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Nishijima, Yoshinori ; 西嶋, 義憲
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金沢大学人間社会研究域経済学経営学系<br />Persons or objects on signs seem to have a culturally preferred direction of facing (Kumakura, 1
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990). Is such a difference in direction also true of pictures on traffic signs between Japan and Germany? People in Japan and Germany drive on the left and the right side of the road, respectively. In this respect, a question arises: Does the difference between left-hand and right-hand traffic in these two countries influence the way the pictures on traffic signs face? The aim of this study is threefold: 1) to collect functionally equivalent traffic signs in Japan and Germany; 2) to compare the pictures on the signs between these countries with respect to their facing directions; and 3) to try to clarify whether and to what extent differences in facing directions are found on the traffic signs. The results are expected to contribute to the study of the relationship between writing directions and facing directions of pictures.
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Nishijima, Yoshinori ; 西嶋, 義憲
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金沢大学人間社会研究域経済学経営学系<br />This study focuses on functionally equivalent, but semantically different sign expressions in Ja
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panese and German, such as o-nori-no-sai-wa tesuri-ni o-tsukamarikudasai [Literally, “when steping on, please grip handrail”], kiiroi-sen-no uchigawani o-tachi-kudasai [please stand inside yellow line], oriru sai-wa o-oashimoto-ni gochūi-kudasai [“when getting off, please pay attention to under foot”], and o-ko-sama tsure-no kata-wa o-ko-sama-no te-o totte o-nori-kudasai [“person with child is asked to ride on taking child’s hand”] in Japanese versus its German counterpart Benutzung auf eigene Gefahr [“using at your own risk”], which are posted near escalators. This example tells us that the Japanese sign consists of four concrete sentences whereas the German one presents a simple and abstract sentence. Such correspondents cannot be adequately explained from only construal and politeness perspectives. In this study, such corresponding expressions in Japanese and German will be contrasted to find out what information is relevant to each society. The results will reveal what communicative behaviors are expected in corresponding situations between Japan and Germany, which can contribute to efficient intercultural communication.
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Nishijima, Yoshinori ; 西嶋, 義憲
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金沢大学人間社会研究域経済学経営学系<br />By comparing some functionally equivalent routine formulas in Japaneseand German in correspondin
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g situations, it is hypothesized that different strategies arereflected in formulation patterns of routine formulas in both languages. For example,different expressions are used by parents in Japanese and German if their childbumps into a post. The two expressions are often used in corresponding situations inboth Japan and Germany and can therefore be regarded as functionally equivalent,although the used strategies differ, i.e., the Japanese expression is based on sharing thedangerous situation between the parent and the child, whereas the German one focuseson providing an appropriate direction to the child. Comparing such functionallyequivalent routine formulas suggests that they reflect different strategies, includingpoliteness, in corresponding situations. This study tested this hypothesis by comparingfunctionally equivalent routine formulas uttered in corresponding apologetic situationsin the socialization process of controlling children’s social behavior in Japan andGermany. The results confirm the hypothesis and suggest that the difference in strategy influences the communicative behaviors of Japanese and German speakers. Concerning politeness, the results reveal the aspects considered polite in corresponding routineformulas of the two languages. Furthermore, the communicative normality of each language is also reflected in its respective routine formulas and focus of attention in interactions. This information may be applied toward more efficient foreign language teaching.
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Nishijima, Yoshinori ; 西嶋, 義憲
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金沢大学人間社会研究域経済学経営学系<br />The aim of this paper is twofold: (1) to compare functionally equivalent English, German, and Ja
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panese sign expressions in public spaces with respect to politeness and (2) to reveal whether and how politeness is formulated in sign expressions in each language in relation to explicitness. A total of 208 Japanese and 198 German sign expressions were collected through fieldwork. Among them, 35 functionally equivalent correspondence pairs between the two languages were confirmed, and they were compared, along with their English equivalents, with respect to politeness. The results showed that English signs tend to use explicit expressions, whereas Japanese signs frequently contain honorific items, and German signs use infinitive phrases to avoid mentioning personal relationships. Based on these findings, it is pointed out that each language has its preferred styles of politeness, even for sign expressions, which are expected to give relevant information or instructions to passengers in a clear, direct manner.
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Nishijima, Yoshinori ; 西嶋, 義憲
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金沢大学人間社会研究域経済学経営学系<br />Interest in the linguistic study of perspectives from which linguistic expressions are formulate
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d has been revived in the past 20 years, due to the recent development of cognitive linguistics. Among the many contributions to the study of such perspectives, Ikegami (2000) clearly showed that Japanese differs from English, through a comparison of a Japanese literary text with its English translation. However, there has been little discussion on the methods employed for comparison in the studies on this topic. The purpose of the present paper is threefold: (1) to describe what methodological problems are recognized in previous contrastive studies on the perspectives, especially in the field of cognitive linguistics; (2) in order to avoid methodological problems, to propose an alternative method for a more objective comparison of the perspectives between two languages; and (3) to demonstrate the validity of the proposed method for contrasting formulation patterns in terms of their perspective by some of the data obtained.
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Nishijima, Yoshinori ; 西嶋, 義憲
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金沢大学人間社会研究域経済学経営学系<br />The present paper discusses the different perspectives from which Japanese and German speakers f
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ormulate utterances. It was hypothesized that these different perspectives are reflected not only in evaluating concepts of communicative behavior, but also in routine formulas for controlling communicative behavior in Japanese and German. This hypothesis was examined by comparing two pairs of functionally equivalent routine formulas in Japanese and German. Furthermore, a questionnaire was administered to compare other Japanese and German routine formulas possibly used in corresponding situations. The results confirmed that in Japanese, linguistic formulation patterns relate to the empathy felt by the speaker toward an interlocutor, arising from the perspective of their situation, whereas in German, these tend to depend on an opposition between the participants involved, characterized by a perspective external to their situation. Because the data employed in the present study are limited, the hypothesis should be verified using extensive data. The results of this study helps clarify the possible misunderstandings between Japanese and German speakers, owing to the different linguistic formulation patterns employed, and could promote more efficient foreign language teaching.
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Nishijima, Yoshinori ; 西嶋, 義憲
概要:
金沢大学人間社会研究域経済学経営学系<br />Research on the perspectives from which linguistic expressions are formulated has increased in t
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he past 20 years due to the development of cognitive linguistics. For example, Ikegami (2000) showed that Japanese and English speakers employ different perspectives by comparing the opening sentence of a Japanese literary text with its English translation. Similarly, Narita (2009) compared sentences from literary texts with their translations in Japanese and German. However, these studies analyzing literary text translations contain little discussion on the validity of the translation-based comparison method, particularly in terms of comparability and objectivity. This paper has three purposes: (1) to claim that the original and translation-based methods are not always appropriate for perspective studies; (2) to propose, as an alternative method, comparing functionally equivalent formulas used on public signs, i.e., Watch your step, Keep out, and Out of Service; and (3) to show how Japanese differs from German in the perspectives from which corresponding expressions in the two languages are formulated. Expressions were collected from signs on buses, trains, and railway stations in Japan and Germany. Examples include Haire-masen/Kein Eingang (‘No entrance’), Senro-ni orite-wa ike-masen/Ausstieg verboten (‘Do not go down to the railway track’), and ishitsubutsu-gakari/Fundbüro (‘Lost and found’). Functionally equivalent expressions were selected for the analysis. For example, a formula telling bus passengers that the bus will stop at the next station is Tsugi tomari-masu (next.TOP stop.HON) in Japanese and Wagen hält (vehicle.NOM stop.PRES) in German. These corresponding expressions can be compared syntactically and semantically. The former has no surface-level subject; it conveys that “I” and “we” or the bus will stop at the next station. The scene is described from the perspective inside the situation, i.e., from within the bus. The latter has a third-person subject, Wagen, signifying that the bus is observed from the perspective outside the situation. These different perspectives and their occurrence distributions are shown through the comparison of corresponding sign expressions. The analysis reveals that Japanese tends to formulate expressions from a perspective inside the scene where the event occurs, whereas German expresses sentences from the perspective outside the scene.<br />19th International Congress of Linguists(19 ICL), 21-27 July 2013 Geneva
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柴田, 正良 ; Shibata, Masayoshi
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PHILOSOPHY OF HUMAN-TECHNOLOGY RELATIONS @ DESIGNLAB, UNIVERSITY OF TWENTE THE NETHERLANDS | NOVEMBER 4-7TH, 2020 (online) における発表論文
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CHEN, Siya ; 陳, 斯雅
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This thesis examines the circumstances of lead-glazed pottery unearthed from the Capitals of Tang Luoyang. On the one ha
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nd, I attempt to deepen the understanding of lead-glazed pottery (both single- and multi-color) unearthed from residential sites of the Middle and Later Tang, which emerged when the practice of placing glazed figures in tombs began to decline after the Flourishing Tang. On the other hand, I develop a model that has been used to classify production systems by incorporating several lines of evidence. First, by analyzing the shape, decoration, and technique, I summarized the individual character and overall circumstance of the lead-glazed ware regarding each of the aforementioned aspects. I suggest that the wares unearthed from Tang Luoyang are dated primarily from the Middle to the Later Tang, while only a small part is dated to the Flourishing Tang. In the Middle Tang, the dominant types are what have been represented as complicated decorations produced by the Huangye kiln. Moreover, in the Later Tang, the typical wares were the single-glazed and less-decorated types, belonging to Phase IV of the Huangye kiln. Second, in accordance with the context in which they were unearthed, the circumstances of usage in the Capitals of Tang Luoyang are also investigated. This indicates that the lead-glazed pottery had a significant function as storage vessels and eating utensils at these sites. Additionally, the wares unearthed from various sites differ greatly from one another in terms of shape, decoration, and production kilns used. Finally, from the viewpoint of their shape, decoration, and unearthed context, I discuss the usage idea in this new stage and conclude that lead-glazed pottery became divorced from its original design concept and was increasingly merged into the daily life of the aristocracy in the Later Tang.
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Adellia, Paramithasari Barnas ; アデリア, パラミタサリ バルナス
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Hindu Balinese’s religion is a unique form of Hinduism, characterized by many rituals. Their daily and ceremonial ritual
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s correspond to each specific offering arranged neatly and decorated in various shapes; one of which is penjor. Penjor is a necessity in each Galungan day, and for many Balinese, making penjor is an essential ceremonial activity through which they practice and embody who they are and what they believe. As people’s attitude changes over the years, due to the development that has influenced people’s mobility, the form of making penjor has also changed. What was a twice-yearly activity has evolved into a source of income for Balinese women. Nowadays, the Balinese tend to buy penjors rather than weave them themselves. This situation has resulted in the emergence of new virtues in the trading of penjor, which leads to a new form of market that brings the new system and strategies for women who utilize these opportunities. The emergence of a new market and the shift surrounding penjor production activity offers a comprehensive approach to shed light on the intricate workings of the current penjor-making industry and unpack its evolving cultural, economic, and psychological significance, particularly for Balinese women.
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Mukaida, Naofumi ; Nakamoto, Yasunari ; 向田, 直史 ; 中本, 安成
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金沢大学がん進展制御研究所<br />Tumor immunity proceeds through multiple processes, which consist of antigen presentation by antigen
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presenting cells (APCs) to educate effector cells and destruction by the effector cytotoxic cells. However, tumor immunity is frequently repressed at tumor sites. Malignantly transformed cells rarely survive the attack by the immune system, but cells that do survive change their phenotypes to reduce their immunogenicity. The resultant cells evade the attack by the immune system and form clinically discernible tumors. Tumor microenvironments simultaneously contain a wide variety of immune suppressive molecules and cells to dampen tumor immunity. Moreover, the liver microenvironment exhibits immune tolerance to reduce aberrant immune responses to massively-exposed antigens via the portal vein, and immune dysfunction is frequently associated with liver cirrhosis, which is widespread in hepatocellular carcinoma (HCC) patients. Immune therapy aims to reduce tumor burden, but it is also expected to prevent non-cancerous liver lesions from progressing to HCC, because HCC develops or recurs from noncancerous liver lesions with chronic inflammatory states and/or cirrhosis and these lesions cannot be cured and/or eradicated by local and/or systemic therapies. Nevertheless, cancer immune therapy should augment specific tumor immunity by using two distinct measures: enhancing the effector cell functions such as antigen presentation capacity of APCs and tumor cell killing capacity of cytotoxic cells, and reactivating the immune system in immune-suppressive tumor microenvironments. Here, we will summarize the current status and discuss the future perspective on immune therapy for HCC. © The Author(s) 2018.<br />Supported by (in part) Research Programs on the Innovative Development and Application for New Drugs for Hepatitis B (No. 17fk0310116h0001) from the Japan Agency for Medical Research and Development (AMED) and Extramural Collaborative Research Grant of Cancer Research Institute, Kanazawa University.
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HAMMOND, Mark ; ハモンド, マーク
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This paper reports on a pilot study that focuses on developing an approach toanalyzing spoken texts produced when people
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give instructions for procedural tasks.Specifically, the study compares procedural monologues of three native speakers ofEnglish to those of three Japanese university students currently studying English as aforeign language. The paper’s primary purpose is to identify salient patterns of languageuse in order to provide a point of departure for future investigations with a larger numberof participants. Towards this goal, a mixed methodology is employed as communicativefunctions are qualitatively categorized and quantitative data of form frequency isextracted via corpus-based tools. A secondary purpose is to determine the viability ofusing the teleconference platform Zoom as an alternative to in-person observation whencollecting data. Additionally, the paper offers preliminary findings that suggest adifference in communicative function and grammatical form found in each group ofparticipants, as well as discussion of how future research efforts may proceed.<br />本論文では、手続き的作業の指示を与える際に生成される音声テキストを解析する手法の開発に焦点を当てたパイロット研究について報告した。具体的には、3 人の英語母語話者と、外国語として英語を学んでいる3 人の日本人学生の手続き的独話を比較した。本論文の主な目的は、より多くの参加者を対象とした将来の研究の出発点を提供するために、言語使用の顕著なパターンを特定することである。この目標に向けて、伝達機能を定性的に分類し、形態頻度の定量的データをコーパスベースのツールを介して抽出する複合的な方法論を採用した。第2 の目的は、データを収集する際に、対面での観察に代わるものとしてテレビ会議プラットフォームのZoom を使用することの可能性を見極めることである。加えて、本論文は、参加者の各グループで見出されたコミュニケーション機能と文法形式の違いを示唆する予備的知見を提供し、今後の研究がどのように進むかについても論じる。
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KUDO, Yoshinobu ; 工藤, 義信
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Fujisawa, Mieko ; Takemura, Kazuhisa ; Funaki, Yukihiko ; Udo, Nobuyuki ; Takahashi, Ryo ; 藤澤, 美恵子
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金沢大学人間社会研究域経済学経営学系<br />Many countries have implemented an energy labeling system that displays the energy savings perfo
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rmance of buildings. However, previous studies have reported mixed findings on the effectiveness of this system.This study is undertaken in Japan to assess whether energy labels are effective and validate the significance of the label design. We use an online survey to determine the effects of energy labels on target consumers. We choose two energy label designs: one with a stairs rating form design and the second with a rating scale of the energy efficiency. Adopting a within-subjects method, each respondent is shown both designs and asked to evaluate the energy-saving level based on the labels. Cross-tabulation confirms the positive effects of labeling on energy-savings levels, which are amplified by increasing the level of the reference point. The highest insulation performance level in Japan complies with a law enacted back in 1993; the results show that greater effects can be realized by increasing the level of the reference point.A logistic regression analysis shows that energy labels with the stairs rating have a negative influence, while labels with a rating scale are preferred based on ease of understanding by the respondents. This suggests that energy labels that offer a rating scale can contribute to facilitating energy savings, although there are problems with the comprehension of the gradation colors which need to be further examined. These results can act as a guideline towards optimal designs of the upcoming task of modifying the energy labeling system in Japan.<br />許可を得て登録 2021-04-09
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Beitner, H. ; Nakatani, Toshio ; 中谷, 壽男
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Beitner, H. ; Nakatani, Toshio ; Hammar, H. ; 中谷, 壽男
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A case of Crohn's disease complicated by Sweet's syndrome is presented. The main ultrastructural findings were the multiplication of basal lamina surrounding the venulea, interendothelial gaps and in perivascular locations mixed infiltrates
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of neutrophiles and erythrocytes. The changes indicate that the initial site of the reaction was the walls of the dermal vessels.
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Hedblad, M. A. ; Nakatani, Toshio ; Beitner, H. ; 中谷, 壽男
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A male patient with clinically and histopathologically verified Darier's disease and a history of deterioration after sun exposure was irradiated on uninvolved skin with 25, 50 and 75 J/cm2 of UVA once a week for five weeks. He also
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received 3 and 5 times his individually established MED of UVB. Since no signs of keratosis follicularis were detected one week after the last irradiation, he was then exposed to 10 times his MED with UVB, whereupon clinically characteristic lesions of keratosis follicularis developed. One week after this exposure, biopsies were taken from the UV-induced lesions and processed for light and transmission electron microscopic investigation. Light microscopy revealed suprabasal lacunae, corps ronds and grains. In the electron microscope, gaps in the basal lamina beneath the suprabasal lacunae were also observed, through which cytoplasmic processes of lymphocyte- and fibroblast-like cells and basal keratinocytes protruded. Parts of keratinocytes with disruptive cell membranes were localized in the gaps of the basal lamina. Also, multiplication of the basal lamina was frequent.
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Ohtani, Yuko ; Ohtani, Osamu ; Nakatani, Toshio ; 大谷, 修 ; 中谷, 壽男
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金沢大学医薬保健研究域保健学系<br />The present study demonstrated the threedimensional microstructure of the rat diaphragm by scanning
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electron microscopy (SEM) of either intact or alkali-treated tissues, enzyme-histochemistry, and confocal laser scanning microscopy (LSM). The peritoneal and pleural surfaces of the diaphragm were covered with mesothelial cells studded with microvilli. Many round gaps were formed between the mesothelial cells. The submesothelial connective tissue contained voluminous, irregularly shaped lymphatics. Some of these lymphatics extended many funnel-like projections of their endothelia towards the pored region of the mesothelium. On coming into contact with the mesothelium, many of the lymphatic projections were perforated at their ends, thus giving rise to stomata connecting the peritoneal cavity and lymphatic lumen. Some projections ended blindly while plugging the mesothelial pores, thereby making visible some intercellular gaps in this contact. The subperitoneal sheet of the collagen fiber network possessed clusters of foramina which tightly fit the passage of the lymphatic projections. Confocal LSM of the diaphragm after intraperitoneal injection of FITC-dextran demonstrated the tracer both in the lymphatic lumina and in the connective tissue spaces. Our results indicate that peritoneal fluid is allowed to flow into the connective tissue spaces of the diaphragm through intercellular gaps and into lymphatics through stomata.
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Haryanto ; Mukai, Kanae ; Nakajima, Yukari ; Okuwa, Mayumi ; Cau, Kim Jiu ; Sugama, Junko ; Nakatani, Toshio ; 向井, 加奈恵 ; 中島, 由加里 ; 大桑, 麻由美 ; 須釜, 淳子 ; 中谷, 壽男
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金沢大学医薬保健研究域保健学系<br />The purpose of this study is to evaluate and clarify the effect of Indonesian honey, two types of J
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apanese honey and hydrocolloid dressing on wound healing process. Four groups of male mice were treated to produce two circular full-thickness skin wounds on the dorsum. They were then randomly allocated to receive daily Indonesian honey, Japanese honey (Buckwheat and Acacia honey) or hydrocolloid dressing as a control for treatment application. Macroscopic findings were observed from day 0 to 14 after wounding. Microscopic evaluation was assessed using qualitative analysis. The ratios of wound areas for honey groups on day 3 and 7 were smaller than those of the control group. Wound areas of honey groups gradually decreased to almost the same wound area as the control group on day 14, while the wound area of the control group peaked on day 5 and rapidly decreased until day 14. Microscopic finding that Indonesian honey was different with Japanese honey especially Buckwheat honey.
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Mukai, Kanae ; Komatsu, Emi ; Nakajima, Yukari ; Urai, Tamae ; Nasruddin ; Sugama, Junko ; Nakatani, Toshio ; 向井, 加奈恵 ; 中島, 由加里 ; 須釜, 淳子 ; 中谷, 壽男
概要:
金沢大学医薬保健研究域保健学系<br />Cutaneous wound healing is delayed by protein malnutrition (PM). On the other hand, estrogen promot
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es cutaneous wound healing by its anti-inflammatory and cell proliferation effects. Therefore, we hypothesized that estrogen administration in protein-malnourished ovariectomized (OVX) female mice might improve the inflammatory response and promote cutaneous wound healing as well as normal nutrition. To test this hypothesis, we used full-thickness excisional wounds in Control SHAM, PM SHAM, PM OVX and PM OVX+17β-estradiol mice. The Control diet included 200 g/kg protein and the PM diet included 30 g/kg protein. The ratio of wound area in the Control SHAM group was significantly smaller than those in the three PM groups. In addition, microscopic findings also showed that the ratio of collagen fibers, the ratio of myofibroblasts and the number of new blood vessels in the Control SHAM group were significantly greater than those in the three PM groups. However, the number of Ym1-positive cells as an anti-inflammatory M2-like macrophage marker in the PM OVX+17β-estradiol group was significantly higher than those in the other three groups. These results indicate that the appearance of anti-inflammatory M2-like macrophages was promoted by estrogen administration; however, it could not promote cutaneous wound healing upon a low-protein diet. Therefore, it may be confirmed that nutrition is more important for promoting cutaneous wound healing than estrogen administration.
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Nakatani, Toshio ; Beitner, Harry ; 中谷, 壽男
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金沢大学医薬保健研究域保健学系<br />Melanosomes in sporadic dysplastic nevi were examined by transmission electron microscope. In parti
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cular the structure of macromelansomes was observed. Macromelanosomes were present in both nevus cells and keratinocytes. They were round and consisted of a core structure and a cortex structure. The core was composed of electron-dense amorphous material and electron-lucent microvesicles. The cortex contained grains of different sizes and electron densities. Occasionally small melanosomes were observed in the cortex. Electron-lucent microvesicles were also present in small spherical and ellipsoid melanosomes. Melanosome complexes observed in nevus cells contained degrading melanosomes with electronlucent microvesicles, dispersed microvesicles and grains. Melanosome complexes with structures resembling those found in macromelanosomes were also present. The result of the investigation suggests that melanosome complexes found in nevus cells might become macromelanosomes through autophagy.
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Shinohara, Harumichi ; Morisawa, Satoshi ; Nakatani, Toshio ; Ohtani, Osamu ; 中谷, 壽男
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金沢大学医薬保健研究域保健学系<br />The auricular length, auricular base length and auricular width were measured in 94 human fetuses w
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ith crownrump (CR) lengths ranging from 49 mm (approximately 11 weeks of gestational age) to 250 mm (approximately 31 weeks of gestational age). The three measurement values showed linear increases as the CR length increased, suggesting that they are useful parameters to indicate intrauterine growth. The measurement values also suggested that the mandibular and hyoid derivatives did not grow independently, but did grow with maintaining a certain relationship.
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Matsuda, Takeshi ; Fukuo, Yoshifumi ; Shinohara, Harumichi ; Morisawa, Satoshi ; Nakatani, Toshio ; 中谷, 壽男
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金沢大学医薬保健研究域保健学系<br />The mouse pericardium is a continuous serous membrane, up to postnatal day 6 (P6), that consists of
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pericardial and pleural mesothelia with sparse connective tissue sandwiched in between. This study shows that on P7 the pericardium becomes fenestrated, and the pericardial and pleural cavities become continuous. We found that the number of pores per pericardium increased continuously with the advance of age and reached as many as 3000 on P21. Transmission electron microscopy of the pericardium revealed various structures of the pericardial and pleural mesothelia that may relate to the formation of the pericardial pores. The pericardial and pleural mesothelia were adjoined with cytoplasmic processes that extended toward the base of the opposing mesothelium. As a result of the adjoinment, a pair of U-shaped folds were formed. The two U-shaped folds were connected with tight junctions at their apices, and separation of these junctions may give rise to the pericardial pores.
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Nakatani, Toshio ; Beitner, Harry ; 中谷, 壽男
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金沢大学医薬保健研究域保健学系<br />Seven female human subjects were irradiated with 4 Gy of grenz rays and 30 J/cm2 of long-wave ultra
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violet (UVA) radiation once a week for three weeks.6/7 subjects when irradiated on the back developed a clearly visible pigmentation due to both grenz-ray and UVA pigmentation. The effect on epidermal melanocytes was observed with transmission electron microscopy. Ultrastructural changes in melanocytes following both grenz-ray and UVA irradiation were an increase in the number of premature and mature melanosomes, elongation and protrusion of cytoplasm, sometimes indented nuclei, and the development of multilamella of basal lamina. Compared with UVA-irradiated skin, in the same individuals the melanocytes seemed somewhat more hypertrophic after grenz-ray irradiation. In general the observed qualitative ultrastructural differences between UVA- and grenz-ray-irradiated melanocytes were limited, indicating that the influence of grenz-rays is similar to that of UVA.
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Mukai, Kanae ; Komatsu, Emi ; Nakajima, Yukari ; Urai, Tamae ; Nasruddin ; Sugama, Junko ; Nakatani, Toshio ; 向井, 加奈恵 ; 中島, 由加里 ; 浦井, 珠恵 ; 須釜, 淳子 ; 中谷, 壽男
概要:
金沢大学医薬保健研究域保健学系<br />Topical estrogen application to wounds is effective in promoting cutaneous wound healing. However,
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whether it promotes cutaneous wound healing in delayed cutaneous wound healing associated with advanced age remains to be elucidated. This study aimed to evaluate the effect of topical estrogen application to wounds in cutaneous wound healing in 80-week-old female mice. C57BL/6J female mice aged 82–85 and 12 weeks old were submitted to two full-thickness wounds. Mice were divided into four groups: aged group, topical estrogen wound treatment aged group (aged-E), vehicle wound treatment aged group (aged-vehicle), and young group. Wound healing was observed until day 14. In the aged group, wound area ratio (wound area / initial wound area) was significantly higher on days 3–14, ratio of re-epithelialization was significantly lower on day 3 and tended to be lower on day 14, and neutrophil number was significantly higher on day 7 compared with the young group. In contrast, in the aged-E group, wound area ratio was significantly smaller on days 1–14, re-epithelialization ratio was significantly higher on days 3–14, and neutrophil and macrophage number was significantly lower on days 3 and 7 compared with the aged group. These results demonstrate that topical estrogen application to wounds in 80-week-old female mice promoted cutaneous wound healing by reducing wound area and inflammatory response and promoting re-epithelialization.
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| 26.
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Asano, Kimi ; Nakajima, Yukari ; Mukai, Kanae ; Urai, Tamae ; Okuwa, Mayumi ; Sugama, Junko ; Konya, Chizuko ; Nakatani, Toshio ; 浅野, きみ ; 中島, 由加里 ; 向井, 加奈恵 ; 浦井, 珠恵 ; 大桑, 麻由美 ; 須釜, 淳子 ; 紺家, 千津子 ; 中谷, 壽男
概要:
金沢大学医薬保健研究域保健学系<br />Background Previously, we showed that lymphatic vessels (LVs) formed detours after lymphatic obstru
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ction, contributing to preventing lymphedema. In this study, we developed detours using lymphatic ligation in mice and we identified the detours histologically. Methods and results Under anesthesia, both hindlimbs in mice were subcutaneously injected with Evans blue dye to detect LVs. We tied the right collecting LV on the abdomen that passes through the inguinal lymph node (LN) at two points. The right and left sides comprised the operation and sham operation sides, respectively. Lymphography was performed to investigate the lymph flow after lymphatic ligation until day 30, using a near-infrared fluorescence imaging system. Anti-podoplanin antibody and 5-ethynyl-2’-deoxyuridine (EdU) were used to detect LVs and lymphangiogenesis. Within 30 days, detours had developed in 62.5% of the mice. Detours observed between two ligation sites were enlarged and irregular in shape. Podoplanin+ LVs, which were located in the subcutaneous tissue of the upper panniculus carnosus muscle, connected to collecting LVs at the upper portion from the cranial ligation site and at the lower portion from the caudal ligation site. EdU+ cells were not observed in these detours. The sham operation side showed normal lymph flow and did not show enlarged pre-collecting LVs until day 30. Conclusions Detours after lymphatic ligation were formed not by lymphangiogenesis but through an enlargement of pre-collecting LVs that functioned as collecting LVs after lymphatic ligation. Further studies are required to explore the developmental mechanism of the lymphatic detour for treatment and effective care of lymphedema in humans. © 2020 Asano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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| 27.
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Nishikawa, Yuichi ; Takahashi, Tetsuya ; Kawade , Shuhei ; Maeda , Noriaki ; Maruyama, Hirofumi ; 西川, 裕一 ; 高橋, 哲也
概要:
金沢大学理工研究域フロンティア工学系<br />Background: Electrical muscle stimulation (EMS) is effective for increasing physical function. H
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owever, there is no evidence regarding the effects of EMS on muscle mass and physical function in older adults with dementia. The aim of the present study was to quantify the effects of EMS on muscle mass and balance in older adults with dementia. Methods: A total of 32 participants were randomly assigned to an intervention group (n = 16, age = 89.4 ± 4.8 years) and a control group (n = 16, age = 88.1 ± 5.2 years). Participants in the intervention group underwent a general rehabilitation program (20 min for three days/week) and an EMS intervention (23 min for three days/week) for 23 weeks. Participants in the control group underwent general rehabilitation only. The efficacy of EMS was evaluated by lower limb muscle mass, the Berg Balance Scale (BBS), and the functional independence measure (FIM). Results: Muscle mass was significantly increased in the intervention group after 12 weeks (p = 0.008), but average muscle mass in the control group did not change (p = 0.18). Participants in the control group showed a significant decrease in BBS after 12 weeks (p = 0.007), unlike those in the intervention group. Furthermore, there was a strong correlation between the mini-mental state examination (MMSE) results and the change in muscle mass, the BBS, and the FIM in the control group (p < 0.05). Conclusions: These findings suggest that EMS is a useful intervention for increasing muscle mass and maintaining balance function in older adults with dementia.<br />CC BY 4.0
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Michiue, Kana ; Nishikawa, Yuichi ; 西川, 裕一
概要:
金沢大学理工研究域フロンティア工学系<br />The aim of this study was to examine the effect of electrical muscle stimulation on muscle atrop
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hy caused by neuromyelitis optica. Two neuromyelitis optica patients with flaccid paralysis participated. The participants underwent a general rehabilitation program (transfer, balance, and gait training) and electrical muscle stimulation on the quadriceps femoris muscle of their paralyzed side. The change in the thickness of the vastus lateralis muscle ranged from −0.6 to 1.4 mm. These changes were minimal and did not indicate muscle atrophy. These findings suggest that in addition to general physiotherapy, electrical muscle stimulation seems safe and feasible in the acute phase of neuromyelitis optica.
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| 29.
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Asano, Tetsuo ; 浅野, 哲夫
概要:
金沢大学理工研究域<br />15th International Conference and Workshops, WALCOM 2021, Yangon, Myanmar, February 28 – March 2, 2021, Proceeding, Editors: Uehara, Ryuhei, Hong, Seok-Hee, Nandy, Subhas C (Eds.)
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Ikeya, Noriyuki ; Tanaka, Gengo ; Tsukagoshi, Akira ; 田中, 源吾
概要:
金沢大学国際基幹教育院GS教育系
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Tanaka, Gengo ; Ikeya, Noriyuki ; 田中, 源吾
概要:
金沢大学国際基幹教育院GS教育系<br />Eighty-five fossil and Recent species of the genus Loxoconcha (Crustacea : Ostracoda) from East As
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ia are systematically reexamined. On the basis of carapace morphology, the genus Loxoconcha from East Asia is divided into five species groups : L. pulchra, L. optima, L. japonica, L. uranouchiensis and L. japonica species groups. The migration and speciation patterns of four species of the L. japonica species group are as follows. In Late Miocene, L. lilljeborgii and L. tumulosa were distributed over the Paleo-Indian Ocean. In Early Pliocene time, these species migrated to the Western Pacific and L. japonica evolved from populations of L. tumulosa by peramorphic evolution. In the Middle Pleistocene, L. shanhaiensis evolved from populations of L. japonica in the Ryukyu Islands by paedomorphic evolution.
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| 32.
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Tanaka, Gengo ; Seto, Koji ; Mukuda, Takao ; Nakano, Yusuke ; 田中, 源吾
概要:
金沢大学国際基幹教育院GS教育系<br />Thirty-five ostracod species belonging to 18 genera are recognized from the Middle Miocene Fujina
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Formation (ca. 14-12 Ma), 3km southwest of Matsue City, Shimane Prefecture, Japan. Most of these species are part of the recent Japan Sea proper water fauna; they are also classified into 4 categories, circumpolar, cryophilic, endemic cool-temperate and temperate species. These ostracod assemblages indicate that the Fujina Formation was deposited under a cold-water environment. Ten new species, Ambtonia shimanensis, A. takayasui, Acanthocythereis fujinaensis, A. izumoensis, Cluthia tamayuensis, C. subjaponica, Kotoracythere tsukagoshii, Laperousecythere ikeyai, Palmoconcha irizukii, and Robertsonites yatsukanus are described.
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| 33.
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Tanaka, Gengo ; 田中, 源吾
概要:
金沢大学国際基幹教育院GS教育系<br />島根県,出雲市菅沢の大森層より26属42種の介形虫化石を抽出し,2つの介形虫群(Ambostracon-Argilloecia-Cytheropteron群集およびPaijenborchella-
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Palmoconcha-Urocythereis pohangensis群集)を認めた.これらの群集は冷温〜温暖な公海の下浅海環境を示唆する.大森層および布志名層からの介形虫化石群の主成分分析は,その堆積環境が上部層準に向かってしだいに深くなっていったことを示唆する.5新種(Cytheropteron shimanense, Loxoconcha izumoensis, Paradoxostoma yakumotatsunus, Schizocythere sakanoueiおよびUrocythereis sugesawensis)を記載した.<br />Ostracods from the Omori Formation in Sugesawa (Izumo City, Shimane Prefecture) comprise 42 species belonging to 26 genera. Five new species, Cytheropteron shimanense, Loxoconcha izumoensis, Paradoxostoma yakumotatsunus, Schizocythere sakanouei and Urocythereis sugesawensis are described. Two ostracod assemblages (Ambostracon-Argilloecia-Cytheropteron assemblage and Paijenborchella-Palmoconcha-Urocythereis pohangensis assemblage) are recognized. These assemblages indicate that the uppermost of the Omori Formation was deposited under the environments from cool to warm open sublittoral condition. Principal components analysis of ostracod assemblages from the Omori and Fujina Formations indicates that, in general, the depositional environment becomes deeper and deeper towards the upper horizon.
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| 34.
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Tanaka, Gengo ; Nakase, Hajime ; Yamashita, Shota ; Arai, Kazuno ; 田中, 源吾
概要:
金沢大学国際基幹教育院GS教育系<br />In Rikuzentakata City, Ostracode assemblages in sediment deposited by the Tohoku‐Oki earthquake an
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d tsunami of 11 March 2011 revealed that the sediment was derived from the seafloor from at least 9 m water depth, and was transported inland more than 1 km. The tsunami wave height at this location was higher than 10 m. Four hundred fifty seven modern ostracode assemblages were used in the modern analogue technique to estimate the depth source of the tsunami deposited assemblages. The application of this method to paleo‐tsunami deposits may provide insight into past tsunami wave height and potentially earthquake slip and magnitude.<br />Embargo Period 6 months
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| 35.
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Tanaka, Gengo ; 田中, 源吾
概要:
Sanyuania cuneata Zhao & Whatley, 1992 was reported initially from Late Pleistocene core samples from the northern part
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of the Yellow Sea and Recent sediments collected from supra tidal pools (17 practical salinity unit (psu)) in Xiangshangang Bay, East China Sea (Zhao & Whatley, 1992). Later, specimens were discovered, but not identified, in Lake Nakaumi, Shimane Prefecture, SW Japan (Fig. 1) (as Cytheridae gen. et. sp. indet. by Tanaka et al. (1998) and Sanyuania sp. by Seto et al. (1999)). Further examination of these Japanese specimens has clarified that they are conspecific with the Chinese specimens. This has provided an opportunity to review the distribution (Fig. 1) and potential environmental significance of Sanyuania cuneata and, for the first time, to describe its appendages (Fig. 2).Specimens figured herein were recovered from Lake Nakaumi (35°26′ 50″ N, 133°07′50″ E) at a depth of 0.3–6.0 m and salinity of 8–17 psu on 9 September 1998. The surface of the sediment was covered by the byssus of the mussel Musculista senhousia (Benson, 1842).Sanyuania cuneata is probably endemic to the East China Sea and the southwestern part of the Sea of Japan and is a potentially useful palaeoenvironmental indicator of brackish (steno-haline) environments in the area. By using the oxygen isotopic data from planktonic foraminifers and the estimated value of salinity flowing into the Japan Sea, Matsui et al. (1998) approximated that the salinity of the surface water of Japan Sea declined to about 20 psu during the Last Glacial Maximum . . .
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Tanaka, Gengo ; Seto, Koji ; 田中, 源吾
概要:
金沢大学国際基幹教育院GS教育系<br />Three living trachyleberidid ostracod species, Acanthocythereis munechikai Ishizaki, Actinocythere
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is kisarazuensis Yajima and Hirsutocythere hanaii Ishizaki, were discovered in the Tsushima Straits, c. 120 km east of Tsushima Island (north Island), N 34° 46′ E 130° 46′ at a depth of 116 m. This is the first description of complete appendages for these genera.
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| 37.
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Tanaka, Gengo ; Parker, Andrew R. ; Hasegawa, Yoshikazu ; Siveter, David J. ; Yamamoto, Ryoichi ; Miyashita, Kiyoshi ; Takahashi, Yuichi ; Ito, Shosuke ; Wakamatsu, Kazumasa ; Mukuda, Takao ; Matsuura, Marie ; Tomikawa, Ko ; Furutani, Masumi ; Suzuki , Kayo ; Maeda, Haruyoshi ; 田中, 源吾
概要:
金沢大学国際基幹教育院GS教育系<br />Vision, which consists of an optical system, receptors and image-processing capacity, has existed
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for at least 520 Myr. Except for the optical system, as in the calcified lenses of trilobite and ostracod arthropods, other parts of the visual system are not usually preserved in the fossil record, because the soft tissue of the eye and the brain decay rapidly after death, such as within 64 days and 11 days, respectively. The Upper Carboniferous Hamilton Formation (300 Myr) in Kansas, USA, yields exceptionally well-preserved animal fossils in an estuarine depositional setting. Here we show that the original colour, shape and putative presence of eumelanin have been preserved in the acanthodii fish Acanthodes bridgei. We also report on the tissues of its eye, which provides the first record of mineralized rods and cones in a fossil and indicates that this 300 Myr-old fish likely possessed colour vision.<br />This work was supported by the Science Research of Education and Science Government of Japan (grant no. 24540501 to G.T. and no. 24340129 to H.M.).
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| 38.
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Tanaka, Gengo ; Smith, Robin J. ; Siveter, David J. ; Parker, Andrew R. ; 田中, 源吾
概要:
金沢大学国際基幹教育院GS教育系<br />Compound eyes are common in decapod crustaceans. Decapods have an abundant post-Palaeozoic fossil
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record, but hitherto morphological information about their eyes has been mainly restricted to Recent material. Here we report the discovery of compound eyes recovered from acetic acid residues of two fish-bearing nodules from the Cretaceous Santana Formation of Brazil; they include what are identified as decapod larval compound eyes. The fossil eyes are comparable to phyllosoma larval eyes because of the following characters: the hemispherical visual surface on a stalked eye; the relatively small-size of the visual surface of the eye; rounded facets are arranged in square arrays in the anterior region; the fact that the neighboring ommatidia are bounded by ridges and/ or grooves; and the more convex inner surface of the cornea lens. This report represents the first description of a three-dimensionally preserved fossil decapod eye. We conclude that the eyes probably represent palinuroid phyllosoma larval eyes and were an adaptation to a planktonic lifestyle. © 2009 Zoological Society of Japan.
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| 39.
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田辺, 勝美 ; Tanabe, Katsumi
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Tazaki, Kazue ; Ishida, Hideki ; 田崎, 和江 ; 石田, 秀樹
概要:
金沢大学理工研究域地球社会基盤学系
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| 41.
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Tazaki, Kazue ; Zhou, Guoping ; Makaino, Koji ; 田崎, 和江 ; 周, 国平 ; 馬飼野, 光治
概要:
金沢大学理工研究域地球社会基盤学系<br />デイーゼルエンジン車の排気ガスを一日2回直接受けたスイセンを採取し, XRF, SEM-EDX, TEMで観察および分析を行った.排気ガスに汚染されたスイセンの葉は黒色に変色し,気孔の内部及び周
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辺には,Sを含む多量の微粒子が被覆し, Al, Si, Cl, Ca, K, Feの増加も認められた.これらの結果は,ディーゼルエンジンの排気ガスが植物の光合成などの生理作用に,短期間で大きく影響を及ぼすことを明らかにした.<br />Polluted narcissuses by exhaust emissions derived from a diesel engine twice a day were investigated by XRF, SEM-EDX and TEM analyses. Polluted narcissus was characterized by no flower, deformed leave and the change of color from green to yellow and black. S was increased about 6 times. About 33% of S-coated carbonaceous soots was retained through breath holes by narcissus, causing the normal breath and photosynthesis of narcissus damaged. This could be a major factor of narcissus growing abnormally during a short period (2 months).
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| 42.
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田崎, 和江 ; Tazaki, Kazue
概要:
金沢大学理工研究域地球社会基盤学系<br />地球上に広く分布する微細な炭素粒子は,環境の変化に最も敏感に対応する物質の一つである.その炭素の起源,微細形態,結晶成長の過程,化学結合,分布などを明かにし,炭素物質を評価するうえで,電子線を用
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いた手法が有効である.ここには,様々な炭素物質について,その目的に応じた有効な分析方法の実例を示した.走査型(SEM)および透過型電子顕微鏡(TEM)による観察は,炭素物質の微細形態,結晶成長過程,結晶度を知るのに適している.バクテリアなどを含む有機物が濃集した非晶質の炭素は,続成作用により,高結晶度のグラファイトヘと変化する.初期の炭素物質は,球粒,管,フレーク,薄膜,シート,リボン状などさまざまな形態をとり,最も成長した結晶であるグラファイトは,六角板状のバウムクーヘン状構造をとる.炭素の分布を知るには,エレクトロンマイクロプローブ(EPMA)やオージェ(Auger)による元素濃度分布図が有効である.オージェは,導電性物質の蒸着を必要としないので,岩石中のカーボンの存在を薄片の状態で検出することが可能である.高い導電性を持つことで知られているワイオミング産のSybille Monzosyeniteに,オージェ分析を適用し,鉱物境界に高濃度の炭素が存在することが,高導電性の要因の一つであることを明かにした.また,オージェは導電性物質の蒸着なしで,オングストロームのオーダの最表面分析が可能である.フーリエ赤外線分析(FT-IR)は,炭素の化学結合や水分子との結合状態を知ることができる.グラファイトは,その結晶度の違いによりOHやC-C結合の吸収の程度が異なる例として,片麻岩中の低結晶度の炭素から水分が抜け,次に酸素が抜けてグラファイトヘと変化するプロセスを示した.また,電子線走査化学分析器(ESCA)による炭素(1S)の高分解能分析は,様々な炭素結合の種類とその量比を知るのに有効である.この方法により,深海底堆積物中の海緑石に含まれる炭素が,COO,C-O,C-Cそしてグラファイトといった異なる炭素結合により構成されていることを明かにした.この結果は,海緑石が有機物起源であり,その後,無機化すること,有機炭素と無機炭素の境界は明瞭ではないことなどを示している.さらに,重イオン加速器(RILAC)は,炭素が表面吸着しているか,または結晶構造に組み込まれているかの判断に有効である.例えば都市ガスのすすの分析は,金属やSiO_2といった標準試料と比べ,炭素が結晶性の構造を待つことを示した.同時に,この方法は,酸素と水素の存在状態の差異も明瞭に表わすことができる.重イオン加速器は,大気からもたらされた汚染物質の炭素と物質本来の結晶構造中の炭素原子との区別に有効である.<br />Very fine carbon particulates formed by both inorganic and biological processes in the Earth have the most sensitive response to global change. Various electron microtechniques are usufu1 to reveal the micromorphology, texture, growing processes, crystalinity, chemical bond and the distribution of carbon materials. In this article useful methods for evaluation of carbon in various carbon materials are introduced. Amorphous organic carbon naturally and artificially transforms into high crystalline graphite. SEM and TEM observations reveal that precursor carbon materials are composed of spherules, tubular, fiakes, thin films ,fla tsheets, and ribbon texture. Bacteri aand nannobacteria may play a prorninent catalyzing role in the precipitatio onf carbon materia]s. Hexagonal onion-like texture is the most stable form ofcarbon durin ggraphitizatio n,EPMA and Auger can be used for carbon elernentary rnapping. Auger-spectrometer depth profiling and carbon content rnap applied to Sybille Monzosyenite having high electrical conductivity revealed a high concentration of carbon on grain boundaries of the minerals. Chemical bonding of carbon and hydrogen can be analyzed by FT-IR method. FT-IR spectra showing different intensity of OH and C-C absorbed bands are related with the degree of crystalinity of graphite in rocks. The result suggests that graphite occurred by dehydration and reduction of organic materials, ESCA is usufu1 method to know various carbon binding. High resolution of C_ls spectra of micro ESCA can discriminate various carbon chemical binding, such as COO, C-O, C-C, and graphite. ESCA spectra of glauconite in deep sea sediments showed various ratios of COO, C-O, C-C and graphite, suggesting organic origin of glauconite. The result also suggests that there are no clear boundary between organic and inorganic carbon. RILAC method can be used for evaluation of atmospheric contamination of carbon from structural carbon. RILAC spectra of soot showed characteristic recoiled carbon, oxygen and hydrogen ions with standards of purity for metalic plate and Si0_2.
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Tazaki, Kazue ; 田崎, 和江
概要:
金沢大学理工研究域地球社会基盤学系<br />Because of increasing population, human activity has become a dominant process modifying the eart
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h environment. Understanding the new environmental stresses includes study of interface processes on macro- and micro-scales. Application of electron microscopy to the study of sulfides and sulfate complexes in atmospheric dust, in acidic river sediment, in sewage sludge and in water solution, provide unique information on the interaction between bacteria and human activities in close-to-environmental conditions. Microorganisms exhibit great powers of trace metal accumulation and immolization. They may be frequently encountered in extreme metal contaminated environment both natural and man-made. The sulfides leading to the formation of sulfide minerals were observed by scanning electron microscopy (SEM), transmission electron microscopy (TEM) equipped with energy-dispersive X-ray analysis (EDX). For example: 1 Atmospheric sulfide minerals in air dust, 2 Sulfides precipitation with bacteria in polluted mining river sediment, 3 Sulfide mineralization in sludge, 4 Experimental sulfide mineralization in 9 K medium. Atmosphere oxidation rate of SO2 is largely balanced by exchange across the hydrosphere-biosphere-land surface interfaces. Fluctuating volcanic emissions or Chinese loess may have profound influence. SEM-EDX observation indicated that the air dust and acid rain-water contained gypsum, barite and sulfur films which may be due to contributions from volcanic eruption. TEM observation showed bacteria with S-rich thin films in dust of rain-water suggesting interaction between polluted S-rich precipitation and bacterial activity in atmospheric environment. The study of acidic river sediment indicates the enormous influence of the biosphere in maintaining river chemistry of sulfate complexes and sulfides. The electron microscopic techniques enable us to examine the reactive surface at the micron scale, the surface where reaction occurs, that control so many of the basic biogeochemical processes. Micro-scopic study showed that all biomass contains a significant quantity of metallic constituents, and mineralization in living and dead biodebris may contribute to sulfides transport from the hydrosphere into sediment. The bacterial cell walls are remarkable in their ability to fix metals and provide sites for nucleation and growth of Mn, Fe, Cu and Zn minerals. The sulfate complexes and sulfides in sludge in Lake Nakaumi were investigated, including study on the formation of minerals and uptake of metals by bacteria or plant. SEM-EDX observation showed that pyrite, pyrrhotite and gypsum were formed on the top of surface sludge. The aggregate of framboidal pyrite gradually grew in diatom shell which composed of S and Fe, suggesting the processes of sulfide mineral formations related with organisms. The sewage sludge is a valuable source of N, P, and heavy metallic elements (e. g. , Cu, Fe, Mn, Zn) and organic matter. Such metals are of environmental concern due to their potential effects on plant uptake and growth. Jarosite used in the laboratory study was produced from a mixture of 9 K medium and Thiobacillus ferroxidans for a period of several days. SEM-EDX observation with XRD showed that jarosite was formed after 3 days and ammoniojarosite was formed after 7 days from the experimental solution. If T. ferroxidans is present, jarosite can be formed at room temperature by aerating solutions of FeSO4, and K2SO4 at pH 2 within few days. Elemental sulfur interacted with the metal-loaded bacterial cells, affected both the eventual earth science and crystal habit of the metal sulfides, and formed a variety of crystalline metal sulfides. Observation of sulfate complexe changes is unique opportunity to better manage all our earth environment.
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APPEL, Randy ; アペール, ランディ
概要:
With the increased availability of many low cost and freely accessible tools that can now be used to analyze large collections of text in (semi)automated ways, corpus approaches to linguistic inquiry have seen a sharp rise in
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popularity over the last 20 years. This increased attention, combined with eased data collection, has led to a wide range of studies making use of corpus approaches to better understand various genres and registers of linguistic output as a way of informing second language acquisition pedagogy and theory. In this paper, two particular areas of research that have benefited from the increased attention provided by corpus approaches to linguistic inquiry are discussed: formulaic sequences and first language related production tendencies. These two areas are used to reveal important pedagogical implications resulting from recent research applying corpus-driven lexical analyses of second language English academic writing.
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| 45.
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MORIKAWA, Tomoaki ; 森川, 智成
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On January 21, 2021, Dr. Jayson Parba of the University of Hawai‘i at Mānoa was virtually invited to Kanazawa University
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to give a public lecture online on critical language pedagogy in the EAP classroom context. Introducing the theoretical entry points of critical pedagogy and illustrating his own praxis, Dr. Parba discusses the pedagogical and curricular implications of incorporating critical perspectives in language teaching.
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| 46.
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BROWN, Dale ; OYABU, Kana ; YAGUCHI, Michiko ; MURRAY, Lewis ; ブラウン, デール ; 大藪, 加奈 ; 家口, 美智子 ; マリー, ルイス
概要:
English-medium instruction (EMI) has quickly become a significant part of higher education around the world. To help stu
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dents prepare for the demands of EMI, English for Academic Purposes (EAP) courses often have a significant role. In order for EAP courses to optimally prepare students for EMI, it is important that those managing EAP programmes have a good understanding of the nature of EMI and of students’ abilities to deal with its demands. This paper reports on a study in which 192 students enrolled in EMI courses at a university in Japan responded to a questionnaire on the challenges of their EMI course and how well the prior EAP courses helped them prepare for those challenges. The questionnaire data revealed that EMI courses at the institution primarily require receptive skills (i.e. listening and reading), but that students also see a need for greater speaking ability since when EMI courses do demand active skills, students find it challenging. The study therefore provides some insights into how the institution’s EAP courses may best evolve in order to better support students in their future studies.<br />世界の高等教育では、英語による教育（EMI）が急速に重要な部分を占めるようになってきた。それに伴い、アカデミック英語に関する教育（EAP）はしばしば、学生の EMI 授業履修を可能にする大切な役割を担っている。学生を最大限EMI コースに適応させるため、EAPコースの運営者は、EMI 授業の性質やそれを受ける学生の能力をしっかり理解している必要がある。本論では、日本のある大学で EMI 授業を受けた学生 192 人のアンケート結果を分析した。学生がEMI 授業の受講にどのような難しさを感じたか、また学内EAP コースがどの程度 EMI コースに役立ったかについて、学生たちの回答を報告する。アンケート結果から、学内の EMI 授業では、主に受動的スキル（リスニングやリーディング）が必要とされていることがわかった。また、EMI 授業で積極的な貢献が求められた時、それを行うことが難しいことから、学生はより高いスピーキング力も必要と考えていることが分かった。学生の将来の学習をよりよく支援するために、EAP コースをどのように改善していくのがよいかについて、本論は一定の示唆をしている。
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| 47.
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Sato, Masahide ; 佐藤, 正英
概要:
金沢大学学術メディア創成センター<br />Considering that one-patch particles rotate three-dimensionally and translate on a two-dimensional
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flat plane, I performed isothermal–isochoric Monte Carlo simulations to study how two-dimensional self-assemblies formed by spherical patchy particles depending on the interaction length and patch area. As the interaction potential between one-patch particles, the Kern–Frenkel (KF) potential is used in the simulations. With increasing patch area, the shape of the most numerous clusters changes from dimers to island-like clusters with a square lattice via triangular trimers, square tetramers, and chain-like clusters when the interaction length is as long as the particle radius. With a longer interaction length, other shapes of polygonal clusters such as another type of square tetramers, two types of pentagonal pentamers, hexagonal hexamers, and hexagonal heptamers also form.<br />Embargo Period 12 months
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| 48.
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Kobayashi, Mio ; Kakuda, Yuko ; Harada, Kenichi ; Sato, Yasunori ; Sasaki, Motoko ; Ikeda, Hiroko ; Terada, Mitsuhiro ; Mukai, Munenori ; Kaneko, Shuichi ; Nakanuma, Yasuni ; 小林, 水緒 ; 原田, 憲一 ; 佐藤, 保則 ; 佐々木, 素子 ; 池田, 博子 ; 金子, 周一 ; 中沼, 安二
概要:
金沢大学医薬保健研究域医学系<br />AIM: To investigate histological and immunohistochemical differences in hepatitis between autoimmune
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hepatitis (AIH) and primary biliary cirrhosis (PBC) with AIH features. METHODS: Liver needle biopsies of 41 PBC with AIH features and 43 AIH patients were examined. The activity of periportal and lobular inflammation was scored 0 (none or minimal activity) to 4 (severe), and the degree of hepatitic rosette formation and emperipolesis was semiquantatively scored 0-3. The infiltration of mononuclear cells positive for CD20, CD38, CD3, CD4, and CD8 and positive for immunoglobulins (IgG, IgM, and IgA) at the periportal areas (interface hepatitis) and in the hepatic lobules (lobular hepatitis) were semiquantitatively scored in immunostained liver sections (score 0-6). Serum aspartate aminotransferase (AST), immunoglobulins, and autoantibodies at the time of liver biopsy were correlated with the histological and immunohistochemical scores of individual lesions. RESULTS: Lobular hepatitis, hepatitic rosette formation, and emperipolesis were more extensive and frequent in AIH than in PBC. CD3+, CD4+, and CD8+ cell infiltration scores were higher in the hepatic lobules and at the interface in AIH but were also found in PBC. The degree of mononuclear cell infiltration correlated well with the degree of interface and lobular hepatitis in PBC, but to a lesser degree in AIH. CD20+ cells were mainly found in the portal tracts and, occasionally, at the interface in both diseases. Elevated AST correlated well with the hepatocyte necroinflammation and mononuclear cell infiltration, specifically CD38+ cells in PBC. No correlation existed between autoantibodies and inflammatory cell infiltration in PBC or AIH. While most AIH cases were IgG-predominant at the interface, PBC cases were divided into IgM-predominant, IgM/IgGequal, and IgG-predominant types, with the latter sharing several features with AIH. CONCLUSION: These results suggest that the hepatocellular injuries associated with interface and lobular hepatitis in AIH and PBC with interface hepatitis may not be identical. © 2014 Baishideng Publishing Group Co., Limited. All rights reserved.
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Okazaki, Mitsuyoshi ; Makino, Isamu ; Kitagawa, Hirohisa ; Nakanuma, Shinichi ; Hayashi, Hironori ; Nakagawara, Hisatoshi ; Miyashita, Tomoharu ; Tajima, Hidehiro ; Takamura, Hiroyuki ; Ohta, Tetsuo ; 岡崎, 充善 ; 牧野, 勇 ; 北川, 裕久 ; 中沼, 伸一 ; 林, 泰寛 ; 中川原, 寿俊 ; 宮下, 知治 ; 田島, 秀浩 ; 高村, 博之 ; 太田, 哲生
概要:
金沢大学医薬保健研究域医学系<br />We herein report a case of anaplastic carcinoma of the pancreas with remarkable intraductal tumor gr
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owth into the main pancreatic duct. A 76-year-old male was referred to our hospital for treatment of a pancreatic tumor. Preoperative examinations revealed a poorly defined tumor in the main pancreatic duct in the body of the pancreas, accompanied with severe dilatation of the main pancreatic duct, which was diagnosed as an intraductal papillary-mucinous neoplasm. We performed distal pancreatectomy and splenectomy. The pathological examination revealed that the tumor consisted of a mixture of anaplastic carcinoma (giant cell type) and adenocarcinoma in the pancreas. There was a papillary projecting tumor composed of anaplastic carcinoma in the dilated main pancreatic duct. The patient is now receiving chemotherapy because liver metastasis was detected 12 mo after surgery. In this case, we could observe a remarkable intraductal tumor growth into the main pancreatic duct. We also discuss the pathogenesis and characteristics of this rare tumor with specific tumor growth. © 2014 Baishideng Publishing Group Co., Limited. All rights reserved.
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Sato, Hirohide ; Sato, Yasunori ; Harada, Kenichi ; Sasaki, Motoko ; Hirano, Katsuyasu ; Nakanuma, Yasuni ; 佐藤, 保則 ; 原田, 憲一 ; 佐々木, 素子 ; 中沼, 安二
概要:
金沢大学医薬保健研究域医学系<br />A 77-year-old woman complained of epigastralgia, and a tumor (5 cm in diameter) of the gallbladder n
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eck was detected by image analysis. Following cholecystectomy, the tumor was pathologically diagnosed as intraductal papillary neoplasm (IPN), gastric type, with associated invasive carcinoma. About 10 mo later, intraluminal multiple masses (3 foci, up to 1.8 cm) were noted in the extrahepatic bile duct, and the resected specimen showed that all tumors had similar gross and microscopic features as seen in gallbladder IPN without invasion, and they were synchronous multiple lesions. This case showed a papillary tumor of the gallbladder of gastric phenotype, and confirmed that the gallbladder is a target of IPN in addition to the bile ducts. © 2013 Baishideng. All rights reserved.
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