Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease

Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease

フォーマット:

論文

責任表示:

Lopatina, Olga ; Yoshihara, Toru ; Nishimura, Tomoko ; Zhong, Jing ; Akther, Shirin ; Fakhrul, Azam A.K.M. ; Liang, Mingkun ; Higashida, Chiharu ; Sumi, Kohei ; Furuhara, Kazumi ; Inahata, Yuki ; Huang, Jina-Jung ; Koizumi, Keita ; Yokoyama, Shigeru ; Tsuji, Takahiro ; Petugina, Yulia ; Sumarokov, Andrei ; Salmina, Alla B. ; Hashida, Koji ; Kitao, Yasuko ; Hori, Osamu ; Asano, Masahide ; Kitamura, Yoji ; Kozaka, Takashi ; Shiba, Kazuhiro ; Zhong, Fangfang ; Xie, Min-Jue ; Sato, Makoto ; Ishihara, Katsuhiro ; Higashida, Haruhiro ; 吉原, 亨 ; 小泉, 恵太 ; 横山, 茂 ; 北尾, 康子 ; 堀, 修 ; 浅野, 雅秀 ; 北村, 暘二 ; 小阪, 孝史 ; 柴, 和弘

言語:

英語

出版情報:

Frontiers Research Foundation, 2014-04-22

著者名:

掲載情報:

Frontiers in Behavioral Neuroscience

ISSN:

1662-5153

巻:

8

通号:

APR

開始ページ:

133

バージョン:

publisher

概要:

金沢大学疾患モデル総合研究センター<br />CD157, known as bone marrow stromal cell antigen-1, is a glycosylphosphatidylinositolanchored ADP-ribosyl cyclase that supports the survival and function of B-lymphocytes and hematopoietic or intestinal stem cel … ls. Although CD157/Bst1 is a risk locus in Parkinson's disease (PD), little is known about the function of CD157 in the nervous system and contribution to PD progression. Here, we show that no apparent motor dysfunction was observed in young knockout (CD157-/-) male mice under less aging-related effects on behaviors. CD157-/- mice exhibited anxiety-related and depression-like behaviors compared with wild-type mice. These behaviors were rescued through treatment with anti-psychiatric drugs and oxytocin. CD157 was weakly expressed in the amygdala and c-Fos immunoreactivity in the amygdala was less evident in CD157-/- mice than in wild-type mice. These results demonstrate for the first time that CD157 plays a role as a neuro-regulator and suggest a potential role in pre-motor symptoms in PD. © 2014 Lopatina, Yoshihara, Nishimura, Zhong, Akther, Fakhrul, Liang, Higashida, Sumi, Furuhara, Inahata, Huang, Koizumi, Yokoyama, Tsuji, Petugina, Sumarokov, Salmina, Hashida, Kitao, Hori, Asano, Kitamura, Kozaka, Shiba, Zhong, Xie, Sato, Ishihara and Higashida.<br />CC-BY 4.0 続きを見る

URL:

http://hdl.handle.net/2297/00065237

タイトル・著者・出版者が同じ資料

詳細

主題:	BST-1; Emotion-related behavior; Non-motor symptoms; Oxytocin; Social behavior
受理日:	2014-04-22

類似資料:

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1 論文 An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator Higashida, Haruhiro, Liang, Mingkun, Yoshihara, Toru, Akther, Shirin, Fakhrul, Azam, Stanislav, Cherepanov, Nam, … BioMed Central Ltd.	7 論文 CD38 and its role in oxytocin secretion and social behavior Higashida, Haruhiro, Yokoyama, Shigeru, Kikuchi, Mitsuru, Munesue, Toshio Elsevier
2 論文 Cyclic ADP-ribose and heat regulate oxytocin release via CD38 and TRPM2 in the hypothalamus during social or psychological stress in mice Zhong, Jing, Amina, Sarwat, Liang, Mingkun, Akther, Shirin, Yuhi, Teruko, Nishimura, Tomoko, Tsuji, Chiharu, Tsuji, … Frontiers Research Foundation	8 論文 Communication impairment in ultrasonic vocal repertoire during the suckling period of Cd157 knockout mice: Transient improvement by oxytocin Lopatina, Olga L., Furuhara, Kazumi, Ishihara, Katsuhiko, Salmina, Alla B., Higashida, Haruhiro Frontiers Research Foundation
3 論文 Integrative neurochemistry and neurobiology of social recognition and behavior analyzed with respect to CD38-dependent brain oxytocin secretion Salmina, Alla B., Lopatina, Olga, Kuvacheva, Natalia V., Higashida, Haruhiro Bentham Science Publishers	9 論文 Oxytocin-induced elevation of ADP-ribosyl cyclase activity, cyclic ADP-riboseor Ca2+ concentrations is involved in autoregulation of oxytocin secretionin the … Lopatina, Olga, Liu, Hong-Xiang, Amina, Sarwat, Hashii, Minako, Higashida, Haruhiro Elsevier
4 論文 Selegiline ameliorates depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson’s disease Kasai, Satoka, Yoshihara, Toru, Lopatina, Olga, Ishihara, Katsuhiko, Higashida, Haruhiro Frontiers Research Foundation	10 論文 Social memory, amnesia, and autism: Brain oxytocin secretion is regulated by NAD + metabolites and single nucleotide polymorphisms of CD38 Higashida, Haruhiro, Yokoyama, Shigeru, Huang, Jian-Jun, Liu, Li, Ma, Wen-Jie, Akther, Shirin, Higashida, Chiharu, … Elsevier
5 論文 Selegiline ameliorates depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson’s disease Kasai, Satoka, Yoshihara, Toru, Lopatina, Olga, Ishihara, Katsuhiko, Higashida, Haruhiro Frontiers Research Foundation	11 論文 Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system Higashida, Haruhiro, Salmina, Alla B., Olovyannikova, Raissa Ya, Hashii, Minako, Yokoyama, Shigeru, Koizumi, Keita, Jin, … Elsevier
6 論文 Somato-axodendritic release of oxytocin into the brain due to calcium amplification is essential for social memory Higashida, Haruhiro 日本生理学会 / Springer-Verlag Tokyo	12 論文 Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice Yamamoto, Yasuhiko, Liang, Mingkun, Munesue, Seiichi, Deguchi, Kisaburo, Harashima, Ai, Furuhara, Kazumi, Yuhi, Teruko, … Nature Research