1.

論文
論文
1. Novel biotransformation of a 2-pyrone to a substituted benzoic acid
Sakurai, Ikuo ; Suzuki, Harumi ; Shimizu, Sakae ; Yamamoto, Yuzuru
出版情報: Chemical & pharmaceutical bulletin.  33  pp.5141-5143,  1985-11-25.  日本薬学会 Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/33672
概要: It was found that Macrophoma commelinae (IFO 9570) had an ability to transform 5-acetyl-4-methoxy-6-methyl-2-pyrone (1) to 4-acetyl-3-methoxy-5-methylbenzoic acid (2). This biotransformation was investigated using 13C- and 14C-labeled … compounds. It is likely that 2 is formed by condensation of the added 2-pyrone and a catabolic pyruvate. 続きを見る
2.

論文
論文
2. Studies on Metabolites of Macrophoma commelinae. IV. : Substrate Specificity in the Biotransformation of 2-Pyrones to Substituted Benzoic Acids
Sakurai, Ikuo ; Miyajima, Hisae ; Akiyama, Katsuyoshi ; Shimizu, Sakae ; Yamamoto, Yuzuru
出版情報: Chemical & pharmaceutical bulletin.  36  pp.2003-2011,  1988-06-25.  日本薬学会 Pharmaceutical Society of Japan
URL: http://hdl.handle.net/2297/33670
概要: Substrate specificity in the novel biotransformation from 2-pyrone derivatives to substituted benzoic acids by Macrophoma commelinae (IFO 9570) was investigated by means of feeding experiments with various compounds. Among them, … 2-pyrone derivatives substituted by an electron-donating group at C-4,by an electron-withdrawing group at C-5 and by an alkyl group at C-6 were converted to the corresponding benzoic acid derivatives in fairly good yields. The C_3-unit precursors and intermediates were examined in stationary or shaking culture. Based on the experimental results obtained, a mechanism for this unique reaction is proposed. 続きを見る