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| 1.
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論文
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中沼, 伸一 ; 萱原, 正都 ; 中川原, 寿俊 ; 伊藤, 博 ; 田島, 秀浩 ; 藤田, 秀人 ; 北川, 裕久 ; 藤村, 隆 ; 太田, 哲生 ; Nakanuma, Shinichi ; Kayahara, Masato ; Nakagawara, Hisatoshi ; Ito, Hiroshi ; Tajima, Hidehiro ; Fujita, Hideto ; Kitagawa, Hirohisa ; Fujimura, Takashi ; Ohta, Tetsuo
概要:
金沢大学附属病院肝胆膵・移植外科<br />症例は30歳の男性で，体重120 kg，BMI 41の高度肥満であった．重症急性膵炎と診断され当院に紹介された．CTでは両側胸水，膵実質の不明瞭化，後腎傍腔に及ぶ滲出液が認められた（Grade I
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V）．また，SIRS，急性循環不全の状態であった．入院後4病日，炎症反応の持続とCTにて膵頭部の血流障害が認められ，感染性膵壊死と判断し，necrosectomyを行った．腸管・組織浮腫のため，閉腹によるabdominal compartment syndromeが危ぐされたため，術後zipper techniqueとして衣類圧縮用袋を腹壁に固定し，腹腔内洗浄を伴うplanned necrosectomyを継続し，残存膵壊死組織の除去を行った．退院1年目の現在，患者は職場復帰している．衣類圧縮用袋を用いたzipper techniqueは高度肥満を有する感染性膵壊死の術後に有用な処置と考えられ若干の文献を加え報告する．<br />A severely obese 30-year-old male (BMI 41) weighing 120 kg and referred based on a diagnosis of severe acute pancreatitis was found in computed tomography (CT) to have bilateral hydrothorax, unclear pancreatic parenchyma, and exudate spreading to the posterior pararenal spacer (Grade IV). He also had SIRS and acute circulatory failure. On hospital day 4, persistent inflammatory reactions and a CT finding of pancreatic-head necrosis were noted. Based on a diagnosis of infectious pancreatic necrosis, he underwent necrosectomy. It was difficult to close the abdominal wall because of intestinal and tissue edema. Postoperatively, we attached a vacuum storage bag to the abdominal wall by a zipper. The planned necrosectomy, accompanied by intraperitoneal lavage, was continued to remove residual pancreatic necrotic tissue. No sign of abdominal compartment syndrome was noted. The patient has been discharged and resumed his previous work. The zipper technique and vacuum storage bag thus proved useful in providing postoperative care to a patient with infectious pancreatic necrosis accompanied by severe obesity.
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| 2.
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Taki, Kentaro ; Taguchi, Takehiro ; Hayashi, Ryota ; Ito, Hiroshi ; 瀧, 健太郎
概要:
金沢大学理工研究域機械工学系<br />UV-curable resin of multifunctional monomers is believed to form a cross-linked network structure. H
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owever, the nature of this network is difficult to analyze. In this study, a kinetic approach was applied to compare the network structures of photopolymerized diurethane dimethacrylate cured by different light sources and photoinitiators. The conversion after UV irradiation was monitored to calculate the rate coefficients of propagation and termination (kp and kt, respectively) under varying irradiation times and at constant UV intensity and temperature. The values of kp and kt, were compared for different UV light sources (a 365-nm peak UV-LED and a high-pressure mercury lamp) and different photoinitiators (1-hydroxycyclohexylphenylketone (HCAP) and 2,4,6-trimethylbenzoylphenyl phosphinate (TPO)). The results indicate that the network structure formed under different light sources with the same photoinitiator could be scaled, namely that the formed cross-linked network structures could be superimposed on top of each other by linear expansion or reduction. The reason is that the light sources only differ in the rate of photon delivery, while the photons are identical to each other in terms of chemical reactivity. In contrast, the network structures formed with different photoinitiators could not be scaled, since the photoinitiators differ in their quantum yield, kinetic constants, affinity, and molecular size. These factors could affect the network structure. Although the kinetic analysis in this study only provides very limited information about the network structure, we experimentally confirmed that the network structure depends on both the UV light source and photoinitiator.
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| 3.
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Taki, Kentaro ; Niinuma, Kanji ; Hariu, Akira ; Ito, Hiroshi ; 瀧, 健太郎
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金沢大学理工研究域機械工学系<br />A low-reflectance film was used to reduce the reflection of light from the displays of electronic de
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vices (personal computers, televisions, smartphones, etc.). In this study, an ultraviolet (UV)-curable resin was used to form a nano/microstructure by organic-solvent-induced crystallization and to fill the cracks in the polycarbonate plate. Two different processes were examined: Process 1: the surface of the polycarbonate plate was crystallized at 40, 60, 80, or 100 oC for 10 min and thoroughly rinsed with isopropyl alcohol; and Process 2: the surface of the polycarbonate plate was crystallized at 40 oC for a desired time. The excess UV-curable resin was removed by UV-induced curing and CO2 foaming during UV exposure using high-pressure CO2 equipment. CO2 pressures of 4.5, 5.5, and 6.5 MPa and CO2 impregnation times of 80, 160, 240 s were investigated to optimize the microstructure. It was clarified that spherulites of polycarbonate existed on the surface by differential scanning calorimetry and scanning electron microscopy. The surface prepared with Process 2 had a relative reflectance that was about 600 and 30 times lower than those of the untreated polycarbonate plate and a commercially available low-reflectance film, respectively.
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Taki, Kentaro ; Kondo, Shunsuke ; Ito, Hiroshi ; 瀧, 健太郎
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金沢大学理工研究域機械工学系<br />Roll-to-roll UV nanoimprint lithography (R2RUVNIL) is a promising technology for fabricating nanostr
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uctures on flexible films, but its application requires finding feasible operating conditions to peel-off the UV resin from the mold. Furthermore, to achieve the required nanostructure, conversion of the UV resin needs to be precisely optimized in terms of the UV intensity and line speed. In this study, (1,6-bis(acryloyloxy)hexane) resin was cured by roll-to-roll UV-curing while monitoring its conversion and surface elasticity by Fourier transform infrared spectroscopy and a nano indenter, respectively. It was found that the conversion increases by up to 85% with a decrease in line speed and increase in UV intensity. The effect of varying the distribution of UV light on the roller mold was also investigated, which revealed that a sharp distribution of UV light is effective in increasing the surface elastic modulus from 0.2 to 1.0 GPa at 0.6 conversion.
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| 5.
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Taki, Kentaro ; Taguchi, Takehiro ; Hayashi, Ryota ; Ito, Hiroshi ; 瀧, 健太郎
概要:
金沢大学理工研究域機械工学系<br />In this study, the photopolymerization kinetics of bifunctional acrylic monomers having different ch
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ain lengths, such as 1,4-bis(acryloyloxy)butane, 1,6-bis(acryloyloxy)hexane, and 1,10-bis(acryloyloxy)decane, was investigated by real-time Fourier transform infrared (FTIR) spectroscopy, using Irgacure 184 (1 wt%) as the photoinitiator. Dark polymerization analysis was employed for measuring the kinetic constants for propagation and termination. Plots of kinetic constants for propagation against double-bond conversion showed a plateau, suggesting that the reaction rate is controlled at low conversion, and with increasing conversion, the reaction rate decreases as the diffusion rate of the monomer controls propagation. At low conversion, as compared to the reaction for a monomer having a long chain length, the propagation reaction for a monomer with a short chain length switched to a diffusion-rate controlled propagation reaction. The results suggested that short chain length monomers form a dense cross-linking network, which hinders the diffusion of the monomer, and the kinetic constants decrease at low conversion. The results obtained from the plot of kinetic chain length versus conversion indicated that at a maximum kinetic chain length of up to 106, the reaction switches to the diffusion-rate controlled propagation of each monomer.
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| 6.
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Taki, Kentaro ; Ito, Hiroshi ; 瀧, 健太郎
概要:
金沢大学理工研究域機械工学系<br />Ultralow-k (dielectric constant) films are promising substrates for next-generation flexible print c
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ircuits. Introducing numerous pores into the film can effectively reduce the substrate's dielectric constant because the relative dielectric constant of air is smaller than that of any polymer substrate. We recently developed a short-cycle time process employing high-pressure CO2 and the CO2-tertiaryamine zwitterions in polyimide precursor solutions to create 1-3 μm pores of >70% porosity. However, the film size was limited to 30 × 30 mm2. A larger film (70 × 150 mm2) was required to measure the signal attenuation of an electrical circuit on a porous PI film as a next-generation flexible cable. In this paper, the developed process was scaled up to obtain 10-fold-larger ultralow-k films of porous polyimide. The process involved a high-intensity UV lamp, thick-quartz window and hydraulically movable sealing plate and produces 70 × 150 mm2 films, which was a suitable size for high-speed data communication transmission tests. The preliminary results of building up a printed circuit on the porous substrate and signal attenuation measurements at 20 GHz demonstrated that the low-k porous PI substrate reduced the signal attenuation compared to a non-porous substrate with the same cross-sectional line area.
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| 7.
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Taki, Kentaro ; Mizoguchi, Akira ; Ito, Hiroshi ; 瀧, 健太郎
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金沢大学理工研究域機械工学系<br />Porous polyimide films are promising insulators for next generation electronic devices. Recently, we
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had developed a high-intensity UV exposure apparatus under a high-pressure CO2 gas atmosphere for the production of porous polyimide films. In this study, the cover-layering process of a porous polyimide layer on two different types of flexible print circuits (FPCs) with insulation materials made of solid polyimide and porous polyimide was examined. Although a portion of the pores above and below the copper line of the FPC collapsed, a conformal porous polyimide layer could be formed on the FPC. Through-holes were formed on the porous polyimide film by a laser ablation technique. The surface of through-holes was electro-plated in a copper-plating solution bath. A portion of the pores on the film were filled with copper as the pores were inter-connected and the plating solution penetrated the pores. The results suggest that the pores should be isolated and firm for a cover-layering process with porous polyimide films for next-generation FPCs.
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| 8.
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伊藤, 宏 ; Ito, Hiroshi
概要:
取得学位：博士(薬学)，学位授与番号：博甲第892号，学位授与年月日：平成19年3月22日
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| 9.
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Hirosawa, Iori ; Ishikawa, Mai ; Ogino, Mio ; Ito, Hiroshi ; Hirao, Takuya ; Yamada, Harumi ; Asahi, Mariko ; Kotaki, Hajime ; Sai, Yoshimichi ; Miyamoto, Ken-ichi
概要:
Clenbuterol is a long-acting β2-adrenoceptor agonist and bronchodilator that is used for the treatment of asthma, but th
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e desired activities reside almost exclusively in the (-)-R-enantiomer. This study examined enantioselectivity in the disposition of clenbuterol following administration of clenbuterol racemate to rats. Concentrations of clenbuterol enantiomers in plasma, urine and bile were determined by LC-MS/MS assay with a Chirobiotic T column. This method was confirmed to show high sensitivity, specificity and precision, and clenbuterol enantiomers in 0.1ml volumes of plasma were precisely quantified at concentrations as low as 0.25ng/ml. The pharmacokinetic profiles of clenbuterol enantiomers following intravenous and intraduodenal administration of clenbuterol racemate (2mg/kg) in rats were significantly different. The distribution volume of (-)-R-clenbuterol (9.17l/kg) was significantly higher than that of (+)-S-clenbuterol (4.14l/kg). The total body clearance of (-)-R-clenbuterol (13.5ml/min/kg) was significantly higher than that of the (+)-S-enantiomer (11.5ml/min/kg). An in situ absorption study in jejunal loops showed no difference in the residual amount between the (-)-R- and (+)-S-enantiomers. Urinary clearance was the same for the two enantiomers, but biliary excretion of (-)-R-clenbuterol was higher than that of the (+)-S-enantiomer. The fractions of free (non-protein-bound) (-)-R- and (+)-S-clenbuterol in rat plasma were 48.8% and 33.1%, respectively. These results indicated that there are differences in the distribution and excretion of the clenbuterol enantiomers, and these may be predominantly due to enantioselective protein binding. © 2013 John Wiley & Sons, Ltd.<br />発行後1年より全文公開
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| 10.
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伊藤, 宏 ; 早川, 和一 ; Ito, Hiroshi ; Hayakawa, Kazuichi
概要:
[研究概要]
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