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| 1.
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論文
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Shibutani, Takayuki ; Nakajima, Kenichi ; Wakabayashi, Hiroshi ; Mori, Hiroshi ; Matsuo, Shinro ; Yoneyama, Hiroto ; Konishi, Takahiro ; Okuda, Koichi ; Onoguchi, Masahisa ; Kinuya, Seigo ; 澁谷, 孝行 ; 中嶋, 憲一 ; 若林, 大志 ; 松尾, 信郎 ; 米山, 寛人 ; 小野口, 昌久 ; 絹谷, 清剛
概要:
金沢大学医薬保健研究域保健学系<br />ObjectivesThe patient-based diagnosis with an artificial neural network (ANN) has shown potential u
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tility for the detection of coronary artery disease; however, the region-based accuracy of the detected regions has not been fully evaluated. The aim of this study was to demonstrate the accuracy of all detected regions compared with expert interpretation.\nMethodsA total of 109 abnormal regions including 33 regions with stress defects and 76 regions with ischemia were examined, which were derived from 21 patients who underwent myocardial perfusion SPECT within 45 days of coronary angiography. The gray and color scale images, a polar map of stress, rest and difference, and left ventricular function were displayed on the monitor to score the extent and severity of stress defect and ischemia. Two experienced nuclear medicine physicians (Observers A and B) scored the abnormality with a 4-point scale and draw abnormal regions on a polar map. The gold standard was determined by the final judgment of normal or abnormal by the consensus of two other independent expert nuclear cardiologists, and was compared with the stress defect and ischemia derived from ANN.\nResultsThe concordance rate of ANN to the gold standard was higher than that of two observers. Furthermore, the κ coefficient indicated moderate to substantial agreement for stress defect and slight to the fair agreement for ischemia. The area under the curve (AUC) of ANN was the highest for both stress defect and ischemia; in particular, the ANN of ischemia showed significantly higher AUC than Observer A (p = 0.005). The ANN of stress defect showed higher specificity compared with two observers, while the ANN of ischemia showed higher sensitivity. Consequently, the accuracy of ANN showed the highest in this study.\nConclusionThe ANN-based regional diagnosis showed a high concordance rate with the gold standard and comparable or even higher than the interpretation by nuclear medicine physicians.<br />Embargo Period 12 months
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米山, 達也
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金沢大学医核医<br />胸部及び心筋ファントムに18Fを注入し,心筋欠損部にプラスチックを封入したモデルを12個作成した.この心筋ファントムに対して二次元収集PET,三次元収集PET及びSPECTを施行した.収集時間と放射性薬剤の濃度を変
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化させ,極座標表示による半定量的解析を行い,心筋欠損容積の左室心筋全体に対する割合(%LV)を算出した.心筋画像の心筋欠損評価の為に最適閾値を決定した後,実際のファントムから計測した真の心筋欠損部容積の%LVとの相関を検討した.後投与法の心筋画像には前投与法と同等の定量性があり,放射性薬剤が低濃度であり,短時間収集であっても三次元収集を行えば心筋PET画像の定量性は保たれることがわかった<br />原著論文
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Okuda, Koichi ; Nakajima, Kenichi ; Motomura, Nobutoku ; Kubota, Masahiro ; Yamaki, Noriyasu ; Maeda, Hisato ; Matsuo, Shinro ; Kinuya, Seigo
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金沢大学医薬保健研究域<br />Objective: Segmentation with scatter and photopeak window data using attenuation correction (SSPAC) met
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hod can provide a patient-specific non-uniform attenuation coefficient map only by using photopeak and scatter images without X-ray computed tomography (CT). The purpose of this study is to evaluate the performance of attenuation correction (AC) by the SSPAC method on normal myocardial perfusion database. Methods: A total of 32 sets of exercise-rest myocardial images with Tc-99 m-sestamibi were acquired in both photopeak (140 keV ± 10%) and scatter (7% of lower side of the photopeak window) energy windows. Myocardial perfusion databases by the SSPAC method and non-AC (NC) were created from 15 female and 17 male subjects with low likelihood of cardiac disease using quantitative perfusion SPECT software. Segmental myocardial counts of a 17-segment model from these databases were compared on the basis of paired t test. Results: AC average myocardial perfusion count was significantly higher than that in NC in the septal and inferior regions (P < 0.02). On the contrary, AC average count was significantly lower in the anterolateral and apical regions (P < 0.01). Coefficient variation of the AC count in the mid, apical and apex regions was lower than that of NC. Conclusions: The SSPAC method can improve average myocardial perfusion uptake in the septal and inferior regions and provide uniform distribution of myocardial perfusion. The SSPAC method could be a practical method of attenuation correction without X-ray CT. © 2009 The Japanese Society of Nuclear Medicine.
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木津, 寛人
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金沢大学医学部附属病院 中央放射線部<br />解説
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橋本, 正明 ; 向井, 裕修 ; 塚田, 利幸 ; 宮崎, 吉春 ; 瀧本, 政盛 ; 塩崎, 潤 ; 井上, 寿
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公立能登総合病院 脳神経外科<br />解説
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鈴木, 道雄
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富山医科薬科大学 医学部精神神経医学<br />解説
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松田, 博史
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埼玉医科大学国際医療センター 核医学<br />解説
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汲田, 伸一郎 ; 趙, 圭一 ; 中條, 秀信 ; 鳥羽, 正浩 ; 福嶋, 善光 ; 吉原, 尚志 ; 隈崎, 達夫 ; 佐野, 純子 ; 酒井, 俊太 ; 櫻井, 薫 ; 佐藤, 直樹 ; 田中, 啓治 ; 高野, 照夫
概要:
日本医科大学 放射線科<br />解説
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梶谷, 定志
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兵庫県立姫路循環器病センター 循環器科<br />解説
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土田, 龍郎 ; 出村, 芳樹 ; 伊藤, 春海 ; 米倉, 義晴
概要:
福井大学 医学部放射線科<br />原著論文/症例報告
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