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| 1.
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Misaki, Koichi ; Uchiyama, Naoyuki ; Inaki, Anri ; Kinuya, Seigo ; Nambu, Iku ; Kamide, Tomoya ; Mohri, Masanao ; Hayashi, Yasuhiko ; Nakada, Mitsutoshi ; 見崎, 孝一 ; 内山, 尚之 ; 稲木, 杏吏 ; 絹谷, 清剛 ; 林, 康彦 ; 中田, 光俊
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金沢大学附属病院脳神経外科<br />Background and purpose: Hemodynamic impairments are considered risk factors of cerebral hyperperfusio
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n after carotid artery stenting (CAS); measurement by Single-photon emission computed tomography (SPECT) using a subjective region of interest (ROI) method lacks consistency and reproducibility. Materials and methods: The present study compared objective perfusion analysis (stereotactic extraction estimation [SEE] method) with the ROI method for preoperative SPECT to predict the hyperperfusion phenomenon (HPP) after CAS. Preoperative resting asymmetry index (cerebral blood flow [CBF] ratio from the affected to unaffected hemisphere) and cerebrovascular reactivity (CVR) to acetazolamide were measured by N-isopropyl-p-[123I]-iodoamphetamine SPECT using the SEE and ROI method in 84 patients. CBF was also measured the day after CAS. Perfusion data with the highest area under the curve (AUC) by receiver-operating characteristic (ROC) analysis was considered a perfusion risk factor of HPP. Multivariate analyses for clinical characteristics and perfusion risk factors were performed to determine predictors of HPP. Results: The HPP was observed in 10 patients (11.9%). Female sex, contralateral stenosis, and degree of stenosis were significantly associated with HPP development on univariate analysis, and symptomatic stenosis was not found to be a significant factor. On SPECT analysis, CVR in the MCA area by SEE method had the highest AUC (0.981). Multivariate analysis showed that CVR in the MCA area was a significant predictor of HPP (P = 0.041). To predict hyperperfusion, the ROC curve of the CVR showed a cutoff value of –0.60%, sensitivity of 94.6%, and specificity of 100% (P < 0.001). Conclusions: Objective SEE method had better a predictive capability than ROI method to identify risk of hyperperfusion after CAS. © 2018 Elsevier Masson SAS<br />Embargo Period 12 months
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| 2.
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Shibutani, Takayuki ; Nakajima, Kenichi ; Wakabayashi, Hiroshi ; Mori, Hiroshi ; Matsuo, Shinro ; Yoneyama, Hiroto ; Konishi, Takahiro ; Okuda, Koichi ; Onoguchi, Masahisa ; Kinuya, Seigo ; 澁谷, 孝行 ; 中嶋, 憲一 ; 若林, 大志 ; 松尾, 信郎 ; 米山, 寛人 ; 小野口, 昌久 ; 絹谷, 清剛
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金沢大学医薬保健研究域保健学系<br />ObjectivesThe patient-based diagnosis with an artificial neural network (ANN) has shown potential u
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tility for the detection of coronary artery disease; however, the region-based accuracy of the detected regions has not been fully evaluated. The aim of this study was to demonstrate the accuracy of all detected regions compared with expert interpretation.\nMethodsA total of 109 abnormal regions including 33 regions with stress defects and 76 regions with ischemia were examined, which were derived from 21 patients who underwent myocardial perfusion SPECT within 45 days of coronary angiography. The gray and color scale images, a polar map of stress, rest and difference, and left ventricular function were displayed on the monitor to score the extent and severity of stress defect and ischemia. Two experienced nuclear medicine physicians (Observers A and B) scored the abnormality with a 4-point scale and draw abnormal regions on a polar map. The gold standard was determined by the final judgment of normal or abnormal by the consensus of two other independent expert nuclear cardiologists, and was compared with the stress defect and ischemia derived from ANN.\nResultsThe concordance rate of ANN to the gold standard was higher than that of two observers. Furthermore, the κ coefficient indicated moderate to substantial agreement for stress defect and slight to the fair agreement for ischemia. The area under the curve (AUC) of ANN was the highest for both stress defect and ischemia; in particular, the ANN of ischemia showed significantly higher AUC than Observer A (p = 0.005). The ANN of stress defect showed higher specificity compared with two observers, while the ANN of ischemia showed higher sensitivity. Consequently, the accuracy of ANN showed the highest in this study.\nConclusionThe ANN-based regional diagnosis showed a high concordance rate with the gold standard and comparable or even higher than the interpretation by nuclear medicine physicians.<br />Embargo Period 12 months
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| 3.
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Takayama, Teruhiko ; Michigishi, Takatoshi ; Tsuji, Shiro ; Kinuya, Seigo ; Tonami, Norihisa ; Hisada, Kinichi ; Shuke, N. ; Aburano, Tamio
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Akhter, Nasima ; Nakajima, Kenichi ; Okuda, Koichi ; Matsuo, Shinro ; Yoneyama, Tatsuya ; Taki, Junichi ; Kinuya, Seigo
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金沢大学医薬保健研究域医学系<br />Purpose: Gated single-photon emission computed tomography (SPECT) imaging of myocardium by 99mTc and
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201Tl is used extensively to measure quantitative cardiac functional parameters. However, factors affecting normal values for myocardial functional parameters and population-specific standards have not yet been established. The aim of the study was to determine the effect of sex, radiotracer, rotation angles and frame rates on resting myocardial wall thickening (WT) and to develop a Japanese standard of normal values for WT. Methods: Data from a total of 202 patients with low possibility of having cardiac problems were collected from nine hospitals throughout Japan. Patients were divided into five groups according to study protocol, and WT was evaluated according to the 17-segment and four-region (basal, mid and apical regions and the apex) polar map distribution. Result: WT was generally higher in women than in men irrespective of the use of radiotracers, rotation angles or frame rates, and the difference was highly significant in the mid and apical regions. In any protocol used, resting myocardial thickening in the apex was higher than in the mid and apical regions, and thickening was lowest in the basal region, suggesting heterogeneous regional myocardial thickening (%) in normal subjects. Different rotation angles showed no significant change on WT, but different frame rates and tracers showed significant WT change in both sexes. Percent thickening of the myocardium was significantly higher in imaging by 99mTc-labelled tracers than in 201Tl. Conclusion: Sex, radiotracers and frame rates had a significant effect on myocardial thickening, and the importance of population-specific standards should be emphasized. A normal database can serve as a standard for gated SPECT evaluation of myocardial thickening in a Japanese population and might be applicable to Asian populations having a similar physique. © 2008 Springer-Verlag.<br />This article has not been published yet.
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Nakajima, Kenichi ; Inaki, Anri ; Hiramatsu, Takashi ; Hasegawa, Minoru ; Fujimoto, Manabu ; Takehara, Kazuhiko ; Kinuya, Seigo
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金沢大学医薬保健研究域医学系<br />Objectives: Esophageal complications are common in patients with systemic sclerosis (SSc). The relat
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ionship between gastroesophageal reflux (GER) symptoms and dysmotility was examined in endoscopically confirmed patients suspected of having reflux esophagitis. Methods: A total of 32 patients with limited and diffuse type SSc (lSSc, dSSc) were examined based on a structured questionnaire score (QS) of GER symptoms, retention fraction of esophageal scintigraphy at 90 s (R90) and gastric emptying time. Results: The QS was significantly higher in the reflux esophagitis group than in the non-esophagitis group (5.4 ± 3.5, 1.4 ± 2.9, P = 0.003). When the non-esophagitis group was further divided into lSSc and dSSc groups, R90 was higher in the reflux esophagitis group (31 ± 18%) and the non-esophagitis group with dSSc (34 ± 32%) than in the non-esophagitis group with lSSc (8 ± 3%, P = 0.02). Both high R90 ≥ 15% and QS ≥ 4 indicated reflux esophagitis. Conversely, both normal R90 and QS indicated no reflux esophagitis. Conclusion: A combination of esophageal scintigraphy and structured questionnaire demonstrated different aspects of esophageal dysfunction, namely dysmotility and GER. Patients with high QS and dysmotility may be indicated for further evaluation including endoscopic examination and medical treatment. © 2009 The Japanese Society of Nuclear Medicine.
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| 6.
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Okuda, Koichi ; Nakajima, Kenichi ; Motomura, Nobutoku ; Kubota, Masahiro ; Yamaki, Noriyasu ; Maeda, Hisato ; Matsuo, Shinro ; Kinuya, Seigo
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金沢大学医薬保健研究域<br />Objective: Segmentation with scatter and photopeak window data using attenuation correction (SSPAC) met
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hod can provide a patient-specific non-uniform attenuation coefficient map only by using photopeak and scatter images without X-ray computed tomography (CT). The purpose of this study is to evaluate the performance of attenuation correction (AC) by the SSPAC method on normal myocardial perfusion database. Methods: A total of 32 sets of exercise-rest myocardial images with Tc-99 m-sestamibi were acquired in both photopeak (140 keV ± 10%) and scatter (7% of lower side of the photopeak window) energy windows. Myocardial perfusion databases by the SSPAC method and non-AC (NC) were created from 15 female and 17 male subjects with low likelihood of cardiac disease using quantitative perfusion SPECT software. Segmental myocardial counts of a 17-segment model from these databases were compared on the basis of paired t test. Results: AC average myocardial perfusion count was significantly higher than that in NC in the septal and inferior regions (P < 0.02). On the contrary, AC average count was significantly lower in the anterolateral and apical regions (P < 0.01). Coefficient variation of the AC count in the mid, apical and apex regions was lower than that of NC. Conclusions: The SSPAC method can improve average myocardial perfusion uptake in the septal and inferior regions and provide uniform distribution of myocardial perfusion. The SSPAC method could be a practical method of attenuation correction without X-ray CT. © 2009 The Japanese Society of Nuclear Medicine.
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| 7.
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Ogawa, Kazuma ; Shiba, Kazuhiro ; Akhter, Nasima ; Yoshimoto, Mitsuyoshi ; Washiyama, Kohshin ; Kinuya, Seigo ; Kawai, Keiichi ; Mori, Hirofumi
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金沢大学医薬保健研究域薬学系<br />It has been reported that sigma receptors are highly expressed in a variety of human tumors. In this
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study, we selected (+)-2-[4-(4-iodophenyl)piperidino] cyclohexanol [(+)-pIV] as a sigma receptor ligand and evaluated the potential of radioiodinated (+)-pIV for tumor imaging and therapy. (+)-[125/131I]pIV was prepared by an iododestannylation reaction under no-carrier-added conditions with radiochemical purity over 99% after HPLC purification. Biodistribution experiments were performed by the intravenous injection of (+)-[125I]pIV into mice bearing human prostate tumors (DU-145). Blocking studies were performed by intravenous injection of (+)-[125I]pIV mixed with an excess amount of unlabeled sigma ligand into DU-145 tumor-bearing mice. For therapeutic study, (+)-[131I]pIV was injected at a dose of 7.4 MBq followed by measurement of the tumor size. In biodistribution experiments, (+)-[125I]pIV showed high uptake and long residence in the tumor. High tumor to blood and muscle ratios were achieved because the radioactivity levels of blood and muscle were low. However, the accumulations of radioactivity in non-target tissues, such as liver and kidney, were high. The radioactivity in the non-target tissues slowly decreased over time. Co-injection of (+)-[125I]pIV with an excess amount of unlabeled sigma ligand resulted in a significant decrease in the tumor/blood ratio, indicating sigma receptor-mediated tumor uptake. In therapeutic study, tumor growth in mice treated with (+)-[131I]pIV was significantly inhibited compared to that of an untreated group. These results indicate that radioiodinated (+)-pIV has a high potential for sigma receptor imaging in tumor and radionuclide receptor therapy. (Cancer Sci 2009). © 2009 Japanese Cancer Association.
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| 8.
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Kinuya, Seigo ; Kawashima, Atsuhiro ; Yokoyama, Kunihiko ; Koshida, Kiyoshi ; Konishi, Shota ; Watanabe, Naoto ; Shuke, Noriyuki ; Bunko, Hisashi ; Michigishi, Takatoshi ; Tonami, Norihisa
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金沢大学大学院医学系研究科<br />Antiangiogenic therapy may prolong the dormancy of cancer lesions. Moreover, radioimmunotherapy (RIT)
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may eradicate this population of cells. This study dealt with determining the benefits associated with the combined usefulness of these 2 therapies with respect to inhibition of tumor growth. Methods: Antiangiogenic therapy using oral thalidomide (daily dose, 200 mg/kg) and RIT involving a single intravenous injection (4.63 MBq 131I-A7, an IgG1 murine monoclonal antibody) were conducted in mice bearing LS180 human colon cancer xenografts. RIT with an irrelevant IgG1, HPMS-1, was also performed as a control. Antiangiogenesis of thalidomide was investigated by immunohistochemical analysis of tumor sections. Results: Antiangiogenic therapy and RIT with 131I-A7 significantly suppressed the growth of xenografts. This combination produced more efficient tumor growth inhibition than did the monotherapy (P < 0.005). RIT using 131I-HPMS-1 was far less effective than 131I-A7, even when combined with thalidomide administration. Immunohistochemistry revealed a decrease in the microvessel number within tumors treated with thalidomide (P < 0.0001). Combined therapy further reduced the microvessel number (P < 0.01 vs. thalidomide monotherapy), Conclusion: The combination of RIT and thalidomide antiangiogenic therapy produces a better response of tumors than does monotherapy. Acting in concert, antiangiogenic therapy may prolong the dormancy of cancer lesions and RIT may eradicate this population of cells.
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Aburano, Tamio ; Takayama, Teruhiko ; Michigishi, Takatoshi ; Shuke, Noriyuki ; Kinuya, Seigo ; Seto, Mikito ; Hisada, Kinichi
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金沢大学大学院医学系研究科
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| 10.
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Takayama, Teruhiko ; Kinuya, Seigo ; Kobayashi, Kazunori ; Onoguchi, Masahisa ; Mizukami, Yuji ; Koshida, Kichiro ; Tsuji, Shiro ; Tonami, Norihisa
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金沢大学大学院医学系研究科
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