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論文

論文
Imamura, S. ; Kobayashi, Junji ; Sakasegawa, S. ; Nohara, Atsushi ; Nakajima, Kenichi ; Kawashiri, Masa-aki ; Inazu, Akihiro ; Yamagishi, Masakazu ; Koizumi, Junji ; Mabuchi, Hiroshi ; 小林, 淳二 ; 野原, 淳 ; 中嶋, 憲一 ; 川尻, 剛照 ; 稲津, 明広 ; 山岸, 正和 ; 小泉, 順二 ; 馬渕, 宏
出版情報: Journal of Lipid Research.  48  pp.453-457,  2007-02.  American Society for Biochemistry and Molecular Biology
URL: http://hdl.handle.net/2297/00050262
概要: 金沢大学医薬保健研究域医学系<br />The objective of this study was to establish a hepatic lipase (HL) assay method that can be applied to automatic clinical analyzers. Seventy-four hyperlipidemic subjects (men/women 45/29) were recruited. Lipase activity was assayed measuring the increase in absorbance at 546 nm due to quinonediimine dye production. Reaction mixture R-1 contained 50 mM Tris-HCl (pH 9.5), 0.5 mM glycerol-1,2-dioleate, 0.4% (unless otherwise noted) polyoxyethylenenonylphenylether, 3 mM ATP, 3 mM MgCl2, 1.5 mM CaCl2, monoacylglycerol-specific lipase, glycerol kinase, glycerol-3-phosphate oxidase, 0.075% N,N-bis-(4-sulfobutyl)-3-methylaniline-2 Na, peroxidase, ascorbic acid oxidase. Reaction mixture R-2 contained 50 mM Tris-HCl (pH9.5), 0.15% 4-aminoantypirine. Automated assay for activity was performed with a Model 7080 Hitachi analyzer. In the lipase assay, 160 μl of R-1 was incubated at 37°C with 3 μl of samples for 5 min, and 80 μl of R-2 was added. Within-run coefficient of variations was 0.9-1.0%. Calibration curve of lipase activity was linear (r = 0.999) between 0 and 320 U/l. Analytical recoveries of purified HL added to plasma were 96.6-99.8%. HL activity in postheparin plasma measured in this method had a closer correlation with HL mass by a sandwich ELISA (r = 0.888, P , 0.0001) than those in the conventional method using [ 14C-]triolein (r = 0.730, P < 0.0001). This assay method for HL activity can be applied to an automatic clinical analyzer. Copyright © 2007 by the American Society for Biochemistry and Molecular Biology, Inc. 続きを見る
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中嶋, 憲一 ; 澁谷, 孝行 ; 小野口, 昌久 ; 奥田, 光一 ; 米山, 寛人 ; 松尾, 信郎 ; 清水, 威志 ; Nakajima, Kenichi ; Shibuya, Takayuki ; Onoguchi, Masahisa ; Okuda, Koichi ; Yoneyama, Hiroto ; Matsuo, Shinro ; Shimizu, Takeshi
出版情報: IQ・SPECTによる心臓核医学.  2018  pp.1-20,  2018.  Kenichi Nakajima[Editing] / Siemens Healthcare Co.[Publication]
URL: http://hdl.handle.net/2297/00051674
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Shibutani, Takayuki ; Onoguchi, Masahisa ; Yoneyama, Hiroto ; Konishi, Takahiro ; Matsuo, Shinro ; Nakajima, Kenichi ; 澁谷, 孝行 ; 松尾, 信郎 ; 中嶋, 憲一
出版情報: Annals of Nuclear Medicine.  33  pp.103-111,  2019-02-25.  日本核医学会 = Japanese Society of Nuclear Medicine
URL: http://hdl.handle.net/2297/00053810
概要: 金沢大学医薬保健研究域保健学系<br />ObjectivesAlthough the utility of IQ-SPECT imaging using 99mTc and 201Tl myocardial perfusion SPECT has been reported, 123I-labeled myocardial SPECT has not been fully evaluated. We determined the characteristics and utility of 123I IQ-SPECT imaging compared with conventional SPECT (C-SPECT).MethodsTwo myocardial phantom patterns were used to simulate normal myocardium and myocardial infarction. SPECT acquisition was performed using a hybrid dual-head SPECT/CT system equipped with a SMARTZOOM collimator for IQ-SPECT or a low-medium energy general purpose collimator for C-SPECT. Projection data were reconstructed using ordered subset expectation maximization with depth-dependent 3-dimensional resolution recovery for C-SPECT and ordered subset conjugate gradient minimizer method for IQ-SPECT. Three types of myocardial image were created; namely, no correction (NC), with attenuation correction (AC), and with both attenuation and scatter corrections (ACSC). Five observers visually scored the homogeneity of normal myocardium and defect severity of the myocardium with inferior defects by a five-point scale: homogeneity scores (5 = homogeneous to 1 = inhomogeneous) and defect scores (5 = excellent to 1 = poor). We also created a 17-segment polar map and quantitatively assessed segmental %uptake using a myocardial phantom with normal findings and defects.ResultsThe average visual homogeneity scores of the IQ-SPECT with NC and ACSC were significantly higher than that of C-SPECT, whereas the average visual defect scores of IQ-SPECT with AC and ACSC were significantly lower. The %uptake of all segments for IQ-SPECT with NC was significantly higher than that of C-SPECT. Furthermore, the subtraction of %uptake for C-SPECT and IQ-SPECT was the largest in inferior wall, which was approximately 10.1%, 14.7% and 14.4% for NC, AC and ACSC, respectively. The median % uptake values of the inferior wall with defect areas for C-SPECT and IQ-SPECT were 46.9% and 50.7% with NC, 59.8% and 69.2% with AC, and 54.7% and 66.5% with ACSC, respectively.Conclusion123I IQ-SPECT imaging significantly improved the attenuation artifact compared with C-SPECT imaging. Although the defect detectability of IQ-SPECT was inferior to that of C-SPECT, 123I IQ-SPECT images with NC and ACSC met the criteria for defect detectability. Use of 123I IQ-SPECT is suitable for routine examinations.<br />Embargo Period 12 months 続きを見る
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Shibutani, Takayuki ; Nakajima, Kenichi ; Wakabayashi, Hiroshi ; Mori, Hiroshi ; Matsuo, Shinro ; Yoneyama, Hiroto ; Konishi, Takahiro ; Okuda, Koichi ; Onoguchi, Masahisa ; Kinuya, Seigo ; 澁谷, 孝行 ; 中嶋, 憲一 ; 若林, 大志 ; 松尾, 信郎 ; 米山, 寛人 ; 小野口, 昌久 ; 絹谷, 清剛
出版情報: Annals of Nuclear Medicine.  33  pp.86-92,  2019-02-25.  日本核医学会 = Japanese Society of Nuclear Medicine
URL: http://hdl.handle.net/2297/00053811
概要: 金沢大学医薬保健研究域保健学系<br />ObjectivesThe patient-based diagnosis with an artificial neural network (ANN) has shown potential u tility for the detection of coronary artery disease; however, the region-based accuracy of the detected regions has not been fully evaluated. The aim of this study was to demonstrate the accuracy of all detected regions compared with expert interpretation.\nMethodsA total of 109 abnormal regions including 33 regions with stress defects and 76 regions with ischemia were examined, which were derived from 21 patients who underwent myocardial perfusion SPECT within 45 days of coronary angiography. The gray and color scale images, a polar map of stress, rest and difference, and left ventricular function were displayed on the monitor to score the extent and severity of stress defect and ischemia. Two experienced nuclear medicine physicians (Observers A and B) scored the abnormality with a 4-point scale and draw abnormal regions on a polar map. The gold standard was determined by the final judgment of normal or abnormal by the consensus of two other independent expert nuclear cardiologists, and was compared with the stress defect and ischemia derived from ANN.\nResultsThe concordance rate of ANN to the gold standard was higher than that of two observers. Furthermore, the κ coefficient indicated moderate to substantial agreement for stress defect and slight to the fair agreement for ischemia. The area under the curve (AUC) of ANN was the highest for both stress defect and ischemia; in particular, the ANN of ischemia showed significantly higher AUC than Observer A (p = 0.005). The ANN of stress defect showed higher specificity compared with two observers, while the ANN of ischemia showed higher sensitivity. Consequently, the accuracy of ANN showed the highest in this study.\nConclusionThe ANN-based regional diagnosis showed a high concordance rate with the gold standard and comparable or even higher than the interpretation by nuclear medicine physicians.<br />Embargo Period 12 months 続きを見る
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Nakajima, Kenichi ; 中嶋, 憲一
出版情報: Heart.  107  pp.93-95,  2021-01-01.  BMJ Publishing Group / the British Cardiac Society
URL: http://hdl.handle.net/2297/00060052
概要: 金沢大学先進予防医学研究科・機能画像人工知能学/Department of Functional Imaging and Artificial Intelligence
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草島, 茂喜 ; 野口, 清治 ; 安川, 孝光 ; 古野, 吉弘 ; 四十九, 一嘉 ; 中嶋, 憲一
出版情報: 核医学画像診断.  7  pp.51-55,  1992-12-01. 
URL: http://hdl.handle.net/2297/4194
概要: 富山赤十字病院<br />心筋201Tl SPECTにおいて,心筋分布の均一性に影響を及ぼすさまざまな因子について検討した。心筋の集積カウント,心筋/肺比,心筋/肝比が高いほど,より均一と判断された。消化管の集積は少ない程心筋が均一に見える 傾向があるが,食後3時間以上では大きな影響はなかった。また,体重が少ない人ほど画像は均一にみえる。一般に64×64マトリクス収集で1投影像の最高値が200カウント/画素であれば均一と判定されるので,この条件で不均一に見える場合は異常の可能性が高いと考えられる。心筋分布の不均一分布の判定にあたっては,技術的な因子を考慮する必要がある<br />原著論文 続きを見る
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論文
高山, 輝彦 ; 中嶋, 憲一 ; 上田, 和彦 ; 小林, 武嗣 ; 河端, 佳子 ; 関本, 繁
出版情報: 核医学画像診断.  7  pp.2-5,  1992-01-01. 
URL: http://hdl.handle.net/2297/4183
概要: 金沢大学 医短大<br />原著論文
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論文
中嶋, 憲一 ; 利波, 紀久 ; 久田, 欣一
出版情報: 核医学画像診断.  6  pp.34-39,  1992-02-01. 
URL: http://hdl.handle.net/2297/4174
概要: 金沢大学 核医<br />原著論文
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論文
岡村, 真人 ; 関本, 繁 ; 中嶋, 憲一 ; 高山, 輝彦
出版情報: 核医学画像診断.  6  pp.22-26,  1991-09-01. 
URL: http://hdl.handle.net/2297/4172
概要: 公立加賀中央病院<br />99mTcによる甲状腺シンチグラフィについて客観的な表示を行うため表示の標準化に関する基礎的検討を行った.甲状腺の最大カウント数で標準化した画像のみでは甲状腺摂取率の評価に不十分であり,バックグラウンドの平均カウ ント数で標準化した画像のみでは甲状腺内RI分布や欠損の評価不十分である.したがって,両面を併用することが必要と思われた.また,バックグラウンドの平均カウント数で標準化した画像から甲状腺摂取率の推定が可能と思われた<br />原著論文 続きを見る
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論文
川本, 孝志 ; 関本, 繁 ; 中嶋, 憲一 ; 高山, 輝彦
出版情報: 核医学画像診断.  5  pp.23-26,  1990-10-01. 
URL: http://hdl.handle.net/2297/4155
概要: 公立加賀中央病院<br />201Tlのデータ収集において,dual peakで収集した場合とsingle-peakで収集した場合とでは異なった画像がえられる.そのため総収集カウント数,分解能,画像の位置ずれなどを比較検討したところ,sin gle peakの撮像と比較してdual peakでは総収集カウント数の増加(+23%),分解能の低下がみられた.また,dual peak像では,single peak像との画像のずれが生じることがあるので,撮像の際には注意が必要である<br />原著論文 続きを見る