※一部利用できない機能があります
| 1.
論文 |
論文
|
Nakanishi, Chiaki ; Nagaya, Noritoshi ; Ohnishi, Shunsuke ; Yamahara, Kenichi ; Takabatake, Shu ; Konno, Tetsuo ; Hayashi, Kenshi ; Kawashiri, Masa-aki ; Tsubokawa, Toshinari ; Yamagishi, Masakazu ; 中西, 千明 ; 今野, 哲雄 ; 林, 研至 ; 川尻, 剛照 ; 山岸, 正和
概要:
金沢大学医薬保健研究域医学系<br />Background: Mesenchymal stem cells (MSC) are multipotent and reside in bone marrow (BM), adipose tis
…
sue and many other tissues. However, the molecular foundations underlying the differences in proliferation, differentiation potential and paracrine effects between adipose tissue-derived MSC (ASC) and BM-derived MSC (BM-MSC) are not well-known. Therefore, we investigated differences in the gene and secretory protein expressions of the 2 types of MSC. Methods and Results: ASC and BM-MSC were obtained from subcutaneous adipose tissue and BM of adult Lewis rats. ASC proliferated as rapidly as BM-MSC, and had expanded 200-fold in approximately 2 weeks. On microarray analysis of 31,099 genes, 571 (1.8%) were more highly (>3-fold) expressed in ASC, and a number of these genes were associated with mitosis and immune response. On the other hand, 571 genes (1.8%) were more highly expressed in BM-MSC, and some of these genes were associated with organ development and morphogenesis. In secretory protein analysis, ASC secreted significantly larger amounts of growth factor and inflammatory cytokines, such as vascular endothelial growth factor, hepatocyte growth factor and interleukin 6, whereas BM-MSC secreted significantly larger amounts of stromal-derived factor-1α. Conclusions: There are significant differences between ASC and BM-MSC in the cytokine secretome, which may provide clues to the molecule mechanisms associated with tissue regeneration and alternative cell sources.<br />出版者照会後に全文公開
続きを見る
|
||||
| 2.
学位論文 |
学位
|
高畠, 周 ; Takabatake, Shu
概要:
博士論文要旨Abstract 以下に掲載：Journal of Interventional Cardiology 27(1) pp.63-72 2014. BioMed Central. 共著者：SHU TAKABATAKE, KENSH
…
I HAYASHI, CHIAKI NAKANISHI, HIROYUKI HAO, KENJI SAKATA, MASA‐AKI KAWASHIRI, TAKEHISA MATSUDA, MASAKAZU YAMAGISHI
続きを見る
|
||||
| 3.
学位論文 |
学位
|
高畠, 周 ; Takabatake, Shu
概要:
博士論文本文Full 以下に掲載：Journal of Interventional Cardiology 27(1) pp.63-72 2014. BioMed Central. 共著者：SHU TAKABATAKE, KENSHI HA
…
YASHI, CHIAKI NAKANISHI, HIROYUKI HAO, KENJI SAKATA, MASA‐AKI KAWASHIRI, TAKEHISA MATSUDA, MASAKAZU YAMAGISHI
続きを見る
|
||||
| 4.
論文 |
論文
|
Furuta, Takuya ; Tsubokawa, Toshinari ; Takabatake, Shu ; Ohtake, Hiroshi ; Watanabe, Go ; Yamagishi, Masakazu
概要:
金沢大学附属病院循環器内科<br />Early and accurate diagnosis of infective aortic aneurysms (IAA) is critical for adequate treatment t
…
o optimize patient outcome. We report the case of an 84-year-old man who complained of severe back pain with high fever and was finally diagnosed as Escherichia coli-related IAA. Computed tomography showed a periaortic soft tissue density and irregular fringe adjacent to the non-dilated abdominal aorta suggesting the presence of pseudoaneurysm. In addition to intravenous antibiotic injection, an aneurysmectomy with extensive debridement and an in situ graft, were successfully performed. The case emphasizes the potential for rapid IAA change and the need for frequent radiologic follow-up. © 2011 The Japanese Society of Internal Medicine.
続きを見る
|
