1.

学位論文
学位
1. A strategy for improving FDG accumulation for early detection of metastasis from primary pancreatic cancer: Stimulation of the Warburg effect in AsPC-1 cells.
小倉, 正人 ; Ogura, Masato
出版情報: 博士論文要旨Abstract. 
URL: http://hdl.handle.net/2297/44678
概要: 博士論文要旨Abstract 以下に掲載：Nuclear medicine and biology 42(5) pp.475-481 2015. Elsevier. 共著者：小倉 正人, 鹿野 直人, 中島 修一, 相良 順一, 山口 直人 … , 草薙 健太郎, 奥井 悠也, 水谷 明日香, 小林 正和, 川井 恵一 続きを見る
2.

学位論文
学位
2. A strategy for improving FDG accumulation for early detection of metastasis from primary pancreatic cancer: Stimulation of the Warburg effect in AsPC-1 cells.
小倉, 正人 ; Ogura, Masato
出版情報: 博士論文本文Full. 
URL: http://hdl.handle.net/2297/44680
概要: 博士論文本文Full 以下に掲載：Nuclear medicine and biology 42(5) pp.475-481 2015. Elsevier. 共著者：小倉 正人, 鹿野, 直人, 中島 修一, 相良 順一, 山口 直人, 草 … 薙 健太郎, 奥井 悠也, 水谷 明日香, 小林 正和, 川井 恵一 続きを見る
3.

その他
その他
3. アストログリア細胞のグルタミントランスポーター機能に関する分子薬理学的研究
小椋, 正人 ; Ogura, Masato
出版情報: 博士学位論文要旨　論文内容の要旨および論文審査結果の要旨／金沢大学大学院自然科学研究科.  平成21年6月  pp.410-413,  2009-06-01.  金沢大学
URL: http://hdl.handle.net/2297/26969
概要: 取得学位：博士(薬学)，学位授与番号：博甲第1114号，学位授与年月日：平成21年3月23日
4.

論文
論文
4. Activator protein-1 responsive to the group II metabotropic glutamate receptor subtype in association with intracellular calcium in cultured rat cortical neurons
Sugiyama, Chie ; Nakamichi, Noritaka ; Ogura, Masato ; Honda, Eriko ; Maeda, Sayaka ; Taniura, Hideo ; Yoneda, Yukio
出版情報: Neurochemistry International.  51  pp.467-475,  2007-12-01.  Elsevier
URL: http://hdl.handle.net/2297/7392
概要: 金沢大学大学院自然科学研究科分子作用学<br />Activation of ionotropic glutamate (Glu) receptors, such as N-methyl-d-aspartate receptors, is … shown to modulate the gene transcription mediated by the transcription factor activator protein-1 (AP1) composed of Fos and Jun family proteins in the brain, while little attention has been paid to the modulation of AP1 expression by metabotropic Glu receptors (mGluRs). In cultured rat cortical neurons, where constitutive expression was seen with all groups I, II and III mGluR subtypes, a significant and selective increase was seen in the DNA binding activity of AP1 120 min after the brief exposure to the group II mGluR agonist (2S,2′R,3′R)-2-(2′,3′-dicarboxycyclopropyl)glycine (DCG-IV) for 5 min. In cultured rat cortical astrocytes, by contrast, a significant increase was induced by a group I mGluR agonist, but not by either a group II or III mGluR agonist. The increase by DCG-IV was significantly prevented by a group II mGluR antagonist as well as by either an intracellular Ca2+ chelator or a voltage-sensitive Ca2+ channel blocker, but not by an intracellular Ca2+ store inhibitor. Moreover, DCG-IV significantly prevented the increase of cAMP formation by forskolin in cultured neurons. Western blot analysis revealed differential expression profiles of Fos family members in neurons briefly exposed to DCG-IV and NMDA. Prior or simultaneous exposure to DCG-IV led to significant protection against neuronal cell death by NMDA. These results suggest that activation of the group II mGluR subtype would modulate the gene expression mediated by AP1 through increased intracellular Ca2+ levels in cultured rat cortical neurons. © 2007. 続きを見る