Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease

Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease

フォーマット:

論文

責任表示:

Sakurai, Masaru ; Takamura, Toshinari ; Ota, Tsuguhito ; Ando, Hitoshi ; Akahori, Hiroshi ; Kaji, Kyosuke ; Sasaki, Motoko ; Nakanuma, Yasuni ; Miura, Katsuyuki ; Kaneko, Shuichi

言語:

英語

出版情報:

Springer Verlag, 2007-04-01

著者名:

掲載情報:

Journal of Gastroenterology

ISSN:

0944-1174

巻:

42

通号:

4

開始ページ:

312

終了ページ:

317

バージョン:

author

概要:

金子, 周一<br />金沢大学大学院医学系研究科環境社会医学<br />Background: To address the hypothesis that liver steatosis causes systemic insulin resistance, we sought to determine the liver histological feature that most strongly contributes to insulin … resistance in patients with nonalcoholic fatty liver disease (NAFLD). Methods: Liver biopsy specimens were obtained from 131 patients with clinically suspected NAFLD. The stage, grade of nonalcoholic steatohepatitis (NASH), and level of steatosis were scored and analyzed in relation to the homeostasis model assessment of insulin resistance (HOMA-IR) and the metabolic clearance rate (MCR), measured using the glucose clamp method. Results: In the univariate analysis, the degree of hepatic steatosis (r = 0.458, P < 0.001), stage (r = 0.360, P < 0.001), and grade (r = 0.349, P < 0.01) of NASH were significantly correlated with the HOMA-IR. Multiple regression analysis adjusting for age, sex, body mass index, and each histological score showed that steatosis was significantly and independently associated with HOMA-IR (coefficient = 1.42, P < 0.001), but not with the stage (coefficient = 0.33, P = 0.307) or grade (coefficient = 0.67, P = 0.134) of NASH. Similar independent relationships were observed between steatosis and MCR, but the relationship was weaker (coefficient = -0.98, P = 0.076). Conclusions: Steatosis of the liver, but not the stage or the grade of NASH, is associated with insulin resistance in patients with NAFLD. © Springer-Verlag Tokyo 2007. 続きを見る

URL:

http://hdl.handle.net/2297/5487

タイトル・著者・出版者が同じ資料

詳細

主題:	Insulin resistance; Liver histology; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Steatosis
受理日:	2007-04-01

類似資料:

1

2

3

4

5

6

7

8

9

10

11

12

1 論文 Histological course of nonalcoholic fatty liver disease in Japanese patients: Tight glycemic control, rather than weight reduction, ameliorates liver fibrosis Hamaguchi, Erika, Takamura, Toshinari, Sakurai, Masaru, Mizukoshi, Eishiro, Zen, Yoh, Takeshita, Yumie, Kurita, … American Diabetes Association	7 論文 A liver-derived secretory protein, selenoprotein P, causes insulin resistance Misu, Hirofumi, Takamura, Toshinari, Takayama, Hiroaki, Hayashi, Hiroto, Matsuzawa-Nagata, Naoto, Kurita, Seiichiro, … Elsevier
2 論文 Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects Kurita, Seiichiro, Takamura, Toshinari, Ota, Tsuguhito, Matsuzawa-Nagata, Naoto, Kita, Yuki, Uno, Masafumi, Nabemoto, … Elsevier	8 論文 Beneficial effect of branched-chain amino acid supplementation on glycemic control in chronic hepatitis C patients with insulin resistance: Implications for … Takeshita, Yumie, Takamura, Toshinari, Kita, Yuki, Ando, Hitoshi, Ueda, Teruyuki, Kato, Kenichiro, Misu, Hirofumi, … Elsevier
3 論文 Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis Uno, Masafumi, Kurita, Seiichiro, Misu, Hirofumi, Ando, Hitoshi, Ota, Tsuguhito, Matsuzawa-Nagata, Naoto, Kita, Yuki, … John Wiley & Sons	9 論文 Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic fatty liver disease Kato, Ken-ichiro, Takamura, Toshinari, Takeshita, Yumie, Ryu, Yasuji, Misu, Hirofumi, Ota, Tsuguhito, Tokuyama, Kumpei, … Public Library of Science
4 論文 Abnormal liver function tests and metabolic syndrome - Is fatty liver related to risks for atherosclerosis beyond obesity? Sakurai, Masaru, Takamura, Toshinari, Miura, Katsuyuki, Kaneko, Shuichi, Nakagawa, Hideaki Japanese Society of Internal Medicine = 日本内科学会	10 論文 Metformin Prevents and Reverses Inflammation in a Non-Diabetic Mouse Model of Nonalcoholic Steatohepatitis Kita, Yuki, Takamura, Toshinari, Misu, Hirofumi, Ota, Tsuguhito, Kurita, Seiichiro, Takeshita, Yumie, Uno, Masafumi, … Public Library of Science
5 論文 Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis. Takamura, Toshinari, Shimizu, Akiko, Komura, Takuya, Ando, Hitoshi, Zen, Yoh, Minato, Hiroshi, Matsushita, Eiki, Kaneko, … 日本内科学会	11 論文 Fulminating Onset Type 1 Diabetes with Positivity for Anti-GAD Antibody and Elevated Pancreatic Exocrine Enzyme Concentrations Kahara, Toshio, Takamura, Toshinari, Ando, Hitoshi, Sakurai, Masaru, Ota, Tsuguhito, Misaki, Tsuguho, Oba, Sakae, … 日本内科学会 = the Japanese Society of Internal Medicine
6 その他 Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease 櫻井, 勝, Sakurai, Masaru, サクライ, マサル金沢大学	12 論文 J-shaped relationship between waist circumference and subsequent risk for Type 2 diabetes: An 8-year follow-up of relatively lean Japanese individuals Sakurai, Sho, Miura, K., Takamura, Toshinari, Ishizaki, Masao, Morikawa, Y., Nakamura, K., Yoshita, Katsushi, Kido, … Blackwell Publishing