※一部利用できない機能があります
| 1.
論文 |
論文
|
常塚, 宣男 ; 清水, 淳三 ; 小田, 誠 ; 関戸, 伸明 ; 和田, 真也 ; 渡辺, 洋宇 ; Tsunezuka, Yoshio ; Shimizu, Junzo ; Oda, Makoto ; Sekido, Nobuaki ; Wada, Masanari ; Watanabe, Yoh
概要:
金沢大学医薬保健研究域医学系<br />症例は55歳, 女性.主訴は咳嗽.胸部X線写真にて, 右上肺野に腫瘤陰影を指摘された.術前に確定診断は得られなかったが肺癌を疑って, 右上葉切除術を施行した.切除標本の病理組織検査では形質細胞の腫瘍性
…
増殖を認めたが, 一部にリンパ濾胞の形成, リンパ球の巣状配列を認め, 形質細胞腫とCastlemanリンパ腫-Plasma cell typeとの鑑別が問題となった.PAP法による免疫組織化学的検査の結果, IgA-λ型の単クローン性の染色性を持つ肺原発性の形質細胞腫と診断された.組織学的にCastlemanリンパ腫と類似した形質細胞腫は, われわれが調べ得た範囲では本邦3例目であるが, 肺原発の症例は過去に報告例がない.<br />Extramedullary plasmacytomas are uncommon tumors that affect various tissues, most commonly in the upper airways. We report a case of solitary plasmacytoma of the lung that was difficult to differentiate histopathologically from Castleman's lymphoma.A 55-year old woman was admitted to our hospital with an abnormal shadow on chest X-ray films but no symptoms. Chest CT scan disclosed a solitary nodule with low density in the right upper lobe. Right upper lobectomy was performed, and histological examination showed diffuse proliferation of plasma cells and lymphoid follicles partially similar to Castleman's lymphoma. Immunohistologically, the plasmacytoma cells were stained with IgA and λ chains in a monoclonal secretory pattern.
続きを見る
|
||||
| 2.
論文 |
論文
|
常塚, 宣男 ; 石川, 紀彦 ; 平沼, 知加志 ; 佐藤, 日出夫 ; 小田, 誠 ; 渡辺, 剛 ; Tsunezuka, Yoshio ; Ishikawa, Norihiko ; Hiranuma, Chikashi ; Sato, Hideo ; Oda, Makoto ; Watanabe, Go
概要:
金沢大学医薬保健研究域医学系<br />From January 1997 to June 1999, we performed surgery in 17 patients with mycobacteria other than tub
…
erculosis (MOTT), and 2 patients with lung cancer among them. Both patients had the diagnosis of MOTT by sputa bacterial cultures preoperatively, but no diagnosis of lung cancer. By computed tomography (CT) scanning, lung cancer was suspected in both patients, therefore they were performed video-assisted thoracoscopic resection of the lung. The diagnosis of malignancy was made by intraoperative frozen section of resected tissue, the patients were performed lobectomy with systematic mediiastinal lymph nodes dissection. According to increment of detection of the small peripheral lesion, infectious disease such as MOTT can be detected as small abnormal shadow by CT. However, it is difficult to distinguish malignancy from infectious disease preoperatively. Even if a preoperative diagnosis, of MOTT was made like present cases, diagnostic video-assisted thoracoscopic surgery must be performed, considering that lung cancer could combined with MOTT.
続きを見る
|
||||
| 3.
論文 |
論文
|
滝沢, 昌也 ; 小田, 誠 ; 太田, 安彦 ; 川上, 和之 ; 常塚, 宣男 ; 松本, 勲 ; 田村, 昌也 ; 谷内, 毅 ; 渡辺, 剛 ; 高仲, 強 ; 西嶋, 博司 ; 松井, 修 ; Takizawa, Masaya ; Oda, Makoto ; Ohta, Yasuhiko ; Kawakami, Kazuyuki ; Tsunezuka, Yoshio ; Matsumoto, Isao ; Tamura, Masaya ; Yachi, Tsuyoshi ; Watanabe, Go ; Takanaka, Tsuyoshi ; Nishijima, Hiroshi ; Matsui, Osamu
概要:
金沢大学医薬保健研究域医学系<br />We evaluated the efficacy of perioperative targeting brachytherapy for lung cancer invading the ches
…
t wall. Between 1998 and 2003, 7 patients underwent perioperative targeting brachytherapy for lung cancer invading the chest wall. There were 5 male and 2 female patients. The mean age was 63.3 years, with a range of 45 to 77 years. All patients underwent complete resection including the chest wall combined resection. During the operation, plastic afterloading catheters fixed on the Vicryl mesh at interval of 1 cm were placed on the site of chest wall resection. From the third to sixth day after the operation, 15 to 32 Gy of radiation was delivered over 3 or 4 days using a high dose rate remote afterloading system. The area targeted for brachytherapy was determined by a computed tomography (CT) scanner translator with a computer program for radiation planning. The median postoperative hospital stay was 35 days. Local recurrences were observed in 2 patients, but there was no evidence of recurrence in the margin of the resected chest wall. We believe that this short period of treatment and the low side effects enhances the quality of the patients. Prevention of local recurrence was achieved in short term follow-up.
続きを見る
|
||||
| 4.
論文 |
論文
|
田村, 昌也 ; 小田, 誠 ; 滝沢, 昌也 ; 谷内, 毅 ; 松本, 勲 ; 常塚, 宣男 ; 川上, 和之 ; 渡辺, 剛 ; Tamura, Masaya ; Oda, Makoto ; Takizawa, Masaya ; Yachi, Tsuyoshi ; Matsumoto, Isao ; Tsunezuka, Yoshio ; Kawakami, Kazuyuki ; Watanabe, Go
概要:
金沢大学医薬保健研究域医学系<br />We report a case of completion pneumonectomy after 4 times of metastasectomy for metastatic lung tum
…
ors from rectal carcinoma. A 63-year-old man underwent Miles' operation for advanced rectal carcinoma. Forty-seven months after the operation, bilateral metastasis was appeared, and bilateral metastasectomy was performed. After the resection, 3 times of metastasectomy were performed during 40 months. Follow-up X-ray and computed tomography (CT) showed abnormal shadow in his left hilum of lung. Completion pneumonectomy with mediastinal lymph node sampling was performed. He is still alive without recurrence 4 years after first thoracotomy. Repeated pulmonary resection can lead to good outcome for selective patients with metastatic colorectal carcinoma, and repeated surgery can be useful for pulmonary recurrences after thoracotomy.
続きを見る
|
||||
| 5.
その他 |
その他
|
常塚, 宣男 ; Tsunezuka, Yoshio
概要:
取得学位 : 博士（医学）, 学位授与番号 : 医博甲第1217号, 学位授与年月日：平成8年3月25日,学位授与年：1996
|
||||
| 6.
論文 |
論文
|
常塚, 宣男 ; Tsunezuka, Yoshio
概要:
金沢大学附属病院<br />【目的】癌の浸潤,進展だけでなく,慢性肺気腫や肺線維症にもマトリックスメタロプロテアーゼ(MMPs)が関与していることが報告されている.我々は,肺移植慢性拒絶反応の代表的な病態である,閉塞性細気管支症候群における
…
MMPsとの関連性を,ラット肺移植モデルを用いて検討した.【方法】Brown Norway種(BN)をdonor, Lewis種(LW)をrecipientとして異所性気管移植(異系群)を行い,4週後にgraftを採取した.対象として,LWおよびLWによる同系移植モデル(同系群)を用いた.1.ゼラチンザイモグラフィー:採取した移植片をゼラチンザイモグラフィーによりゼラチナーゼ活性を測定し,その分子量により,MMP-9(92kDa),MMP-2(68-72kDa)の発現を検索した.2.in situ zymography:移植片の薄切をFilm in situ Zymography(FIZ)フイルムRを用いて,ゼラチナーゼ活性の局在を検索した.3.RT-PCR:移植片より抽出した全RNAを用いてRT-PCRを行い,MMPsならびにMT1-MMPのm-RNAの発現を定量した.【結果】1.ゼラチンザイモグラフイー:異系群のみにMMP-9(92kDa)の発現を認めた.MMP-2(68-72kDa)は,同系,異系群ともに発現を認めた.活性型MMP-2(62kDa)の発現の割合を検索すると,異系群は同系群に比べ有意に多く発現していた.2.In situ zymography:気管支断面における内腔閉塞率は異系群が有意に高く,肥厚閉塞しているのは上皮下〜粘膜下組織であった.同部位にに一致して,ゼラチナーゼ活性の局在を認めた.同系群では内腔閉塞をほとんど認めず,ゼラチナーゼ活性部位は極わずかであった.3.Northern Blotting:MMP-9は異系群にのみ認められた.MMP-2およびMT1-MMPのm-RNAの発現は異系群において有意に高かった.【総括】ラット気管支移植モデルにおいて,MMP-9, MMP-2およびMT1-MMPの発現を認めた.これにより,閉塞性細気管支症候群のメカニズムにおいて,MMPs, MT1-MMPsが寄与していることが示唆された.<br />研究課題/領域番号:13770733, 研究期間(年度):2001-2002<br />出典：「肺移植後慢性拒絶反応に対するアンチセンスMTI-MMP遺伝子導入の効果」研究成果報告書 課題番号13770733（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-13770733/)を加工して作成
続きを見る
|
