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論文 |
論文
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Izumi, Kouji ; Shigehara, Kazuyoshi ; Nohara, Takahiro ; Narimoto, Kazutaka ; Kadono, Yoshifumi ; Nanjo, Shigeki ; Yamada, Tadaaki ; Ohtsubo, Koushiro ; Yano, Seiji ; Mizokami, Atsushi ; 泉, 浩二 ; 重原, 一慶 ; 野原, 隆弘 ; 角野, 佳史 ; 南條, 成輝 ; 山田, 忠明 ; 大坪, 公士郎 ; 矢野, 聖二 ; 溝上, 敦
概要:
金沢大学附属病院泌尿器科<br />Recent studies reveal that hypogonadism with low serum androgen levels is associated with advanced can
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cer and induction of most cancer-related symptoms. We designed an ARTFORM study to evaluate the efficacy of androgen replacement therapy in male advanced cancer patients. The ARTFORM study is an investigator-initiated, randomised controlled trial comparing intramuscle injection of testosterone enanthate with non-ad-ministration in male advanced cancer patients with non-curative locally advanced or metastatic lesions. Serum total and free testosterone levels are measured and patients with low testosterone level are randomised. The primary endpoint is the difference in validated health-related quality of life questionnaires at week 12. Trial registration of the ARTFORM study is assigned to University hospital Medical Information Network, Center identifier UMIN 000010939. © 2017, University of Tokushima. All rights reserved.
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論文 |
論文
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Taya, Masaki ; Koh, Eitetsu ; Izumi, Kouji ; Iijima, Masashi ; Maeda, Yuji ; Matsushita, Tomohiko ; Iwamoto, Teruaki ; Namiki, Mikio
概要:
Objectives: To determine testosterone fractions in Japanese men and to compare these values with those of Framingham Hea
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rt Study participants. Methods: We enrolled 498 healthy Japanese men. Total testosterone was assayed by liquid chromatography tandem mass spectrometry, sex hormone-binding globulin was assayed by immunoassay and free testosterone was calculated by a laboratory at the Boston Medical Center. Analog-based free testosterone and immunoassay-based total testosterone were determined by immunoassay. We compared mass spectrometry assay-based total testosterone and calculated free testosterone values in the Japanese participants with values in the American Framingham Heart Study third generation cohort. Results: The mean serum mass spectrometry assay-based total testosterone, sex hormone-binding globulin, and calculated free testosterone values were 439.4±167ng/dL, 65.34±30.61nmol/L, and 58.75±20.0pg/mL, respectively. The correlation coefficients with age for mass spectrometry assay-based total testosterone, sex hormone-binding globulin, and calculated free testosterone were 0.0010, 0.5041, and -0.496, respectively. There were no age-related changes in mass spectrometry assay-based total testosterone values in healthy men (P=0.981), whereas sex hormone-binding globulin and calculated free testosterone levels showed similar age-related changes (P<0.0001). Serum analog-based free testosterone levels (8.24±2.9pg/mL) showed age-related changes (P<0.0001) regardless of immunoassay-based total testosterone levels (P=0.828). Serum immunoassay-based total testosterone values (486.1±162.5ng/dL) correlated with serum mass spectrometry assay-based total testosterone values (r=0.740, 95% confidence interval 0.6965-0.7781, P<0.0001). Similarly, analog-based free testosterone and calculated free testosterone values showed a highly significant correlation (r=0.706, 95% confidence interval 0.6587-0.7473, P<0.0001). The analog-based free testosterone values were approximately 10% of the calculated free testosterone values. Conclusions: In contrast to the Framingham Heart Study cohort, total testosterone values in Japanese men are not associated with advancing age; thus, they cannot be used to diagnose late-onset hypogonadism in Japan. The analog-based free testosterone value can be considered instead as a suitable biochemical determinant for diagnosing late-onset hypogonadism syndrome. © 2014 The Japanese Urological Association.
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