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論文

論文
Ikeya, Noriyuki ; Tanaka, Gengo ; Tsukagoshi, Akira ; 田中, 源吾
出版情報: Palaeontological Society of Japan Special Paper.  2003  pp.37-131,  2003.  日本古生物学会 Palaeontological Society of Japan
URL: http://hdl.handle.net/2297/00061606
概要: 金沢大学国際基幹教育院GS教育系
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論文

論文
Tanaka, Gengo ; Ikeya, Noriyuki ; 田中, 源吾
出版情報: Paleontological Research.  6  pp.265-284,  2002-09-30.  日本古生物学会 Palaeontological Society of Japan
URL: http://hdl.handle.net/2297/00061607
概要: 金沢大学国際基幹教育院GS教育系<br />Eighty-five fossil and Recent species of the genus Loxoconcha (Crustacea : Ostracoda) from East As ia are systematically reexamined. On the basis of carapace morphology, the genus Loxoconcha from East Asia is divided into five species groups : L. pulchra, L. optima, L. japonica, L. uranouchiensis and L. japonica species groups. The migration and speciation patterns of four species of the L. japonica species group are as follows. In Late Miocene, L. lilljeborgii and L. tumulosa were distributed over the Paleo-Indian Ocean. In Early Pliocene time, these species migrated to the Western Pacific and L. japonica evolved from populations of L. tumulosa by peramorphic evolution. In the Middle Pleistocene, L. shanhaiensis evolved from populations of L. japonica in the Ryukyu Islands by paedomorphic evolution. 続きを見る
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Tanaka, Gengo ; Seto, Koji ; Mukuda, Takao ; Nakano, Yusuke ; 田中, 源吾
出版情報: Paleontological Research.  6  pp.1-22,  2002-04-28.  日本古生物学会 Palaeontological Society of Japan
URL: http://hdl.handle.net/2297/00061608
概要: 金沢大学国際基幹教育院GS教育系<br />Thirty-five ostracod species belonging to 18 genera are recognized from the Middle Miocene Fujina Formation (ca. 14-12 Ma), 3km southwest of Matsue City, Shimane Prefecture, Japan. Most of these species are part of the recent Japan Sea proper water fauna; they are also classified into 4 categories, circumpolar, cryophilic, endemic cool-temperate and temperate species. These ostracod assemblages indicate that the Fujina Formation was deposited under a cold-water environment. Ten new species, Ambtonia shimanensis, A. takayasui, Acanthocythereis fujinaensis, A. izumoensis, Cluthia tamayuensis, C. subjaponica, Kotoracythere tsukagoshii, Laperousecythere ikeyai, Palmoconcha irizukii, and Robertsonites yatsukanus are described. 続きを見る
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論文
Tanaka, Gengo ; 田中, 源吾
出版情報: Earth Science = 地球科学.  57  pp.111-127,  2003-06-25.  地学団体研究会 The Association for the Geological Collaboration in Japan (AGCJ)
URL: http://hdl.handle.net/2297/00061617
概要: 金沢大学国際基幹教育院GS教育系<br />島根県,出雲市菅沢の大森層より26属42種の介形虫化石を抽出し,2つの介形虫群(Ambostracon-Argilloecia-Cytheropteron群集およびPaijenborchella- Palmoconcha-Urocythereis pohangensis群集)を認めた.これらの群集は冷温〜温暖な公海の下浅海環境を示唆する.大森層および布志名層からの介形虫化石群の主成分分析は,その堆積環境が上部層準に向かってしだいに深くなっていったことを示唆する.5新種(Cytheropteron shimanense, Loxoconcha izumoensis, Paradoxostoma yakumotatsunus, Schizocythere sakanoueiおよびUrocythereis sugesawensis)を記載した.<br />Ostracods from the Omori Formation in Sugesawa (Izumo City, Shimane Prefecture) comprise 42 species belonging to 26 genera. Five new species, Cytheropteron shimanense, Loxoconcha izumoensis, Paradoxostoma yakumotatsunus, Schizocythere sakanouei and Urocythereis sugesawensis are described. Two ostracod assemblages (Ambostracon-Argilloecia-Cytheropteron assemblage and Paijenborchella-Palmoconcha-Urocythereis pohangensis assemblage) are recognized. These assemblages indicate that the uppermost of the Omori Formation was deposited under the environments from cool to warm open sublittoral condition. Principal components analysis of ostracod assemblages from the Omori and Fujina Formations indicates that, in general, the depositional environment becomes deeper and deeper towards the upper horizon. 続きを見る
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論文
Tanaka, Gengo ; 田中, 源吾
出版情報: Journal of Micropalaeontology.  25  pp.187-188,  2006-11.  British Micropalaeontological Society
URL: http://hdl.handle.net/2297/00061631
概要: Sanyuania cuneata Zhao & Whatley, 1992 was reported initially from Late Pleistocene core samples from the northern part of the Yellow Sea and Recent sediments collected from supra tidal pools (17 practical salinity unit (psu)) in Xiangshangang Bay, East China Sea (Zhao & Whatley, 1992). Later, specimens were discovered, but not identified, in Lake Nakaumi, Shimane Prefecture, SW Japan (Fig. 1) (as Cytheridae gen. et. sp. indet. by Tanaka et al. (1998) and Sanyuania sp. by Seto et al. (1999)). Further examination of these Japanese specimens has clarified that they are conspecific with the Chinese specimens. This has provided an opportunity to review the distribution (Fig. 1) and potential environmental significance of Sanyuania cuneata and, for the first time, to describe its appendages (Fig. 2).Specimens figured herein were recovered from Lake Nakaumi (35°26′ 50″ N, 133°07′50″ E) at a depth of 0.3–6.0 m and salinity of 8–17 psu on 9 September 1998. The surface of the sediment was covered by the byssus of the mussel Musculista senhousia (Benson, 1842).Sanyuania cuneata is probably endemic to the East China Sea and the southwestern part of the Sea of Japan and is a potentially useful palaeoenvironmental indicator of brackish (steno-haline) environments in the area. By using the oxygen isotopic data from planktonic foraminifers and the estimated value of salinity flowing into the Japan Sea, Matsui et al. (1998) approximated that the salinity of the surface water of Japan Sea declined to about 20 psu during the Last Glacial Maximum . . . 続きを見る
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Tanaka, Gengo ; Smith, Robin J. ; Siveter, David J. ; Parker, Andrew R. ; 田中, 源吾
出版情報: Zoological Science.  26  pp.846-850,  2009-12.  日本動物学会 Zoological Society of Japan
URL: http://hdl.handle.net/2297/00061634
概要: 金沢大学国際基幹教育院GS教育系<br />Compound eyes are common in decapod crustaceans. Decapods have an abundant post-Palaeozoic fossil record, but hitherto morphological information about their eyes has been mainly restricted to Recent material. Here we report the discovery of compound eyes recovered from acetic acid residues of two fish-bearing nodules from the Cretaceous Santana Formation of Brazil; they include what are identified as decapod larval compound eyes. The fossil eyes are comparable to phyllosoma larval eyes because of the following characters: the hemispherical visual surface on a stalked eye; the relatively small-size of the visual surface of the eye; rounded facets are arranged in square arrays in the anterior region; the fact that the neighboring ommatidia are bounded by ridges and/ or grooves; and the more convex inner surface of the cornea lens. This report represents the first description of a three-dimensionally preserved fossil decapod eye. We conclude that the eyes probably represent palinuroid phyllosoma larval eyes and were an adaptation to a planktonic lifestyle. © 2009 Zoological Society of Japan. 続きを見る
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Hattori, Yuki ; Gabata, Toshifumi ; Matsui, Osamu ; Mochizuki, Kentaro ; Kitagawa, Hirohisa ; Kayahara, Masato ; Ohta, Tetsuo ; Nakanuma, Yasuni ; 蒲田, 敏文 ; 松井, 修 ; 北川, 裕久 ; 萱原, 正都 ; 太田, 哲生 ; 中沼, 安二
出版情報: World Journal of Gastroenterology.  15  pp.3114-3121,  2009.  Baishideng Publishing Group Co
URL: http://hdl.handle.net/2297/00061733
概要: 金沢大学医薬保健研究域医学系<br />Aim: To evaluate retrospectively the correlation between enhancement patterns on dynamic computed to mography (CT) and angiogenesis and fibrosis in pancreatic adenocarcinoma. Methods: Twenty-three patients with pancreatic adenocarcinoma underwent dynamic CT and tumor resection. In addition to the absolute and relative enhanced value that was calculated by subtracting the attenuation value on pre-contrast from those on contrast-enhanced CT in each phase, we defined one parameter, "tumor-aorta enhancement ratio", which was calculated by dividing enhancement of pancreatic cancer by enhancement of abdominal aorta in each phase. These enhancement patterns were correlated with the level of vascular endothelial growth factor (VEGF), microvessel density (MVD), and extent of fibrosis. Results: The absolute enhanced value in the arterial phase correlated with the level of VEGF and MVD (P = 0.047, P = 0.001). The relative enhanced value in arterial phase and tumor-aorta enhancement ratio (arterial) correlated with MVD (P = 0.003, P = 0.022). Tumor-aorta enhancement ratio (arterial) correlated negatively with the extent of fibrosis (P = 0.004). The tumors with greater MVD and higher expression of VEGF tended to show high enhancement in the arterial dominant phase. On the other hand, the tumors with a larger amount of fibrosis showed a negative correlation with the grade of enhancement during the arterial phase. Conclusion: Enhancement patterns on dynamic CT correlated with angiogenesis and may be modified by the extent of fibrosis. © 2009 The WJG Press and Baishideng. All rights reserved. 続きを見る
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論文
Sasaki, Motoko ; Araki, Ichiro ; Yasui, Toshiaki ; Kinoshita, Masaru ; Itatsu, Keita ; Nojima, Takayuki ; Nakanuma, Yasuni ; 佐々木, 素子 ; 野島, 孝之 ; 中沼, 安二
出版情報: World Journal of Gastroenterology.  15  pp.615-621,  2009.  Baishideng Publishing Group Co
URL: http://hdl.handle.net/2297/00061734
概要: 金沢大学医薬保健研究域医学系<br />We report a case of primary localized malignant biphasic mesothelioma of the liver in a 66-year-old man associated with asbestosis. The tumor was detected as a hepatic nodule, 4 cm in diameter, in the right lobe (S8 segment) on CT scan. Histopathological examination demonstrated an intrahepatic tumor with central necrosis consisting of a papillary epithelioid pattern on the surface of the liver, microcystic (microglandular or adenomatoid) pattern mainly in the subcapsular area and sarcomatoid pattern intermingled with microcystic pattern in the major part of the hepatic nodular tumor. Tumor cells, especially of epithelioid type, showed distinct immunoreactivity for mesothelial markers (WT-1, calretinin, D2-40, CK5/6, mesothelin, thrombomodulin) and no immunoreactivity for epithelial (adenocarcinoma) markers (CEA, CD15, BerEP4, BG8, MOC31). P53 immunoreactivity was detected focally in papillary epithelioid tumor cells and extensively in microcystic and sarcomatoid components, suggesting that the papillary epithelioid mesothelioma arose on the surface of the liver, and tumor cells showing microcystic and sarcomatoid patterns invaded and grew into the liver. To date, this is the first case of primary localized malignant biphasic mesothelioma of the liver, since all three primary hepatic mesotheliomas reported so far were epithelioid type. © 2009 The WJG Press and Baishideng. All rights reserved. 続きを見る
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論文
Yoshikawa, Seiichi ; Zen, Yoh ; Fujii, Takahiko ; Sato, Yasunori ; Ohta, Tetsuo ; Aoyagi, Yutaka ; Nakanuma, Yasuni ; 全, 陽 ; 佐藤, 保則 ; 太田, 哲生 ; 中沼, 安二
出版情報: World Journal of Gastroenterology.  15  pp.4896-4906,  2009.  Baishideng Publishing Group Co
URL: http://hdl.handle.net/2297/00061735
概要: 金沢大学医薬保健研究域医学系<br />AIM: To reveal the characteristics of CD133+ cells in the liver. METHODS: This study examined the hi stological characteristics of CD133 + cells in non-neoplastic and neoplastic liver tissues by immunostaining, and also analyzed the biological characteristics of CD133 + cells derived from human hepatocellular carcinoma (HCC) or cholangiocarcinoma cell lines. RESULTS: Immunostaining revealed constant expression of CD133 in non-neoplastic and neoplastic biliary epithelium, and these cells had the immunophenotype CD133+/CK19+/HepPar -1-. A smal l number of CD133+/CK19-/HepPar-1+ cells were also identified in HCC and combined hepatocellular and cholangiocarcinoma. In addition, small ductal structures, resembling the canal of Hering, partly surrounded by hepatocytes were positive for CD133. CD133 expression was observed in three HCC (HuH7, PLC5 and HepG2) and two cholangiocarcinoma cell lines (HuCCT1 and CCKS1). Fluorescence-activated cell sorting (FACS) revealed that CD133+ and CD133-cells derived from HuH7 and HuCCT1 cells similarly produced CD133+ and CD133- cells during subculture. To examine the relationship between CD133+ cells and the side population (SP) phenotype, FACS was performed using Hoechst 33342 and a monoclonal antibody against CD133. The ratios of CD133+/CD133-cells were almost identical in the SP and non-SP in HuH7. In addition, four different cellular populations (SP/CD133+, SP/CD133-, non-SP/CD133+, and non-SP/CD133-) could similarly produce CD133+ and CD133- cells during subculture. CONCLUSION: This study revealed that CD133 could be a biliary and progenitor cell marker in vivo. However, CD133 alone is not sufficient to detect tumor-initiating cells in cell lines. © 2009 The WJG Press and Baishideng. All rights reserved. 続きを見る
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論文
Fujimura, Takashi ; Ohta, Tetsuo ; Oyama, Katsunobu ; Miyashita, Tomoharu ; Miwa, Koichi ; 藤村, 隆 ; 太田, 哲生 ; 尾山, 勝信 ; 宮下, 知治 ; 三輪, 晃一
出版情報: World Journal of Gastroenterology.  12  pp.1336-1345,  2006.  Baishideng Publishing Group Co
URL: http://hdl.handle.net/2297/00061736
概要: 金沢大学医薬保健研究域医学系<br />Selective cyclooxygenase (COX)-2 inhibitors (coxibs) were developed as one of the anti-inflammatory drugs to avoid the various side effects of non-steroidal anti-inflammatory drugs (NSAIDs). However, coxibs also have an ability to inhibit tumor development of various kinds the same way that NSAIDs do. Many experimental studies using cell lines and animal models demonstrated an ability to prevent tumor proliferation of COX-2 inhibitors. After performing a randomized study for polyp chemoprevention study in patients with familial adenomatous polyposis (FAP), which showed that the treatment with celecoxib, one of the coxibs, significantly reduced the number of colorectal polyps in 2000, the U.S. Food and Drug Administration (FDA) immediately approved the clinical use of celecoxib for FAP patients. However, some coxibs were recently reported to increase the risk of serious cardiovascular events including heart attack and stroke. In this article we review a role of COX-2 in carcinogenesis of gastrointestinal tract, such as the esophagus, stomach and colorectum, and also analyze the prospect of coxibs for chemoprevention of gastrointestinal tract tumors. © 2006 The WJG Press. All rights reserved. 続きを見る