2. MSP-T2 is a unique tool to analyze physiologic and pathologic roles of MMP-2 and MT1-MMP in comparison with TIMP-2. ©2008 American Association for Cancer Research.全文公開200911 続きを見る
4.

論文
論文
4. A Novel Synthesis of 1-(2-Methyl-1-propenyl)-2-aminoindan Derivatives
Somei, Masanori ; Yamada, Fumio ; Yamazaki, Yoshihisa ; Shinkura, Akiko
出版情報: Chemical and Pharmaceutical Bulletin.  44  pp.21-28,  1996-01-01.  Pharmaceutical Society of Japan = 日本薬学会
URL: http://hdl.handle.net/2297/43982
概要: We developed a novel synthesis of 2-aminoindan derivatives, having a 2-methyl-1-propenyl group at the 1-position and oxygen functional groups in the benzene ring, in 8 or 9 steps from vanillin.
5.

論文
論文
5. Genetic polymorphisms in the 5'-flanking region of human UDP-glucuronosyltransferase 2B7 affect the Nrf2-dependent transcriptional regulation.
Nakamura, Akiko ; Nakajima, Miki ; Higashi, Eriko ; Yamanaka, Hiroyuki ; Yokoi, Tsuyoshi
出版情報: Pharmacogenetics and genomics.  18  pp.709-720,  2008-08-01.  Lippincott, Williams & Wilkins
URL: http://hdl.handle.net/2297/12396
概要: 医薬保健研究域薬学系<br />OBJECTIVES: Human uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7) plays important roles in the … metabolism of some clinical drugs, carcinogens, and steroid hormones. The molecular mechanisms of the inducible expression of UGT2B7 in response to xenobiotics have not been fully clarified. We sought to investigate whether the UGT2B7 is under the control of NF-E2 p45-related factor 2 (Nrf2), a key transcriptional factor regulating the expression of cytoprotective enzymes. METHODS: HepG2, HuH7, HLE, and Caco-2 cells were treated with sulforaphane (SFN), and the UGT2B7 mRNA levels were determined by real-time reverse transcriptase PCR. These cells were genotyped for the UGT2B7*2 (H268Y) allele using the PCR-restriction fragment length polymorphism method. Luciferase analyses and gel shift analyses were performed to identify the responsive regions for Nrf2 signaling. RESULTS: The UGT2B7 mRNA was induced by SFN in HepG2 and HuH7 genotyped as UGT2B7*1/*1, but not in HLE and Caco-2 cells genotyped as UGT2B7*2/*2. In HepG2 cells, the UGT2B7 protein level and morphine glucuronosyltransferase activity were also significantly induced by SFN. The induction was prominently decreased with small interfering RNA for Nrf2. In the 5'-flanking region (-2.5 kb) of the UGT2B7*2 allele, a 324-base pair insertion at -2067 and 12 single nucleotide polymorphisms simultaneously existed. Luciferase analyses and gel shift analyses revealed that an antioxidant responsive element at -1170 was responsible for the transactivation by Nrf2. In addition, a region from -990 to -858 on the UGT2B7*1 allele was also responsible for the transactivation by Nrf2. Abrogation of the Nrf2-dependent transactivation of the UGT2B7*2 allele was owing to the single nucleotide polymorphism -900A>G. CONCLUSION: UGT2B7 is transcriptionally regulated by Nrf2, but the mechanism is hindered by polymorphisms in the promoter region of UGT2B7*2. The allele-specific mechanism may cause variability of the glucuronidation in response to oxidative stress.全文公開200908 続きを見る
6.

図書
図書
6. Patañjali's Vyākaraṇa-Mahābhāṣya : Tatpuruṣāhnika (p. 2.2.2-2.2.23). 1st ed
edited with translation and explanatory notes by S.D. Joshi and J.A.F. Roodbergen
出版情報: Poona : University of Poona, 1973
シリーズ名: Publications of the Centre of Advanced Study in Sanskrit ; class C ; no. 7
7.

論文
論文
7. The first preparation of the unstable 1-hydroxy-2,3-dimethylindole, andstructural determination of its air-oxidized product,3-hydroxy-2,3-dimethyl-3H-indole N-oxide
Yamada, Fumio ; Kawanishi, Atsuko ; Tomita, Akiko ; Somei, Masanori
出版情報: Arkivoc.  2003  pp.102-111,  2003-01-01.  Arkat USA
URL: http://hdl.handle.net/2297/19723
概要: 1-Hydroxy-2,3-dimethylindole (1) has been prepared for the first time. Under atmospheric oxygen, 1 was converted rapidly into 3-hydroxy-2,3-dimethyl- 3H-indole N-oxide (2). The structure was deduced, based on its products obtained … by the reaction with Ac2O in pyridine and confirmed by X-ray single crystallographic analysis. 続きを見る
8.

論文
論文
8. Stereoselective synthesis of (2 Z,4 E)-2,4-pentadien-1-ols via sequential 1,4-elimination reaction and [1,2]-wittig rearrangement starting from (E)-4-alkoxy-2-butenyl benzoates
Nakano, Takeo ; Soeta, Takahiro ; Endo, Kohei ; Inomata, Katsuhiko ; Ukaji, Yutaka
出版情報: Journal of Organic Chemistry.  78  pp.12654-12661,  2013-12-20.  American Chemical Society
URL: http://hdl.handle.net/2297/36468
概要: The sequential 1,4-elimination reaction of (E)-4-alkoxy-2-butenyl benzoates and [1,2]-Wittig rearrangement gave (2Z,4E)- … 2,4-pentadien-1-ols stereoselectively. Z-Selective formation of intermediary vinyl ethers, whose stereochemistry was well elucidated by the "syn-effect", was achieved by treatment of the 2-butenyl benzoates with KOH in the presence of Pd catalyst. The subsequent [1,2]-Wittg rearrangement by use of n-BuLi proceeded with retention of the stereochemistry of the intermediary vinyl ethers. © 2013 American Chemical Society. 続きを見る
9.

論文
論文
9. Syntheses of 3,4-disubstituted 2-tosylpyrroles and 5-tosyl-1,5-dihydro-2H-pyrrol-2-ones starting from ethyl 3,4-disubstituted 2-pyrrolecarboxylates
Murata, Yasue ; Kinoshita, Hideki ; Inomata, Katsuhiko
出版情報: Bulletin of the Chemical Society of Japan.  69  pp.3339-3344,  1996-01-01.  The Chemical Society of Japan = 日本化学会
URL: http://hdl.handle.net/2297/38263
概要: The syntheses of 3,4-disubstituted 2-tosylpyrroles and 5-tosyl-1,5-dihydro-2H-pyrrol-2-ones were accomplished via 3,4-disubstituted 2-iodo-5-tosylpyrroles starting from ethyl 3,4-disubstituted 2-pyrrolecarboxylates.
10.

電子ブック
ＥＢ
10. Crystal structures of gaylussite, CaNa2(CO3) sub 2 . 5H2O and pirssonite, CaNa sub 2(CO3) sub 2 . 2H2O : progress report
Dickens, Brian.
出版情報: Gaithersburg, MD
オンライン: ジャーナル/ブックへリンク