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Nishijima, Yoshinori ; 西嶋, 義憲
出版情報: Intercultural communication studies : ICS.  27  pp.115-132,  2018.  Institute for Cross-Cultural Research
URL: http://hdl.handle.net/2297/00061316
概要: 金沢大学人間社会研究域経済学経営学系<br />Persons or objects on signs seem to have a culturally preferred direction of facing (Kumakura, 1 990). Is such a difference in direction also true of pictures on traffic signs between Japan and Germany? People in Japan and Germany drive on the left and the right side of the road, respectively. In this respect, a question arises: Does the difference between left-hand and right-hand traffic in these two countries influence the way the pictures on traffic signs face? The aim of this study is threefold: 1) to collect functionally equivalent traffic signs in Japan and Germany; 2) to compare the pictures on the signs between these countries with respect to their facing directions; and 3) to try to clarify whether and to what extent differences in facing directions are found on the traffic signs. The results are expected to contribute to the study of the relationship between writing directions and facing directions of pictures. 続きを見る
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Nishijima, Yoshinori ; 西嶋, 義憲
出版情報: Intercultural communication studies : ICS.  28  pp.152-169,  2019.  Institute for Cross-Cultural Research
URL: http://hdl.handle.net/2297/00061317
概要: 金沢大学人間社会研究域経済学経営学系<br />This study focuses on functionally equivalent, but semantically different sign expressions in Ja panese and German, such as o-nori-no-sai-wa tesuri-ni o-tsukamarikudasai [Literally, “when steping on, please grip handrail”], kiiroi-sen-no uchigawani o-tachi-kudasai [please stand inside yellow line], oriru sai-wa o-oashimoto-ni gochūi-kudasai [“when getting off, please pay attention to under foot”], and o-ko-sama tsure-no kata-wa o-ko-sama-no te-o totte o-nori-kudasai [“person with child is asked to ride on taking child’s hand”] in Japanese versus its German counterpart Benutzung auf eigene Gefahr [“using at your own risk”], which are posted near escalators. This example tells us that the Japanese sign consists of four concrete sentences whereas the German one presents a simple and abstract sentence. Such correspondents cannot be adequately explained from only construal and politeness perspectives. In this study, such corresponding expressions in Japanese and German will be contrasted to find out what information is relevant to each society. The results will reveal what communicative behaviors are expected in corresponding situations between Japan and Germany, which can contribute to efficient intercultural communication. 続きを見る
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Nishijima, Yoshinori ; 西嶋, 義憲
出版情報: Intercultural communication studies : ICS.  25  pp.156-167,  2016.  Institute for Cross-Cultural Research
URL: http://hdl.handle.net/2297/00061318
概要: 金沢大学人間社会研究域経済学経営学系<br />By comparing some functionally equivalent routine formulas in Japaneseand German in correspondin g situations, it is hypothesized that different strategies arereflected in formulation patterns of routine formulas in both languages. For example,different expressions are used by parents in Japanese and German if their childbumps into a post. The two expressions are often used in corresponding situations inboth Japan and Germany and can therefore be regarded as functionally equivalent,although the used strategies differ, i.e., the Japanese expression is based on sharing thedangerous situation between the parent and the child, whereas the German one focuseson providing an appropriate direction to the child. Comparing such functionallyequivalent routine formulas suggests that they reflect different strategies, includingpoliteness, in corresponding situations. This study tested this hypothesis by comparingfunctionally equivalent routine formulas uttered in corresponding apologetic situationsin the socialization process of controlling children’s social behavior in Japan andGermany. The results confirm the hypothesis and suggest that the difference in strategy influences the communicative behaviors of Japanese and German speakers. Concerning politeness, the results reveal the aspects considered polite in corresponding routineformulas of the two languages. Furthermore, the communicative normality of each language is also reflected in its respective routine formulas and focus of attention in interactions. This information may be applied toward more efficient foreign language teaching. 続きを見る
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Nishijima, Yoshinori ; 西嶋, 義憲
出版情報: Intercultural communication studies : ICS.  23  pp.110-123,  2014.  Institute for Cross-Cultural Research
URL: http://hdl.handle.net/2297/00061319
概要: 金沢大学人間社会研究域経済学経営学系<br />The aim of this paper is twofold: (1) to compare functionally equivalent English, German, and Ja panese sign expressions in public spaces with respect to politeness and (2) to reveal whether and how politeness is formulated in sign expressions in each language in relation to explicitness. A total of 208 Japanese and 198 German sign expressions were collected through fieldwork. Among them, 35 functionally equivalent correspondence pairs between the two languages were confirmed, and they were compared, along with their English equivalents, with respect to politeness. The results showed that English signs tend to use explicit expressions, whereas Japanese signs frequently contain honorific items, and German signs use infinitive phrases to avoid mentioning personal relationships. Based on these findings, it is pointed out that each language has its preferred styles of politeness, even for sign expressions, which are expected to give relevant information or instructions to passengers in a clear, direct manner. 続きを見る
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論文
Nishijima, Yoshinori ; 西嶋, 義憲
出版情報: Intercultural communication studies : ICS.  22  pp.110-123,  2013.  Institute for Cross-Cultural Research
URL: http://hdl.handle.net/2297/00061320
概要: 金沢大学人間社会研究域経済学経営学系<br />Interest in the linguistic study of perspectives from which linguistic expressions are formulate d has been revived in the past 20 years, due to the recent development of cognitive linguistics. Among the many contributions to the study of such perspectives, Ikegami (2000) clearly showed that Japanese differs from English, through a comparison of a Japanese literary text with its English translation. However, there has been little discussion on the methods employed for comparison in the studies on this topic. The purpose of the present paper is threefold: (1) to describe what methodological problems are recognized in previous contrastive studies on the perspectives, especially in the field of cognitive linguistics; (2) in order to avoid methodological problems, to propose an alternative method for a more objective comparison of the perspectives between two languages; and (3) to demonstrate the validity of the proposed method for contrasting formulation patterns in terms of their perspective by some of the data obtained. 続きを見る
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Nishijima, Yoshinori ; 西嶋, 義憲
出版情報: Intercultural communication studies : ICS.  19  pp.55-63,  2010.  Institute for Cross-Cultural Research
URL: http://hdl.handle.net/2297/00061321
概要: 金沢大学人間社会研究域経済学経営学系<br />The present paper discusses the different perspectives from which Japanese and German speakers f ormulate utterances. It was hypothesized that these different perspectives are reflected not only in evaluating concepts of communicative behavior, but also in routine formulas for controlling communicative behavior in Japanese and German. This hypothesis was examined by comparing two pairs of functionally equivalent routine formulas in Japanese and German. Furthermore, a questionnaire was administered to compare other Japanese and German routine formulas possibly used in corresponding situations. The results confirmed that in Japanese, linguistic formulation patterns relate to the empathy felt by the speaker toward an interlocutor, arising from the perspective of their situation, whereas in German, these tend to depend on an opposition between the participants involved, characterized by a perspective external to their situation. Because the data employed in the present study are limited, the hypothesis should be verified using extensive data. The results of this study helps clarify the possible misunderstandings between Japanese and German speakers, owing to the different linguistic formulation patterns employed, and could promote more efficient foreign language teaching. 続きを見る
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Nishijima, Yoshinori ; 西嶋, 義憲
出版情報: 19 ICL (19th International Congress of Linguists) Papers.  19  pp.9p.-,  2013-07.  19th International Congress of Linguists (19 ICL)
URL: http://hdl.handle.net/2297/00061322
概要: 金沢大学人間社会研究域経済学経営学系<br />Research on the perspectives from which linguistic expressions are formulated has increased in t he past 20 years due to the development of cognitive linguistics. For example, Ikegami (2000) showed that Japanese and English speakers employ different perspectives by comparing the opening sentence of a Japanese literary text with its English translation. Similarly, Narita (2009) compared sentences from literary texts with their translations in Japanese and German. However, these studies analyzing literary text translations contain little discussion on the validity of the translation-based comparison method, particularly in terms of comparability and objectivity. This paper has three purposes: (1) to claim that the original and translation-based methods are not always appropriate for perspective studies; (2) to propose, as an alternative method, comparing functionally equivalent formulas used on public signs, i.e., Watch your step, Keep out, and Out of Service; and (3) to show how Japanese differs from German in the perspectives from which corresponding expressions in the two languages are formulated. Expressions were collected from signs on buses, trains, and railway stations in Japan and Germany. Examples include Haire-masen/Kein Eingang (‘No entrance’), Senro-ni orite-wa ike-masen/Ausstieg verboten (‘Do not go down to the railway track’), and ishitsubutsu-gakari/Fundbüro (‘Lost and found’). Functionally equivalent expressions were selected for the analysis. For example, a formula telling bus passengers that the bus will stop at the next station is Tsugi tomari-masu (next.TOP stop.HON) in Japanese and Wagen hält (vehicle.NOM stop.PRES) in German. These corresponding expressions can be compared syntactically and semantically. The former has no surface-level subject; it conveys that “I” and “we” or the bus will stop at the next station. The scene is described from the perspective inside the situation, i.e., from within the bus. The latter has a third-person subject, Wagen, signifying that the bus is observed from the perspective outside the situation. These different perspectives and their occurrence distributions are shown through the comparison of corresponding sign expressions. The analysis reveals that Japanese tends to formulate expressions from a perspective inside the scene where the event occurs, whereas German expresses sentences from the perspective outside the scene.<br />19th International Congress of Linguists(19 ICL), 21-27 July 2013 Geneva 続きを見る
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西嶋, 義憲 ; Nishijima, Yoshinori
出版情報: 社会言語科学 = The Japanese journal of language in society.  21  pp.175-190,  2018.  社会言語科学会 = The Japanese Association of Sociolinguistic Sciences
URL: http://hdl.handle.net/2297/00061323
概要: 金沢大学人間社会研究域経済学経営学系<br />異なる言語間の対応する言語表現を比較する場合,どのようにすればより客観的で妥当な比較が可能になるのかを考察する.従来,言語間の比較の際,とくに認知言語学分野では翻訳を利用する研究が多く見られた .しかしながら,翻訳を用いた比較は比較可能性という観点から問題がないわけではない.その問題点を確認し,それとは異なる新たな比較方法を提案し,それによる成果を紹介する.<br />The aim of this study is to consider the possibility of a more objective comparison of equivalent expressions of two languages. In comparing linguistic expressions of two languages, especially in cognitive linguistics, translations have been often used. However, comparisons using translations can be problematic. In this study, problems of translation-based comparison are discussed and a new method for a more objective linguistic comparison of two languages is proposed. Some results of the studies based on this method are also described as case studies. 続きを見る
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Mukaida, Naofumi ; Nakamoto, Yasunari ; 向田, 直史 ; 中本, 安成
出版情報: World Journal of Gastroenterology.  24  pp.1839-1858,  2018-05-07.  W J G Press / Baishideng Publishing Group Co
URL: http://hdl.handle.net/2297/00061539
概要: 金沢大学がん進展制御研究所<br />Tumor immunity proceeds through multiple processes, which consist of antigen presentation by antigen presenting cells (APCs) to educate effector cells and destruction by the effector cytotoxic cells. However, tumor immunity is frequently repressed at tumor sites. Malignantly transformed cells rarely survive the attack by the immune system, but cells that do survive change their phenotypes to reduce their immunogenicity. The resultant cells evade the attack by the immune system and form clinically discernible tumors. Tumor microenvironments simultaneously contain a wide variety of immune suppressive molecules and cells to dampen tumor immunity. Moreover, the liver microenvironment exhibits immune tolerance to reduce aberrant immune responses to massively-exposed antigens via the portal vein, and immune dysfunction is frequently associated with liver cirrhosis, which is widespread in hepatocellular carcinoma (HCC) patients. Immune therapy aims to reduce tumor burden, but it is also expected to prevent non-cancerous liver lesions from progressing to HCC, because HCC develops or recurs from noncancerous liver lesions with chronic inflammatory states and/or cirrhosis and these lesions cannot be cured and/or eradicated by local and/or systemic therapies. Nevertheless, cancer immune therapy should augment specific tumor immunity by using two distinct measures: enhancing the effector cell functions such as antigen presentation capacity of APCs and tumor cell killing capacity of cytotoxic cells, and reactivating the immune system in immune-suppressive tumor microenvironments. Here, we will summarize the current status and discuss the future perspective on immune therapy for HCC. © The Author(s) 2018.<br />Supported by (in part) Research Programs on the Innovative Development and Application for New Drugs for Hepatitis B (No. 17fk0310116h0001) from the Japan Agency for Medical Research and Development (AMED) and Extramural Collaborative Research Grant of Cancer Research Institute, Kanazawa University. 続きを見る
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論文
佐無田, 光
出版情報: 地域政策研究年報.  2019  pp.1-15,  2019-03.  金沢大学人間社会研究域附属地域政策研究センター — CURES
URL: http://hdl.handle.net/2297/00061541
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渡會, 兼也 ; 酒井, 佑士 ; Watari, Kenya ; Sakai, Yuji
出版情報: 物理教育 = Journal of the Physics Education Siciety of Japan.  66  pp.181-183,  2018-10-01.  日本物理教育学会 = Physics Education Siciety of Japan
URL: http://hdl.handle.net/2297/00061572
概要: 金沢大学附属高等学校<br />タブレット端末の音センサーでピンポン玉の反発係数を測定した結果を紹介する。この方法は従来の距離を測定する方法よりも簡易であること,距離の測定が最初の1回で済むこと,などの利点がある。体育館などでのボールの反発 係数を見積もるのに役立つ可能性がある。 続きを見る
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藤澤, 美恵子 ; 竹村, 和久 ; 船木, 由喜彦 ; 高橋, 遼 ; Fujisawa, Mieko ; Takemura, Kazuhisa ; Funaki, Yukihiko ; Takahashi, Ryo
出版情報: 行動経済学会第12回大会プロシーディング.  11  pp.S54-S59,  2018.  行動経済学会
URL: http://hdl.handle.net/2297/00061576
概要: 金沢大学人間社会研究域経済学経営学系<br />CO2削減に向けて政府は,エネルギーラベルによる建物のエネルギー使用量の表示制度を整備予定である.本研究ではこのラベルが,消費者にどう認識され,CO2削減に至る省エネ誘導ができるのかに焦点を当 て,ラベルへの評価等の調査をおこなった.クロス集計の結果,2型あるエネルギーラベルのうちタコメータ型の方がABC型に比較して混同する比率が高くわかりにくい反面,省エネ誘導は優れていることが明らかになった.省エネ誘導は,ラベルに表示される基準レベルを増やすより,判断の参考となる参照点を上昇させる場合に効果が大きいことがわかった.ロジスティック回帰分析から,環境への関心度が高い消費者や寒冷地居住者は省エネ誘導されやすい傾向にあるが,無職やABC型を先に回答した者は逆の反応を示すことが確認できた.ABC型を先に回答したことが省エネ誘導に負の影響があることから,タコメータ型の方が省エネ誘導しやすいことが分析結果からも示唆された. 続きを見る
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論文
藤澤, 美恵子 ; Fujisawa, Mieko
出版情報: 都市住宅学 = Urban housing sciences.  2017  pp.154-161,  2017.  都市住宅学会 Association of Urban Housing Sciences
URL: http://hdl.handle.net/2297/00061577
概要: 金沢大学人間社会研究域経済学経営学系
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Mukai, Kanae ; Komatsu, Emi ; Nakajima, Yukari ; Urai, Tamae ; Nasruddin ; Sugama, Junko ; Nakatani, Toshio ; 向井, 加奈恵 ; 中島, 由加里 ; 須釜, 淳子 ; 中谷, 壽男
出版情報: Journal of Hormones.  2014  pp.1-8,  2014-12-07.  Hindawi
URL: http://hdl.handle.net/2297/00061588
概要: 金沢大学医薬保健研究域保健学系<br />Cutaneous wound healing is delayed by protein malnutrition (PM). On the other hand, estrogen promot es cutaneous wound healing by its anti-inflammatory and cell proliferation effects. Therefore, we hypothesized that estrogen administration in protein-malnourished ovariectomized (OVX) female mice might improve the inflammatory response and promote cutaneous wound healing as well as normal nutrition. To test this hypothesis, we used full-thickness excisional wounds in Control SHAM, PM SHAM, PM OVX and PM OVX+17β-estradiol mice. The Control diet included 200 g/kg protein and the PM diet included 30 g/kg protein. The ratio of wound area in the Control SHAM group was significantly smaller than those in the three PM groups. In addition, microscopic findings also showed that the ratio of collagen fibers, the ratio of myofibroblasts and the number of new blood vessels in the Control SHAM group were significantly greater than those in the three PM groups. However, the number of Ym1-positive cells as an anti-inflammatory M2-like macrophage marker in the PM OVX+17β-estradiol group was significantly higher than those in the other three groups. These results indicate that the appearance of anti-inflammatory M2-like macrophages was promoted by estrogen administration; however, it could not promote cutaneous wound healing upon a low-protein diet. Therefore, it may be confirmed that nutrition is more important for promoting cutaneous wound healing than estrogen administration. 続きを見る
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木森, 佳子 ; 須釜, 淳子 ; 中谷, 壽男 ; 福田, 汐里 ; 宮地, 利明 ; 紺家, 千津子 ; 大桑, 麻由美 ; 真田, 弘美 ; Kimori, Keiko ; Sugama, Junko ; Nakatani, Toshio ; Fukuda, Shiori ; Miyati, Toshiaki ; Konya, Chizuko ; Okuwa, Mayumi ; Sanada, Hiromi
出版情報: 日本看護技術学会誌 = Japanese journal of nursing art and science.  10  pp.103-110,  2011-04.  日本看護技術学会 Japanese Society of Nursing Art and Science
URL: http://hdl.handle.net/2297/00061596
概要: 金沢大学医薬保健研究域保健学系<br />末梢静脈内カテーテル留置法では,対象静脈が目視困難な場合,確実な穿刺,合併症の発生に影響を及ぼす.本研究の目的は目視困難静脈の穿刺技術向上に向け,目視の可否による血管径 ・ 深さ,動脈との位置関係を 超音波診断装置で,皮膚色を色差計で計測し違いを明らかにすることである.研究デザインは実態調査型研究である.対象者は健常若年女性 20名,計測静脈は 58本,計測動脈は 18本であった.その結果,目視の可否に有意差があったのは深さのみで,血管径,動脈との位置関係,皮膚色は同等であることが明らかになった.静脈の深さの平均 (SD) は,目視可能静脈が2.7 (0.7) mm,目視困難静脈が4.6 (1.8) mmであった (p=.0001).目視の可否の分離値は 3.0mm (AUC=0.919,95%CI 0.84-0.99)で,深さ3mm以上の留置カテーテル用末梢静脈は目視困難になることが明らかとなった.したがって,目視困難な静脈は深さ3mm以上の穿刺技術が,動脈穿刺の防止は,目視の可否に関わらない穿刺技術の必要性が示唆された.<br />During catheter placement, peripheral intravenous access is affected by the visibility of the vein, such that the risk of peripheral nerve injuries and arterial punctures, increases as the visibility decreases. This study examined the relation between vein visibility and (a) vein width, (b) vein depth, (c) position of the artery relative to the vein, and (d) skin color. This was an observational study with prospective data collection. A total of 20 healthy young women (58 veins and 18 arteries) were examined. As a result, vein visibility demonstrated significant differences in relation to vein depth, but not in relation to the other three factors. The mean depth (SD) was 2.7 (0.7) mm for visible veins and 4.6 (1.8) mm for invisible veins (p=0.0001). The cut off point was 3.0 mm (AUC=0.919 95% CI-0.84 to 0.99), indicating that peripheral veins for catheter placement are more likely to be invisible when the depth is 3.0 mm or more. These findings highlight the need for two kinds of venipuncture skills : those for invisible veins with a depth of 3.0 mm or more, and those that will prevent arterial puncture regardless of vein visibility. 続きを見る
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Ikeya, Noriyuki ; Tanaka, Gengo ; Tsukagoshi, Akira ; 田中, 源吾
出版情報: Palaeontological Society of Japan Special Paper.  2003  pp.37-131,  2003.  日本古生物学会 Palaeontological Society of Japan
URL: http://hdl.handle.net/2297/00061606
概要: 金沢大学国際基幹教育院GS教育系
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Tanaka, Gengo ; Ikeya, Noriyuki ; 田中, 源吾
出版情報: Paleontological Research.  6  pp.265-284,  2002-09-30.  日本古生物学会 Palaeontological Society of Japan
URL: http://hdl.handle.net/2297/00061607
概要: 金沢大学国際基幹教育院GS教育系<br />Eighty-five fossil and Recent species of the genus Loxoconcha (Crustacea : Ostracoda) from East As ia are systematically reexamined. On the basis of carapace morphology, the genus Loxoconcha from East Asia is divided into five species groups : L. pulchra, L. optima, L. japonica, L. uranouchiensis and L. japonica species groups. The migration and speciation patterns of four species of the L. japonica species group are as follows. In Late Miocene, L. lilljeborgii and L. tumulosa were distributed over the Paleo-Indian Ocean. In Early Pliocene time, these species migrated to the Western Pacific and L. japonica evolved from populations of L. tumulosa by peramorphic evolution. In the Middle Pleistocene, L. shanhaiensis evolved from populations of L. japonica in the Ryukyu Islands by paedomorphic evolution. 続きを見る
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Tanaka, Gengo ; Seto, Koji ; Mukuda, Takao ; Nakano, Yusuke ; 田中, 源吾
出版情報: Paleontological Research.  6  pp.1-22,  2002-04-28.  日本古生物学会 Palaeontological Society of Japan
URL: http://hdl.handle.net/2297/00061608
概要: 金沢大学国際基幹教育院GS教育系<br />Thirty-five ostracod species belonging to 18 genera are recognized from the Middle Miocene Fujina Formation (ca. 14-12 Ma), 3km southwest of Matsue City, Shimane Prefecture, Japan. Most of these species are part of the recent Japan Sea proper water fauna; they are also classified into 4 categories, circumpolar, cryophilic, endemic cool-temperate and temperate species. These ostracod assemblages indicate that the Fujina Formation was deposited under a cold-water environment. Ten new species, Ambtonia shimanensis, A. takayasui, Acanthocythereis fujinaensis, A. izumoensis, Cluthia tamayuensis, C. subjaponica, Kotoracythere tsukagoshii, Laperousecythere ikeyai, Palmoconcha irizukii, and Robertsonites yatsukanus are described. 続きを見る
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小松 , 俊文 ; 前川, 匠 ; 重田, 康成 ; 高橋, 修 ; 田中, 源吾 ; Dang T., Huyen ; Komatsu, Toshifumi ; Maekawa, Takumi ; Shigeta, Yasunari ; Tanaka, Gengo
出版情報: 化石 = Fossils.  96  pp.1-2,  2014-09-30.  日本古生物学会 Palaeontological Society of Japan
URL: http://hdl.handle.net/2297/00061609
概要: 金沢大学国際基幹教育院GS教育系
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田中, 源吾 ; Tanaka, Gengo
出版情報: 化石 = Fossils.  96  pp.56-,  2014-09-30.  日本古生物学会 Palaeontological Society of Japan
URL: http://hdl.handle.net/2297/00061610
概要: 金沢大学国際基幹教育院GS教育系
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田中, 源吾 ; Suzuki, Yutaro ; Tanaka, Gengo
出版情報: 化石 = Fossils.  77  pp.1-2,  2005.  日本古生物学会 Palaeontological Society of Japan
URL: http://hdl.handle.net/2297/00061611
概要: 金沢大学国際基幹教育院GS教育系
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田中, 源吾 ; Tanaka, Gengo
出版情報: 化石 = Fossils.  91  pp.15-30,  2012.  日本古生物学会 Palaeontological Society of Japan
URL: http://hdl.handle.net/2297/00061612
概要: 金沢大学国際基幹教育院GS教育系<br />The Light-Switch Hypothesis' proposed by Parker (2003) is reviewed on the basis of recent relevant literature in order to test the hypothesis. This review revealed the following: 1) Diversification of bilaterian animals occurred during the Late Ediacaran Period, based on paleontological and molecular clock evidences. 2) Developmental genetic studies of eyes suggest that the eyes of bilaterian animals were formed from those of the Urbilateria, which hypothetically had both rhabdom and cilium photoreceptors during the Ediacaran period. During evolution, vertebrates utilized cilium photoreceptors, while invertebrates selected rhabdom photoreceptors for the development of eyes. On the basis of the detailed research of the ommatidium surface of the low-light adapted compound eye of the fruit fly, the phenotype of corneal nipple protuberances has changed in a extremely short time period from the view point of the geologic time scale. 3) The oldest fossilized eyes discovered are those of trilobite and bradoriid arthropods from 521 Ma. Increases in body size, and the corresponding increase of energy required, during 630Ma-521Ma may have been triggered by the evolution of the eye. 続きを見る
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前田, 晴良 ; 上田, 直人 ; 西村, 智弘 ; 田中, 源吾 ; 野村, 真一 ; 松岡, 廣繁 ; Maeda, Haruyoshi ; Ueda, Naoto ; Nishimura, Tomohiro ; Tanaka, Gengo ; Nomura, Shin'ichi ; Matsuoka, Hiroshige
出版情報: 地質学雑誌 = The journal of the Geological Society of Japan.  118  pp.741-747,  2012.  日本地質学会 The Geological Society of Japan
URL: http://hdl.handle.net/2297/00061613
概要: 金沢大学国際基幹教育院GS教育系<br />高知県佐川地域に分布する七良谷層の模式層序周辺の泥質砂岩中から,最上部ジュラ系を示す2種類のアンモノイド化石を発見した.そのうちAspidoceras属は,テチス海地域の最上部ジュラ系から多産し, Hybonoticeras属は同地域のキンメリッジアン−チトニアン階境界付近を示準するタクサである.これらの化石の産出により,七良谷層は最上部ジュラ系(キンメリッジアン−チトニアン階)に対比される可能性が高い.この結論は放散虫化石層序とおおむね調和的である.これまで七良谷層は,上部ジュラ系−下部白亜系鳥巣層群の層序的下位にあたる地層と考えられてきた.しかし七良谷層から産出したアンモノイドの示す時代は,鳥巣層群産アンモノイドのレンジと明らかに重複し,アンモノイド化石からは両岩相層序ユニットの時代差は識別できない.したがって,今後,七良谷層と鳥巣層群の層序関係を再検討する必要がある.<br />The Naradani Formation is located to the south of the Torinosu Group in the Sakawa district of Kochi, southwest Japan, and consists of a linear, narrowly distributed series of marine clastic deposits that contain allochthonous limestone blocks. This formation was previously correlated to the Bajocian–Bathonian Middle Jurassic using brachiopods extracted from the limestone blocks, with later radiolarian correlations suggesting an Oxfordian–Kimmeridgian Upper Jurassic age. The formation has also been interpreted to underlie the Upper Jurassic–Lower Cretaceous Torinosu Group. However, the discovery of two stage-diagnostic aspidoceratid ammonoids, Aspidoceras sp. and Hybonoticeras sp., from muddy sandstones in the stratotype area of the Naradani Formation casts doubt on these previous interpretations. Aspidoceras was widespread during the latest Jurassic, and the presence of Hybonoticeras limits this short stratigraphic interval to the Kimmeridgian–Tithonian boundary in various Tethyan sections. This clearly suggests a latest Jurassic age for the Naradani Formation and generally supports the radiolarian biostratigraphy age-assignment. However, the ranges of ammonoids from the Naradani Formation overlap those from the Torinosu Group, meaning that it is not possible to determine an age-difference between these two lithostratigraphic units. Further research is needed to test other hypotheses, for example to determine whether heterotopic facies relationships exist between the Naradani Formation and the Torinosu Group. 続きを見る
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田中, 源吾 ; 伊丹, 美穂 ; 黒澤, 幸愛 ; 吉岡, あゆみ ; 横田, 麻莉 ; 新井, 理菜 ; 出原, 祐樹 ; 林, 広樹 ; Tanaka, Gengo ; Itami, Miho ; Kurosawa, Sachie ; Yoshioka, Ayumi ; Yokota, Mari ; Arai, Rna ; Idehara, Yuki ; Hayashi, Hiroki
出版情報: 地質学雑誌 = The journal of the Geological Society of Japan.  119  pp.17-24,  2013.  日本地質学会 The Geological Society of Japan
URL: http://hdl.handle.net/2297/00061614
概要: 金沢大学国際基幹教育院GS教育系<br />群馬県富岡市南西部の大島付近の鏑川沿いに分布する中部中新統富岡層群小幡層において‘古蛇崩い礁’と呼ばれる隣接地域とは岩相が著しく異なった地層が露出している.今回,微化石群集を用いて,当該地層の堆積 年代と堆積環境の再検討を行った.介形虫化石および岩相解析の結果,‘古蛇崩い礁’は,漸深海の石英斑岩の海底面上に浅海からの堆積物重力流による流れ込みで形成された堆積物であることが明らかとなった.また有孔虫と介形虫化石から,当該地層は前期中新世後期〜中期中新世前期のいわゆる「中新世熱帯海中気候事件」期に堆積したものであることが判明した.本邦における「中新世熱帯海中気候事件」期の漸深海性介形虫化石群としては2例目の報告となる.<br />We present a micropaleontological re-examination of the depositional environment of the ‘Kojyakui-sho’ sediments of the Middle Miocene Obata Formation, part of the Tomioka Group, located along the Kabura-gawa River near Tajima, Tomioka City, western Gunma Prefecture, central Japan. These sediments contain sublittoral and bathyal ostracods, and were deposited in the bathyal zone on a quartz-porphyry bedrock seafloor during the late Early to early Middle Miocene. Planktonic foraminifera and ostracods within these samples indicate that the ‘Kojyakui-sho’ sediments formed during the Miocene Climatic Optimum; this is the second reported occurrence of these Miocene Climatic Optimum bathyal ostracod species in Japan. 続きを見る
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田中, 源吾 ; 野村, 律夫 ; Tanaka, Gengo ; Nomura, Ritsuo
出版情報: 地質学雑誌 = The journal of the Geological Society of Japan.  115  pp.261-265,  2009.  日本地質学会 The Geological Society of Japan
URL: http://hdl.handle.net/2297/00061615
概要: 金沢大学国際基幹教育院GS教育系<br />島根半島に分布する中部中新統古江層より,介形虫化石群を報告した.本群集はMacrocypris sp., Palmoconcha saboyamensis, Falsobuntonia hayam iiおよびPalmenella limicolaで特徴づけられる.同様なMacrocypris属が卓越する群集は,現在の島根半島沖の寒冷な下部陸棚域に認められる.このことから,本化石群は下部陸棚の環境を示唆すると考えられる.<br />This report provides the first description of ostracod assemblages from the Middle Miocene Furue Formation, Shimane Peninsula, Southwest Japan. The assemblage consists mainly of Macrocypris sp., Palmoconcha saboyamensis, Falsobuntonia hayamii and Palmenella limicola. Based on a comparison among Recent ostracod assemblages, the reported fossil assemblage indicates a cool lower-shelf environment similar to the Recent off Shimane Peninsula. 続きを見る
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金子, 稔 ; 野村, 正弘 ; 田中, 源吾 ; Kaneko, Minoru ; Nomura, Masahiro ; Tanaka, Gengo
出版情報: 地学教育と科学運動.  79  pp.1-8,  2017-11-24.  地学団体研究会 The Association for the Geological Collaboration in Japan (AGCJ)
URL: http://hdl.handle.net/2297/00061616
概要: 金沢大学国際基幹教育院GS教育系
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Tanaka, Gengo ; 田中, 源吾
出版情報: Earth Science = 地球科学.  57  pp.111-127,  2003-06-25.  地学団体研究会 The Association for the Geological Collaboration in Japan (AGCJ)
URL: http://hdl.handle.net/2297/00061617
概要: 金沢大学国際基幹教育院GS教育系<br />島根県,出雲市菅沢の大森層より26属42種の介形虫化石を抽出し,2つの介形虫群(Ambostracon-Argilloecia-Cytheropteron群集およびPaijenborchella- Palmoconcha-Urocythereis pohangensis群集)を認めた.これらの群集は冷温〜温暖な公海の下浅海環境を示唆する.大森層および布志名層からの介形虫化石群の主成分分析は,その堆積環境が上部層準に向かってしだいに深くなっていったことを示唆する.5新種(Cytheropteron shimanense, Loxoconcha izumoensis, Paradoxostoma yakumotatsunus, Schizocythere sakanoueiおよびUrocythereis sugesawensis)を記載した.<br />Ostracods from the Omori Formation in Sugesawa (Izumo City, Shimane Prefecture) comprise 42 species belonging to 26 genera. Five new species, Cytheropteron shimanense, Loxoconcha izumoensis, Paradoxostoma yakumotatsunus, Schizocythere sakanouei and Urocythereis sugesawensis are described. Two ostracod assemblages (Ambostracon-Argilloecia-Cytheropteron assemblage and Paijenborchella-Palmoconcha-Urocythereis pohangensis assemblage) are recognized. These assemblages indicate that the uppermost of the Omori Formation was deposited under the environments from cool to warm open sublittoral condition. Principal components analysis of ostracod assemblages from the Omori and Fujina Formations indicates that, in general, the depositional environment becomes deeper and deeper towards the upper horizon. 続きを見る
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田中, 源吾 ; 森脇, 広 ; 永迫, 俊郎 ; 西澤, 文勝 ; 松島, 義章 ; 鈴木 ; Morikawa, Hiroshi ; Nagasako, Toshiro ; Nishizawa, Fumikatsu ; Matsushima, Yoshiaki ; Suzuki, Takehiko ; Tanaka, Gengo
出版情報: 地学雑誌 = Journal of Geography.  126  pp.557-579,  2017-10-25.  東京地学協会 Tokyo Geographical Society
URL: http://hdl.handle.net/2297/00061618
概要: 金沢大学国際基幹教育院GS教育系<br />Shinjima (Moeshima) Island in Kagoshima Bay, southern Kyushu, Japan is noteworthy in volcanology, paleontology, and palaeo-environmental studies, because the island emerged from the bay bottom during volcanic activity at Sakurajima in 1780 AD. As a result, Holocene and late-Pleistocene deposits of the bay including muddy deposits, a thick pyroclastic flow deposit, and prominent molluscan shell beds occur on this island. Several tephras included in the bay deposits are critical for deriving their precise chronology. The chronology of those tephras was constructed on the basis of their identification using both refractive indices and major element compositions of constituent glass shards, as well as stratigraphic features in the field. Tephras identified in sediments from younger to older are Sakurajima-Taisho (Sz-Ts)-/P1, Sakurajima-Sueyoshi(Sz-Sy)-/P11, Yonemaru, Sakurajima-Uwaba(Sz-Ub)-/P12, Sakurajima-Takatoge3 (Sz-Tk3)-/P13, Sakurajima-Satsuma (Sz-S)-/P14, and Shinjima pyroclastic flow deposit. The Shinjima pyroclastic flow deposit, which differs stratigraphically between northern and southern areas of Shinjima Island, is the same tephra in the two areas, and is estimated to be c. 13,000 cal BP in age. The pumice clasts of Sz-Sy/P11 provided a suitable environment for the habitat of a prominent shell bed (Moeshima Shell Bed) composed mainly of Neopycnodonte musashiana. Sz-Ub/P12, Sz-Tk3/P13, and associate secondary deposits of Sz-S/P14 indicate that the deposit was formed in the last 13,000 cal BP. The chronology of the deposits of Shinjima Island is based on the findings of stratigraphic positions and ages of those tephras, and 14C ages obtained in this study, and will play an important role when examining the palaeo-environmental history of Kagoshima Bay since the last deglaciation. 続きを見る
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Tanaka, Gengo ; Nakase, Hajime ; Yamashita, Shota ; Arai, Kazuno ; 田中, 源吾
出版情報: Geophysical Research Letters.  39  pp.L05406-,  2012-03.  American Geophysical Union / Wiley
URL: http://hdl.handle.net/2297/00061630
概要: 金沢大学国際基幹教育院GS教育系<br />In Rikuzentakata City, Ostracode assemblages in sediment deposited by the Tohoku‐Oki earthquake an d tsunami of 11 March 2011 revealed that the sediment was derived from the seafloor from at least 9 m water depth, and was transported inland more than 1 km. The tsunami wave height at this location was higher than 10 m. Four hundred fifty seven modern ostracode assemblages were used in the modern analogue technique to estimate the depth source of the tsunami deposited assemblages. The application of this method to paleo‐tsunami deposits may provide insight into past tsunami wave height and potentially earthquake slip and magnitude.<br />Embargo Period 6 months 続きを見る
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Tanaka, Gengo ; 田中, 源吾
出版情報: Journal of Micropalaeontology.  25  pp.187-188,  2006-11.  British Micropalaeontological Society
URL: http://hdl.handle.net/2297/00061631
概要: Sanyuania cuneata Zhao & Whatley, 1992 was reported initially from Late Pleistocene core samples from the northern part of the Yellow Sea and Recent sediments collected from supra tidal pools (17 practical salinity unit (psu)) in Xiangshangang Bay, East China Sea (Zhao & Whatley, 1992). Later, specimens were discovered, but not identified, in Lake Nakaumi, Shimane Prefecture, SW Japan (Fig. 1) (as Cytheridae gen. et. sp. indet. by Tanaka et al. (1998) and Sanyuania sp. by Seto et al. (1999)). Further examination of these Japanese specimens has clarified that they are conspecific with the Chinese specimens. This has provided an opportunity to review the distribution (Fig. 1) and potential environmental significance of Sanyuania cuneata and, for the first time, to describe its appendages (Fig. 2).Specimens figured herein were recovered from Lake Nakaumi (35°26′ 50″ N, 133°07′50″ E) at a depth of 0.3–6.0 m and salinity of 8–17 psu on 9 September 1998. The surface of the sediment was covered by the byssus of the mussel Musculista senhousia (Benson, 1842).Sanyuania cuneata is probably endemic to the East China Sea and the southwestern part of the Sea of Japan and is a potentially useful palaeoenvironmental indicator of brackish (steno-haline) environments in the area. By using the oxygen isotopic data from planktonic foraminifers and the estimated value of salinity flowing into the Japan Sea, Matsui et al. (1998) approximated that the salinity of the surface water of Japan Sea declined to about 20 psu during the Last Glacial Maximum . . . 続きを見る
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Tanaka, Gengo ; Parker, Andrew R. ; Hasegawa, Yoshikazu ; Siveter, David J. ; Yamamoto, Ryoichi ; Miyashita, Kiyoshi ; Takahashi, Yuichi ; Ito, Shosuke ; Wakamatsu, Kazumasa ; Mukuda, Takao ; Matsuura, Marie ; Tomikawa, Ko ; Furutani, Masumi ; Suzuki , Kayo ; Maeda, Haruyoshi ; 田中, 源吾
出版情報: Nature Communications.  5  pp.5920-,  2014-12.  Nature Research | Nature Publishing Group
URL: http://hdl.handle.net/2297/00061633
概要: 金沢大学国際基幹教育院GS教育系<br />Vision, which consists of an optical system, receptors and image-processing capacity, has existed for at least 520 Myr. Except for the optical system, as in the calcified lenses of trilobite and ostracod arthropods, other parts of the visual system are not usually preserved in the fossil record, because the soft tissue of the eye and the brain decay rapidly after death, such as within 64 days and 11 days, respectively. The Upper Carboniferous Hamilton Formation (300 Myr) in Kansas, USA, yields exceptionally well-preserved animal fossils in an estuarine depositional setting. Here we show that the original colour, shape and putative presence of eumelanin have been preserved in the acanthodii fish Acanthodes bridgei. We also report on the tissues of its eye, which provides the first record of mineralized rods and cones in a fossil and indicates that this 300 Myr-old fish likely possessed colour vision.<br />This work was supported by the Science Research of Education and Science Government of Japan (grant no. 24540501 to G.T. and no. 24340129 to H.M.). 続きを見る
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Tanaka, Gengo ; Smith, Robin J. ; Siveter, David J. ; Parker, Andrew R. ; 田中, 源吾
出版情報: Zoological Science.  26  pp.846-850,  2009-12.  日本動物学会 Zoological Society of Japan
URL: http://hdl.handle.net/2297/00061634
概要: 金沢大学国際基幹教育院GS教育系<br />Compound eyes are common in decapod crustaceans. Decapods have an abundant post-Palaeozoic fossil record, but hitherto morphological information about their eyes has been mainly restricted to Recent material. Here we report the discovery of compound eyes recovered from acetic acid residues of two fish-bearing nodules from the Cretaceous Santana Formation of Brazil; they include what are identified as decapod larval compound eyes. The fossil eyes are comparable to phyllosoma larval eyes because of the following characters: the hemispherical visual surface on a stalked eye; the relatively small-size of the visual surface of the eye; rounded facets are arranged in square arrays in the anterior region; the fact that the neighboring ommatidia are bounded by ridges and/ or grooves; and the more convex inner surface of the cornea lens. This report represents the first description of a three-dimensionally preserved fossil decapod eye. We conclude that the eyes probably represent palinuroid phyllosoma larval eyes and were an adaptation to a planktonic lifestyle. © 2009 Zoological Society of Japan. 続きを見る
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田崎, 和江 ; 田崎, 史江 ; 奥野, 正幸 ; 竹原, 照明 ; 石垣, 靖人 ; 中川, 秀昭 ; Tazaki, Kazue ; Tazaki, Fumie ; Okuno, Masayuki ; Takehara, Teruki ; Ishigaki, Yasuhito ; Nakagawa, Hideki
出版情報: 地質学雑誌 = The Journal of the Geological Society of Japan.  122  pp.45-60,  2016-02-15.  日本地質学会 The Geological Society of Japan
URL: http://hdl.handle.net/2297/00061644
概要: 金沢大学理工研究域地球社会基盤学系<br />イタリア・トスカーナ州南部のマレンマという地域には,イオウ臭が強くpH7,水温37°Cの棚田状のサトゥルニア天然温泉がある.本研究では,サトゥルニア天然温泉で産出される,豆石,褐色石灰岩および緑 色バイオマットについて,化学組成,鉱物組成,微生物的特徴を調べた.全岩試料のXRD分析により,豆石は方解石,自然硫黄,石英から構成されており,褐色石灰岩は雲母,自然硫黄,菱沸石,7 Å粘土鉱物から構成されていることを明らかにした.また,全岩試料のXRF分析により,褐色石灰岩にはO,Si,Al,K,Ca,Fe,Naが多く,豆石にはC,O,Ca,Sr,Sが多いことを明らかにした.更に,豆石の断面をSEM-EDSで観察・分析・元素濃度分布図を行ったところ,全岩試料のXRDおよびXRF分析では検出されなかった微生物とSrを含むフランボイダル黄鉄鉱や燐灰石が発見された.<br />A well-known terrace-forming hot spring is located at Saturnia in the Maremma area of southern Toscana, Italy. The waters are circumneutral (pH around 7), mesophilic (around 37°C), and give off a strong sulfurous odor. Pisoliths, brown limestone, and green microbial mats are found in the area. Hot spring structures and compositions are determined based on mineralogical and chemical data obtained with a powder X-ray diffractometer (XRD) and an X-ray fluorescence analyzer (XRF). Microbial parameters are determined on sub-millimeter scales using a scanning electron microscope, equipped with an energy-dispersive X-ray spectrometer (SEM-EDS).XRD results indicate that the pisoliths are composed of calcite, native sulfur, and quartz, whereas the brown limestone contains mica, native sulfur, chabazite, and 7 Å clay minerals. XRF analysis indicates that the pisoliths contain mainly C, O, Ca, S, Si, and Sr, whereas the brown limestone contains high concentrations of O, S, Al, K, Ca, Fe, and Na. Because the pisoliths are Ca-rich, concentrations of heavy metals (Sr, Sn, and Pb) at the aqueous interface can be explained by combining XRF chemistry, XRD mineralogy, and SEM-EDS observations of green microbial mats. SEM-EDS elemental maps of the pisolith indicate the presence of apatite and framboidal pyrite crystals. 続きを見る
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田崎, 和江 ; 縄谷, 奈緒子 ; 国峯, 由貴江 ; 森川, 俊和 ; 名倉, 利樹 ; 脇元, 理恵 ; 朝田, 隆二 ; 渡辺, 弘明 ; 永井, 香織 ; 池田, 頼正 ; 佐藤, 一博 ; 瀬川, 宏美 ; 宮田, 浩志郎 ; Tazaki, Kazue ; Nawatani, Naoko ; Kunimine, Yukie ; Morikawa, Toshikazu ; Wakimoto, Rie ; Asada, Ryuji ; Watanabe, Hiroaki ; Nagai, Kaori ; Ikeda, Yorimasa ; Sato, Kazuhiro ; Segawa, Hiromi ; Miyata, Koshirou
出版情報: 地質学雑誌 = The Journal of the Geological Society of Japan.  108  pp.435-452,  2002-07-15.  日本地質学会 The Geological Society of Japan
URL: http://hdl.handle.net/2297/00061646
概要: 金沢大学理工研究域地球社会基盤学系<br />1991年12月,排砂ゲートを設けた出し平ダム(富山県黒部川水系1985年設立)から,初の直接排砂が行われ,その際,多量のヘドロが排出された.その後も1999年までに計8回の排砂が行われた.本研 究において,出し平ダム湖および富山湾堆積物の特性について分析を行った.その結果,特に芦野沖にヘドロが堆積していること,そして,富山湾堆積物は他の湾堆積物と比べカオリン鉱物,スメクタイトが多く,出し平ダム湖堆積物と類似した粘土鉱物組成を持つことが明らかとなった.実験より,ニジマスのエラにスメクタイトが吸着することで,エラの変形や脱水を引き起こすことが明らかとなり,また,富山湾で採取されたヒラメのエラ表面が,微細粒子で覆われているのが観察された.以上の結果と1991年から1999年の出し平ダム排砂量とヒラメの漁獲量の変遷には密接な関係が認められ,ダム湖や富山湾底質の経時変化を観察することの重要性が示された.<br />In 1985, a dam with a discharge gate was built at Dashidaira at Kurobe River, Toyama Prefecture for the first time in Japan. The dam sediments were first flushed out in December, 1991. The sediments with bad smell, such as sludge, spread all over the downstream of Kurobe River. After the first discharge of the dam sediments, benthic fishes decreased year by year in Toyama Bay. In this study, the sediments in Dashidaira Dam Reservoir and Toyama Bay were collected in 1997, 2000 and 2001. The Toyama Bay sediments which were considered to have been affected by discharged dam sediments were collected on July 20, 2000, November 19, 2000, and March 3, 2001. The sediments in the dam reservoir and the bay were studied chemically, physically and mineralogically for comparative study. The quantity of clay minerals, mainly smectite, increase toward the discharge gate at Dashidaira Dam. The distribution of clay minerals approximately corresponded to distribution of the N, C, and S concentration in Toyama Bay. XRD data show similar clay mineral components and patterns between dam sediments and suspended particles from the seabed at the offing of Kurobe River mouth. The sediments in Dashidaira Dam Reservoir and Toyama Bay contain relatively high content of kaolin minerals associated with chlorite, vermiculite, smectite, and mica clay minerals compared with sediments of the other bays. Rainbow trouts in water with smectite suspension result clearly indicated the damage to the fish. In the highest concentration of smectite (lOg/l), all 7 rainbow trouts died in five hours. The fish's gills were deformed and dehydrated, suggesting influence of smectite particles adhered to the surface of the gills. Furthermore, SEM observation and EDX analysis of the flat fish's gill in Toyama Bay clearly showed the presence of particle-like thin films with organic materials sticking on the surface. The volume of discharged sediments from Dashidaira Dam Reservoir is clearly related to the decrease of annual haul of benthic fishes in Toyama Bay within the past nine years (1991-1999). 続きを見る
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白石, 秀一 ; 高橋, 直人 ; 霜島, 康浩 ; 朝田, 隆二 ; 渡辺, 弘明 ; 田崎, 和江 ; Shiraishi, Shuichi ; Takahashi, Naoto ; Shimojima, Yasuhiro ; Asada, Ryuji ; Watanabe, Hiroaki ; Tazaki, Kazue
出版情報: 粘土科学 = Journal of the Clay Science Society of Japan.  44  pp.176-190,  2005-07-25.  日本粘土学会 The Clay Science Society of Japan
URL: http://hdl.handle.net/2297/00061658
概要: 金沢大学理工研究域地球社会基盤学系<br />Bluish green Zn-S-and yellowish brown Fe-microbial mats were found on outer surfaces of well rise r pipes on Kakuma campus of Kanazawa University, Ishikawa Prefecture. The microscopic observation and XRF chemical analysis revealed that the formative conditions of microbial mats differ in depth due to stationary and pumping groundwater levels. Bluish green microbial mats formed in 61.6-75.6 m depth were characterized by high content of Zn and S. The microbial mats mainly consist of spherical fifine particles of several Am in size. A small amount of coccoid-and bacilli-form bacteria were found in the aggregation. While, yellowish brown microbial mats formed in 30.8-61.6 m depth and were characterized by high content of Fe, Ca, P, Si and Zn. The microbial mats mainly consist of spiral materials that were metabolized from an iron oxidizing bacterium, Gallionella ferruginea. Harp-like materials metabolized from another iron oxidizing bacteria, Toxothirixspp. were also found below 56 m in depth. A large amount of coccoid-, bacilli-and filamentous-form bacteria were found in the assemblage of the metabolic materials and the number of filamentous-form bacteria increased with depth.TEM observations and FE-TEM-EDX elemental maps revealed that some spherical particles on the cell surface of bacteria in the bluish green microbial mats are rich in Zn and S stick, suggesting that Zn exist as sulfide. The other adhesion materials consisted of Fe, Si, 0, and Zn were also formed around cell wall. The bacteria inthe bluish green microbial mats might be tolerant to heavy metal Zn. 続きを見る
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田崎, 和江 ; 金沢大学理学部地球学科田崎ゼミ生調査団 ; Tazaki, Kazue
出版情報: 地球科学 = Earth Science.  58  pp.357-359,  2004-11-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061662
概要: 金沢大学理工研究域地球社会基盤学系
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田崎, 和江 ; 鈴木, 祐恵 ; 藤沢, 瑛子 ; Tazaki, Kazue ; Suzuki, Sachie ; Fujisawa, Eiko
出版情報: 地球科学 = Earth Science.  63  pp.29-40,  2009-01-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061663
概要: 金沢大学理工研究域地球社会基盤学系<br />2007年12月7日7時ごろに韓国泰安半島沖10kmで香港籍タンカーの衝突事故が発生した.3つのタンクから重油と原油が12,547kl流出し海岸一帯が汚染された.万里浦海岸(Mallipo Be ach)には厚さ30cmの重油が漂着し汚染が最も深刻であった.韓国中からボランティアが集まり,干潮時に毎日6時間の浄化作業を行った.ボランテイアは政府機関のみならず会社,研究所,地域のクラブ,女性組織なども参加した.また,12月30,31日,1月3日には,カナダ,ドイツ,アメリカ,韓国から約50名の科学者や専門家が浄化計画会議をもった.被害はおよそ300億円といわれている.本研究では事故発生から1ヶ月後の2008年1月5-6日に韓国泰安半島の万里浦海岸と蟻項海岸(Euhang Beach)の汚染調査を行った.現地でのボランテイア活動の様子,大気中の芳香族炭化水素の測定,海水の水質測定,重油の化学成分,微生物による油分解実験結果について報告し,1997年1月に日本で起きたナホトカ号重油流出事故の場合と比較検討した.ナホトカ号のC重油流出量の1.7-2.0倍という韓国史上最大の事故にもかかわらず,1ヶ月弱できれいになった砂海岸の浄化作業は驚異的である.早急な浄化作業の要因を考察し,今後の課題と提言を行った.<br />The oil spill accident occurred when a Hong Kong-registered supertanker (Hebei Spirit) was rammed by a South Korean-owned barge that came unmoored from its tugboat in rough seas about 10km off Mallipo Beach at Taean Peninsula, South Korea. The 3 kinds of oil spill accidents started at 7:00 on December 7th 2007, when a tanker collided with a barge, and blackened once-scenic beach along South Korea's western coast, about 150km, southwest of Seoul. A total of 12,547kl of both heavy oil and crude oil gushed into the ocean, more than twice as much as in South Korea's previous worst spill, in 1995. Local residents worked with about 8,800 peoples of volunteers, civil servants, police officers and military personnel, were engaged in the effort to clear away oil on the region's shores. The seafood, oyster farms and tourism industries in the Taean region have been devastated. Oil blanketed the sand of Mallipo Beach and the rocks of Euhang Beach at Taean Peninsula, South Korea, were studied on January 5-6th 2008, just after one month of the accident. Residents wore overalls, used shovels, buckets, adsorption mats, tatters, oil fences, hand-made adsorption roller, heated water at 50-70℃ washing bath, and high-pressured nozzle to clean up the oil muck. The purification of oil on the sand beach was made so quickly within one month in sandy Mallipo Beach, whereas abundant oil drops between rocks with oil slick on the seawater surface on the rocky beach in Euhang Beach still remain. The oilcontaminated hazard map by Marine Environmental Risk Assessment Research Division, Korea Ocean Research and Development Institute, Korea, reported on December 18-19th 2007. In this study, on-site surveys for checking and observing the oiling condition have started on January 5-6th 2008 one month after the spill at Mallipo Beach and Euhang Beach. The values of pH and EC in two places indicated that the bioremediation process of oil took place under neutral conditions. The analytical data of volatile aromatic hydrocarbon concentrations for 0.5l/min at two beaches indicated that the concentration of toluene is quite higher in the atmosphere than that of C typed heavy oil from the Nakhodka tanker in January 1997 in Japan. In particular, toluene concentrations were unbelievably 100-1000 times higher than those in the Nakhodka tanker accident in Japan. They succeed to cleanup beach within one month by volunteer works of manpower, and keep the clean beautiful seashore. Furthermore, we must find new defensive measure systems which are safe, low cost, easy, and sustainable by using local natural materials without manmade chemical substances. It is right time to act locally in Asian countries and think globally about environmental seawater. 続きを見る
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田崎, 和江 ; 中西, 孝 ; 横山, 明彦 ; Tazaki, Kazue ; Nakanishi, Takashi ; Yokoyama, Akihiko
出版情報: 地球科学 = Earth Science.  62  pp.367-368,  2008-09-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061664
概要: 金沢大学理工研究域地球社会基盤学系
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田崎, 和江 ; 竹原, 照明 ; 橋田, 由美子 ; 橋田, 省三 ; 中村, 圭一 ; 横山, 明彦 ; 青木, 小波 ; 田崎, 史江 ; Tazaki, Kazue ; Takehara, Teruaki ; Hashida, Yumiko ; Hashida, Shozo ; Nakamura, Keiichi ; Yokoyama, Akihiko ; Aoki, Conami ; Tazaki, Fumie
出版情報: 地球科学 = Earth Science.  71  pp.97-113,  2017-07-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061665
概要: 金沢大学理工研究域地球社会基盤学系<br />黒柿はカキノキ科の一つであり,幹・枝・根の断面に黒色の部分があり,心材や辺材には縞が美しい孔雀の羽根のような模様(孔雀杢 くじゃくもく)がある.孔雀杢は何百年と樹齢を重ね,かつ,様々な条件を満た した柿の木だけが黒と白の美しい模様を持つようになった希少な銘木である.材質が竪硬で粘りもあり,細かい細工をする指物に適しており和家具,茶道具などが金沢伝統工芸品となっている.しかし,江戸時代に加賀藩が黒柿の栽培を行っていたとされるものの,その科学的な記録はない.なぜ柿の木の幹に黒い色の美しい模様ができるのかを究明するために,石川県金沢市内に生育している黒柿を採取して,IP,XRD,ICP-MS,XRF,SEM-EDS,放射能測定器を用いて物理化学的,鉱物学的,微生物学的特徴を調べた.本研究試料の「黒柿」のXRD 分析では,セルロースの他に低温型α- クリストバライト,生体アパタイト(燐灰石),ハロイサイトなどの粘土鉱物が含まれていた.黒柿の黒色化した幹に形成する孔雀杢は“珪化木”ということができる.本研究結果から,①黒柿が“珪化木”になるには,まず,根の中心の白色部に認められた微生物がCa >>> P,S >> Mg > Si,Fe,Cl,K,Mn を取り込み,生体アパタイトを形成する.②成長するにしたがって,放射能核種やB,Br を伴って, さらにCa,P,S >> K,Mg,Si,Sr > Cl,Mn,Fe などの元素を取り込みながら黒色化する.③そして,年月を経るにしたがって, 幹の辺材部に黒色の縞模様(孔雀杢)を作りながら低温型α- クリストバライト(珪化木)を形成することが明らかになった.<br />Kurogaki (Black persimmon; Diospyros kaki) grows very slowly and has extremely hard wood known for its striking black coloration, referred to as the “peacock pattern”. It was formerly planted in Kanazawa, Ishikawa, Japan. Kurogaki is currently very rare, found in only one of every 1,000 to 10,000 trees. Therefore, scientific data on Kurogaki are currently very limited but these trees are highly valuable for manufacturing furniture, tea ceremony goods, boxes, and other miscellaneous articles.Here we report the characterization of Kurogaki at Kanazawa, Ishikawa, Japan, based on radioactivity, purple mineral light, and H2 O2 reactions in the field. To date, no report has described the results of electron microscopy observations and chemical analyses, which could elucidate simple identification of species. Here we studied the microstructure, mineralogy, chemical composition, and radioactivity associated with microorganisms in Kurogaki wood using analytical data based on X-ray diffraction (XRD), X-ray fluorescence (XRF), inductively coupled plasma-mass spectrometry (ICP-MS), imaging plate (IP), scanning electron microscopy equipped with energy dispersive spectroscopy (SEM-EDS), and semiconductor detectors. We investigated the distribution, location, identification, structure, and differentiation of the black “peacock pattern” parts and ordinarily colored wooden parts and roots.We evaluated the mineralogy, chemistry, and micromorphology of Kurogaki using a combination of micro techniques. Using XRD, the black “peacock pattern” parts were found to mainly comprise cellulose associated with spherical and beaded microorganisms, mineralized living apatite, α-cristobalite, and halloysite. Particular elements associated with microorganisms were identified using SEM-EDS, which revealed the elemental content maps of the central white spot in cross sections of the “peacock pattern”, indicating high concentrations of Ca, P and S. The chemical compositions of the black and white parts were determined based on mineralogical and chemical data obtained using XRF analyzer and ICP-MS.Furthermore, we used imaging plate methods to obtain radioactive images of the cross sections of the “peacock pattern”. The objective was to illustrate the association of minerals with various microorganisms that are capable of absorbing both radionuclides and stable isotopes from soil and water. A radio dosage analysis of the higher black parts was performed by imaging plate pictures. We investigated the quantitative radiation dosages of the “peacock pattern” using Ge and Si semiconductor detectors, which revealed 137Cs concentrations.The black “peacock pattern” parts were richer in almost all elements such as K, Ca, Mg, S, Al, Fe, P, Na, Mn, B and Ba, than the white cellulose parts, indicating a role of microorganisms in mediating the transfer of metal solutes from the hydrosphere and soils. Using SEM-EDS micromorphology, the chemical composition of the black “peacock pattern” parts was found to be associated with α-cristobalite and living apatite having wooden clapper-like microcrystals. The distribution of elements indicated the influences of soils in their surrounding environment. Our results provide the evidence of the ability of microorganisms to immobilize radionuclides in the soils. The microorganisms grow in the black “peacock pattern” parts of Kurogaki.In conclusion, α-cristobalite and living apatite crystals physically and biologically grow in the sap with cellulose under neutral conditions (pH7) in association with microorganisms using carbon dioxide supplied by bacteria. Therefore, the crystals produced the “peacock pattern” in Kurogaki were formed at late times during the year. 続きを見る
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高橋, 直人 ; 田崎, 和江 ; Takahashi, Naoto ; Tazaki, Kazue
出版情報: 地球科学 = Earth Science.  61  pp.293-300,  2007-07-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061667
概要: 金沢大学理工研究域地球社会基盤学系<br />金沢大学角間2号井戸(深度150m,取水区間深度62〜73m,同78.5〜95m,同106〜138m)では,これまで地下水位・地下水温・電気伝導度の自動観測を行っており, 2007年3月25日に 発生した能登半島地震前後における10分間隔の詳細な経時変動データを取得することができた.地下水位は,揚水ポンプの停止時に深度31m,稼動時には深度39m程度の値を示した.電気伝導度は,ポンプの停止時に18.2mS/m,稼動時には18.7mS/mの値を示した.季節変動として,夏〜秋にわずかに高く,冬〜春にかけて低くなる現象が見られている.地下水位および電気伝導度については,地震の前後で異常な水位変動は見られなかった.地下水温は,地震時直近のポンプの停止時に12.3℃,稼動時に12.6℃の値を示した.通常地下水温は夏に低く,冬に高い傾向が見られているが,能登半島地震の前約2週間の間,地下水温が約0.5℃高い傾向が継続する現象が見られた.この傾向はポンプの稼動・停止や,気温,通年の季節変動傾向などとは異なるパターンの変動であった.今後は,より震央に近い地域における地下水位・水温・水質の観測記録との照合や,余震にともなう変化の観察などの再検証が必要であるものと考える.<br />The effect on groundwater in Kakuma-No.2-well at Kanazawa University by the Noto Hanto Earthquake struck at 9:41 a.m. 25th March 2007, reported in this study. The groundwater level indicated 39m in depth during operation, whereas the level indicated 31m in depth without operation. The electric conductivity (EC) of the groundwater during operation showed 18.7mS/m, whereas the EC showed 18.2mS/m without operation, using automatic measurement system. The EC tend to be higher in summer-autumn than that of winter-spring, which had not changed the value before and after the earthquake. On the other hand, the groundwater temperature showed 12.6℃ during operation whereas the temperature showed 12.3℃ without operation. The temperature clearly increased 0.5℃ for 2 weeks before the earthquake, and decreased the temperature after the earthquake. The results suggest that the earthquake gave the effect on the groundwater temperature as well. We need comparison with the record collected from the nearest area of epicenter in our future work. 続きを見る
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今井, 茂雄 ; 北川, 陽 ; 田崎, 和江 ; Imai, Shigeo ; Kitagawa, Yo ; Tazaki, Kazue
出版情報: 地球科学 = Earth Science.  56  pp.153-163,  2002-05-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061668
概要: 金沢大学理工研究域地球社会基盤学系<br />日本の九州の南に位置する沖永良部島は,石灰岩からなるため地下水による沈殿物の形成が速い.島内では,こうしたCa濃度の高い地下水を飲料水として使っているため,水洗用便器や水道管が沈殿物で閉塞する問 題を引き起こす.本研究では,知名町の水洗便器と赤嶺地区の上水ポンプ場の配管の2ヵ所で沈殿物を採取した.2つの沈殿物には,繊維状のシアノバクテリアが認められた.また,これらの沈殿物はカルサイトが主成分であり,水道水中から濃集したCu, Zn, Mn, Fe, Pbなどの重金属を含有していた.EPMA分析によって,PとNの濃集部位と重金属の濃集層とが一致していることが観察された.これら沈殿物の分析から,炭酸塩形成に適した生物化学的条件となっていたと解釈できる.われわれの生活環境の中で,設備に付着するこうした沈殿物は,汚れとして問題視される.しかしながら,こうした環境で微生物が水道水中の重金属を濃集することが示唆された.<br />Precipitates grow rapidly from underground water in limestone terrain of Okinoerabu Island located southern Kyusyu, Japan. In this island, Ca-rich underground water are used as drinking water which cause and effect choking toilet bowl and water pipes by the precipitates. In this study the precipitates were collected from toilet bowl at China-cho and from the water pipe of pump well at Akamine. Filamentous cyanobacteria are observed on the surface of the precipitates in both cases. These precipitates consist mainly of calcite with heavy metals, such as Cu, Zn, Mn, Fe and Pb which are concentrated from water. The accumulation of P and N are also detected at heavy metal layers by using EPMA. The precipitates can explain that biochemical conditions are favorable for carbonate formation. In human daily life the precipitates adhered to equipments are displeased as a dirt. However in this environments, the results suggest that microorganism can accumulate heavy metals from drinking water. 続きを見る
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脇元, 理恵 ; 田崎, 和江 ; Wakimoto, Rie ; Tazaki, Kazue
出版情報: 地球科学 = Earth Science.  60  pp.275-286,  2006-07-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061669
概要: 金沢大学理工研究域地球社会基盤学系<br />新潟県月岡温泉は,原油と共に噴出したpH7.3,Eh-184mV,49.2℃の化石海水型の温泉で,その源泉井戸には黒色の原油と緑色バイオマットが存在する.このバイオマット中には糸状細菌および球菌 が存在し,銅藍(covellite; CuS)の鉱物化が認められた.銅藍の構成元素であるCuは原油に由来している.SEM観察により,油滴表面での糸状細菌のコロニー形成および溶菌作用によるバイオフィルムの形成が認められ,さらに,その表面に銅藍の結晶化が認められた.微生物の培養実験により,バイオマット中には石油分解菌である糸状細菌と硫酸還元菌である球菌が同定された.さらに,有機結合およびリン脂質分析により,バイオマット中のリン脂質,特に,界面活性作用を持つレシチンおよびリン酸エステルの存在が明らかになった.また,糸状細菌は二重膜および細胞外多糖類(EPS)を持ち,リン脂質はこの部分に含まれると考えられる.糸状細菌はバイオマット表面に付着した油滴を栄養源とし,球菌が生成した硫酸塩を電子授与体として代謝を行い,溶菌後,バイオフィルムを形成する.油滴中のCuは温泉水中に溶出し,中性で還元的な環境下において銅藍の結晶を形成する.すなわち,本研究において,石油分解菌の細胞膜およびEPSの有機界面活性作用と硫酸還元菌による水質の還元化が,油滴表面での銅藍の形成に重要な役割を果たしていることが明らかになった.この結果は,土壌および地下水圏の石油汚染地域における石油の分解・除去メカニズムの解明の糸口となると考えられる.<br />The inner wall of the Tsukioka hot spring well was covered with green microbial mats which contained black crude oil. The hot spring is located in Tsukioka, Niigata, Japan. The hot spring water (pH 7.3, Eh -184 mV and 49.2℃) that was produced from a 280m in depth originated from fossil seawater. The aim of this study was to investigate of covellite biomineralization in the green microbial mats with crude oil from the Tsukioka hot spring water. Observations by optical and electron microscopy, phospholipid analysis and bacterial cultivation showed that the biomineralization of covellite (CuS) was found on the surface of crude oil droplets. ED-XRF analysis showed that the crude oil contained SO3 (67.6wt%), CaO (24.8wt%) and Cu2O (2.6wt%). Observations by optical and epifluorescence microscopy as well as scanning electron microscopy (SEM) showed that two morphological types of bacteria (i.e., filamentous and coccus typed bacteria) were found on crude oil droplets. Transmission electron microscopic (TEM) observations further revealed that the cell wall of the filamentous bacteria had a double membrane and was surrounded by Extracellular Polymeric Substance (EPS), which might provide the favorable nucleation sites for CuS. X-ray diffraction and electron diffraction analyses of the microbial mats showed that the materials precipitated on the surface of the oil droplets were highly crystallized covellite (CuS). FT-IR spectra of the microbial mats that contained covellite showed the appearance of C-N-H, P=O, P-O-C and N-H bands, indicating the presence of phospholipids (lecithin and phosphoric ester) in the microbial mats. Cultivation experiments, furthermore, demonstrated that the cultivated bacteria were identified as sulfate reducing bacteria (for coccus typed bacteria) and oil decomposing bacteria (for filamentous bacteria). A schematic formation model is here suggested to better understand the interaction between bacterial cells and oil droplets under anaerobic conditions in the Tsukioka hot spring water. The biomineralization of covellite described in this study might have profound implications for bioremediation of oilcontaminated site. 続きを見る
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三津野, 真澄 ; 渡辺, 弘明 ; 田崎, 和江 ; 長沼, 毅 ; Mitsuno, Masumi ; Watanabe, Hiroaki ; Tazaki, Kazue ; Naganuma, Takeshi
出版情報: 地球科学 = Earth Science.  54  pp.184-190,  2000-05-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061670
概要: 金沢大学理工研究域地球社会基盤学系
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児玉, 一八 ; 田崎, 和江 ; Kodama, Kazuya ; Tazaki, Kazue
出版情報: 地球科学 = Earth Science.  63  pp.107-112,  2009-03-25. 
URL: http://hdl.handle.net/2297/00061672
概要: 金沢大学理工研究域地球社会基盤学系<br />In the past 55 years no floods have occurred in Asanogawa River which has no dam. Early on the mo rning of July 28th, 2008, localized torrential rain in the area around Asanogawa River in Kanazawa City, Japan, brought inundations, flooding homes, causing landslides, and leaving serious damage. In the upper stream, two houses were destroyed completely by flooding and landslides. The muddy flood water flowed into fields and rice paddies, fruit trees were washed down, and the rice was killed. In several areas where the river narrowed, or at bends, flood waters overflowed the dike. Because of delays in closing the floodgate, the river overflowed at opening in the dike called "Kirikaki". 続きを見る
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田崎, 和江 ; 中西, 孝 ; 鈴木, 祐恵 ; 佐藤, 和也 ; 森井, 一誠 ; 鈴木, 健之 ; Tazaki, Kazue ; Nakanishi, Takashi ; Suzuki, Sachie ; Satoh, Kazuya ; Morii, Issei ; Suzuki, Kenji
出版情報: 地球科学 = Earth Science.  61  pp.343-361,  2007-09-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061673
概要: 金沢大学理工研究域地球社会基盤学系<br />2007年3月25日9時41分にマグニチュウド6.9の激震が石川県能登半島を襲い,舗装道路に大きなダメージを与え,交通網が寸断された.本研究調査団はGMサーベーメータを使用し,車によるカーボーン 法と徒歩によるハンドボーン法の併用により,能登半島地震災害地の空間β線と舗装道路の亀裂,陥没,隆起,地滑り地帯におけるβ線を測定した.測定日は2007年4月4日から19日の間の4回であり,約240kmの距離を2-4台のGMサーベーメータで,毎回同じルートを往復して測定した.また,地震の被害がなかった金沢市内においても4月12日に測定を行い,災害地と比較した.2007年4月4日8:20に輪島市大沢において2300cpmを記録し,同日の13:20には古和秀水にて1500cpmを記録した.これはともにM3.8,深さ10km,震源地37.2N,136.7E,およびM3.3,比較的浅い震源37.2N,136.5Eの余震に合致した,舗装道路の亀裂,陥没,隆起,液状化の箇所は100-200cpmと高い値を示し,かつ,その場の大気はそれ以下であった.一方,地震被害のなかった金沢市内は40-80cpmと低い値を示した.空間β線計数率分布地図は地震の被害が大きい地域で高く,時間が経過するに従い低下することが明らかになった.<br />The magnitude-6.9 Noto Hanto Earthquake struck at 9 : 41 a.m. 25th March 2007, off the north coast of Ishikawa Prefecture, Japan. The quake started under the ocean about 30km southwest of Wajima, shaking up Ishikawa, Toyama and Niigata prefectures and killing one person and damaging hundreds of houses. The quake crippled public transportation, traffic network, including highway at Noto Peninsula, because of landslide, subsidence, chasm and cracks. Radon has measured in air and ground fissures using portable natural gamma ray system while the Noto Hanto Earthquake struck the Noto Peninsula, in April 4, 8, 10, 12, and 19th 2007. The car-borne and hand-borne measurement system was assembled for easily and rapidly detecting full features of the fissures buried in the ground, and the applicability of the system was detected in the field, such as geological feature, fault fissure zone, distribution/accumulation of new/old chasm and cracks in the surface layer, and direct earthquake itself. The amount of radon reflects the scale of fissures and an abnormal increase in earthquake and new chasm or cracks. The quite high gammaray of 2300cpm was detected in April 4th 8 : 20 at Ozawa, Monzen, Wazima City, near the fault fissure zone, and 1500cpm was detected in April 4th 13 : 20 at Kowashudo, Monzen, Wajima City. Both high radon counts were due to the earthquake of M 3.8, depth 10km, hypocenter was Noto region 37.2N, 136.7E, and the other earthquake of M 3.3 was relatively shallow depth, hypocenter at Noto offshore 37.2N, 136.5E, respectively. The abnormal increase (100-200cpm) detected at large deep subsidence and new crack on the paved road. For comparison, normal air radon without earthquake counted as low as 40-80cpm. Observation of radon at earthquake region such as Monzen-cho related to radon anomaly to compare with other normal region in Kanazawa City has been studied. 続きを見る
46.

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論文
小林, 昭二 ; 田崎, 和江 ; Kobayashi, Shoji ; Tazaki, Kazue
出版情報: 地球科学 = Earth Science.  60  pp.49-62,  2006-01-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061674
概要: 金沢大学理工研究域地球社会基盤学系<br />系統的にDusisiren jordaniとHydrodamalis gigasの間にあるヤマガタダイカイギュウD. dewana,アイヅタカサトカイギュウD. takasatensis,タキカ ワカイギュウH. spissa等をふくむヒドロダマリス亜科の下顎(咀嚼),頭の背屈・側屈,脊柱運動機能の変化について,骨格の観察と現生の海牛(ジュゴンとマナティー)の筋学的な知見をもとに考察を試み,次の結果を得た.1)後期中新世のD. takasatensisとD. dewanaでは歯が小さくなった後,翼状突起腹側部が広がり,下顎骨の吻部咀嚼面が狭い長方形となることから下顎骨を動かし吻部で餌をはさむ力が増したと考えられる.歯を欠如した鮮新世のH. spissaではそれがさらに強くなったと推測される.また側頭稜の発達から鮮新世のH. cuestae, H. spissaでは側頭筋の力が現世のH. gigas以上に強いと考えられる.2)鱗状骨外側部,上後頭骨・外後頭骨背外側縁の形状比較から,後期中新世のD. jordaniのように板状筋が発達する傾向はD. takasatensis, D. dewanaにも認められる.しかし,H. gigasのように板状筋より頭半棘筋の発達が目立つのはすでにH. spissaから認められる.3) D. dewanaとD. takasatensisはほぼ同じ大きさの頭蓋をもつが,鱗状骨外側部,上後頭骨・外後頭骨背外側縁の形状の差異から,D. takasatensisが頭の背屈・側屈がより強く,頭の可動範囲も広いと考えられる.4)ヒドロダマリス亜科は中位胸椎の棘突起が低いことから,最長筋などの軸上筋の発達が弱く,脊柱を背屈させる力もジュゴンの場合より弱い,特にH. spissaで顕著であると考えられる.ヒドロダマリス亜科は水流エネルギーのあまり強くない環境に穏やかな脊柱の動きで生息していたと推測できる.<br />Evolutional change in function of the jaw, mobility of the neck and the vertebral column in Hydrodamalinae is examined on the basis of the fossil skeleton, the myological and osteological knowledge of living sirenians. In Dusisiren dewana, Dusisiren takasatensis and Hydrodamalis spissa, the holding function of their rostra probably had been developed like Hydrodamalis gigas, because they had a mandibular masticating surface which is narrow and rectangular in outline, ventrally broadened pterygoid process that attached the pterygoid muscles. In D. dewana and D. takasatensis, the splenius muscles may have been developed like Dusisiren jordani, but in H. spissa, the semispinalis capitis muscle may have been more developed than the splenius muscle like H. gigas. D. takasatensis has some other features, longer sigmoid ridge of squamosal, larger occipital condyle and occipitosphenoidal eminence, and thicker lateral flange of exoccipital than those of D. dewana. Therefore, there is a possibility that in D. takasatensis the neck force for raising and depressing the head had been strengthened by the developed splenius, semispinalis capitis and longus capitis muscles. The low spinous process of the middle part of the thoracic vertebrae in Hydrodamalinae indicates that the epaxial muscles (longissimus dorsi and transversospinalis muscles) are less developed, and therefore that the mobilities of the vertebral column are gentle. They might have been swimming in the calm environment. 続きを見る
47.

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論文
脇元, 理恵 ; 田崎, 和江 ; 縄谷, 奈緒子 ; 池田, 頼正 ; 今井, 茂雄 ; 佐藤, 一博 ; 奥野, 正幸 ; Wakimoto, Rie ; Tazaki, Kazue ; Nawatani, Naoko ; Ikeda, Yorimasa ; Imai, Shigeo ; Sato, Kazuhiro ; Okuno, Masayuki
出版情報: 地球科学 = Earth Science.  58  pp.199-214,  2004-07-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061675
概要: 金沢大学理工研究域地球社会基盤学系<br />大島紬は使用する泥田の状態により,染色の仕上りが異なると言われている.本研究では,現在使用中の泥田,現在は使われていない旧泥田,来期使用のために一年間休閑中の泥田の泥について鉱物学的,微生物学的 特徴を検討した.3つの泥田のEh,DOは,ともに休閑中の田で最も還元状態を示した.泥の中には石英,長石類の他に鉄酸化物や鉄に富むクロライト,バーミキュライト,雲母類粘土鉱物,カオリン鉱物などの粘土鉱物が確認された.一年休閑させている泥田の泥と現在使用中の泥田の泥の総Fe量はともに多く,鉄酸化物や粘土鉱物中に含まれている.一方,有機成分は,現在使用中の泥田で最も高く,この結果は光学顕微鏡観察および偏性嫌気性細菌培養により,多種多様の微生物が観察された事と一致する.また,偏性嫌気性細菌培養結果は,特に鉄還元細菌と考えられる球菌,桿菌が多いことを示した.泥により黒く染色された絹糸部分からは,Fe,S,Ca,Al,Si,P,K,Mnが検出され,これらの元素は,泥およびテーチ木起源と考えられる.よって,大島紬を独特の深い黒色に染色する泥田の条件として,泥田の水質が還元状態である事,染色に重要な鉄は二価鉄である事,泥中には鉄還元細菌をはじめとする多種多様の微生物が存在し,鉄を二価に変えている事があげられる.<br />"Dorozome" is one of the traditional dying methods with muddy clays in Amami-Ohshima Island, Kagoshima, Japan. The brilliant black color of dyed "Ohshima Tsumugi" derives from muddy clays in Dorota (small ponds with muddy clays). In this paper, muddy clays for dying were mineralogically, chemically and microbiologically characterized. The muddy clays consist of Fe-rich chlorite, vermiculite, mica clay minerals, kaolin minerals as well as a large amount of iron hydroxides associated with high P2O5, N, C and S contents in the muddy field. Principally, iron is a key element which constitutes not only crystalline/amorphous hydroxides iron minerals, but also clay minerals. After one year of using the muddy clays, the Eh and DO are significantly reduced in fallow field. Various microorganisms were observed in the muddy clays, such as coccus and bacillus typed bacteria and fungi. Anaerobic bacteria may contribute for reducing condition in the muddy field. The black parts of "Ohshima Tsumugi" contain high concentrations of S, Ca and Fe, whereas white parts without dye contain a small amount of such elements. The heavy metals are originated from both muddy clays and Rhaphiolepis umbellata. The results suggest that specific condition of iron hydroxides is an important factor for brilliant black dye under reducing condition. 続きを見る
48.

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論文
佐藤, 大介 ; 田崎, 和江 ; Sato, Daisuke ; Tazaki, Kazue
出版情報: 地球科学 = Earth Science.  54  pp.328-336,  2000-09-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061676
概要: 金沢大学理工研究域地球社会基盤学系<br />尾小屋鉱山の坑口(第六立坑)からは,現在も高濃度の重金属を含む酸性の廃水(pH3.5)が流出し続けており,消石灰の投入による中和凝集沈殿処理が行われている.処理後の廃水が流入する沈殿池から採取し たコアサンプル(44層)の鉱物組成をX線粉末回折(XRD)によって,また含有元素の割合をエネルギー分散型蛍光X線分析(ED-XRF),NCSコーダーによって分析した.コアサンプルの上部には茶褐色の層が多く,下層になるにつれて色は薄れていく.茶褐色は含有するFeの量により,それらは低結晶性の水酸化鉄鉱物の存在を示唆し,Cu,ZnおよびPbが吸着していると考えられる.また,Sの含有量は深層になるに従って多くなる.カルサイトはコアの上層部に多く,下層部にはエトリンガイトが形成されているが,Cdの含有量はカルサイトやエトリンガイトと同じようなプロファイルを示す.その他,堆積物中には,ジプサム,石英,ブルーサイトが認められた.Caは上層部ではカルサイトとして,また,下層部ではエトリンガイトとして堆積している.本研究により,消石灰の投入によって中和処理された鉱山廃水中の重金属イオンは,水酸化鉄,カルサイト,エトリンガイトに伴って堆積,蓄積されていることが明らかになった.<br />Depositional formula of heavy metals after disposal of the mine drainage from the Ogoya Mine in Ishikawa Prefecture, Japan, was mineralogically investigated. Strong acidic wastewater (pH3.5) from pithead of the mine contains high concentration of heavy metals. In this mine, neutralizing coagulation treatment is going on by slaked lime (calcium hydroxides: Ca (OH)_2). Core samples were collected at disposal pond to which the treated wastewater flows. The core samples were divided into 44 layers based on the color variation. The mineralogical and chemical compositions of each layer were analyzed by an X-ray powder diffractometer (XRD), an energy dispersive X-ray fluorescence analyzer (ED-XRF) and a NCS elemental analyzer. The upper parts are rich in brown colored layers, whereas discolored are the deeper parts. The color variation is relevant to Fe concentration. Brown colored core sections are composed of abundant hydrous ferric oxides with heavy metals, such as Cu, Zn, and Cd. On the other hand, S concentration gradually increases with depth. XRD data indicated that calcite decreases with increasing depth, and ettringite is produced at the deeper parts. Cd concentration shows similar vertical profile to those of calcite and ettringite. The results revealed that hydrous ferric oxides, calcite and ettringite are formed on deposition, whereby incorporating the heavy metals. 続きを見る
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論文
田崎, 和江 ; 高橋, 正則 ; 鈴木, 祐恵 ; 井本, 香如 ; Tazaki, Kazue ; Takahashi, Masanori ; Suzuki, Sachie ; Imoto, Konyo
出版情報: 地球科学 = Earth Science.  65  pp.175-177,  2011-07-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061679
概要: 金沢大学理工研究域地球社会基盤学系
50.

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論文
大野, 源広 ; 田崎, 和江 ; Ohno, Motohiro ; Tazaki, Kazue
出版情報: 地球科学 = Earth Science.  54  pp.298-309,  2000-09-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061682
概要: 金沢大学理工研究域地球社会基盤学系<br />高温環境である平湯温泉,おばこ原の湯には3種のバイオマット(白色,茶色,緑色)が存在する.これらのバイオマットは水温,pH,Eh,DO,光および温泉水の流れの変化に伴い,上流部から下流部に向かっ て色調が白色→茶色→緑色へと変化する.白色バイオマットは主として大鎌型細菌から構成され,硫黄を濃集するのに対し,茶色バイオマットは多量の桿菌および少量の糸状菌で構成され,水酸化鉄を濃集する.また,緑色バイオマットは糸状菌から構成され,カルシウムを濃集し,方解石を形成する.すなわち,バイオマットの色は生息する微生物種と形成された生体鉱物を反映している.その中でも高温環境下に存在する大鎌型細菌は夾膜の表面に雁行状に硫黄の結晶を成長させる特徴がある.<br />Colorful biomats were found at Obakoharanoyu in Hirayu Hot Springs, Gifu, Japan. At the upper stream white biomats were commonly found, whereas brown and green biomats occur at the down stream, according to change of environmental conditions, such as temperature, pH, Eh, DO, S2-, photosynthesis and water flow velocities. The pH, WT, Eh, and DO diagrams of the hot spring water from upper to down stream have responded to the occurrence of biomats. White biomats occur in low pH (6.1), reducing (Eh:-270mV), micro-aerobic (DO: 0.3mg/l) and high temperature (70℃) conditions. On the other hand, brown biomats occur in wide ranges of pH (6.5-7.8), Eh (-125〜90mV), DO (2.0〜5.0mg/l) and WT (42-60℃) respectively. In contrast, the occurrence of green biomats are high pH (8.4), oxidizing (Eh: 100mV), aerobic (DO: 7.5mg/l) and middle temperature (30℃). Sulfur ions are detected in water on the white biomats (1-2ppm), while not detected from both brown and green biomats. The white biomats comprising sausage shaped bacteria contain abundant sulfur. The green biomats consist of filamentous bacteria with abundant calcite. The results have revealed that the color of biomats reflects the environmental conditions. TEM and SEM observations indicate that sulfur particles adhere to capsule on the cell wall of sausage shaped bacteria in white biomats. The sulfur particles might be grown to a-sulfur crystals of 10μm insize. The results have revealed that sulfur-biomineralization of sausage shaped bacteria in white biomats is a very important factor for sulfur removal in hot springs. 続きを見る
51.

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論文
田崎, 和江 ; Tazaki, Kazue
出版情報: 地球科学 = Earth Science.  61  pp.239-242,  2007-07-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061683
概要: 金沢大学理工研究域地球社会基盤学系
52.

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論文
田崎, 和江 ; 中野, 幹夫 ; 竹原, 照明 ; 石垣, 靖人 ; 中川, 秀明 ; Tazaki, Kazue ; Nakano, Mikio ; Takehara, Teruaki ; Ishigaki, Yasuhito ; Nakagawa, Hideaki
出版情報: 地球科学 = Earth Science.  69  pp.99-108,  2015-03-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061684
概要: 金沢大学理工研究域地球社会基盤学系<br />2011年3月11日に発生した福島第一原発事故により放射能汚染した福島県南相馬市原町区馬場の農業用水にプラスチック製品を7ヶ月間浸して置いたところ,全9試料のうち3試料において放射線量の上昇が認 められた.そのカーペット,PE防鳥網,荷造り用ひもの3種類について詳細な分析・観察を行った.特に,カーペットの繊維の放射線量が高く,ゲルマニウム半導体検出器による分析では,セシウム134とセシウム137が検出された.また,蛍光X線分析により,Rb,Sr,Nb,Pbも認められた.分析電子顕微鏡観察によれば,この繊維の表面には粘土の微粒子といっしょにケイソウが繁茂しており,Rb,Sr,Pbが濃集していた.放射能汚染した農業用水に浸したプラスチック繊維の表面にはケイソウが多数生息し,粘土の微粒子とともに放射性物質を吸着することが明らかになった.<br />After the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident on 11 March, 2011, the high radioactive dosage was found in polluted water for agriculture use at Baba, Haramachi, Minami-Soma, Fukushima Prefecture, Japan. Field experiment for decontamination of water had been studied by using commercial plastic materials. The agricultural water comes from Tetsuzan dam is full of radioactive-contaminated water. Experimental analysis showed that the plastic materials can take up radioactive elements for several months soaked in the polluted agricultural water. The quantitative analyses using X-ray fluorescence analysis, Ge semiconductor and scanning electron microscopy equipped with energy dispersive X-ray spectrometer (SEM-EDS), revealed the detection of the radionuclides on the plastic materials with diatom and clays. The results suggest the adsorption of radionuclides on the surface of plastic materials due to FDNPP accident. The plastic materials associated with clays and diatoms could be stronger carriers of radionuclides in the polluted water. Adherence of diatoms to the plastic fiber in the water for 7 months suggested that some plastic materials were taking up heavy metals (Zn, Ba, Pb, Sb) with radioactive elements (Cs etc.). Mechanisms by which radioactive pollutants and microorganisms are adsorbed onto and desorbed from clays at aqueous interface can be understood by combining chemical analysis with electron microscopy observation. 続きを見る
53.

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田崎, 和江 ; 野村, 正純 ; 森井, 一誠 ; 佐藤, 和也 ; 馬場, 奈緒子 ; 中西, 孝 ; 横山, 明彦 ; Chaerun, Siti Khodijah ; Tazaki, Kazue ; Nomura, Masazumi ; Morii, Issei ; Satoh, Kazuya ; Baba, Naoko ; Nakanishi, Takashi ; Yokoyama, Akihiko
出版情報: 地球科学 = Earth Science.  62  pp.325-330,  2008-09-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061687
概要: 金沢大学理工研究域地球社会基盤学系<br />The magnitude-6.8 Chuetsu-Oki Earthquake struck at 10:13 a.m. 16th July 2007, off the northwester n coast of Japan in Niigata Prefecture, Japan. The hypocenter was Chuetsu-Oki region 37.33N, 138.36E (17km in depth). The quake started under the ocean about 9km North of Kashiwazaki Kariwa nuclear plant, killing 11 peoples, and flattening several hundreds of buildings. In this study, Radon has measured in air and ground fissures using portable natural gamma ray system on July 16-17, and 20-21th, 2007. The quite high gamma ray of 300-340 cpm was detected on July 21th at Ohminato, Kariwa village which is the nearest of the fault fissure zone. The abnormal increase (200-300cpm) was detected at large deep subsidence and new crack on the paved road. For comparison, normal air radon without earthquake was counted as low as 60-80cpm. The car-borne and hand-borne measurement system was assembled for easily and rapidly detecting full features of the fissures buried in the ground. 続きを見る
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佐藤, 和也 ; 田崎, 和江 ; 奥野, 正幸 ; 久保, 博 ; Satoh, Kazuya ; Tazaki, Kazue ; Okuno, Masayuki ; Kubota, Hiroshi
出版情報: 地球科学 = Earth Science.  64  pp.63-75,  2010-03-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061690
概要: 金沢大学理工研究域地球社会基盤学系<br />長野県の松代温泉は,大量のほう素(B)を含む温泉としてよく知られている.その排水溝には茶褐色および黒色のバイオマットが形成されている.特に河川水と温泉排水が交わる部分には黒色のバイオマットが形成 されている.いずれのバイオマット中にも多量のBが濃集しており,これによって,排水中のB濃度は,排出直後よりも4割程度減少する.これは,バイオマット中に生息するシアノバクテリアがカルサイトを作る時に,二酸化炭素のかわりに炭酸塩イオンを取り込むからである.その際に細胞周辺に局所的に高アルカリ環境を作り出し,温泉中のHBO2を電離させ,よりBを他の物質に結合しやすい状態にするためである.シアノバクテリアはカルサイトを作り出すことによって,Bを濃集させ,温泉水中のBを軽減する働きがある.<br />Matsushiro Hot springs in Nagano Prefecture, Japan is known as one of the hot springs in which the concentration of boron (B) is quite high. The hot spring water drainage ditch was covered with dark brown microbial mats. Before the drainage meets the river, the microbial mats deposit is more than 2m in depth. The microbial mats deposit has two layers. In the upper parts, dark brown microbial mats covered the surface. Underneath are black microbial mats which make up a portion of the two layer structure. At the junction of the drainage and river water, only black microbial mats occurred. The aim of this study was to reduce the boron concentration of the drainage water with microbial mats at Matsushiro Hot Springs. ASS analysis showed that microbial mats collected from five different points contain 854mg B/kg, 8628mg Fe/kg, 120mg As/kg, and 912mg Mg/kg on average. ED-XRF analysis showed that all microbial mats contained more than 50wt% of Ca. XRD analysis and FT-IR spectra of the microbial mats indicated the presence of calcite. Observations by optical and electron microscopy showed that cyanobacteria inhabited dark brown microbial mats, whereas cyanobacteria and diatoms inhabited in black mierobial mats. Cyanobacteria use an enzyme named carbonate anhydrase (CA). HCO3- dissolved in the hot spring water was broken down into CO2 and OH- by CA. That OH- made temporary alkaline conditions around the cyanobacteria. Such alkaline conditions facilitate the break down of HBO2 into H+ and BO2-. BO2- can form many chemical compounds. The concentration of boron described in this study might have profound implications for bioremediation of boron contaminated sites. 続きを見る
55.

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田崎, 和江 ; 野村, 正純 ; 馬場, 奈緒子 ; Tazaki, Kazue ; Nomura, Masazumi ; Baba, Naoko
出版情報: 地球科学 = Earth Science.  61  pp.389-400,  2007-09-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061691
概要: 金沢大学理工研究域地球社会基盤学系<br />2007年3月25日9時41分にマグニチュード6.9の地震が石川県能登半島を襲った.その地震のため1〜2週間電気や水道が止まった.住民は近所の井戸,湧き水,山水を注意深く使用した.なぜならば,地 震後のそれらの水は,泥などで色が変化し,pHも硫酸イオンのために中性から酸性に変化し飲料不可になった井戸水があったからである.一方,地震から2ヶ月後の6月初旬,石川県七尾市中島町において、亀裂や陥没等々の地下構造の変化のため,海水が水田に浸透し稲が枯れる塩害が発生した.塩害が発生した水田を始め,周辺の用水路,貯水池の水を現地で測定したところ,pH8を示し電気伝導度(EC)も高い値を示した.また,塩害を起こした水田の土壌と稲を蛍光X線分析により定量分析をおこなったところ高濃度の塩素のほか典型的な塩害現象を示すNa,S,Feが高濃度に検出された.<br />The Noto Hanto Earthquake with a magnitude of 6.9 struck off the North coast of Ishikawa Prefecture that occurred at 9 : 41 a.m. on the 25th March 2007. It was an undersea earthquake with an epicentre of about 30km Southwest of Wajima, shaking up the Hokuriku district and cutting electricity and drinking water system for 1-2 weeks. All residents, especially those who are near the hardest hit areas, were advised to use drinking water collected from springs, wells and mountain natural waters with extra caution, because the water had become muddy after the quake. Some of waters were shifted from neutral to acidic pH (pH 5) that was not drinkable due to SO4_2- On the other hand, the rice fields were also damaged by sea salt after 2 months of the earthquake, because of several factors to consider, such as cracks, faults, and subsidence near reservoir water for rice field irrigation at Nakajima-machi, Nanao City, Ishikawa Prefecture at the beginning of June 2007. The field measurements of the pH of the water (pH 8) and high electrical conductivity (EC) suggest that seawater flowed into the rice fields, which agreed with X-ray Fluorescence quantitative analysis, showing high chlorine content. The soil and rice at damaged fields indicated high Na, S, Cl, and Fe contents, showing typical phenomenon of sea-salt damage. Farmers have asked the government for compensation and prevention of the damaged rice fields even after 2-3 months of the earthquake. 続きを見る
56.

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田崎, 和江 ; 馬場, 奈緒子 ; 佐藤, 和也 ; 奥野, 正幸 ; 福士, 圭介 ; Tazaki, Kazue ; Baba, Naoko ; Satoh, Kazuya ; Okuno, Masayuki ; Fukushi, Keisuke
出版情報: 地球科学 = Earth Science.  61  pp.281-292,  2007-07-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061692
概要: 金沢大学理工研究域地球社会基盤学系<br />2007年3月25日9時41分にマグニチュード6.9の地震が石川県能登半島を襲った.その折,水道が断水し,住民は周囲の井戸水,湧き水,山水を生活水として使用した.その水は地震直後から白色,灰色, 茶色に濁り,2-3日から2週間続いた.本研究は被害地の住民からの聞き取り調査,現地における水質検査,採水試料を実験室に持ち帰り,蛍光X線分析,イオンクロマト分析,走査型電子顕微鏡観察を行った.地震前は中性であった井戸水が地震後にpH5.4-5.9と酸性になり,かつ, SO4が非常に高くなり飲料不可となった.一方,中性であった温泉水がpH8とアルカリ性に変化し, NaCl含有量が高くなり,海水の浸入を示唆した.また,飲料水の6項目についての検査を行政に依頼したところ, 2箇所の水から基準以上の一般細菌と大腸菌が見つかり飲料不可となった.なお,この検査項目にはpHが含まれていないので,今後,災害時にはいち早く生活水についてpHや集落形成単位(CFU)を含めた水質検査が必要である.さらに,避難所における生活水はノロウィルスなどによる病気と直結しているため,行政による迅速な措置と指導が必要である.<br />The magnitude-6.9 Noto Hanto Earthquake struck at 9:41 a.m. 25th March 2007, off the north coast of Ishikawa Prefecture. The quake started under the ocean about 30 km southwest of Wajima, shaking up Ishikawa, Toyama and Niigata prefectures and cutting electricity and drinking water system to some 160,000 households, killing one person and damaging hundreds of houses. The quake also crippled public transportation, including Noto airport, and cut water to about 9,500 households. All residents, especially those who are near the hardest-hit area, are advised to use drinking water collected from spring, well and mountain natural water with extra caution, because the water got become muddy in white, gray, and brown color after the quake. Some of water changed to acidic pH 5.4-5.9 from neutral pH is not drinkable due to SO4. The legal standard of pH for drinking water is pH 5.8-8.6. The water contained 5-10 times of SO4 higher than standard concentration of SO4, but looking transparent after one week. The field measurements of water pH suggest that high SO4 contents are due to acidic drinking water, agreed with XRF, ion-chromatography, and SEM-EDX analyses. After 3 weeks, water pH 5.9 backed to the normal pH 6.5, but NO3, Ca and Mg contents were still higher than before the quake. We have ordered the government to work, toward securing the citizen's safety and take all possible measures of drinking water to rescue them. The health center office must take care of spring water, well, and mountain natural water to check pH as soon as possible associated with CPU (Colony Forming Unit) check. 続きを見る
57.

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田崎, 和江 ; 山内 , 順公 ; 犬飼, 将成 ; 中山, 和正 ; 犬塚, 俊裕 ; 森井, 一誠 ; 片桐, 有由未 ; 糸野, 妙子 ; Tazaki, Kazue ; Yamauchi, Yoritaka ; Inukai, Masanari ; Nakayama, Kazumasa ; Inuzuka, Toshihiro ; Morii, Issei ; Katagiri, Ayumi ; Itono, Taeko
出版情報: 地球科学 = Earth Science.  58  pp.389-405,  2004-11-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061693
概要: 金沢大学理工研究域地球社会基盤学系<br />雨水が樹冠を通過することにより水質がどのように変化するのかを明らかにするため,スギ,コナラ,モウソウチタの林外雨,林内雨および樹幹流の水質測定と溶存イオンをED-XRFにより分析した.雨水の採取 や測定は2004年2-3月金沢大学角間キャンパスで行った.また,雨水が森林の樹木を伝わり土壌に行く物質循環を明らかにするため,スギ,コナラ,モウソウチクの樹皮の浸出実験と土壌の透過実験を行った.その結果,スギ,コナラの樹皮の浸出液のpHは酸性化し,モウソウチクは弱酸性化した.このpHの変化は溶出したK,Caなどのイオンによって生じる.樹皮の浸出実験の前と後をSEM-EDXで観察したところ,浸出後の表面は平滑になっていた.また,3種の樹木の樹幹流を土壌に透過させるとpHは4-6の一定の値に収束した.これは土壌中に存在する粘土鉱物のイオン交換能を示唆している.さらに,土壌は植生によって溶脱するイオンの種類と量が異なる.以上の結果は,雨水が樹幹を伝わることにより大きく水質および化学成分を変化させることを明らかにした.この結果は森林環境保全を行う上で重要である.<br />Field and laboratory studies were conducted to investigate the successive changes in the chemical and physical characteristics of rainwater through stemflow as well as soil in three different forest ecosystems. That is, Sugi (Cryptomeria japonica), Konara (Quercus serrata), and Mousoutiku (Phyllostachys heterocycla) forests which are located in the Kakuma campus of Kanazawa University, Ishikawa Prefecture, Japan. Rainwater outside those forests was also sampled as control precipitation. For field investigation, the rainwater samples as throughfall and stemflow were collected from February 25 to March 18, 2004. For laboratory investigation, the batch leaching experiment using control rainwater was performed over a period of one week, and the continuous filtration experiment using downflow soil bed system with the stemflow of those trees was undertaken as well. XRD analyses of bulk soil and < 2 μ m fraction of soil samples collected from those forests showed similar mineral compositions composed of quartz, feldspars, cristobalite, gibbsite, chlorite, vermiculite, and kaolin minerals. The leaching experimental data showed similar mineral decreases in the rainwater pH of Sugi forest (pH〜4), while little change in the rainwater pH of Konara forest was observed. Conversely, the rainwater pH of Mousoutiku forest tended to increase. These pH changes may be the result of dissolution of K and Ca contained in the bark of those trees in agreement with the experimental data of chemical composition of rainwater analyzed by ED-XRF. Scanning electron microscopic observations of tree bark showed that the surfaces of bark after leaching became smoother than those before leaching, and their EDX spectra showed that there were decreases in the K and Ca contents after leaching. The continuous filtration experiment demonstrated that there were significant changes in the pH, EC, and Eh of the effluent rainwater after filtering through a soil filter bed with several kinds of minerals, indicating that minerals serve as a natural buffer. These results indicate that the type of plants and mineralogical composition of soils in forest ecosystems have effects on the successive changes in the chemical and physical characteristics of rainwater. 続きを見る
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田崎, 和江 ; 長谷川, 香織 ; 松本, 和也 ; Tazaki, Kazue ; Hasegawa, Kaori ; Matsumoto, Kazuya
出版情報: 地球科学 = Earth Science.  56  pp.87-104,  2002-03-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061694
概要: 金沢大学理工研究域地球社会基盤学系<br />かつての鉱山活動は重金属を外界に排出し,今日でも水質や土壌汚染の原因となっている.岐阜県神岡町にある大規模なZn-Pb鉱山の一つである神岡鉱山は,神通川の重金属汚染源となってきた.Cd,Pb,Z nそしてFeなどの重金属が高原川-神通川水系に未処理のまま廃棄され,下流域の住民の健康に影響を与えた.重金属の中でも特にCdは,イタイイタイ病の病原物質と見なされた.Cd汚染問題は未だに解決されていない.消石灰を投入し,中和凝集処理された廃滓の沈殿池が神岡鉱山にいくつか存在する.廃滓や廃棄場から排出された汚染水は,神通川の上流の高原川に流れ込んでいる.本研究では,重金属を含む堆積物の特性を明らかにするため,高原川-神通川水系にある五つのダムの堆積物を採取した.ダム堆積物の鉱物的・化学的組成を明らかにするため,それぞれの試料についてXRD,ED-XRFによる分析を行った.その結果,神岡鉱山の上流域に位置する浅井田ダムの堆積物はCd,粘土鉱物そして有機物が少なく,神岡鉱山の下流域に位置する新猪谷ダム,神通川第一,第二,第三ダムにおいては,汚泥,スメクタイトそしてZn,Cdのような重金属が多く含まれていることが明らかになった.また,本研究では,水中の重金属の浄化能力を見積もるための実験を行った.その結果,バクテリアを使ったバイオレメディエーションは重金属の固定に効果的であることを示した.室内実験系においてバイオフロック中の糸状菌は,一週間で細胞壁の表面にPb,Zn,Cdを選択的に濃集した.バイオレメディエーションの能力を持つバクテリアは,鉱山地域における下流のダム堆積物中でも重金属を固定する重要な役割を演じている.<br />Contamination of water and soils is one of grave problems at mining area. Kamioka Mine, one of the largest Zn-Pb mine in Gifu prefecture in Japan, has been the source of heavy metal pollution in Jinzu River. Cd, Pb, Zn, and Fe have been released from an abandoned dump into the Takahara-Jinzu River system, and serious health problem occurred in the down stream areas. Heavy metals, Cd, in particular, is regarded to be the pathogenic substance causing Itai-Itai Disease. The Cd pollution problems have not yet been solved. Some tailing ponds with neutralizing coagulation treatment (slaked lime) are present in the Kamioka Mine. Heavy metal-contaminated wasted water from tailing and dumping areas were discharged into the Takahara River (the upper stream of the Jinzu River). In this study, five dam sediments along the Takahara-Jinzu River were collected, in order to clarify characteristics of sediments with heavy metals. Each sample was analyzed by using an X-ray powder diffractometer (XRD) and an energy dispersive X-ray fluorescence analyzer (ED-XRF) in order to clarify the mineralogical and chemical compositions of the dam sediments. As a result, the sediment from Asaida dam on the upper course of the Kamioka Mine has little Cd, clay minerals and organic matter, whereas Shininotani dam, Jinzu 1st dam, Jinzu 2nd dam, Jinzu 3rd dam in the down stream of the Kamioka Mine have much sludge, smectite and heavy metals, such as Zn and Cd. Smectite and organic matter have been concentrated with heavy metals in the down stream dam sediments of Jinzu River. In this study, arrange of experimental observation has carried out in order to estimate the ability of heavy metals for the purification of water. The results suggest that bioremediation methods using bacteria is effective as a fixing heavy metals. Filamentous bacteria in biofloc selectively accumulated Pb, Zn, and Cd on the surface of cell wall in laboratory experimental system after one week aging. The bacteria have an ability as a bioremediation, play a key role in the fixation of heavy metals in the down stream dam sediments at mining area. 続きを見る
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田崎, 和江 ; 倉繁, 和也 ; Tazaki, Kazue ; Kurashige, Kazuya
出版情報: 地球科学 = Earth Science.  54  pp.287-297,  2000-09-25.  地学団体研究会 The Association for the Geological Collaboration in Japan
URL: http://hdl.handle.net/2297/00061695
概要: 金沢大学理工研究域地球社会基盤学系<br />北陸地方では泥漬け,つまり野菜を泥でつける食文化が伝承されている.本研究では,泥漬けで用いられる泥"赤ベト"の特性および漬け込むだナスの表皮が染色するメカニズムを明らかにした.数日間,赤ベトに漬 けたナスの表皮は鮮やかなコバルトブルーになる.一般に,赤褐色の泥の化学的特性は豊富な鉄によると認識されてきた.赤ベトには,粘土鉱物の他に,石英や長石などのケイ酸塩鉱物,鉄ミョウバン,そして水酸化鉄が含まれていた.これらの鉱物の含有量は各地域の泥により変化した.蒸留水,塩酸水溶液および溶液の水質(pH, Eh,EC,そしてDO)の変化を9日間測定したところ,酸性条件下で加水分解により鉄イオンが溶出することが示された.以上の結果から,加水分解によりナスの表皮がコバルトブルーに変色する現象は,ナスの主要な色素であるanthocyanやhyacinに関係していることが示唆される.<br />Abstract"Mud-Pickles" soaking vegetables has been handed down in Hokuriku District from generation to generation. The characteristics of the mud for soaking, and the mechanisms of dyeing eggplants in "Aka-beto" were revealed in this study. The eggplant kept in "Aka-beto" for few days exhibits brilliant cobalt blue. Chemical characteristics of the reddish brown-colored mud were commonly acknowledged as abundant Fe. "Aka-beto" contains silicate minerals such as quartz, feldspars, jarosite, and hydrated iron oxides, in addition to clay minerals. The content of these minerals was varied, depending on the local mud. Values of pH, Eh, EC and DO of the mud which added to distilled water, HCl and NaCl, were measured for 9 days respectively. The results indicated that ion leaching of Fe, occurred in acidic condition, due to hydrolysis. Accordingly, it is suggested that such a hydrolysis change of the color of eggplants into cobalt blue, in association with anthocyan and hyacin, major pigments of eggplant. 続きを見る
60.

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Kobayashi, Mio ; Kakuda, Yuko ; Harada, Kenichi ; Sato, Yasunori ; Sasaki, Motoko ; Ikeda, Hiroko ; Terada, Mitsuhiro ; Mukai, Munenori ; Kaneko, Shuichi ; Nakanuma, Yasuni ; 小林, 水緒 ; 原田, 憲一 ; 佐藤, 保則 ; 佐々木, 素子 ; 池田, 博子 ; 金子, 周一 ; 中沼, 安二
出版情報: World Journal of Gastroenterology.  20  pp.3597-3608,  2014.  Baishideng Publishing Group Co
URL: http://hdl.handle.net/2297/00061729
概要: 金沢大学医薬保健研究域医学系<br />AIM: To investigate histological and immunohistochemical differences in hepatitis between autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) with AIH features. METHODS: Liver needle biopsies of 41 PBC with AIH features and 43 AIH patients were examined. The activity of periportal and lobular inflammation was scored 0 (none or minimal activity) to 4 (severe), and the degree of hepatitic rosette formation and emperipolesis was semiquantatively scored 0-3. The infiltration of mononuclear cells positive for CD20, CD38, CD3, CD4, and CD8 and positive for immunoglobulins (IgG, IgM, and IgA) at the periportal areas (interface hepatitis) and in the hepatic lobules (lobular hepatitis) were semiquantitatively scored in immunostained liver sections (score 0-6). Serum aspartate aminotransferase (AST), immunoglobulins, and autoantibodies at the time of liver biopsy were correlated with the histological and immunohistochemical scores of individual lesions. RESULTS: Lobular hepatitis, hepatitic rosette formation, and emperipolesis were more extensive and frequent in AIH than in PBC. CD3+, CD4+, and CD8+ cell infiltration scores were higher in the hepatic lobules and at the interface in AIH but were also found in PBC. The degree of mononuclear cell infiltration correlated well with the degree of interface and lobular hepatitis in PBC, but to a lesser degree in AIH. CD20+ cells were mainly found in the portal tracts and, occasionally, at the interface in both diseases. Elevated AST correlated well with the hepatocyte necroinflammation and mononuclear cell infiltration, specifically CD38+ cells in PBC. No correlation existed between autoantibodies and inflammatory cell infiltration in PBC or AIH. While most AIH cases were IgG-predominant at the interface, PBC cases were divided into IgM-predominant, IgM/IgGequal, and IgG-predominant types, with the latter sharing several features with AIH. CONCLUSION: These results suggest that the hepatocellular injuries associated with interface and lobular hepatitis in AIH and PBC with interface hepatitis may not be identical. © 2014 Baishideng Publishing Group Co., Limited. All rights reserved. 続きを見る
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Okazaki, Mitsuyoshi ; Makino, Isamu ; Kitagawa, Hirohisa ; Nakanuma, Shinichi ; Hayashi, Hironori ; Nakagawara, Hisatoshi ; Miyashita, Tomoharu ; Tajima, Hidehiro ; Takamura, Hiroyuki ; Ohta, Tetsuo ; 岡崎, 充善 ; 牧野, 勇 ; 北川, 裕久 ; 中沼, 伸一 ; 林, 泰寛 ; 中川原, 寿俊 ; 宮下, 知治 ; 田島, 秀浩 ; 高村, 博之 ; 太田, 哲生
出版情報: World Journal of Gastroenterology.  20  pp.852-856,  2014.  Baishideng Publishing Group Co
URL: http://hdl.handle.net/2297/00061730
概要: 金沢大学医薬保健研究域医学系<br />We herein report a case of anaplastic carcinoma of the pancreas with remarkable intraductal tumor gr owth into the main pancreatic duct. A 76-year-old male was referred to our hospital for treatment of a pancreatic tumor. Preoperative examinations revealed a poorly defined tumor in the main pancreatic duct in the body of the pancreas, accompanied with severe dilatation of the main pancreatic duct, which was diagnosed as an intraductal papillary-mucinous neoplasm. We performed distal pancreatectomy and splenectomy. The pathological examination revealed that the tumor consisted of a mixture of anaplastic carcinoma (giant cell type) and adenocarcinoma in the pancreas. There was a papillary projecting tumor composed of anaplastic carcinoma in the dilated main pancreatic duct. The patient is now receiving chemotherapy because liver metastasis was detected 12 mo after surgery. In this case, we could observe a remarkable intraductal tumor growth into the main pancreatic duct. We also discuss the pathogenesis and characteristics of this rare tumor with specific tumor growth. © 2014 Baishideng Publishing Group Co., Limited. All rights reserved. 続きを見る
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Sato, Hirohide ; Sato, Yasunori ; Harada, Kenichi ; Sasaki, Motoko ; Hirano, Katsuyasu ; Nakanuma, Yasuni ; 佐藤, 保則 ; 原田, 憲一 ; 佐々木, 素子 ; 中沼, 安二
出版情報: World Journal of Gastroenterology.  19  pp.6125-6126,  2013.  Baishideng Publishing Group Co
URL: http://hdl.handle.net/2297/00061731
概要: 金沢大学医薬保健研究域医学系<br />A 77-year-old woman complained of epigastralgia, and a tumor (5 cm in diameter) of the gallbladder n eck was detected by image analysis. Following cholecystectomy, the tumor was pathologically diagnosed as intraductal papillary neoplasm (IPN), gastric type, with associated invasive carcinoma. About 10 mo later, intraluminal multiple masses (3 foci, up to 1.8 cm) were noted in the extrahepatic bile duct, and the resected specimen showed that all tumors had similar gross and microscopic features as seen in gallbladder IPN without invasion, and they were synchronous multiple lesions. This case showed a papillary tumor of the gallbladder of gastric phenotype, and confirmed that the gallbladder is a target of IPN in addition to the bile ducts. © 2013 Baishideng. All rights reserved. 続きを見る
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Onishi, Ichiro ; Kitagawa, Hirohisa ; Harada, Kenichi ; Maruzen, Syogo ; Sakai, Seisyo ; Makino, Isamu ; Hayashi, Hironori ; Nakagawara, Hisatoshi ; Tajima, Hidehiro ; Takamura, Hiroyuki ; Fujimura, Takashi ; Kayahara, Masato ; Ikeda, Hiroko ; Ohta, Tetsuo ; Nakanuma, Yasuni ; 北川, 裕久 ; 原田, 憲一 ; 牧野, 勇 ; 林, 泰寛 ; 中川原, 寿俊 ; 田島, 秀浩 ; 高村, 博之 ; 藤村, 隆 ; 萱原, 正都 ; 池田, 博子 ; 太田, 哲生 ; 中沼, 安二
出版情報: World Journal of Gastroenterology.  19  pp.3161-3164,  2013.  Baishideng Publishing Group Co
URL: http://hdl.handle.net/2297/00061732
概要: 金沢大学医薬保健研究域医学系<br />We present the first case of an intraductal papillary neoplasm of the bile duct (IPNB) accompanying a mixed adenoneuroendocrine carcinoma (MANEC). A 74-yearold woman presented with fever of unknown cause. Laboratory data revealed jaundice and liver injury. Contrast-enhanced computed tomography revealed a 20 mm polypoid tumor in the dilated distal bile duct, which exhibited early enhancement and papillary growth. Upper gastrointestinal endoscopy revealed mucus production from the papilla of Vater, characterized by its protruding and dilated orifice. Endoscopic ultrasonography visualized the polypoid tumor in the distal bile duct, but no invasive region was suggested by diagnostic imaging. Therefore, the initial diagnosis was IPNB. After endoscopic nasobiliary drainage, a pylorus-preserving pancreaticoduodenectomy was performed. Pathological examination of the resected bile duct revealed papillary proliferation of biliary-type cells with nuclear atypia, indicating pancreaticobiliary-type IPNB. In addition, solid portions comprised of tumor cells with characteristic salt-and-pepper nuclei were evident. Immunohistochemistry revealed expression of the neuroendocrine marker synaptophysin in this solid component, diagnosing it as a neuroendocrine tumor (NET). Furthermore, the MIB-1 proliferation index of NET was higher than that of IPNB, and microinvasion of the NET component was found, indicating neuroendocrine carcinoma (NET G3). This unique case of MANEC, comprising IPNB and NET, provides insight into the pathogenesis of biliary NET. © 2013 Baishideng. All rights reserved. 続きを見る
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Hattori, Yuki ; Gabata, Toshifumi ; Matsui, Osamu ; Mochizuki, Kentaro ; Kitagawa, Hirohisa ; Kayahara, Masato ; Ohta, Tetsuo ; Nakanuma, Yasuni ; 蒲田, 敏文 ; 松井, 修 ; 北川, 裕久 ; 萱原, 正都 ; 太田, 哲生 ; 中沼, 安二
出版情報: World Journal of Gastroenterology.  15  pp.3114-3121,  2009.  Baishideng Publishing Group Co
URL: http://hdl.handle.net/2297/00061733
概要: 金沢大学医薬保健研究域医学系<br />Aim: To evaluate retrospectively the correlation between enhancement patterns on dynamic computed to mography (CT) and angiogenesis and fibrosis in pancreatic adenocarcinoma. Methods: Twenty-three patients with pancreatic adenocarcinoma underwent dynamic CT and tumor resection. In addition to the absolute and relative enhanced value that was calculated by subtracting the attenuation value on pre-contrast from those on contrast-enhanced CT in each phase, we defined one parameter, "tumor-aorta enhancement ratio", which was calculated by dividing enhancement of pancreatic cancer by enhancement of abdominal aorta in each phase. These enhancement patterns were correlated with the level of vascular endothelial growth factor (VEGF), microvessel density (MVD), and extent of fibrosis. Results: The absolute enhanced value in the arterial phase correlated with the level of VEGF and MVD (P = 0.047, P = 0.001). The relative enhanced value in arterial phase and tumor-aorta enhancement ratio (arterial) correlated with MVD (P = 0.003, P = 0.022). Tumor-aorta enhancement ratio (arterial) correlated negatively with the extent of fibrosis (P = 0.004). The tumors with greater MVD and higher expression of VEGF tended to show high enhancement in the arterial dominant phase. On the other hand, the tumors with a larger amount of fibrosis showed a negative correlation with the grade of enhancement during the arterial phase. Conclusion: Enhancement patterns on dynamic CT correlated with angiogenesis and may be modified by the extent of fibrosis. © 2009 The WJG Press and Baishideng. All rights reserved. 続きを見る
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Sasaki, Motoko ; Araki, Ichiro ; Yasui, Toshiaki ; Kinoshita, Masaru ; Itatsu, Keita ; Nojima, Takayuki ; Nakanuma, Yasuni ; 佐々木, 素子 ; 野島, 孝之 ; 中沼, 安二
出版情報: World Journal of Gastroenterology.  15  pp.615-621,  2009.  Baishideng Publishing Group Co
URL: http://hdl.handle.net/2297/00061734
概要: 金沢大学医薬保健研究域医学系<br />We report a case of primary localized malignant biphasic mesothelioma of the liver in a 66-year-old man associated with asbestosis. The tumor was detected as a hepatic nodule, 4 cm in diameter, in the right lobe (S8 segment) on CT scan. Histopathological examination demonstrated an intrahepatic tumor with central necrosis consisting of a papillary epithelioid pattern on the surface of the liver, microcystic (microglandular or adenomatoid) pattern mainly in the subcapsular area and sarcomatoid pattern intermingled with microcystic pattern in the major part of the hepatic nodular tumor. Tumor cells, especially of epithelioid type, showed distinct immunoreactivity for mesothelial markers (WT-1, calretinin, D2-40, CK5/6, mesothelin, thrombomodulin) and no immunoreactivity for epithelial (adenocarcinoma) markers (CEA, CD15, BerEP4, BG8, MOC31). P53 immunoreactivity was detected focally in papillary epithelioid tumor cells and extensively in microcystic and sarcomatoid components, suggesting that the papillary epithelioid mesothelioma arose on the surface of the liver, and tumor cells showing microcystic and sarcomatoid patterns invaded and grew into the liver. To date, this is the first case of primary localized malignant biphasic mesothelioma of the liver, since all three primary hepatic mesotheliomas reported so far were epithelioid type. © 2009 The WJG Press and Baishideng. All rights reserved. 続きを見る
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Yoshikawa, Seiichi ; Zen, Yoh ; Fujii, Takahiko ; Sato, Yasunori ; Ohta, Tetsuo ; Aoyagi, Yutaka ; Nakanuma, Yasuni ; 全, 陽 ; 佐藤, 保則 ; 太田, 哲生 ; 中沼, 安二
出版情報: World Journal of Gastroenterology.  15  pp.4896-4906,  2009.  Baishideng Publishing Group Co
URL: http://hdl.handle.net/2297/00061735
概要: 金沢大学医薬保健研究域医学系<br />AIM: To reveal the characteristics of CD133+ cells in the liver. METHODS: This study examined the hi stological characteristics of CD133 + cells in non-neoplastic and neoplastic liver tissues by immunostaining, and also analyzed the biological characteristics of CD133 + cells derived from human hepatocellular carcinoma (HCC) or cholangiocarcinoma cell lines. RESULTS: Immunostaining revealed constant expression of CD133 in non-neoplastic and neoplastic biliary epithelium, and these cells had the immunophenotype CD133+/CK19+/HepPar -1-. A smal l number of CD133+/CK19-/HepPar-1+ cells were also identified in HCC and combined hepatocellular and cholangiocarcinoma. In addition, small ductal structures, resembling the canal of Hering, partly surrounded by hepatocytes were positive for CD133. CD133 expression was observed in three HCC (HuH7, PLC5 and HepG2) and two cholangiocarcinoma cell lines (HuCCT1 and CCKS1). Fluorescence-activated cell sorting (FACS) revealed that CD133+ and CD133-cells derived from HuH7 and HuCCT1 cells similarly produced CD133+ and CD133- cells during subculture. To examine the relationship between CD133+ cells and the side population (SP) phenotype, FACS was performed using Hoechst 33342 and a monoclonal antibody against CD133. The ratios of CD133+/CD133-cells were almost identical in the SP and non-SP in HuH7. In addition, four different cellular populations (SP/CD133+, SP/CD133-, non-SP/CD133+, and non-SP/CD133-) could similarly produce CD133+ and CD133- cells during subculture. CONCLUSION: This study revealed that CD133 could be a biliary and progenitor cell marker in vivo. However, CD133 alone is not sufficient to detect tumor-initiating cells in cell lines. © 2009 The WJG Press and Baishideng. All rights reserved. 続きを見る
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Fujimura, Takashi ; Ohta, Tetsuo ; Oyama, Katsunobu ; Miyashita, Tomoharu ; Miwa, Koichi ; 藤村, 隆 ; 太田, 哲生 ; 尾山, 勝信 ; 宮下, 知治 ; 三輪, 晃一
出版情報: World Journal of Gastroenterology.  12  pp.1336-1345,  2006.  Baishideng Publishing Group Co
URL: http://hdl.handle.net/2297/00061736
概要: 金沢大学医薬保健研究域医学系<br />Selective cyclooxygenase (COX)-2 inhibitors (coxibs) were developed as one of the anti-inflammatory drugs to avoid the various side effects of non-steroidal anti-inflammatory drugs (NSAIDs). However, coxibs also have an ability to inhibit tumor development of various kinds the same way that NSAIDs do. Many experimental studies using cell lines and animal models demonstrated an ability to prevent tumor proliferation of COX-2 inhibitors. After performing a randomized study for polyp chemoprevention study in patients with familial adenomatous polyposis (FAP), which showed that the treatment with celecoxib, one of the coxibs, significantly reduced the number of colorectal polyps in 2000, the U.S. Food and Drug Administration (FDA) immediately approved the clinical use of celecoxib for FAP patients. However, some coxibs were recently reported to increase the risk of serious cardiovascular events including heart attack and stroke. In this article we review a role of COX-2 in carcinogenesis of gastrointestinal tract, such as the esophagus, stomach and colorectum, and also analyze the prospect of coxibs for chemoprevention of gastrointestinal tract tumors. © 2006 The WJG Press. All rights reserved. 続きを見る
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捶井, 達也 ; 小田, 誠 ; 田村, 昌也 ; 早稲田, 龍一 ; 松本, 勲 ; 渡邊, 剛 ; Tarui, Tatsuya ; Oda, Makoto ; Tamura, Masaya ; Waseda, Ryuichi ; Matsumoto, Isao ; Watanabe, Go
出版情報: 日本呼吸器外科学会雑誌 = The journal of the Japanese association for chest surgery.  25  pp.505-508,  2011-07-15.  日本呼吸器外科学会 Japanese Association for Chest Surgery
URL: http://hdl.handle.net/2297/00061738
概要: 金沢大学医薬保健研究域医学系<br />症例は32歳,女性.乳房痛を自覚し,精査のため胸部造影CTを施行したところ後縦隔に均一な造影効果を伴う径3.1cmの腫瘤を認めた.右上肢からの静脈造影では造影剤が上大静脈から奇静脈弓へ逆行性に流入し, 腫瘤が濃染した.これにより腫瘤を静脈瘤と診断した.血栓による肺血栓塞栓症や瘤の破裂の可能性を考え外科的切除の方針とした.手術は胸腔鏡下にて施行した.まず血栓の流出を防止するため奇静脈弓の上大静脈合流部を自動縫合器にて切離した.次に瘤に流入する肋間静脈と奇静脈本幹を結紮,切離し,血行を遮断したのち瘤を切除した.術後合併症はなく10日目に退院した.<br />The patient was a 32-year-old female with a chief complaint of mastodynia. A computed tomography (CT) scan incidentally presented a homogeneously enhanced tumor, 3.1 cm in diameter, in the posterior mediastinum. Venography by the right brachial vein showed retrograde flow from the superior vena cava to azygos vein in the early phase. In the delayed phase, pooling of contrast medium in the tumor was observed. Based on the above findings, the tumor was diagnosed as an azygos vein aneurysm. She underwent aneurysm resection under video-assisted thoracic surgery (VATS) due to the risk of pulmonary thrombosis and rupture of the aneurysm. Initially, the proximal end of the azygos vein was resected due to the risk of pulmonary embolism, and, then, three intercostal veins and the distal end of the azygos vein were resected. Finally, after complete blockage of the azygos vein, the aneurysm was resected. The patient followed an uneventful postoperative course, and was discharged on the 10th postoperative day without complication. 続きを見る
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古山, 和憲 ; 松本, 勲 ; 吉田, 周平 ; 懸川, 誠一 ; 竹村, 博文 ; Koyama, Kazunori ; Matsumoto, Isao ; Yoshida, Shunhei ; Kakegawa, Seichi ; Takemura, Hirofumi
出版情報: 日本呼吸器外科学会雑誌 = The journal of the Japanese association for chest surgery.  33  pp.-52-57,  2019-01-15.  日本呼吸器外科学会 Japanese Association for Chest Surgery
URL: http://hdl.handle.net/2297/00061744
概要: 金沢大学医薬保健研究域医学系<br />症例は49歳,男性.髄膜炎様症状のため当院神経内科へ紹介となった.胸部CTで左肺上葉肺門部に大きさ2.1 cmの不整形結節を認め,気管支鏡検査を行ったが確定診断に至らなかった.肺癌も否定できない画像所 見のため外科的肺生検目的に当科紹介となった.手術は左肺上葉切除術を施行し,病理学的診断で肺クリプトコッカス症と診断された.術前の髄液検査ではクリプトコッカス抗原,培養検査ともに陰性であったが,術前の保存血液検体からクリプトコッカス抗原が検出されたため,髄膜炎様症状もクリプトコッカス症に伴うものと考え,抗真菌薬による治療を行った.症状は速やかに改善し,術後2年の現在,再発なく経過している.肺クリプトコッカス症は画像所見だけでは鑑別が難しく,診断に難渋する場合が多いが,切除生検が診断に有用であると考えられた.<br />A 49-year-old man was admitted to the Department of Neurological and Internal Medicine of our hospital with mild fever and headache, suggestive of meningitis. Computed tomography (CT) showed an approximately 2.1-cm- diameter nodule in the hilum of the left lung. He underwent bronchoscopy, but no diagnosis was made. Because the CT image led to a suspicion of lung cancer, he was referred to our department for diagnosis by therapeutic resection. Left upper lobectomy was performed. Histopathological examination of the resected specimen resulted in a diagnosis of pulmonary cryptococcosis. His cerebrospinal fluid (CSF) was negative for cryptococcal antigen and Cryptococcus neoformans was not grown on mycological culture of the CSF. However, a preserved preoperative blood sample was positive for cryptococcal antigen. Thus, cryptococcal meningitis was diagnosed and he was treated with antifungal therapy, which resulted in marked improvement of his fever and headache. There was no recurrence during the following 2 years. It is difficult to diagnose pulmonary cryptococcosis because the imaging findings vary markedly. We present a patient with pulmonary cryptococcosis diagnosed by resection of the affected lobe of the lung. 続きを見る
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西田, 沙貴 ; 小田, 誠 ; 松本, 勲 ; 田村, 昌也 ; 早稲田, 龍一 ; 渡邊, 剛 ; Nishida, Saki ; Oda, Makoto ; Matsumoto, Isao ; Tamura, Masaya ; Waseda, Ryuichi ; Watanabe, Go
出版情報: 日本呼吸器外科学会雑誌 = The journal of the Japanese association for chest surgery.  25  pp.418-423,  2011-05-15.  日本呼吸器外科学会 Japanese Association for Chest Surgery
URL: http://hdl.handle.net/2297/00061745
概要: 金沢大学医薬保健研究域医学系<br />症例は59歳,女性.3年前に子宮体癌を疑われ準広汎子宮全摘術,S状結腸切除術を施行された.病理診断および精査の結果,原発性肺腺癌の腹腔内転移と診断された.その後の経過で,計6レジメンの化学療法と計10 0Gyの放射線治療が施行された.転移巣の制御は良好であったが,原発巣の増大傾向を認めたため,手術目的に当科紹介となった.手術は,肺門部において,肺動脈および上葉気管支と周囲組織との強固な癒着を認めたため,これらを一括して鉗子にてクランプした後に切離し,断端を3-0vicryl糸にて縫合して閉鎖した.断端は有茎傍心膜脂肪織にて被覆した.術後の病理診断で,低分化肺腺癌と診断された.術後さらに補助化学療法を追加し,術後9ヵ月間再発転移は認めていない.高容量化学放射線療法による炎症にて肺門部の処理が困難な症例に対しては,肺門部一括処理および有茎傍心膜脂肪織による気管支・肺動脈切離断端の被覆が有用であると考える.<br />A 59-year-old female was referred to our hospital for stage IV (cT3N2M1b) adenocarcinoma of the right lung. At the age of 56, at another hospital, she had undergone extended hysterectomy and resection of the sigmoid colon for suspected endometrial carcinoma and had received a diagnosis of lung adenocarcinoma based on pathological findings, a CT scan, and other examinations. A total of six regimens of chemotherapy and radiotherapy with a total dose of 100 Gy had been performed over 3 years, but it was resistant. Therefore, she was referred to our hospital to consider surgical treatment. We performed a right upper lobectomy because the tumor was localized and no other metastatic lesion was found. We ablated the tumor from the chest wall because it grew to the apical chest wall. In the hilum of the lung, individual ligation and closure of the pulmonary vessels and bronchus was found to be impossible because they tightly adhered to the peripheral tissue. Therefore, the hilar vessels and bronchus were clamped and cut in one mass. Their stumps were oversewn with 3-0 vicryl and covered with a pedicled pericardial flap. The post operative course was favorable, and the patient underwent adjuvant chemotherapy at the hospital that had originally referred her to us. She was free of clinically evident recurrence 9 months after treatment. We suggest that the mass closure of the hilar vessels and bronchus and covering the stumps with a pedicled pericardial flap are useful for cases in which it is difficult to individually close the vessels and bronchus due to ligneous scarring caused by radiation. 続きを見る
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中沼, 伸一 ; 萱原, 正都 ; 中川原, 寿俊 ; 伊藤, 博 ; 田島, 秀浩 ; 藤田, 秀人 ; 北川, 裕久 ; 藤村, 隆 ; 太田, 哲生 ; Nakanuma, Shinichi ; Kayahara, Masato ; Nakagawara, Hisatoshi ; Ito, Hiroshi ; Tajima, Hidehiro ; Fujita, Hideto ; Kitagawa, Hirohisa ; Fujimura, Takashi ; Ohta, Tetsuo
出版情報: 日本消化器外科学会雑誌 = The Japanese Journal of Gastroenterological Surgery.  43  pp.55-60,  2010-01-01.  日本消化器外科学会, The Japanese Society of Gastroenterological Surgery
URL: http://hdl.handle.net/2297/00061859
概要: 金沢大学附属病院肝胆膵・移植外科<br />症例は30歳の男性で,体重120 kg,BMI 41の高度肥満であった.重症急性膵炎と診断され当院に紹介された.CTでは両側胸水,膵実質の不明瞭化,後腎傍腔に及ぶ滲出液が認められた(Grade I V).また,SIRS,急性循環不全の状態であった.入院後4病日,炎症反応の持続とCTにて膵頭部の血流障害が認められ,感染性膵壊死と判断し,necrosectomyを行った.腸管・組織浮腫のため,閉腹によるabdominal compartment syndromeが危ぐされたため,術後zipper techniqueとして衣類圧縮用袋を腹壁に固定し,腹腔内洗浄を伴うplanned necrosectomyを継続し,残存膵壊死組織の除去を行った.退院1年目の現在,患者は職場復帰している.衣類圧縮用袋を用いたzipper techniqueは高度肥満を有する感染性膵壊死の術後に有用な処置と考えられ若干の文献を加え報告する.<br />A severely obese 30-year-old male (BMI 41) weighing 120 kg and referred based on a diagnosis of severe acute pancreatitis was found in computed tomography (CT) to have bilateral hydrothorax, unclear pancreatic parenchyma, and exudate spreading to the posterior pararenal spacer (Grade IV). He also had SIRS and acute circulatory failure. On hospital day 4, persistent inflammatory reactions and a CT finding of pancreatic-head necrosis were noted. Based on a diagnosis of infectious pancreatic necrosis, he underwent necrosectomy. It was difficult to close the abdominal wall because of intestinal and tissue edema. Postoperatively, we attached a vacuum storage bag to the abdominal wall by a zipper. The planned necrosectomy, accompanied by intraperitoneal lavage, was continued to remove residual pancreatic necrotic tissue. No sign of abdominal compartment syndrome was noted. The patient has been discharged and resumed his previous work. The zipper technique and vacuum storage bag thus proved useful in providing postoperative care to a patient with infectious pancreatic necrosis accompanied by severe obesity. 続きを見る
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Nakanuma, Shinichi ; Miyashita, Tomoharu ; Hayashi, Hironori ; Tajima, Hidehiro ; Takamura, Hiroyuki ; Makino, Isamu ; Oyama, Katsunobu ; Nakagawara, Hisatoshi ; Fushida, Sachio ; Ohta, Tetsuo ; 中沼, 伸一 ; 宮下, 知治 ; 高村, 博之 ; 林, 泰寛 ; 田島, 秀浩 ; 牧野, 勇 ; 尾山, 勝信 ; 中川原, 寿俊 ; 伏田, 幸夫 ; 太田, 哲生
出版情報: Experimental and Clinical Transplantation.  13  pp.556-562,  2015-12.  Baskent University, Publishers / The Middle East Society for Organ Transplantation (MESOT)
URL: http://hdl.handle.net/2297/00061860
概要: 金沢大学附属病院肝胆膵・移植外科<br />Objectives: Continuous thrombocytopenia after liver transplant is associated with a less favorable prognosis, but this pathogenesis remains unclear. We focused on the consumption of platelets in the allograft. We assessed platelet consumption in allografts, and evaluated the pathology of platelet aggregation in an allograft tissue and its involve-ment in clinical outcomes.Materials and Methods: We took biopsy specimens from 20 patients. To examine the localization of platelet aggregation, CD42b was assayed immuno-histochemically, and its level of expression correlated with clinical data and outcomes.Results: Platelet aggregation in zone 3 was 70%, compared with 30% in zone 1 and 50% in zone 2. Platelets were found mainly as extravasated platelet aggregates in local microenvironments. Patients were stratified according to the extent of extravasated platelet aggregates in zone 3 into extravasated platelet aggregate-negative and -positive groups. Graft weight/recipient body weight ratio with the extravasated platelet aggregate-positive group was significantly lower than that of the extravasated platelet aggregate-negative group. Platelet count after surgery was lower, while total bilirubin and prothrombin time/international normalized ratio were higher in the extravasated platelet aggregate-positive than they were in the extravasated platelet aggregate-negative group.Conclusions: Extravasated platelet aggregates in the zone 3 of allograft tissue cause the consumption of platelets and continuous thrombocytopenia after transplant, and may be the clinical marker for deterioration of graft function. Platelet activation and degranulation following the release by platelets of some negative regulators may be involved partially in liver damage. 続きを見る
73.

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Nakanuma, Shinichi ; Takamura, Hiroyuki ; Shoji, Masatoshi ; Hayashi, Hironori ; Tajima, Hidehiro ; Nakagawara, Hisatoshi ; Miyashita, Tomoharu ; Kitagawa, Hirohisa ; Tani, Takashi ; Ohta, Tetsuo ; 中沼, 伸一 ; 高村, 博之 ; 林, 泰寛 ; 田島, 秀浩 ; 中川原, 寿俊 ; 宮下, 知治 ; 北川, 裕久 ; 太田, 哲生
出版情報: Experimental and Clinical Transplantation.  13  pp.479-481,  2014-09-19.  Baskent University, Publishers / The Middle East Society for Organ Transplantation (MESOT)
URL: http://hdl.handle.net/2297/00061888
概要: 金沢大学附属病院肝胆膵・移植外科<br />Liver transplant is a treatment for familial amyloid polyneuropathy. Few cases of ABO-incompatible living-donor liver transplant for familial amyloid polyneuropathy exist. The outcome of an ABO-incompatible living-donor liver transplant has improved recently, using local infusion therapy and rituximab prophylaxis. Here, we describe a successful ABO-incompatible living-donor liver transplant in a patient with familial amyloid polyneuropathy in whom disease progression ceased at 2 years’ follow-up. Additionally, no evidence of acute or chronic rejection, or adverse events of the immuno-suppressive therapy, was seen. As a postoperative complication, fatty changes in the grafted liver because of malnutrition or adverse events of corticosteroids were confirmed by a liver biopsy taken early after transplant. The main cause of malnutrition was considered to be gastrointestinal dysfunction caused by familial amyloid poly-neuropathy. Therefore, before deterioration of digestive function, liver transplants should be considered for familial amyloid polyneuropathy. This case suggests that an ABO-incompatible living-donor liver transplant may provide greater opportunities for familial amyloid polyneuropathy patients. 続きを見る
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中沼, 伸一 ; 森, 和弘 ; 岩田, 啓子 ; 経田, 淳 ; 佐藤, 就厚 ; 安居, 利晃 ; Nakanuma, Shinichi ; Mori, Kazuhiro ; Iwata, Keiko ; Tsuneda, Atsushi ; Sato, Nariatsu ; Yasui, Toshiaki
出版情報: 日本内視鏡外科学会雑誌 = Journal of Japan Society for Endoscopic Surgery.  17  pp.491-497,  2012-08.  日本内視鏡外科学会 Japan Society for Endoscopic Surgery (JSES)
URL: http://hdl.handle.net/2297/00061889
概要: 金沢大学附属病院肝胆膵・移植外科<br />患者は70 歳,男性.腹部食道癌に対して胸腔鏡下食道亜全摘,胸骨後胃管再建,頸部吻合を施行した.第2 病日に右胸腔ドレーンより腸液色の排液を認め,CT,上部消化管透視にて胃管穿孔と診断し,再手術を 行った.頸部吻合より肛門側約10 cm に胃管穿孔を認めた.胃管切除は手術侵襲が大きいと判断し,消化管内視鏡の先端を穿孔部へ通し,把持鉗子を腹腔内に進め,大網を把持して胃管内まで吊上げ,クリップにて胃壁に固定した.再手術後,ドレーン排液量は漸減し,穿孔部は再生組織に覆われた.食道癌術後胃管穿孔に対して胃管切除が選択できない場合,穿孔部の大網被覆と穿孔部周囲のドレナージは有効な場合もあると考えられたため,若干の考察を加えて報告する.<br />A 70 -year-old man underwent retrosternal gastric tube reconstruction following subtotal esophagectomyfor advanced abdominal esophageal cancer. On the second post-operative day, drained fluid changed to intestinaljuice. Computed tomography and gastrointestinal fluoroscopy showed perforation of the gastric tube. Wethen performed emergency surgery, and laparotomy was redone. During surgery, gastrointestinal endoscopydemonstrated gastric tube perforation at 10 cm from the anastomosis of stomach to cervical esophagus. Itwas too invasive to perform the resection of gastric tube, so we pulled the greater omentum into the stomachthrough the perforation site and fastened with clips( omental patch method). The drainage then graduallydecreased, and the perforation healed with regenerating epithelium. The omental patch method and drainageproved useful to treat gastric tube perforation following esophagectomy, and should be considered if resectionof the gastric tube is difficult. 続きを見る
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Saito, Motonobu ; Goto, Akiteru ; Abe, Noriko ; Saito, Katsuharu ; Maeda, Daichi ; Ohtake, Tohru ; Murakami, Yoshinori ; Takenoshita, Seiichi ; 前田, 大地
出版情報: Oncology Letters.  15  pp.2401-2406,  2017-12-06.  Spandidos Publications
URL: http://hdl.handle.net/2297/00062676
概要: 金沢大学医薬保健研究域医学系<br />Cell adhesion molecule (CADM) genes encode immunoglobulin superfamily molecules, which are involved in cell-cell adhesion in a number of human epithelia. Through the maintenance of epithelia, CADM genes protect against malignant conversion and metastasis. Whilst numerous in vitro studies have investigated the molecular characteristics of CADM1 and CADM4 and in vivo studies have investigated CADM1 and CADM4 expression in a number of tumor types, the roles of CADM1 and CADM4 have yet to be elucidated. Therefore, in the present study, CADM1 and CADM4 expression levels were evaluated using immunohistochemistry staining in 208 patients with breast cancer and compared with clinicopathological factors. CADM1 and CADM4 expression levels were negative in 160 (76.9%) and 166 (79.8%) of the 208 cases, respectively. The lack of expression in these cases was associated with advanced tumor stage, suggesting that inactivation of CADM1 and CADM4 promotes breast cancer development. The prognostic role of CADM1 and CADM4 in breast cancer was also evaluated and the expression of CADM1 and CADM4 were not associated with cancer-specific survival or overall survival rate in the cohort of patients in the present study. Whilst these results suggested that CADM1 and CADM4 possess tumor suppressive roles, further functional experiments are required to address the important mechanisms involving CADM1 and CADM4. © 2018, Spandidos Publications. All rights reserved. 続きを見る
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Ikeda, Yuji ; Oda, Katsutoshi ; Hiraike-Wada, Osamu ; Koso, Takahiro ; Miyasaka, Aki ; Kashiyama, Tomoko ; Tanikawa, Michihiro ; Sone, Kenbun ; Nagasaka, Kazunori ; Maeda, Daichi ; Kawana, Kei ; Nakagawa, Shunsuke ; Fukayama, Masashi ; Tetsu, Osamu ; Fujii, Tomoyuki ; Yano, Tetsu ; Kozuma, Shiro ; 前田, 大地
出版情報: Oncology Reports.  30  pp.584-588,  2013-06-03.  Spandidos Publications
URL: http://hdl.handle.net/2297/00062677
概要: 金沢大学医薬保健研究域医学系<br />Cyclin D1 is an important regulator of cell cycle progression. Phosphorylation of cyclin D1 at Thr28 6 by GSK3β triggers its nuclear export and cytoplasmic proteolysis via the 26S proteasome. Cyclin D1 overexpression is a common event in various types of human cancers; however, reports of mutations are extremely rare. We analyzed mutations of the cyclin D1 gene, CCND1, in 88 endometrial cancer tissue specimens and detected mutations in 2 cases (2.3%). Both were unreported mutations with substitution of threonine to isoleucine at codon 286 (T286I). These two tumors harbored coexisting mutations in K-ras, PIK3CA and/or PTEN and showed accumulation of cyclin D1 in the nucleus by immunohistochemistry. Furthermore, we analyzed the functions of mutant cyclin D1 (T286I) by luciferase assays, immunofluorescence, western blotting and clonogenic cell survival assays in HEK-293T cells. We found that exogenous mutant cyclin D1 (T286I) accumulated in the nuclei in HEK-293T cells, and that it inhibited the expression of pRb. Additionally, the number of colonies was increased by introduction of mutant cyclin D1 (T286I) compared to that of wild-type cyclin D1. In conclusion, we identified an unreported CCND1 mutation (T286I) in two endometrial cancers and revealed that the mutation was functional for inducing cell proliferation in human cells. 続きを見る
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Ohmatsu, Hanako ; Sugaya, Makoto ; Fujita, Hideki ; Miyagaki, Tomomitsu ; Kadono, Takafumi ; Maeda, Daichi ; Takazawa, Yutaka ; Fukayama, Masashi ; Tamaki, Kunihiko ; Sato, Shinichi ; 前田, 大地
出版情報: Acta Dermato-Venereologica.  90  pp.324-325,  2010.  Society for Publication of Acta Dermato-Venereologica
URL: http://hdl.handle.net/2297/00062678
概要: 金沢大学医薬保健研究域医学系
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Suzuki, Kensuke ; Nagasaka, Kazunori ; Oda, Katsutoshi ; abe, Hiroyuki ; Maeda, Daichi ; Matsumoto, Yoko ; Arimoto, Takahide ; Kawana, Kei ; Fukayama, Masashi ; Osuga, Yutaka ; Fujii, Tomoyuki ; 前田, 大地
出版情報: BMC Cancer.  16  pp.390-,  2016-07-04.  BioMed Central Ltd.
URL: http://hdl.handle.net/2297/00062679
概要: 金沢大学医薬保健研究域医学系<br />Background: Lymphangioleiomyomatosis (LAM) is a rare idiopathic disorder that occurs in women of chi ldbearing age, and consists of a diffuse proliferation of abnormal smooth muscle cells along the thoracic and abdominal lymphogenous route. Case presentation: We experienced a case of a 47-yo woman with recent history of systemic lupus erythematosus (SLE) diagnosed with endometrial cancer, initially suspected to have metastasized to pelvic and para-aortic lymph nodes based on preoperative diagnostic imaging. Subsequent pathological diagnosis revealed stage IB endometrial cancer without evidence of lymph node involvement. Instead, enlarged pelvic and para-aortic lymph nodes were found to be due to extrapulmonary LAM, from a primary lesion found inside the uterine myometrium. SLE improved after surgery. Conclusion: This is the first reported case of comorbid endometrial cancer, SLE, and aggressive LAM metastasizing to regional lymph nodes, and strengthens the clinical evidence for a common role of mTOR pathway hyperactivity and estrogen responsiveness in the pathophysiology of metastasizing lesions of the genital tract. © 2016 The Author(s). 続きを見る
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Seiki, Takayuki ; Nagasaka, Kazunori ; Kranjec, Christian ; Kawana, Kei ; Maeda, Daichi ; Nakamura, Hiroe ; Taguchi, Ayumi ; Matsumoto, Yoko ; Arimoto, Takahide ; Wada-Hiraike, Osamu ; Oda, Katsutoshi ; Nakagawa, Shunsuke ; Yano, Tetsu ; Fukayama, Masashi ; Banks, Lawrence ; Osuga, Yutaka ; Fujii, Tomoyuki ; 前田, 大地
出版情報: BMC Cancer.  15  pp.230-,  2015-04-07.  BioMed Central Ltd.
URL: http://hdl.handle.net/2297/00062680
概要: 金沢大学医薬保健研究域医学系<br />Background: The high risk Human Papillomavirus (HPV) E6 oncoproteins play an essential role in the d evelopment of cervical malignancy. Important cellular targets of E6 include p53 and the PDZ domain containing substrates such as hScrib and Dlg. We recently showed that hScrib activity was mediated in part through recruitment of protein phosphatase 1γ (PP1γ). Methods: Expression patterns of hScrib and PP1γ were assessed by immunohistochemistry of HPV-16 positive cervical intraepithelial neoplasm (CIN), classified as CIN1 (n=4), CIN2 (n=8), CIN3 (n=8), cervical carcinoma tissues (n=11), and HPV-negative cervical tissues (n=8), as well as by subfractionation assay of the HPV-16 positive cervical cancer cell lines, CaSki and SiHa. To explore the effects of the HPV-16 oncoproteins, we have performed siRNA knockdown of E6/E7 expression, and monitored the effects on the expression patterns of hScrib and PP1γ. Results: We show that PP1γ levels in HPV-16 positive tumour cells are reduced in an E6/E7 dependent manner. Residual PP1γ in these cells is found mostly in the cytoplasm as opposed to the nucleus where it is predominantly found in normal cells. We have found a striking concordance with redistribution in the pattern of expression (9/11; 81.8%) and loss of PP1γ expression in HPV-16 positive cervical tumours (2/11; 18.2%). Furthermore, this loss of PP1γ expression and redistribution in the pattern of expression occurs progressively as the lesions develop (8/8; 100%). Conclusion: Together, these results suggest that PP1γ may be a novel target of the HPV-16 oncoproteins and indicate that it might be a potential novel biomarker for HPV-16 induced malignancy. © Seiki et al. 続きを見る
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Oda, Katsutoshi ; Ikeda, Yuji ; Maeda, Daichi ; Arimoto, Takahide ; Kawana, Kei ; Fukayama, Masashi ; Osuga, Yutaka ; Fujii, Tomoyuki ; 前田, 大地
出版情報: BMC Women's Health.  14  pp.104-,  2014-09-03.  BMC
URL: http://hdl.handle.net/2297/00062682
概要: 金沢大学医薬保健研究域医学系<br />Background: Surgical site infections are potential complications following open myomectomy. These in fections usually develop immediately after the surgery, and are most often located in the myometrium. Pyogenic cervical cysts are rare and have not been previously reported to occur at the site of myomectomy.Case presentation: A 41-year-old nulligravida Japanese woman was referred to our hospital with a large cervical cyst (>15 cm in diameter). She had undergone a myomectomy 13 years previously, and the surgical site had extended to the endocervical gland. Standard blood tests did not show any evidence of inflammation. The patient underwent a total abdominal hysterectomy, which revealed that the cyst contained multiple components, including Escherichia coli, old blood, and evidence of endometriosis. A pathological review did not show malignant cells within the cyst. The pyogenic cyst originated from the upper anterior cervix, which was one of the sites involved in the previous myomectomy.Conclusion: We reported a huge pyogenic cervical cyst exhibiting signs of endometriosis, in the vicinity of the uterine scar from the open myomectomy. The previous surgery and endometriosis might have contributed to the formation of this rare pyogenic cyst. © 2014 Oda et al.; licensee BioMed Central Ltd. 続きを見る
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Inoue, Tomoko ; Oda, Katsutoshi ; Arimoto, Takahide ; Samejima, Taiki ; Takazawa, Yutaka ; Maeda, Daichi ; Fukayama, Masashi ; Kawana, Kei ; Osuga, Yutaka ; Fujii, Tomoyuki ; 前田, 大地
出版情報: BMC Women's Health.  14  pp.82-,  2014-07-15.  BMC
URL: http://hdl.handle.net/2297/00062683
概要: 金沢大学医薬保健研究域医学系<br />Background: Xanthogranulomatous inflammation is an uncommon form of chronic inflammation that is des tructive to the normal tissue of affected organs. Although xanthogranulomatous endometritis and xanthogranulomatous salpingitis of the female genital tract has been described previously, to the best of our knowledge, this is the first report of xanthogranulomatous inflammation with infiltration into the uterine myometrium from the perimetrium without endometritis.Case presentation: A 68-year-old Japanese woman with intermittent lower abdominal pain and low-grade fever who was initially treated with antibiotics underwent hysterectomy due to abscess formation in the posterior wall of the myometrium and perimetrium (the outer serosal layer of the uterus). Histopathological findings revealed that the abscess was caused by xanthogranulomatous inflammation with the granulation tissue and chronic inflammatory cells that consisted of focal and sheets of foam cells. The inflammation destroyed the perimetrial elastic lamina, and the myometrium was deeply infiltrated by the xanthoma cells. Neither endometritis nor salpingitis was coexistent with the xanthogranulomatous inflammation.Conclusion: The patient was diagnosed as xanthogranulomatous inflammation, most likely arising from the perimetrium. Our findings suggest that the perimetrium, as well as the endometrium and adnexae, is one of the origins of xanthogranulomatous inflammation in female genital tract. © 2014 Inoue et al.; licensee BioMed Central Ltd. 続きを見る
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Matsumoto, Yoko ; Miyamoto, Yuichiro ; Cabral, Horacio ; Matsumoto, Yu ; Nagasaka, Kazunori ; Nakagawa, Shunsuke ; Yano, Tetsu ; Maeda, Daichi ; Oda, Katsutoshi ; Kawana, Kei ; Nishiyama, Nobuhiro ; Kataoka, Kazunori ; Fujii, Tomoyuki ; 前田, 大地
出版情報: Cancer Science.  107  pp.773-781,  2016-06-10.  Japanese Cancer Association 日本癌学会 / Wiley Open Access
URL: http://hdl.handle.net/2297/00062684
概要: 金沢大学医薬保健研究域医学系<br />Treatment of recurrent or advanced cervical cancer is still limited, and new therapeutic choices are needed for improving prognosis and quality of life of patients. Because human papilloma virus (HPV) infection is critical in cervical carcinogenesis, with the E6 and E7 oncogenes of HPV degrading tumor suppressor proteins through the ubiquitin proteasome system, the inhibition of the ubiquitin proteasome system appears to be an ideal target to suppress the growth of cervical tumors. Herein, we focused on the ubiquitin proteasome inhibitor MG132 (carbobenzoxy-Leu-Leu-leucinal) as an anticancer agent against cervical cancer cells, and physically incorporated it into micellar nanomedicines for achieving selective delivery to solid tumors and improving its in vivo efficacy. These MG132-loaded polymeric micelles (MG132/m) showed strong tumor inhibitory in vivo effect against HPV-positive tumors from HeLa and CaSki cells, and even in HPV-negative tumors from C33A cells. Repeated injection of MG132/m showed no significant toxicity to mice under analysis by weight change or histopathology. Moreover, the tumors treated with MG132/m showed higher levels of tumor suppressing proteins, hScrib and p53, as well as apoptotic degree, than tumors treated with free MG132. This enhanced efficacy of MG132/m was attributed to their prolonged circulation in the bloodstream, which allowed their gradual extravasation and penetration within the tumor tissue, as determined by intravital microscopy. These results support the use of MG132 incorporated into polymeric micelles as a safe and effective therapeutic strategy against cervical tumors. © 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. 続きを見る
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Nishimura, Riki ; Takita, Junko ; Sato-Otsubo, Aiko ; Kato, Motohiro ; Koh, Katsuyoshi ; Hanada, Ryoji ; Tanaka, Yukichi ; Kato, Keisuke ; Maeda, Daichi ; Fukayama, Masashi ; Sanada, Masashi ; Hayashi, Yasuhide ; Ogawa, Seishi ; 前田, 大地
出版情報: Cancer Science.  104  pp.856-864,  2013-04-11.  Japanese Cancer Association 日本癌学会 / Wiley Open Access
URL: http://hdl.handle.net/2297/00062685
概要: 金沢大学医薬保健研究域医学系<br />Rhabdomyosarcoma (RMS) is a common solid tumor in childhood divided into two histological subtypes, embryonal (ERMS) and alveolar (ARMS). The ARMS subtype shows aggressive clinical behavior with poor prognosis, while the ERMS subtype has a more favorable outcome. Because of the rarity, diagnostic diversity and heterogeneity of this tumor, its etiology remains to be completely elucidated. Thus, to identify genetic alterations associated with RMS development, we performed single nucleotide polymorphism array analyses of 55 RMS samples including eight RMS-derived cell lines. The ERMS subtype was characterized by hyperploidy, significantly associated with gains of chromosomes 2, 8 and 12, whereas the majority of ARMS cases exhibited near-diploid copy number profiles. Loss of heterozygosity of 15q was detected in 45.5% of ARMS that had been unrecognized in RMS to date. Novel amplifications were also detected, including IRS2 locus in two fusion-positive tumors, and KRAS or NRAS loci in three ERMS cases. Of note, gain of 13q was significantly associated with good patient outcome in ERMS. We also identified possible application of an ALK inhibitor to RMS, as ALK amplification and frequent expression of ALK were detected in our RMS cohort. These findings enhance our understanding of the genetic mechanisms underlying RMS pathogenesis and support further studies for therapeutic development of RMS. © 2013 Japanese Cancer Association. 続きを見る
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Hiraike, Haruko ; Wada-Hiraike, Osamu ; Nakagawa, Shunsuke ; Saji, Shigehira ; Maeda, Daichi ; Miyamoto, Yuichiro ; Sone, Kenbun ; Tanikawa, Michihiro ; Oda, Katsutoshi ; Nakagawa, Keiichi ; Yano, Tetsu ; Fukayama, Masashi ; Taketani, Yuji ; 前田, 大地
出版情報: Experimental and Therapeutic Medicine.  2  pp.1105-1109,  2011-08-12.  Spandidos Publications
URL: http://hdl.handle.net/2297/00062687
概要: 金沢大学医薬保健研究域医学系<br />DBC1/KIAA1967 (deleted in breast cancer 1) is a putative tumor-suppressor gene cloned from breast ca ncer specimens and is reported to regulate p53-dependent apoptosis through its specific inhibition of SIRT1 deacetylase. Although SIRT1 plays a pivotal role in carcinogenesis by regulating cellular proliferation, survival and death, its role in breast cancer remains controversial. Therefore, we aimed to investigate the expression status and clinicopathological significance of DBC1 and SIRT1 in breast cancer tissues. We evaluated the expression of DBC1 and SIRT1 in breast core-needle biopsy specimens from 48 primary breast cancer patients between 2005 and 2008. These patients were treated with primary systemic chemotherapy and subsequent surgical resection of the lesions. Immunohistochemical expression scores of DBC1 and SIRT1 were evaluated, and the relationship between their expression levels and clinicopathological features of breast cancer was analyzed. The expression was observed exclusively in the nuclei of normal and neoplastic ductal cells. In breast biopsy specimens, positive expression of DBC1 and SIRT1 was noted in 85 and 98% of patients, respectively. Expression of DBC1 was significantly associated with the tumor nuclear grade (P=0.019). DBC1 and SIRT1 expression was inversely correlated with HER2 expression (P=0.026 and 0.003, respectively). Lower expression of DBC1 and SIRT1 indicated a tendency for a favorable pathological response to chemotherapy, although this was not statistically significant. Our results reveal that the expression of DBC1 and SIRT1 in breast tissues is associated with tumor characteristics. © 2011 Spandidos Publications Ltd. 続きを見る
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Tamura, Daisuke ; Maeda, Daichi ; Sato, Toshiharu ; Sugawara, Tae ; Shirasawa, Hiromitsu ; Shimizu, Dai ; Sato, Naoki ; Goto, Akiteru ; Terada, Yukihiro ; 前田, 大地
出版情報: Genes Chromosomes and Cancer.  59  pp.209-213,  2019-07-30.  Wiley
URL: http://hdl.handle.net/2297/00062689
概要: 金沢大学医薬保健研究域医学系<br />An extragonadal yolk sac tumor (YST) is a rare malignant germ cell tumor that usually occurs in chil dhood. The pathogenesis of extragonadal YST remains largely unknown, especially with regards to its cell of origin. Herein, we report a case of extragonadal YST arising in the uterine round ligament. A 31-year-old Japanese woman, para 2, underwent partial resection of a left-sided, 5-cm, solid inguinal mass. Intraoperative findings showed enlargement of the uterine round ligament in the inguinal canal. Pathological evaluation diagnosed the mass as YST with a mature teratoma (MT) component. The preoperative α-fetoprotein level was markedly elevated, at 24 790 ng/mL. Postoperative magnetic resonance imaging revealed a right ovarian MT and a 3-cm mass remaining in the left lower abdominal wall. The patient underwent total abdominal hysterectomy, bilateral adnexectomy, and left inguinal mass resection. We sampled three frozen tissues (YST, right ovarian MT, and left normal ovary) and performed a single nucleotide polymorphism (SNP) array. Pathological evaluation revealed remnant extragonadal YST in the left inguinal region. The SNP array demonstrated a completely homozygous YST genotype. Copy number variations were gains of 1p, 1q, 2p, 3p, 7p, 8p, 10q, 14q, 18p, 20q, Xp, and Xq and losses of 12q, 20p, and Xq. The right ovarian MT and left normal ovary were partially homozygous and heterozygous, respectively. The evidence suggests that this neoplasm is presumed to be a postmeiotic germ cell origin. © 2019 Wiley Periodicals, Inc. 続きを見る
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Uni, Masahiro ; Yoshimi, Akihide ; Maki, Hiroaki ; Maeda, Daichi ; Nakazaki, Kumi ; Nakamura, Fumihiko ; Fukayama, Masashi ; Kurokawa, Mineo ; 前田, 大地
出版情報: International Journal of Clinical and Experimental Pathology.  6  pp.1190-1194,  2013-05-15.  e-Century Publishing
URL: http://hdl.handle.net/2297/00062691
概要: 金沢大学医薬保健研究域医学系<br />We report here a 47-year-old male with the diagnosis of high-grade B-cell lymphoma and hemophagocyto sis accompanying disseminated intravascular coagulation (DIC). Lymphoma-associated hemophagocytic syndrome (LAHS) is a life-threatening disorder, and LAHS secondary to B-cell lymphoma is relatively rare compared to that secondary to T- or NK/T-cell lymphoma in Western countries. T- or NK/T-cell LAHS is sometimes combined with DIC, which makes patients' outcomes even worse, but few reports of B-cell LAHS accompanying DIC has been published so far. We successfully treated a patient with this condition with recombinant thrombomodulin (rTM), a novel agent for DIC. We believe that rTM is a therapeutic option in cases with B-cell LAHS accompanying DIC. 続きを見る
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Maeda, Daichi ; Tsui-Lien, Mao ; Fukayama, Masashi ; Nakagawa, Shunsuke ; Yano, Tetsu ; Taketani, Yuji ; Shih, Ie-Ming ; 前田, 大地
出版情報: International Journal of Molecular Sciences.  11  pp.5120-5128,  2010-12-13.  MDPI
URL: http://hdl.handle.net/2297/00062692
概要: 金沢大学医薬保健研究域医学系<br />Recent genome-wide analysis has demonstrated that somatic mutations in ARID1A (BAF250) are the most common molecular genetic changes in ovarian clear cell carcinoma (OCCC). ARID1A mutations, which occur in approximately half of OCCC cases, lead to deletion of the encoded protein and inactivation of the putative tumor suppressor. In this study, we determined the significance of loss of ARID1A immunoreactivity with respect to several clinicopathological features in a total of 149 OCCCs. First, we demonstrated that ARID1A immunohistochemistry showed concordance with the mutational status in 91% of cases with 100% sensitivity and 66% specificity. Specifically, among 12 OCCC cases for which ARIDA mutational status was known, ARIDIA immunoreactivity was undetectable in all 9 cases harboring ARID1A mutations and was undetectable in one of 3 cases with wild-type ARID1A. With respect to the entire cohort, ARID1A immunoreactivity was undetectable in 88 (59%) of 149 OCCCs. There was no significant difference between ARID1A negative and positive cases in terms of histopathologic features, age, clinical stage, or overall survival. In conclusion, this study provides further evidence that mutations in ARID1A resulted in loss of ARID1A protein expression in OCCC, although no significant differences between ARID1A positive and negative cases were observed with respect to any clinicopathological features examined. © 2010 by the authors. 続きを見る
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Shiraishi, Kouya ; Okada, Yukinori ; Takahashi, Atsushi ; Kamatani, Yoichiro ; Momozawa, Yukihide ; Ashikawa, Kyota ; Kunitoh, Hideo ; Matsumoto, Shingo ; Takano, Atsushi ; Shimizu, Kimihiro ; Goto, Akiteru ; Tsuta, Koji ; Watanabe, Shun-ichi ; Ohe, Yuichiro ; Watanabe, Yukio ; Goto, Yasushi ; Nokihara, Hiroshi ; Furuta, Koh ; Yoshida, Akihiko ; Goto, Koichi ; Hishida, Tomoyuki ; Tsuboi, Masahiro ; Tsuchihara, Katsuya ; Miyagi, Yohei ; Tanaka, Kazumi ; Nakayama, Haruhiko ; Yokose, Tomoyuki ; Nagashima, Toshiteru ; Ohtaki, Yoichi ; Maeda, Daichi ; Imai, Kazuhiro ; Minamiya, Yoshihiro ; Sakamoto, Hiromi ; Saito, Akira ; Shimada, Yoko ; Sunami, Kuniko ; Saito, Motonobu ; Inazawa, Johji ; Nakamura, Yusuke ; Yoshida, Teruhiko ; Yokota, Jun ; Matsuda, Fumihiko ; Matsuo, Keitaro ; Daigo, Yataro ; Kubo, Michiaki ; Kohno, Takashi ; 前田, 大地
出版情報: Nature Research.  7  pp.12451-,  2016-08-09.  Nature Publishing Group
URL: http://hdl.handle.net/2297/00062694
概要: 金沢大学医薬保健研究域医学系<br />Lung adenocarcinoma driven by somatic EGFR mutations is more prevalent in East Asians (30-50%) than in European/Americans (10-20%). Here we investigate genetic factors underlying the risk of this disease by conducting a genome-wide association study, followed by two validation studies, in 3,173 Japanese patients with EGFR mutation-positive lung adenocarcinoma and 15,158 controls. Four loci, 5p15.33 (TERT), 6p21.3 (BTNL2), 3q28 (TP63) and 17q24.2 (BPTF), previously shown to be strongly associated with overall lung adenocarcinoma risk in East Asians, were re-discovered as loci associated with a higher susceptibility to EGFR mutation-positive lung adenocarcinoma. In addition, two additional loci, HLA class II at 6p21.32 (rs2179920; P =5.1 × 10 '17, per-allele OR=1.36) and 6p21.1 (FOXP4) (rs2495239; P=3.9 × 10 '9, per-allele OR=1.19) were newly identified as loci associated with EGFR mutation-positive lung adenocarcinoma. This study indicates that multiple genetic factors underlie the risk of lung adenocarcinomas with EGFR mutations. 続きを見る
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Oki, Shinya ; Sone, Kenbun ; Oda, Katsutoshi ; Hamamoto, Ryuji ; Ikemura, Masako ; Maeda, Daichi ; Takeuchi, Makoto ; Tanikawa, Michihiro ; Mori-Uchino, Mayuyo ; Nagasaka, Kazunori ; Miyasaka, Aki ; Kashiyama, Tomoko ; Ikeda, Yuji ; Arimoto, Takahide ; Kuramoto, Hiroyuki ; Wada-Hiraike, Osamu ; Kawana, Kei ; Fukayama, Masashi ; Osuga, Yutaka ; Fujii, Tomoyuki ; 前田, 大地
出版情報: Oncotarget.  8  pp.40402-40411,  2017-03-17.  Impact Journals LLC
URL: http://hdl.handle.net/2297/00062695
概要: 金沢大学医薬保健研究域医学系<br />The histone methyltransferase EZH2, a key epigenetic modifier, is known to be associated with human tumorigenesis. However, the physiological importance of EZH2 and its clinical relevance in endometrial cancer remain unclear. Hence, in the present study, we investigated the expression and function of EZH2 in endometrial cancer. In a quantitative real-time PCR analysis of 11 endometrial cancer cell lines and 52 clinical endometrial cancer specimens, EZH2 was significantly overexpressed in cancer cells and tissues compared to that in corresponding normal control cells and tissues. Kaplan-Meier survival analysis using data of the TCGA RNA-seq database and tissue microarrays (TMAs) indicated that EZH2 overexpression is associated with endometrial cancer prognosis. In addition, knockdown of EZH2 using specific siRNAs resulted in growth suppression and apoptosis induction of endometrial cancer cells, accompanied by attenuation of H3K27 trimethylation. Consistent with these results, treatment with GSK126, a specific EZH2 inhibitor, suppressed endometrial cancer cell growth and decreased the number of cancer cell colonies. Furthermore, GSK126 showed additive effects with doxorubicin or cisplatin, which are conventional drugs for treatment of endometrial cancer. Further studies should explore the therapeutic potential of inhibiting EZH2 in patients with endometrial cancer. © Oki et al. 続きを見る
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Goto, Akiteru ; Masamitsu, Tanaka ; Yoshida, Makoto ; Umakoshi, Michinobu ; Nanjo, Hiroshi ; Shiraishi, Kouya ; Saito, Motonobu ; Kohno, Takashi ; Kuriyama, Sei ; Konno, Hayato ; Imai, Kazuhiro ; Hajime, Saito ; Minamiya, Yoshihiro ; Maeda, Daichi ; 前田, 大地
出版情報: PLoS ONE.  12  pp.e0181270-,  2016-07-12.  Public Library of Science
URL: http://hdl.handle.net/2297/00062696
概要: 金沢大学医薬保健研究域医学系<br />Purpose miR-451 is a tumor suppressive microRNA with several target genes, including Macrophage migr ation inhibitory factor (MIF). As little is known about the expression and clinicopathological significance of mir-451 in NSCLC, we performed a clinicopathological study of 370 NSCLC cases to clarify them. Cell biological experiments were also performed on NSCLC cell lines to confirm the tumor-suppressive role of miR-451 and whether or not MIF is targeted by miR-451. Methods We analyzed 370 NSCLC cases for the miR-451 expression by quantitative real-time polymerase chain reaction and the MIF expression by immunohistochemistry. Eighty-four background lung tissue samples were also evaluated for the miR-451 expression. The clinicopathological and genetic factors surveyed were the disease-free survival, smoking status, histological type, disease stage, EGFR gene mutations and ALK rearrangements. In 286 adenocarcinoma cases, the invasive status (adenocarcinoma in situ, minimally invasive adenocarcinoma and invasive adenocarcinoma) was also evaluated. Five NSCLC cell lines (H23, H441, H522, H1703, and H1975) were cultured and evaluated for their miR-451 and MIF expression. The cell lines with lower miR-451 and higher MIF expressions were then selected and transfected with miR-451-mimic to observe its effects on MIF expression, Akt and Erk status, cell proliferation, and cell migration. Results The miR-451 expression was down-regulated in cancer tissues compared with background lung tissues (P<0.0001). Factors such as advanced disease stage, positive pleural invasion and nodal status and being a smoker were significantly correlated with a lower expression of miR-451 (P<0.05 each), while EGFR gene mutations and ALK rearrangements were not. In adenocarcinoma, invasive and minimally invasive adenocarcinoma showed lower expression of miR-451 than adenocarcinoma in situ (P<0.0005, respectively). A survival analysis showed that a lower expression of miR-451 was an independent predictor of a poor prognosis for NSCLC (P<0.05). The MIF expression was inversely correlated with the miR-451 expression. Out of 5 NSCLC cell lines examined, H441 and H1975 showed higher MIF and lower miR-451 expressions. After the transfection of miR-451-mimic, the MIF expression and phosphorylated Akt expression of these cell lines was suppressed, as were cell proliferation and cell migration. Conclusion This clinicopathological study of 370 NSCLC cases and the cell biological studies of NSCLC cell lines clarified the tumor-suppressive role of miR-451 and its prognostic value. We also validated MIF as a target of miR-451 in NSCLC. © 2017 Goto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 続きを見る
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Kito, Masahiko ; Maeda, Daichi ; Kudo-Asabe, Yukitsugu ; Sato, Naoki ; Ie-Ming, Shih ; Wang, Tian-Li ; Tanaka, Masamitsu ; Terada, Yukihiro ; Goto, Akiteru ; 前田, 大地
出版情報: PLoS ONE.  11  pp.e0160136-,  2016-07-21.  Public Library of Science
URL: http://hdl.handle.net/2297/00062697
概要: 金沢大学医薬保健研究域医学系<br />In Table 1, the values in the Case column should be listed from 1 to 18. Please see the corrected Ta ble 1 here. © 2016 Kito et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.<br />Correction to: PLoS ONE https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156069 続きを見る
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Kito, Masahiko ; Maeda, Daichi ; Kudo-Asabe, Yukitsugu ; Sato, Naoki ; Ie-Ming, Shih ; Wang, Tian-Li ; Tanaka, Masamitsu ; Terada, Yukihiro ; Goto, Akiteru ; 前田, 大地
出版情報: PLoS ONE.  11  pp.e0156069-,  2016-06-03.  Public Library of Science
URL: http://hdl.handle.net/2297/00062698
概要: 金沢大学医薬保健研究域医学系<br />There is a growing body of evidence regarding cell competition between normal and mutant mammalian c ells, which suggest that it may play a defensive role in the early phase of carcinogenesis. In vitro study in the past has shown that overexpression of vimentin in normal epithelial cells at the contact surface with transformed cells is essential for the cell competition involved in epithelial defense against cancer. In this study, we attempted to examine cell competition in human tissue in vivo by investigating surgically resected human fallopian tubes that contain p53 signatures and serous tubal intraepithelial lesions (STILs), a linear expansion of p53-immunopositive/TP53 mutant tubal epithelial cells that are considered as precursors of pelvic high grade serous carcinoma. Immunofluorescence double staining for p53 and the cell competition marker vimentin was performed in 21 sections of human fallopian tube tissue containing 17 p53 signatures and 4 STILs. The intensities of vimentin expression at the interface between p53-positive cells at the end of the p53 signature/STIL and adjacent p53-negative normal tubal epithelial cells were compared with the background tubal epithelium. As a result, the average vimentin intensity at the interfaces relative to the background intensity was 1.076 (95% CI, 0.9412-1.211 for p53 signature and 0.9790 (95% CI, 0.7206-1.237) for STIL. Thus, it can be concluded that overexpression of the cell competition marker vimentin are not observed in human tissue with TP53 alterations. © 2016 Kito et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 続きを見る
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Maeda, Daichi ; Yoshiyuki, Akiyama ; Morikawa, Teppei ; Kunita, Akiko ; Ota, Yasunori ; Katoh, Hiroto ; Niimi, Aya ; Nomiya, Akira ; Ishikawa, Shumpei ; Goto, Akiteru ; Igawa, Yasuhiko ; Fukayama, Masashi ; Homma, Yukio ; 前田, 大地
出版情報: PLoS ONE.  10  pp.e0143316-,  2015-11-20.  Public Library of Science
URL: http://hdl.handle.net/2297/00062699
概要: 金沢大学医薬保健研究域医学系<br />Interstitial cystitis (IC) is a chronic bladder disease with urinary frequency, bladder discomfort o r bladder pain of unknown etiology. Based on cystoscopic findings, patients with IC are classified as either Hunner-type/classic IC (HIC), presenting with a specific Hunner lesion, or non-Hunner-type IC (NHIC), presenting with no Hunner lesion, but post-hydrodistension mucosal bleeding. Inflammatory cell infiltration, composed predominantly of lymphocytes, plasma cells and epithelial denudation, has in the past been documented as a major pathological IC finding. However, the significance of the pathological evaluation of IC, especially with regard to the difference between HIC and NHIC, has been downplayed in recent years. In this study, we performed immunohistochemical quantification of infiltrating T-lymphocytes, B-lymphocytes and plasma cells, and measured the amount of residual epithelium in urinary bladder biopsy specimens taken from patients with HIC and NHIC, and those with no IC, using image analysis software. In addition, in situ hybridization of the light chains was performed to examine clonal B-cell expansion. Lymphoplasmacytic infiltration was significantly more severe in HIC specimens than in NHIC specimens (P <0.0001). Substantial lymphoplasmacytic inflammation (≥200 cells/mm2) was observed in 93% of HIC specimens, whereas only 8% of NHIC specimens were inflamed. Plasmacytic infiltration was more prominent in HIC specimens compared with NHIC and non-IC cystitis specimens (P <0.005). Furthermore, expansion of light-chain-restricted B-cells was observed in 31% of cases of HIC. The amount of residual epithelium was decreased in HIC specimens compared with NHIC specimens and non-IC cystitis specimens (P <0.0001). These results suggest that NHIC and HIC are distinct pathological entities, with the latter characterized by pancystitis, frequent clonal B-cell expansion and epithelial denudation. An abnormality in the B-cell population may be involved in the pathogenesis of HIC. © 2015 Maeda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 続きを見る
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Uehara, Yuriko ; Oda, Katsutoshi ; Ikeda, Yuji ; Koso, Takahiro ; Tsuji, Shingo ; Yamamoto, Shogo ; Asada, Kayo ; Sone, Kenbun ; Kurikawa, Reiko ; Makii, Chinami ; Hagiwara, Otoe ; Tanikawa, Michihiro ; Maeda, Daichi ; Hasegawa, Kosei ; Nakagawa, Shunsuke ; Wada-Hiraike, Osamu ; Kawana, Kei ; Fukayama, Masashi ; Fujiwara, Keiichi ; Yano, Tetsu ; Osuga, Yutaka ; Fujii, Tomoyuki ; Aburatani, Hiroyuki ; 前田, 大地
出版情報: PLoS ONE.  10  pp.e0132751-,  2015-07-06.  Public Library of Science
URL: http://hdl.handle.net/2297/00062700
概要: 金沢大学医薬保健研究域医学系<br />Correction to: PLoS ONE https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128066
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Uehara, Yuriko ; Oda, Katsutoshi ; Ikeda, Yuji ; Koso, Takahiro ; Tsuji, Shingo ; Yamamoto, Shogo ; Asada, Kayo ; Sone, Kenbun ; Kurikawa, Reiko ; Makii, Chinami ; Hagiwara, Otoe ; Tanikawa, Michihiro ; Maeda, Daichi ; Hasegawa, Kosei ; Nakagawa, Shunsuke ; Wada-Hiraike, Osamu ; Kawana, Kei ; Fukayama, Masashi ; Fujiwara, Keiichi ; Yano, Tetsu ; Osuga, Yutaka ; Fujii, Tomoyuki ; Aburatani, Hiroyuki ; 前田, 大地
出版情報: PLoS ONE.  10  pp.e0128066-,  2015-06-04.  Public Library of Science
URL: http://hdl.handle.net/2297/00062701
概要: 金沢大学医薬保健研究域医学系<br />Ovarian clear cell carcinoma (CCC) is generally associated with chemoresistance and poor clinical ou tcome, even with early diagnosis; whereas high-grade serous carcinomas (SCs) and endometrioid carcinomas (ECs) are commonly chemosensitive at advanced stages. Although an integrated genomic analysis of SC has been performed, conclusive views on copy number and expression profiles for CCC are still limited. In this study, we performed single nucleotide polymorphism analysis with 57 epithelial ovarian cancers (31 CCCs, 14 SCs, and 12 ECs) and microarray expression analysis with 55 cancers (25 CCCs, 16 SCs, and 14 ECs). We then evaluated PIK3CA mutations and ARID1A expression in CCCs. SNP array analysis classified 13% of CCCs into a cluster with high frequency and focal range of copy number alterations (CNAs), significantly lower than for SCs (93%, P < 0.01) and ECs (50%, P = 0.017). The ratio of whole-arm to all CNAs was higher in CCCs (46.9%) than SCs (21.7%; P < 0.0001). SCs with loss of heterozygosity (LOH) of BRCA1 (85%) also had LOH of NF1 and TP53, and LOH of BRCA2 (62%) coexisted with LOH of RB1 and TP53. Microarray analysis classified CCCs into three clusters. One cluster (CCC-2, n = 10) showed more favorable prognosis than the CCC-1 and CCC-3 clusters (P = 0.041). Coexistent alterations of PIK3CA and ARID1A were more common in CCC-1 and CCC-3 (7/11, 64%) than in CCC-2 (0/10, 0%; P < 0.01). Being in cluster CCC-2 was an independent favorable prognostic factor in CCC. In conclusion, CCC was characterized by a high ratio of whole-arm CNAs; whereas CNAs in SC were mainly focal, but preferentially caused LOH of well-known tumor suppressor genes. As such, expression profiles might be useful for sub-classification of CCC, and might provide useful information on prognosis. © 2015 Uehara et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 続きを見る
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Ito, Yukinobu ; Yoshida, Makoto ; Maeda, Daichi ; Takahashi, Masato ; Nanjo, Hiroshi ; Masuda, Hirotake ; Gopto, Akiteru ; 前田, 大地
出版情報: Scientific Reports.  8  pp.3156-,  2018-02-16.  Nature Research
URL: http://hdl.handle.net/2297/00062703
概要: 金沢大学医薬保健研究域医学系<br />Arteriovenous malformations consist of tangles of arteries and veins that are often connected by a f istula. The causes and mechanisms of these clinical entities are not fully understood. We discovered that suturing an arterial patch into the common jugular vein of rabbits led to spontaneous neovascularization, the formation of an arteriovenous fistula and the development of an arteriovenous shunt. An arterial patch excised from the common carotid artery was sutured into the common jugular vein. Within a month, a dense nidus-like neovasculature formed around the patch. Angiography and pulse-oximeter analyses showed that the blood flowing into the neovasculature was arterial blood. This indicated that an arteriovenous shunt had formed. Fluorescence in situ hybridization with a Y chromosome probe in female rabbits that received an arterial patch from male rabbits showed that the vessels close to the graft bore the Y chromosome, whereas the vessels further away did not. Enzyme-linked immunosorbent assays and cDNA microarray analysis showed that multiple angiogenic factors were upregulated after patch transplantation. This is the first in vivo model of spontaneous arteriovenous fistula formation. Further research on these differences may help to improve understanding of human vascular anomaly diseases and the basic principles underlying vasculogenesis and/or angiogenesis. © 2018 The Author(s). 続きを見る
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Takahashi, Kenichi ; Mashima, Hirosato ; Miura, Kouichi ; Maeda, Daichi ; Goto, Akiteru ; Gotio, Takashi ; Sun-Wada, Ge-Hong ; Wada, Yoh ; Ohnishi, Hirohide ; 前田, 大地
出版情報: Scientific Reports.  7  pp.2817-,  2017-06-06.  Nature Research
URL: http://hdl.handle.net/2297/00062704
概要: 金沢大学医薬保健研究域医学系<br />Although aberrations of intracellular vesicle transport systems towards lysosomes including autophag y and endocytosis are involved in the onset and progression of acute pancreatitis, the molecular mechanisms underlying such aberrations remain unclear. The pathways of autophagy and endocytosis are closely related, and Rab7 plays crucial roles in both. In this study, we analyzed the function of Rab7 in acute pancreatitis using pancreas-specific Rab7 knockout (Rab7Δpan) mice. In Rab7Δpan pancreatic acinar cells, the maturation steps of both endosomes and autophagosomes were deteriorated, and the lysosomal functions were affected. In experimental models of acute pancreatitis, the histopathological severity, serum amylase concentration and intra-pancreatic trypsin activity were significantly higher in Rab7Δpan mice than in wild-type mice. Furthermore, the autophagy process was blocked in Rab7Δpan pancreas compared with wild-type mice. In addition, larger autophagic vacuoles that colocalize with early endosome antigen 1 (EEA1) but not with lysosomal-associated membrane protein (LAMP)-1 were much more frequently formed in Rab7Δpan pancreatic acinar cells. Accordingly, Rab7 deficiency exacerbates the severity of acute pancreatitis by impairing the autophagic and endocytic pathways toward lysosomes. 続きを見る
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Akiyama, Yoshiyuki ; Morikawa, Teppei ; Maeda, Daichi ; Shintani, Yukako ; Niimi, Aya ; Nomiya, Akira ; Nakayama, Atsuhito ; Igawa, Yasuhiko ; Fukayama, Masashi ; Homma, Yukio ; 前田, 大地
出版情報: Scientific Reports.  6  pp.28652-,  2016-06-24.  Nature Research
URL: http://hdl.handle.net/2297/00062705
概要: 金沢大学医薬保健研究域医学系<br />An up-regulated CXCR3 pathway and affluent plasma cell infiltration are characteristic features of H unner type interstitial cystitis (HIC). We further examined these two features using bladder biopsy samples taken from 27 patients with HIC and 15 patients with non-IC cystitis as a control. The number of CD3-positive T lymphocytes, CD20-positive B lymphocytes, CD138-positive plasma cells, and CXCR3-positive cells was quantified by digital image analysis. Double-immunofluorescence for CXCR3 and CD138 was used to detect CXCR3 expression in plasma cells. Correlations between CXCR3 positivity and lymphocytic and plasma cell numbers and clinical parameters were explored. The density of CXCR3-positive cells showed no significant differences between HIC and non-IC cystitis specimens. However, distribution of CXCR3-positivity in plasma cells indicated co-localization of CXCR3 with CD138 in HIC specimens, but not in non-IC cystitis specimens. The number of CXCR3-positive cells correlated with plasma cells in HIC specimens alone. Infiltration of CXCR3-positive cells was unrelated to clinical parameters of patients with HIC. These results suggest that infiltration of CXCR3-positive plasma cells is a characteristic feature of HIC. The CXCR3 pathway and specific immune responses may be involved in accumulation/retention of plasma cells and pathophysiology of the HIC bladder. 続きを見る
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Inagaki, Chiaki ; Maeda, Daichi ; Kimura, Akie ; Otsuru, Toru ; Iwagami, Yoshifumi ; Nishida, Naohiro ; Sakai, Daisuke ; Shitotsuki, Ryo ; Yachida, Shinichi ; Doki, Yuichiro ; Satoh, Taroh ; 前田, 大地
出版情報: World Journal of Gastrointestinal Oncology.  11  pp.761-767,  2019-09-15.  Baishideng Publishing Group Co
URL: http://hdl.handle.net/2297/00062707
概要: 金沢大学医薬保健研究域医学系<br />BACKGROUND Bile duct cancer constitutes gallbladder cancer (GBC), intrahepatic cholangiocarcinoma (I CA), and extrahepatic cholangiocarcinoma (ECA). These three entities show morphological and immunohistochemical resemblance so that it is difficult to differentiate between primary ICA and liver metastasis of GBC, which sometimes becomes a point of discussion in clinical practice. Although these cancers demonstrate significant differences in their mutational landscape, several reports demonstrated shared genomic alteration in paired primary and metastatic site aids in distinguishing metastatic recurrence from second primary cancers. CASE SUMMARY We present a 73-year-old female patient who underwent curative resection for GBC harboring epidermal growth factor receptor 2 (ERBB2) activating mutation on next-generation sequencing (NGS)-based genomic testing. One year later, a hepatic lesion was observed on follow-up imaging and she underwent surgical resection for a pathological diagnosis. The histological findings of the hepatic lesion were similar to those of the primary lesion. Additionally, using NGS panel testing, the hepatic lesion was found to have ERBB2 activating mutation, which is the identical mutation detected in the sequencing result of the primary site. ERBB2 activating mutation occurs more frequently in GBC than ICA and ECA. Therefore, in the present case, we think this molecular finding potentiated the diagnosis of the liver mass toward a metastatic recurrence. Additionally, this patient underwent HER2-targeted treatment with lapatinib in combination with capecitabin and obtained clinical benefit. CONCLUSION This case illustrated NGS panel usefulness in distinguishing GBC recurrence from second primary cancer and HER2-targeted agent efficacy on ERBB2 mutated GBC. © The Author(s) 2019. 続きを見る
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津田, 武明 ; Tsuda, Takeaki
出版情報: 日本機械学会論文集. B編 = Transactions of the Japan Society of Mechanical Engineers, Part B.  77  pp.1335-1349,  2011.  日本機械学会 The Japan Society of Mechanical Engineers
URL: http://hdl.handle.net/2297/00062708
概要: 金沢大学先端科学・社会共創推進機構<br />The characteristics of four roll coating system were numerically investigated compared with exper imental data to validate theoretical models used in this research. In the theoretical models, a film splitting model using a power-law type equation, a roll gap model based on elasto-hydrodynamics and a flow model from a rotating cylinder system were applied. The parametric computations to each operation condition revealed the steady and dynamic behaviors of a coating film and liquid films on coating rolls. From the results of the frequency response to the speed disturbances of the coating rolls, it was found that the sensitivity of the lowest coating roll to the disturbance was a half of others, which implies that the requirement for the accuracy of a driving system for the coating roll is not so severe compared with others. The experimental data and the numerical results at steady state agreed in large part. The actual properties of materials used in the coating process will be required to predict the coating thickness precisely. © 2011 The Japan Society of Mechanical Engineers. 続きを見る