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| 1.
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Ueki, Koichiro ; Okabe, Katsuhiko ; Mukozawa, Aya ; Miyazaki, Mao ; Marukawa, Kohei ; Hashiba, Yukari ; Nakagawa, Kiyomasa ; Yamamoto, Etsuhide
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金沢大学医薬保健研究域医学系<br />Purpose: The purpose of this study was to examine the relationship between the morphologies of the m
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asseter muscle and the ramus and occlusal force before and after sagittal split ramus osteotomy (SSRO) in patients with mandibular prognathism. Patients and methods: The study group consisted of 26 patients with mandibular prognathism. All patients underwent bilateral SSRO as well as 3-dimensional computed tomography on which the masseter muscle, ramus, and condyle were measured preoperatively and at 1 year postoperation. Occlusal force and contact area were also recorded with pressure-sensitive sheets. Results: In the cross-sectional area of the masseter muscle, there were no significant differences between the pre- and postoperative status. However, postoperative ramus width and area were significantly larger than preoperative values (P < .0001). Postoperative right condylar area was significantly larger than the preoperative value (P = .0120). Occlusal force and contact area 1 year after surgery were significantly larger than the preoperative values (P = .0016, P = .0190). Conclusion: This study suggested that the masseter muscle area did not significantly differ from preoperative status 1 year after SSRO, although occlusal force, contact area, and ramus area and width increased significantly 1 year after SSRO. © 2009.
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Alam, Shamiul ; Ueki, Koichiro ; Nakagawa, Kiyomasa ; Marukawa, Kohei ; Hashiba, Yukari ; Yamamoto, Etsuhide ; Sakulsak, Natthiya ; Iseki, Shoichi
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金沢大学医薬保健研究域医学系<br />Objectives: The purpose of this study was to investigate bone morphogenetic protein (BMP) 2 expressi
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on after implantation of a statin and recombinant human BMP-2 (rhBMP-2) and to compare the bone regeneration capability of these substances in the rabbit nasal bone using immunohistologic methods. Study design: Twelve adult male Japanese white rabbits (n = 12; age 12-16 weeks, weight 2.5-3.0 kg) were divided into 3 experimental groups and 1 control group. A total of 48 bone defects, 4 per rabbit, were created in the nasal bone while preserving the nasal membrane. In the experimental groups, 1 group was implanted with 10 mg of a statin dissolved in 0.2 mL water with an atelocollagen sponge (ACS); the second group was implanted with 5 μg rhBMP-2 with an ACS; and in the third group only the ACS was implanted. No material was implanted in the control group. Animals were killed at 1, 2, and 4 weeks after surgery. The parts that had been operated on were removed and prepared for histologic assessment. The expression of BMP-2 was evaluated using immunohistochemistry, and double-immunostaining for BMP-2 and Ki-67 was observed by fluorescent microscopy. Results: No significant differences were observed between the statin/ACS group and rhBMP-2/ACS group at 1, 2, and 4 weeks after surgery. The number of cells which stained positively for BMP-2 increased significantly in both of the implanted groups compared with the control group (P < .0001). The positive fluorescent double-immunostaining for BMP-2 and Ki-67 was similar in both implanted groups. Conclusion: This study suggests that statin/ACS implants show BMP-2 expression and osteoinductive activity that is similar to those of rhBMP-2/ACS implants. © 2009 Mosby, Inc. All rights reserved..
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Ueki, Koichiro ; Degerliyurt, Kagan ; Hashiba, Yukari ; Marukawa, Kohei ; Nakagawa, Kiyomasa ; Yamamoto, Etsuhide
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金沢大学医薬保健研究域医学系<br />Objective: The purpose of this study was to evaluate the horizontal changes in the condylar head wit
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h bent plate fixation after sagittal split ramus osteotomy (SSRO) with and without a Le Fort I osteotomy. Study design: Of 47 Japanese patients with mandibular prognathism, 24 underwent SSRO and 23 underwent SSRO in combination with a Le Fort I osteotomy. A 3-5-mm gap was made between the proximal and distal segments, and a bent plate was fixed with 4 screws in each side of the mandible. The angle of the condylar long axis, as well as the anteroposterior and mediolateral displacement of the condylar head were assessed preoperatively and postoperatively by computerized tomography (CT). Results: There was no significant difference in reduction in mandibular length between SSRO alone and SSRO with Le Fort I on the axial view of a 3-dimensional CT. There were no significant differences between pre- and postoperative horizontal changes in the condylar long axis or in the anteroposterior and mediolateral displacement of the condylar head, although the length of the proximal segment in SSRO with Le Fort I osteotomy was significantly shorter than in SSRO alone (P < .05). Conclusion: These results suggest that the use of a bent plate for SSRO does not change preoperative angle or position significantly in setback surgery, regardless of the addition of Le Fort I osteotomy. © 2008 Mosby, Inc. All rights reserved.<br />This article has not been published yet.
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Ueki, Koichiro ; Hashiba, Yukari ; Marukawa, Kohei ; Nakagawa, Kiyomasa ; Alam, S. ; Yamamoto, Etsuhide
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金沢大学医薬保健研究域医学系<br />Purpose: It is unclear whether surgical factors can affect the upper lip sensitivity. The aim of thi
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s study was to assess the factors that can affect the recovery period of hypoaesthesia of the upper lip after Le Fort I osteotomy, using trigeminal somatosensory evoked potential (TSEP) objectively. Patients and methods: Twenty-nine patients with mandibular prognathism underwent Le Fort I osteotomy with and without artificial pterygoid plate fracture. Trigeminal nerve hypoaesthesia at the region of the upper lip was assessed bilaterally by the TSEP method. The distance between the infraorbital foramen and the osteotomy line (IO) or the nearest plate/screw position (IP) was measured on three-dimensional computed tomography (CT). The relationship between the recovery period in upper lip hypoaesthesia and surgical factors (these distances, movement amount, pterygoid plate fracture) were analysed statistically. Results: The recovery period in upper lip hypoaesthesia did not significantly correlate with IO, IP and movement amount. There was no significant difference between pterygoid plate fracture group and non-fracture group. Conclusion: Temporary hypoaesthesia of upper lip after Le Fort I osteotomy could not be avoided, however, osteotomy line, plate/screw position and pterygoid plate fracture in Le Fort I osteotomy did not affect the recovery period of upper lip hypoaesthesia with TSEP. © 2008 European Association for Cranio-Maxillofacial Surgery.<br />This article has not been published yet.
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Ueki, Koichiro ; Hashiba, Yukari ; Marukawa, Kohei ; Nakagawa, Kiyomasa ; Alam, Shamiul ; Okabe, Katsuhiko ; Yamamoto, Etsuhide
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金沢大学医薬保健研究域医学系<br />The authors evaluated changes in position and angle of the proximal segment, including the condyle,
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after intraoral vertical ramus osteotomy (IVRO) with and without a Le Fort I osteotomy to verify whether displacement of the proximal segment could induce postoperative complications. Changes in condylar angle, ramus angle, and displacement of proximal segment were measured pre- and postoperatively. The position of the temporomandibular joint (TMJ) disc was examined pre- and postoperatively. Trigeminal nerve hypoesthesia in the lower lip was assessed bilaterally. The postoperative horizontal condylar angle was significantly smaller than the preoperative one on the deviated and non-deviated sides (P<0.0001). The postoperative coronal condylar angle was significantly larger than the preoperative one on the deviated side (P=0.0483). The postoperative sagittal ramus angle was larger than the preoperative one on the deviated (P<0.0001) and non-deviated (P=0.00005) side. Most joints with an anteriorly-displaced disc with and without reduction improved on the non-deviated side; 5 of 16 joints improved on the deviated side. Results suggest the position and angle of the proximal segment, including the condyle, could change after IVRO. This could be associated with symptomatic improvement in TMJ, and extreme medial displacement of the proximal segment could delay recovery from lower lip hypoesthesia. © 2009 International Association of Oral and Maxillofacial Surgeons.
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Ueki, Koichiro ; Miyazaki, Mao ; Okabe, Katsuhiko ; Mukozawa, Aya ; Marukawa, Kohei ; Moroi, Akinori ; Nakagawa, Kiyomasa ; Yamamoto, Etsuhide
概要:
金沢大学医薬保健研究域医学系<br />Purpose: The purpose of this study was to examine bone healing after Le Fort I osteotomy in Class II
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I patients. Patients and methods: The study group consisted of 18 Japanese patients with mandibular prognathism with and without asymmetry, maxillary retrognathism or open bite. A total of 36 sides were examined. Le Fort I osteotomy was performed without a pterygoid osteotome, with an ultrasonic curette used to remove interference at the pterygomaxillary region. Titanium plates (Universal Mid-face fixation module, Stryker, Freiburg, German) were used for four patients, absorbable plates (poly-l-lactic acid (PLLA): NEOFIX®, Gunze, kyoto, Japan) were used for four patients and other absorbable plates (uncalcined and unsintered hydroxyapatite and poly-L-lactic acid (uHA/PLLA): super FIXSORB®MX, Takiron Co. Ltd, Osaka, Japan) were used for 10 patients, in the same manner. Postoperative computed tomography (CT) was analyzed for all patients pre-operatively and 1 year postoperative. The anterior and lateral areas between the maxillary segments were measured with 3-dimensional (3D) CT. Bone healing at the pterygomaxillary region was also assessed. Results: There were no significant differences in the area of bone defect healing among the plate types. The areas of bone defect after 1 year were significantly smaller than that immediately after surgery on the right side (p = 0.0145) and left side (p = 0.0010) in the frontal view and right side in the lateral view (p = 0.0118). Bone healing at the pterygomaxillary junction was found in all cases without artificial pterygoid plate fracture. Fourteen of 22 sides with artificial pterygoid plate fracture by an ultrasonic curette showed bone continuity between the pterygoid plate and posterior part of maxilla. Conclusion: This study suggested that bony healing could occur in spaces between the segments of maxilla and pterygomaxillary regions as well as the region of the anterior and lateral walls in the maxilla, but it is not always complete within 1 year after Le Fort I osteotomy. © 2010 European Association for Cranio-Maxillo-Facial Surgery.
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Ueki, Koichiro ; Marukawa, Kohei ; Okabe, Katsuhiko ; Moroi, Akinori ; Nakagawa, Kiyomasa ; Yamamoto, Etsuhide ; Niizawa, Shigeru
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金沢大学医薬保健研究域医学系
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8. The effect of mandibular setback or two-jaws surgery on pharyngeal airway among different genders
Kagan, Degerliyurt ; Ueki, Koichiro ; Hashiba, Yukari ; Marukawa, Kohei ; Simsek, Baris ; Okabe, Katsuhiko ; Nakagawa, Kiyomasa ; Yamamoto, Etsuhide
概要:
金沢大学医薬保健研究域医学系<br />Cephalometric studies show significant gender differences in the size of the pharyngeal airway space
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. This study aimed to investigate and compare morphologic changes after mandibular setback or two-jaws surgery on the pharyngeal airway in men and women using computed tomography (CT). The sample included 34 women and 13 men diagnosed with Class III skeletal deformities, who had been treated by mandibular setback or bimaxillary surgery (maxillary advancement and mandibular setback). Anteroposterior, lateral and cross-sectional area dimensions of the airway, at the level of soft palate and base of tongue, were measured pre- and postoperatively on CT images. In the mandibular setback group, the anteroposterior and cross-sectional area of the pharyngeal airway at the level of the soft palate and base of tongue were significantly reduced for men or women (P < .05). In the two-jaws surgery group, only midsagittal anteroposterior dimensions at the same levels were significantly decreased for men or women (P < .05). The difference between any values measured between men and women who received bilateral sagittal split ramus osteotomy setback surgery or two-jaws surgery for the treatment of class III anteroposterior discrepancy were not statistically significant (P > .05). This study suggests that oropharyngeal airway measurements, important for airway patency, do not demonstrate sex dimorphism. © 2009 International Association of Oral and Maxillofacial Surgeons.
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| 9.
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Ueki, Koichiro ; Takeuchi, N. ; Nakagawa, Kiyomasa ; Yamamoto, Etsuhide
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金沢大学医薬保健研究域医学系<br />To cite this article: Ueki K, Takeuchi N, Nakagawa K, Yamamoto E: Simplified stress analysis on the
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temporomandibular joint in Class III patients with and without mandibular asymmetry using a rigid body spring model Orthod Craniofac Res 2009;12:312-318 Structured AbstractAuthors - Ueki K, Takeuchi N, Nakagawa K, Yamamoto E Objective - Aim of this study was to investigate the differences in stress on the temporomandibular joint (TMJ) between Class III patients with and without mandibular asymmetry using a rigid body spring model (RBSM). Design - Menton (Me), the centre point of occlusal force on the line that connected the bilateral buccal cusps of the second molars and the most lateral, superior and medial points of the condyle were plotted on frontal cephalograms, and stress on the condyles was calculated with the 2-dimensional RBSM program of fortran. Setting and Sample Population - Eighty Japanese patients with diagnosed mandibular prognathism were divided into two groups, a symmetry group and asymmetry group on the basis of the Mx-Md midline position. Outcome measure - The degree (force partition) of the resultant force, the direction (angulation) and displacement (X, Y) of each condyle were calculated. The horizontal displacement vector (u), the vertical displacement vector (v) and rotation angle (θ) of the mandibular body at Menton were also calculated. Results - There were significant differences between the deviated and non-deviated sides of both groups regarding resultant force (symmetry group: p = 0.0372, asymmetry group: p = 0.0054), X (symmetry group: p < 0.0001, asymmetry group: p = 0.0001) and Y (symmetry group: p = 0.0354, asymmetry group: p = 0.0043). For angulation, there was a significant difference between the deviated and non-deviated sides in the asymmetry group (p = 0.0095). Conclusion - The results of this study suggest that difference in stress angulation on the condyles could be associated with asymmetry in mandibular prognathism. © 2009 John Wiley & Sons A/S.
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Ueki, Koichiro ; Okabe, Katsuhiko ; Miyazaki, Mao ; Mukozawa, Aya ; Marukawa, Kohei ; Nakagawa, Kiyomasa ; Yamamoto, Etsuhide
概要:
金沢大学医薬保健研究域医学系<br />Purpose: The purpose of this study was to evaluate changes in the mandibular canal and ramus morphol
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ogy before and after a sagittal split ramus osteotomy. Patients and Methods: The subjects were 30 patients (60 sides) with mandibular prognathism who had undergone bilateral sagittal split ramus osteotomy setback surgery. The mandibular canal position and ramus morphology were measured at the 3 horizontal planes under the mandibular foramen level (level A), 1 cm lower than level A (level B), and 2 cm lower than level A (level C) preoperatively and 1 year postoperatively by computed tomography. Results: Postoperative ramus width, lateral distance, lateral marrow distance, and canal length were significantly larger than the preoperative values at the foramen, 1 cm lower, and 2 cm lower. The mandibular canal completely contacted the lateral cortex without lateral bone marrow in 6 sides (10%) in levels A and B and 4 sides (6.7%) in level C preoperatively and 6 sides (10%) in level C postoperatively. Conclusion: This study suggested that postoperative mandibular canal position was located more posteriorly and the postoperative lateral bone marrow became thicker compared with the preoperative state. ﾂｩ 2010 American Association of Oral and Maxillofacial Surgeons.
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